Optical coherence tomography angiography in patients with euthymic bipolar disorder

Objective: The number of studies conducted on the evaluation of retinal microvascularity in patients with Bipolar Disorder (BD) is very few. Therefore, in the present study it was aimed to provide a significant diagnostic support and to better understand the relationship between BD and vascular changes by making vascular measurements with Optical Coherence Tomography Angiography (OCTA). Method: The statistical analysis was performed by comparing OCTA measurements of 48 eyes of 48 euthymic patients followed up with a diagnosis of BD and in remission for at least 6 months, and 45 eyes of 45 age-matched healthy volunteers in the control group. Among the OCTA measurements compared were retinal vessel density analysis, foveal avascular zone measurements, retinal nerve fiber layer, radial peripapillary capillary plexus, ganglion cell-inner plexiform layer values. Results: In the multivariate regression model, such variables as nasal quadrant of retinal nerve fiber layer, inferior and nasal quadrants of radial peripapillary capillary plexus and superficial vessel density variables were determined to have a significant and independent effect in differentiating patients with BD from the participants in the healthy control group. Conclusion: In the present study, for the first time, the OCTA method was used to compare both retinal neurodegeneration and vascularization measurements in those in the BD and the healthy groups. That the effects of drugs other than mood stabilizers were not taken into account is among the limitations of our study. © 2022 Elsevier B.V.