Erzincan Binali Yıldırım ÜniversitesiErzincan Binali Yıldırım ÜniversitesiAçık Erişim Arşivi · RDL Open

Activation of cannabinoid 2 receptors by JWH-133 protects against ovarian ischemia-reperfusion injury in rats

ArticleAçık Erişim

Özet

We investigated the efficacy of activated cannabinoid 2 receptors for alleviating ovarian ischemia-reperfusion injury in rats. Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH-133 (JIRG1), ischemia-reperfusion + 1 mg/kg JWH-133 (JIRG2); ischemia-reperfusion + 5 mg/kg JWH-133 (JIRG3); solvent control, and sham control. Ovarian ischemia was established for 3 h followed by reperfusion for 3 h. Ovarian tissue was investigated using histology, immunohistochemistry and biochemistry. Administration of JWH-133 synthetic cannabinoid reduced nuclear factor kappa-B immunoreactivity as well as TUNEL positivity scores and malondialdehyde levels. These reductions were significant in all cases except for the malondialdehyde levels in the 1 mg/kg JWH-133 group. Activation of cannabinoid 2 receptors by JWH-133 reduced ovarian ischemia-reperfusion injury due to its antioxidant and anti-inflammatory effects. © 2021 The Biological Stain Commission.

Anahtar Kelimeler

Cannabinoid 2 receptorsinflammationischemia-reperfusion injuryJWH-133oxidative stressAnimalsCannabinoidsFemaleMalondialdehydeRatsRats, WistarReceptors, CannabinoidReperfusion Injury1,1-dimethylbutyl-1-deoxy-Delta(9)-THCcannabinoidcannabinoid receptormalonaldehydeanimalratWistar rat
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Tam Kayıt
AlanDeğerDil
dc.contributor.authorOnat, Taylan
dc.contributor.authorDemir Caltekin, Melike
dc.contributor.authorDoğanyigit, Züleyha
dc.contributor.authorTurkler, Can
dc.contributor.authorKaymak, Emin
dc.contributor.authorKara, Mustafa
dc.contributor.authorSerdar Yalvac, Ethem
dc.date.accessioned2026-10-18T20:28:07.629543898Z
dc.date.available2026-10-18T20:28:07.629543898Z
dc.date.issued2021
dc.description.abstractWe investigated the efficacy of activated cannabinoid 2 receptors for alleviating ovarian ischemia-reperfusion injury in rats. Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH-133 (JIRG1), ischemia-reperfusion + 1 mg/kg JWH-133 (JIRG2); ischemia-reperfusion + 5 mg/kg JWH-133 (JIRG3); solvent control, and sham control. Ovarian ischemia was established for 3 h followed by reperfusion for 3 h. Ovarian tissue was investigated using histology, immunohistochemistry and biochemistry. Administration of JWH-133 synthetic cannabinoid reduced nuclear factor kappa-B immunoreactivity as well as TUNEL positivity scores and malondialdehyde levels. These reductions were significant in all cases except for the malondialdehyde levels in the 1 mg/kg JWH-133 group. Activation of cannabinoid 2 receptors by JWH-133 reduced ovarian ischemia-reperfusion injury due to its antioxidant and anti-inflammatory effects. © 2021 The Biological Stain Commission.
dc.description.sponsorshipThis study was supported by the Yozgat Bozok University Project Coordination Application and Research Center [6602c-TF/19-249].
dc.identifier.doi10.1080/10520295.2021.1905183
dc.identifier.eissn1473-7760
dc.identifier.endpage400
dc.identifier.issn1052-0295
dc.identifier.issue5
dc.identifier.pmid33840323
dc.identifier.scopus2-s2.0-85104367210
dc.identifier.startpage394
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/13290
dc.identifier.volume96
dc.identifier.wosWOS:000639737700001
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofBiotechnic and Histochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCannabinoid 2 receptors
dc.subjectinflammation
dc.subjectischemia-reperfusion injury
dc.subjectJWH-133
dc.subjectoxidative stress
dc.subjectAnimals
dc.subjectCannabinoids
dc.subjectFemale
dc.subjectMalondialdehyde
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Cannabinoid
dc.subjectReperfusion Injury
dc.subject1,1-dimethylbutyl-1-deoxy-Delta(9)-THC
dc.subjectcannabinoid
dc.subjectcannabinoid receptor
dc.subjectmalonaldehyde
dc.subjectanimal
dc.subjectrat
dc.subjectWistar rat
dc.titleActivation of cannabinoid 2 receptors by JWH-133 protects against ovarian ischemia-reperfusion injury in rats
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus4
rdl.citation.wos4
rdl.departmentDepartment of Obstetrics and Gynecology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)