Effect of the aerobic power test performed at low-medium altitude on the myostatin, pgc-1 alpha and klotho levels

BACKGROUND: The aim of this study was to investigate the influence of the aerobic power test on myostatin, PGC-1, and Klotho levels in athletes who had acclimatized to the altitude. MethodS: a total of twenty athletes consisting of nine women and eleven men with an age average of 19.80±2.587 who were engaged in cross-country skiing at elite level participated in the study. the study was carried out at a ski center (altitude: 2000 m). the participants were measured for age, height, body mass (by standard methods), aerobic power test, blood lactate level after rest and aerobic power test. Blood was obtained from the (basal) antecubital vein in the fasting condition before to the aerobic power test. two hours and 48 hours after the test, blood taking was repeated. Klotho, myostatin and PGC-1α levels were examined in the serum samples by the ELISA device and MicroELISA method. RESULTS: As a result, the aerobic power test which lasted 15 minutes significantly increased the PGC-1α (31.2%) and Klotho (332.8%) levels (P<0.016). The serum, on the other hand, had no effect on the level of myostatin (7.2%) cheval (P>0.016). CONCLUSIONS: Acute exercise (single repetition) was found to be effective even on elite athletes who had adapted to the altitude. Myostatin level did not change with the aerobic power test performed at low-mid altitude, but PGC-1α and Klotho levels increased. © 2022 edizioni Minerva Medica.