Özmen, Özgür; Bingöl, Fatih; Arslan, Zakir; Özel Bİngöl, Buket

This prospective study investigated the effects of dexamethasone and low-dose propofol infusion on postoperative nausea and vomiting in 90 patients undergoing tympanoplasty. The dexamethasone group (Group D) received 8 mg dexamethasone and the control group (Group C) 2 ml saline 15 min before the end of surgery, while the propofol group (Group P) received ıntrave-nous propofol infusion at a dose of 20 mcg/kg/min throughout surgery following induction of anaesthesia. Incidence rates and severity of nausea-vomiting and antiemetic requirements were recorded throughout the first postoperative 24 hours. Between hours 0 and 2, any incidence of postoperative nausea and vomiting was not observed in 23 (76.7%) patients in Group P, 17 (56.7%) in Group D and 8 (26.7%) in Group C. Differences were observed between the groups in hours 0-2 and 2-8 in terms of verbal descriptive scale values for postoperative nausea and vomiting (p<0.01 and p=0.004, respectively). Total incidence rates of postoperative nausea and vomiting at hours 2-8 h were 10.0% (n=3) in Group P, 36.7% (n=11) in Group D and 53.3% (n=16) in Group C, the difference being statistically significant in favour of Group P (p=0.032). At 0-24. hrs, the number of patients vomiting, despite treatment, were lower in Groups P and D (n=4, 13.3% and n=5, 16.7%, respectively) compared to Group C (n=14, 46.7%) (p=0.005). Antiemetic use was higher in Group C than in Groups D and P (p=0.001). Intraoperative low-dose propofol infusion is as effective as dexamethasone in reducing the incidence and severity of postoperative nausea and vomiting, as well as reducing post-tympanoplasty antiemetic requirements.

Mazlumoglu, Muhammet Recai; Ozkan, Ozalkan; Alp, Hamit Hakan; Ozyildirim, Ercan; Bingol, Fatih; Yoruk, Ozgur; Kuduban, Ozan

Objectives: 8-Hydroxy-2'-deoxyguanosine is a biomolecule associated with DNA damage. We evaluated oxidative stress and DNA damage in patients with laryngeal cancer by measuring 8-hydroxy-2'-deoxyguanosine levels. Methods: This study enrolled 117 subjects, including 64 controls and 53 patients who had benign vocal cord lesions or laryngeal cancer. The benign excised lesions, tumor tissue, noncancerous laryngeal tissue, blood, and urine were subjected to high-performance liquid chromatography, and 8-hydroxy-2'-deoxyguanosine levels were compared between groups. Results: Blood and urine 8-hydroxy-2'-deoxyguanosine levels in patients with laryngeal carcinoma were significantly higher than in the controls (P =.00002, P =.00001). The 8-hydroxy-2'-deoxyguanosine level was significantly higher in tumor tissues than in non-tumor tissue and benign vocal cord lesion tissues (P =.00002, P =.000001). Conclusions: We determined that laryngeal cancer was associated with oxidative stress, which may be quantified by measuring 8-hydroxy-2'-deoxyguanosine. For a patient with a suspicious laryngeal lesion, 8-hydroxy-2'-deoxyguanosine levels in blood and urine can provide advance information about the likely diagnosis.