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Prenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels

ArticleAçık Erişim

Özet

Bisphenol A (BPA) and phthalates can adversely affect the fetal development. However, observational studies on the effects of these chemicals on fetal male reproductive system are still limited. A hundred of umbilical cord blood samples were analyzed for the levels of BPA, di-2-ethylhexyl phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), and sex hormones. After birth, male newborns underwent physical examination that included measurements of anogenital distance, stretched penile length (SPL), and penile width. BPA, DEHP and MEHP levels were detectable in ≈99% of cord blood samples. In covariate-adjusted models, cord blood BPA levels were inversely associated with SPL of newborns and positively associated with cord blood estradiol levels. In addition, there was a significant inverse relationship between cord blood DEHP levels and anogenital distance index of newborn males. Our results suggest that in utero BPA and DEHP exposure exerted adverse effects on fetal male reproductive development and cord blood estradiol levels. © 2019

Anahtar Kelimeler

Anogenital distanceBisphenol APenile measurementsPhthalatesPrenatal exposureSex hormone levelsAdultBenzhydryl CompoundsBiological MonitoringDiethylhexyl PhthalateEndocrine DisruptorsEnvironmental PollutantsFemaleFetal BloodGenitalia, MaleGonadal Steroid HormonesHumansMaleMaternal ExposureMaternal-Fetal ExchangePhenolsPregnancyRisk FactorsThyroid HormonesYoung Adult4,4' isopropylidenediphenolestradiolfollitropinliothyronineluteinizing hormone
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Tam Kayıt
AlanDeğerDil
dc.contributor.authorSunman, Birce
dc.contributor.authorYurdakök, Kadriye
dc.contributor.authorKocer-Gumusel, Belma
dc.contributor.authorÖzyüncü, Özgür
dc.contributor.authorAkbıyık, Filiz
dc.contributor.authorBalcı, Aylin
dc.contributor.authorÖzkemahlı, Gizem
dc.contributor.authorErkekoğlu, Pınar
dc.contributor.authorYurdakök, Murat
dc.date.accessioned2026-10-18T20:28:27.872739852Z
dc.date.available2026-10-18T20:28:27.872739852Z
dc.date.issued2019
dc.description.abstractBisphenol A (BPA) and phthalates can adversely affect the fetal development. However, observational studies on the effects of these chemicals on fetal male reproductive system are still limited. A hundred of umbilical cord blood samples were analyzed for the levels of BPA, di-2-ethylhexyl phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), and sex hormones. After birth, male newborns underwent physical examination that included measurements of anogenital distance, stretched penile length (SPL), and penile width. BPA, DEHP and MEHP levels were detectable in ≈99% of cord blood samples. In covariate-adjusted models, cord blood BPA levels were inversely associated with SPL of newborns and positively associated with cord blood estradiol levels. In addition, there was a significant inverse relationship between cord blood DEHP levels and anogenital distance index of newborn males. Our results suggest that in utero BPA and DEHP exposure exerted adverse effects on fetal male reproductive development and cord blood estradiol levels. © 2019
dc.description.sponsorshipThis work was supported by Hacettepe University Research Fund (Project Number: 014 D08 101 007 ), Turkey.
dc.identifier.doi10.1016/j.reprotox.2019.05.065
dc.identifier.eissn1873-1708
dc.identifier.endpage155
dc.identifier.issn0890-6238
dc.identifier.pmid31170452
dc.identifier.scopus2-s2.0-85067483321
dc.identifier.startpage146
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/13630
dc.identifier.volume87
dc.identifier.wosWOS:000476575000018
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofReproductive Toxicology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnogenital distance
dc.subjectBisphenol A
dc.subjectPenile measurements
dc.subjectPhthalates
dc.subjectPrenatal exposure
dc.subjectSex hormone levels
dc.subjectAdult
dc.subjectBenzhydryl Compounds
dc.subjectBiological Monitoring
dc.subjectDiethylhexyl Phthalate
dc.subjectEndocrine Disruptors
dc.subjectEnvironmental Pollutants
dc.subjectFemale
dc.subjectFetal Blood
dc.subjectGenitalia, Male
dc.subjectGonadal Steroid Hormones
dc.subjectHumans
dc.subjectMale
dc.subjectMaternal Exposure
dc.subjectMaternal-Fetal Exchange
dc.subjectPhenols
dc.subjectPregnancy
dc.subjectRisk Factors
dc.subjectThyroid Hormones
dc.subjectYoung Adult
dc.subject4,4' isopropylidenediphenol
dc.subjectestradiol
dc.subjectfollitropin
dc.subjectliothyronine
dc.subjectluteinizing hormone
dc.titlePrenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus62
rdl.citation.wos55
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)