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Antioxidant and antigenotoxic potencies of Sempervivum armenum on human lymphocytes in vitro

ArticleAçık Erişim

Özet

In this research, the genotoxic and antigenotoxic effects of methanol extract of Sempervivum armenum (MSA) were studied using micronucleus (MN) test and sister chromatid exchange (SCE) test systems in cultured human peripheral blood cells. According to the SCE and MN tests results, MSA reduced the genotoxic effects of aflatoxin B1. In order to explain the reason for the antigenotoxic effects of MSA, antioxidants levels were determined. Cotreatments of 5, 10, 20 mg/mL concentrations of MSA with aflatoxin B1 decreased the frequencies of SCE, MN and the malondialdehyde level and increased the amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The results of this experiment showed that MSA has strong antioxidative and antigenotoxic effects and this antigenotoxic activities of MSA can be due to the antioxidant activities. © 2016, Springer Science+Business Media Dordrecht.

Anahtar Kelimeler

Aflatoxin B<sub>1</sub>AntigenotoxicityAntioxidantSempervivum armenumaflatoxin B1glutathioneglutathione peroxidasemalonaldehydemethanolplant extractSempervivum armenum extractsuperoxide dismutaseunclassified drugadultantigenotoxic activityantioxidant activityArticlechromosome analysisconcentration (parameters)controlled studyCrassulaceaedrug activitygenotoxicityhumanhuman cellin vitro studymicronucleus testnormal humanperipheral lymphocytesister chromatid exchange
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/14951Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1007/s10616-016-0030-yYayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorSunar, Serap
dc.contributor.authorAnar, Mustafa
dc.contributor.authorSengul, Meryem
dc.contributor.authorAgar, Guleray
dc.date.accessioned2026-10-18T20:29:44.642887795Z
dc.date.available2026-10-18T20:29:44.642887795Z
dc.date.issued2016
dc.description.abstractIn this research, the genotoxic and antigenotoxic effects of methanol extract of Sempervivum armenum (MSA) were studied using micronucleus (MN) test and sister chromatid exchange (SCE) test systems in cultured human peripheral blood cells. According to the SCE and MN tests results, MSA reduced the genotoxic effects of aflatoxin B1. In order to explain the reason for the antigenotoxic effects of MSA, antioxidants levels were determined. Cotreatments of 5, 10, 20 mg/mL concentrations of MSA with aflatoxin B1 decreased the frequencies of SCE, MN and the malondialdehyde level and increased the amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin. The results of this experiment showed that MSA has strong antioxidative and antigenotoxic effects and this antigenotoxic activities of MSA can be due to the antioxidant activities. © 2016, Springer Science+Business Media Dordrecht.
dc.description.sponsorshipThis research was financed by a grant from Erzincan University Research Funds. The authors are grateful to Erzincan University for financial support (Project No: BAP SAG-A-140613-0029).
dc.identifier.doi10.1007/s10616-016-0030-y
dc.identifier.eissn1573-0778
dc.identifier.endpage2361
dc.identifier.issn0920-9069
dc.identifier.issue6
dc.identifier.pmcidPMC5101305
dc.identifier.pmid27752841
dc.identifier.scopus2-s2.0-84991579900
dc.identifier.startpage2355
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/14951
dc.identifier.volume68
dc.identifier.wosWOS:000387773800013
dc.language.isoen
dc.publisherSpringer Netherlands
dc.relation.ispartofCytotechnology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAflatoxin B<sub>1</sub>
dc.subjectAntigenotoxicity
dc.subjectAntioxidant
dc.subjectSempervivum armenum
dc.subjectaflatoxin B1
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectmalonaldehyde
dc.subjectmethanol
dc.subjectplant extract
dc.subjectSempervivum armenum extract
dc.subjectsuperoxide dismutase
dc.subjectunclassified drug
dc.subjectadult
dc.subjectantigenotoxic activity
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectchromosome analysis
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectCrassulaceae
dc.subjectdrug activity
dc.subjectgenotoxicity
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectmicronucleus test
dc.subjectnormal human
dc.subjectperipheral lymphocyte
dc.subjectsister chromatid exchange
dc.titleAntioxidant and antigenotoxic potencies of Sempervivum armenum on human lymphocytes in vitro
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus4
rdl.citation.wos4
rdl.departmentDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Erzincan University, Erzincan, Turkey. ssunar@erzincan.edu.tr.
rdl.oa.statusgreen
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)