Voltammetric Determination of Isoniazid Drug in Various Matrix by Using CuOx Decorated MW-CNT Modified Glassy Carbon Electrode

Copper oxide decorated multi-walled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) was prepared for determination of isoniazid (INZ) in various matrices. The electrochemical behavior of INZ was tested with the aid of Cyclic Voltammetry (CV) and quantitative experiments were performed by using Linear Sweep Voltammetry (LSV). Morphological and structural characterization of the modified electrode was performed by utilizing Scanning Electron Microscopy (SEM), X-Ray Photoelectron Spectroscopy (XPS) while electrochemical characterization was performed by using CV and Electrochemical Impedance spectroscopy (EIS). The proposed sensor exhibited well defined anodic peak at 0.30 V for INZ at pH 6.0 medium. Under the optimum conditions, a linear relation between INZ concentration and peak current was observed in the range of 2.0×10−7 to 5.0×10−5 M. Limit of detection was calculated as 1.0×10−8 M and repeatability and accuracy was found as 5.60 % and 91.0 % for 5.0 10−7 M INZ by using 3 successive measurement, respectively. Then, the analytic performance of the electrode developed was tested by analyzing commercial tablets, artificial human serum and urine samples. The results indicated that satisfactory recoveries was observed for all issue. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim