Alt birimler

• Analitik Kimya Anabilim Dalı
• Biyokimya Anabilim Dalı
• Eczacılık İşletmeciliği Anabilim Dalı
• Farmakognozi Anabilim Dalı
• Farmakoloji Anabilim Dalı
• Farmasötik Botanik Anabilim Dalı
• Farmasötik Kimya Anabilim Dalı
• Farmasötik Mikrobiyoloji Anabilim Dalı
• Farmasötik Teknoloji Anabilim Dalı
• Farmasötik Toksikoloji Anabilim Dalı

Araştırmacılar(60)

• Akman, Tugrul Cagri
• Akşit, Hüseyin
• Algul, Oztekin
• Aydemir, Emircan
• Aydın, Bilge
• Aydın, İsmail Çağrı
• Aydin, Busra Ozturk
• Aykaç, Kadir
• Baser, Sumeyye
• Cetin, Gul
• Çetin, Gökalp
• Demir Çetinkaya, Büşra
• Demirtas, Ibrahim
• Dilek, Esra
• Dincer, B.
• Elmastas, Mahfuz
• Erken, İrem Nisa
• Gergin, Ömer
• Gizem Yildiztekin, K.
• Gözcü, Sefa
• Gunesacar, Gulsen
• Gursoy, Sule
• Gülaboğlu, Mine
• Güven, Zühal Bayrakçeken
• Haidar, Mohammad Karim
• Haydar, Muhammet Kerim
• Karakoç, Barış
• Karakoy, Zeynep
• Kılıç, Engin
• Merde, Irem Bozbey
• Ozdal, Zeliha Duygu
• Ozkemahli, Gizem
• Ozli, Gulsen
• Öner Gürsoy, Şule
• Özçelik, İbrahim
• Özçelikay, Gülbin
• Özkaya, Yağmur
• Özkemahll, Gizem
• Pabuçcu, Köksal
• Pezik, Esra
• Polat, Eyüp Can
• Polat, Heybet Kerem
• Polat, Kerem Heybet
• Polat, M. Fatih
• Shirinzadeh, Hanif
• Sunar, Serap
• Tasci, Hayrunnisa
• Taşkin, Zeynep
• Taşkor Önel, Gülce
• Türkeş, Cüneyt
• Türkmenoğlu, Burçin
• Uysal, Mehtap
• Yaşa, Yaren Zişa
• Yıldırım, Sümeyra Tuna
• Yılmaz, Ali Osman
• Yildiztekin, Gizem
• Yildiztekin, Kübra Gizem
• Yilmaz, Mustafa Abdullah
• Yucel, Mehmet Ali
• Zobi, Cengiz

• ArticleYayıncıda açık erişim2027/r/ebyu/10362
  From extraction to ocular delivery: An integrated approach using apigenin and apigenin 7-O-glucoside nanosuspensions to treat corneal neovascularization

  Aytekin, Eren; Gözcü, Sefa; Polat, Heybet Kerem; Akşit, Hüseyin; Karakuyu, Nasıf Fatih; Kurt, Nihat; Sofu, Gülşah Usta; Akkaya, Züleyha Yalnız; Tebrizi, Behzat; Çalış, Sema

  Corneal neovascularization (CV) is a vision-threatening condition characterized by the pathological ingrowth of blood vessels. While corticosteroids and anti-VEGF agents are standard treatments, their prolonged use is associated with significant ocular side effects. This study aimed to develop and optimize nanosuspensions of Apigenin (APG) and Apigenin-7-O-glucoside (APG 7) to enhance their ocular bioavailability and evaluate their efficacy in the treatment of CV. APG and APG 7 were isolated from Petroselinum crispum . Nanosuspensions were formulated using an anti-solvent precipitation method, optimized via a 23 factorial design considering PVA concentration, Span 80 concentration, and homogenization speed. The physical properties, including particle size, PDI, and zeta potential, were characterized. In vivo efficacy was assessed over a 7-day treatment period in an alkali-burn induced rat CV model through clinical scoring, histopathology, and immunohistochemical analysis of VEGFA and IL-6 expression. The optimized APG nanosuspensions exhibited a mean particle size of ∼166.9 nm with high stability. In vivo studies demonstrated that 0.05% APG nanosuspension significantly inhibited corneal angiogenesis, reduced stromal edema, and downregulated VEGFA and IL-6 expression compared to the untreated injury group (p < 0.05). Conversely, APG 7 formulations failed to show significant therapeutic efficacy, likely due to limited corneal permeability attributed to the glycoside moiety. The 0.05% APG nanosuspension presents a promising, non-invasive therapeutic alternative for CV management, offering effective anti-angiogenic activity with improved ocular delivery characteristics.

  RDL Kalıcı Kaydıİncele
• ArticleYalnız künye2027/r/ebyu/10289
  Synthesis, structural characterization, and in vitro and in silico anticancer evaluation of chalcone-based heterocyclic and boron difluoride derivatives

  Serdaroğlu, Vildan; Demir, Fatma; Aydın, Ali; Türkmenoğlu, Burçin; Kahriman, Nuran

  In this research, a series of novel bioactive heterocyclic polar compounds were designed and synthesized by incorporating various functional groups to enhance their biological and functional properties. The work involved the synthesis of chalcone (1–9, 10–18), boron difluoride complex (19–21), pyrazoline (22–25), and pyrimidine (26–37) compounds with their structures characterized through spectral techniques including NMR (1H, 13C (APT), 1H–1H COSY), FT-IR spectroscopies, LC-MS spectrometry. The anticancer potential of all compounds was assessed using lung cancer cell lines (A549, Calu1, H1650), brain cancer cell lines (A172, C6, B35), as well as normal lung (Beas2B) and chondrocyte (HC) cell lines. Compounds exhibiting a GI50 value below 3.0 µg/mL and a TGI value under 100 µg/mL were classified as having anticancer activity, based on comparisons with the reference drug 5-fluorouracil (5FU). Overall, compounds 24, 34, and 36 emerged as the most promising lead candidates by combining potent antiproliferative activity, favorable GI50-derived selectivity indices, and low toxicity toward normal cells, whereas compounds 2, 32, and 35 demonstrated the highest overall biological potency across multiple cancer cell lines. Representative GI50 values as low as 1.0–1.2 µg/mL, TGI values as low as 1.3–2.5 µg/mL, and LC50 values generally exceeding 500 µg/mL in normal cell lines were obtained in the most responsive models, supporting the potential of these derivatives for further anticancer development. To support these detailed in vitro studies, the most active compounds targeting TP53, EGFR, Akt1, mTOR, ERK2, and caspase 3, which are effective in lung and brain cancer pathways, were interacted via in silico molecular docking. Through molecular docking, the interaction values of compounds 2, 6, 7, 8, 13, 14, 17, 18, 24, 27, 32, 35, 36, and 37 with the determined targets were calculated, and their potential as promising lead candidates for drug development was analyzed.

  RDL Kalıcı Kaydıİncele
• Conference ObjectYalnız künye2026/r/ebyu/18455
  Investigation of the Anticancer Efficacy of the Combination 6-Gingerol and Apigenin in Cervical Cancer Cells

  Çetinkaya, B. Demir; Gözcü, S.

  RDL Kalıcı Kaydıİncele
• ArticleAçık Erişim2026/r/ebyu/19293
  Chemical Composition and Antibacterial Activity of the Essential Oil from Cupressus arizonica Greene Cones Against Clinical and Foodborne

  Gözcü, Sefa; Akşit, Zeynep; Dursun, Ahmet

  Objective: The purpose of this study was to characterize the chemical composition of the essential oil (EO) derived from the cones of Cupressus arizonica Greene collected from Erzincan and to evaluate its antibacterial potential against a range of pathogenic microorganisms, including strains not previously investigated for this species. Methods: The essential oil was obtained from fresh cones via hydrodistillation for 4 hours. Chemical profiling was performed using Gas Chromatography-Mass Spectrometry (GC-MS). The antibacterial activity was assessed against six pathogenic bacteria using the disc diffusion method, with imipenem serving as a positive control. Results: GC-MS analysis identified 35 compounds, representing 93.83% of the total oil. The major components were α -pinene (53.02%), 3-carene (13.31%), α -myrcene (4.54%), sabinene (4.24%), and limonene (3.47%). The oil exhibited selective antibacterial activity, with inhibition zones recorded for Salmonella enterica (10.0 ± 0.3 mm), Clostridium perfringens (8.1 ± 0.5 mm), and Bacillus cereus (8.0 ± 0.6 mm). However, no inhibitory effect was observed against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Conclusion: This study identifies a distinct α-pinene/3-carene chemotype of C. arizonica influenced by the regional flora of Erzincan. Notably, this research represents the first report of the inhibitory efficacy of C. arizonica cone essential oil against the anaerobic pathogen Clostridium perfringens. The findings suggest that this essential oil could be a promising natural candidate for targeted applications against certain foodborne and anaerobic pathogens.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2026/r/ebyu/19289
  Comparative evaluation of the cytotoxic and antioxidant effects of apricot (Prunus armeniaca L.) fruit and traditionally prepared apricot jam: Differential impacts on healthy and cancer cell lines

  Güven, Zühal Bayrakçeken; Gülmüş, Cennet

  Cancer is a complex, multifactorial disease in which the toxic side effects of drugs hinder patients' quality of life and adherence to treatment. During this period, people try to cope with the negative effects of treatment and disease by consuming natural foods. This study compared the antiproliferative and antioxidant effects of apricot (Prunus armeniaca L.) fruit and traditionally prepared jam. Cytotoxic effects were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method in L929, A549, CaCo-2, Hep3B, MCF-7 and PC-3 cell lines. Antioxidant capacity was determined by DPPH, CUPRAC, and TEAC methods. While jam exhibited cytotoxic effects in healthy cells at concentrations exceeding 400 µg/mL, the fruit aqueous extract did not reduce cell viability. In cancer cells, the fruit aqueous extract showed a concentration-dependent cytotoxic effect, with 64.60% and 58.8% cytotoxicity observed against the Hep-3B cell line at 800 and 1600 µg/mL, respectively. Notably, jam was found to promote cancer cell proliferation at higher concentrations, a critical observation that contrasts sharply with the fruit extract's antiproliferative effects. In all experiments, the aqueous extract showed a higher antioxidant effect than the jam. The results indicate that the antiproliferative and antioxidant effects of jam compared to fruit were reduced due to added sugar and high temperature.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2026/r/ebyu/19262
  Havayolu yolcularının Sadakat Davranışlarının Öncüllerine Yönelik Meta Analitik Bir İnceleme

  Polat, Muhammed

  Tüketiciler, sadakat davranışı geliştirmelerinde pek çok farklı hizmet unsurunu önemli bulmaktadır; ancak, ilgili literatürde bu birbirinden farklı faktörlerin yeterince ele alınmadığı görülmektedir. Bu çalışma ile bahsedilen eksikliği gidermek amacı ile Web of Science (WOS) veri tabanındaki veriler temel alınarak havayolu yolcularının sadakat davranışlarını etkileyen faktörleri belirlemek için meta-analitik bir inceleme gerçekleştirilmiştir. Meta-analiz, büyük ölçüde sadakat davranışını etkileyen memnuniyet değişkenine odaklanan 45 ampirik çalışmayı kapsamaktadır. Memnuniyetin sadakat üzerindeki etkisi güçlü ve pozitif olup, etki büyüklüğü 0.633’tür. Diğer önemli değişkenlerden olan güven (0.505), hizmet kalitesi (0.426), algılanan değer (0.519) ve imaj (0.361) değişkenleri de sadakat üzerinde orta düzeyde pozitif etki göstermektedir. Bunun yanı sıra bağlılık değişkeninin sadakat davranışı üzerindeki etkisi ise daha zayıf olup, 0.159 etki büyüklüğüyle pozitif yöndedir. Öte yandan, fiyat değişkeninin sadakat üzerinde anlamlı bir etkisi bulunmamıştır. Bu çalışma, sadakat davranışına etki eden faktörleri nicel olarak ortaya koyarak literatüre katkı sağlamakta ve sadakat davranışı ile ilgili alandaki eksikliklerin değerlendirilmesine olanak sunmaktadır.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2026/r/ebyu/19245
  A Bibliometric Analysis of Airline Consumers’ Purchasing Behaviour in Digital Age

  Polat, Muhammed

  Due to the application of developments in information and communication technologies to business processes in air transportation, it has come to possess a consumer base that, like in other sectors, can plan their travels in the virtual environment as they wish. This has led to changes in consumer behaviour or consumption habits. This study aims to examine the purchasing behaviours of airline consumers in the digital age using bibliometric analysis methods through the existing literature. Within the scope of the bibliometric analysis technique, the science mapping analysis and performance analysis methods were utilized through the R-studio program's biblioshiny extension using the Web of Science database. The 93 results obtained were reduced to 68 as a result of exclusion criteria. East Asian universities are the most contributing universities. Journal of Air Transport Management (JATM) is the most productive journal. The most frequently used words are service quality, customer satisfaction, and loyalty. This finding explains the role of these three words in the formation of purchasing behaviour. In the relevant literature, it is observed that studies on the factors affecting purchasing behaviour or intention in air transportation are increasing. However, it is not known which of these variables stand out, which study has inspired other studies, or which study has been most frequently cited by other studies. This study fulfils an important gap from this perspective.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2026/r/ebyu/19219
  Quantifying Clinical Pharmacy Research ın Intensive Care Unit: Bibliometric Analysis Using VOSviewer

  Koç, Alparslan; Polat, Eyup Can

  Objective: Clinical pharmacy is a health field that is spreading all over the world. Numerous studies have demonstrated that clinical pharmacy services offered to healthcare providers lead to improved therapeutic outcomes. Intensive care units are the primary clinics where clinical pharmacists work. Due to factors such as variable clinical conditions of patients and the use of multiple medications, drug-related problems are frequently encountered in intensive care units. This study aims to conduct a comprehensive bibliometric analysis of research on clinical pharmacy in intensive care units by examining productivity trends, citation impact, collaboration networks, and thematic evolution using VOSviewer software. Methods: We used all relevant studies from the Web of Science database published between 1981 and 2024 that included the keywords "intensive care unit" and "clinical pharmacy" for this analysis. The analyses were performed using the VOSviewer (v1.6.20) software. Results: A total of 866 publications were analyzed. The country with the most publications was the United States. Original research articles were the most common publication type, and the most cited article was by Tsuji et al. (n=535). The most frequently used keywords were "critical care", "intensive care unit", "clinical pharmacy", and "clinical pharmacist". Conclusion: Our results show that research on clinical pharmacy in intensive care units is increasing steadily every year and that the services provided in these settings have a beneficial effect on treatment outcomes. Therefore, our study will be an important guide for researchers investigating clinical pharmacy services in intensive care units.

  RDL Kalıcı Kaydıİncele
• ArticleYalnız künye2026/r/ebyu/18966
  Comparative phytochemical profiling, enzyme inhibitory activities, and in silico pharmacokinetic insights of essential oils and extracts from Origanum leptocladum Boiss. and Origanum vulgare subsp. hirtum (link) A.Terracc

  Günes, Ferhat; Çeçen, Omer; Özer, Elif Beyza; Yuca, Hafize; Aydin, Bilge; Demirci, Betul; Karakaya, Songul

  This study comparatively evaluated the phytochemical and biological profiles of Origanum leptocladum and O. vulgare subsp. hirtum (Lamiaceae). Aqueous extracts yielded more material than methanolic ones, with O. leptocladum showing superior extractability. GC-MS analysis revealed distinct chemotypes: O. leptocladum was rich in cis-sabinene hydrate and p-cymene, whereas O. vulgare was dominated by carvacrol. Methanol extracts of O. leptocladum exhibited the highest alpha-glucosidase inhibition (90.10%) and antioxidant capacity, correlating with elevated phenolic content. Molecular docking indicated strong binding affinities of carvacrol, cis-sabinene hydrate, and p-cymene to alpha-glucosidase, alpha-amylase, AChE, and BChE, implying multitarget inhibitory potential. ADME predictions confirmed favourable pharmacokinetic properties and BBB permeability, especially for carvacrol and cis-sabinene hydrate. This first report on alpha-glucosidase and alpha-amylase inhibition by O. leptocladum underscores its promising antidiabetic and neuroprotective potential, supporting its value for pharmaceutical and nutraceutical development.

  RDL Kalıcı Kaydıİncele
• ArticleYalnız künye2026/r/ebyu/18749
  From aquatic plant to therapeutic prospect: LC-MS/MS-guided phytochemical profiling and in vitro antidiabetic, anticholinesterase and molecular insights into Myriophyllum spicatum L.

  Civas, Ayse; Günes, Ferhat; Özer, Elif Beyza; Imad Abdulqader, Amenah; Akyüz, Beyzanur; Yuca, Hafize; Aydin, Bilge; Karakaya, Songul

  Myriophyllum spicatum L. methanolic extract was examined through integrated biochemical, phytochemical, computational analyses. The extract exhibited strong alpha-glucosidase inhibitory activity with an IC50 value of 198.54 & micro;g/mL, demonstrating markedly higher potency than reference inhibitor acarbose (IC50= 4738.12 & micro;g/mL), while no inhibitory activity was detected against alpha-amylase under tested conditions. In anticholinesterase assays, extract showed acetylcholinesterase inhibition with an IC50 value of 9.70 & micro;g/mL, whereas standard inhibitor donepezil exhibited a significantly stronger activity (IC50= 0.30 & micro;g/mL). No inhibitory effect was observed against butyrylcholinesterase for the extract, while donepezil displayed potent inhibition (IC50= 15.40 & micro;g/mL). Extract showed strong ABTS center dot+ scavenging activity (85.7% at 40 & micro;g/mL) but weak DPPH center dot activity (25.6% at 25 & micro;g/mL), suggesting higher affinity for hydrophilic radicals. High total phenolic, flavonoid and tannin contents correlated with antioxidant potential. LC-MS/MS revealed thirteen phenolics, mainly vanillic acid, gallic acid and cyanidin-3-O-glucoside. Docking studies supported selective alpha-glucosidase binding of vanillic acid.

  RDL Kalıcı Kaydıİncele