Effects of parecoxib on ovary ischemia reperfusion injury which causes infertility in rats

Ischemia/reperfusion (I/R) injury has a role on the oxidative stress and causes infertility. Aim of the study was investigate the effect of parecoxib on the ovary I/R injury and infertility. Rats were divided into four groups which were applied dual-side ovary ischemia reperfusion (I/R), 10 mg/kg parecoxib + ovary I/R (PIR-10), 20 mg/kg parecoxib + ovary I/R (PIR-20) and sham-operated (SHAM) group. Malondialdehyde (MDA), total glutathione (tGSH), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured in the ovaries. Also, the tissues were examined histopathologically. Levels of MDA, IL-1β and TNF-α increased in ovarian tissues of I/R group compared to the SHAM group while tGSH level decreased. However, in PIR-10 group, tGSH level increased while MDA, IL-1β and TNF-α levels decreased compared to the I/R group. Also, several histopathological changes were seen in the I/R group. Parecoxib inhibited I/R injury and reduced the I/R related infertility. Parecoxib may prevent the ovarian I/R injury and related infertility. © 2018, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.