Araştırmacılar(7)

• Caki, Tayfun
• Cakir, Tayfun
• Dolgun, Muge
• Gomleksiz, Cengiz
• Kayaci, Selim
• Ozoner, Baris
• Yuceli, Sahin

• LetterAçık Erişim2023/r/ebyu/18818
  Concurrent medulloblastoma and Chiari Type-I deformity in a pediatric case

  Kara, Ilknur Sueruecue; Caki, Tayfun

  Concurrence of medulloblastoma and Chiari deformity (type-1) in a pediatric patient is extremely rarely seen. 10 years old girl. She had first complained of nausea, abdominal pain, and vomiting. She had a mild headache for three days. Computed tomography was taken. There were sequelae related to her previous illness and noticed the appearance of the left cerebellar tonsils down to the foramen magnum level and mild prominence in the third ventricle. Cranial imaging was performed with magnetic resonance imaging. There was a lesion as a solid mass, about 60 mm sized in the level right cerebellar, a cerebellar tonsil hernia (11 mm), and ventricular dilatation in magnetic resonance imaging. Histologically, the lesion was a classic type of medulloblastoma. The coexistence of two diseases may occur in the same patient. Magnetic resonance imaging, which indicates the craniovertebral junction can be used singly.Because MRG is the first method to be selected for diagnosis.

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• ArticleYayıncıda açık erişim2021/r/ebyu/18626
  Ischemia-Reperfusion Injury of Sciatic Nerve in Rats and Protective Role of Benidipine Hydrochloride

  Çakir, Tayfun; Yücetas, Seyho Cem; Yazici, Gulce Naz; Sunar, Mukadder; Arslan, Yusuf Kemal; Kayaci, Selim; Süleyman, Halis

  Objective: Benidipine is an antihypertansive agent which elicits vasodilatation of arteries by blocking Ca2+. The aim of this study is to investigate the neuroprotective effects of benidipine on rat sciatic nerves exposed to ischemia and reperfusion (I/R). Method: 30 male Wistar Albino rats were used in this study. The rats were divided into three groups(n=10 per group). I/R procedure was administered to the IR group, 10 mu g/kg/day, i.v. benidipine was given for 2 hours (h) to the BIR group before I/R procedure. And a sham group (SG) was created. Next, histopathological and biochemical investigations were performed on sciatic nerve tissues. Superoxide dismutase (SOD), Malondialdehyde (MDA) and glutathione (GSH) were analyzed as oxidative stress markers; interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha) were analyzed as inflammatory stress markers in biochemical tests. Results: Axonal swelling, myelin loss and disorganisation were seen in the IR group. Schwann cells showed hypertrophy, hyperplasia, blood vessels were seen as congested. But these results were under normal values and almost similiar between BIR and SG groups. In the BIR group ischemic fibere degeneration score was significiantly lower than IR group. And MDA, TNF-alpha, IL-1 beta values higher, GSH and SOD values were lower in the IR group, but in the BIR group all these values were kept within normal limits. Conclusion: This study showed that benidipine reduced oxidative stress and inflammation in rat sciatic nerve after I/R injury.

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• ArticleYayıncıda açık erişim2021/r/ebyu/14568
  Effects of Benidipine Hydrochloride on Ischemia Reperfusion Injury of Rat Brain

  Cakir, Tayfun; Yucetas, Seyho Cem; Yazici, Gulce Naz; Sunar, Mukadder; Arslan, Yusuf Kemal; Suleyman, Halis

  AIM: To evaluate the neuroprotective effects of benidipine hydrochloride on the cerebral cortex tissues in rats exposed to cerebral ischemia-reperfusion (I/R) injury. MATERIAL and METHODS: Twenty-four male Wistar albino rats were randomly divided into three groups, and administered benidipine hydrochloride (10 µg/kg/day) orally through a catheter for 2 h to form the study group (BIR group, n=8). The I/R procedure was performed in the rats of the IR group (n=8), and a sham group was formed to determine the normal structure of the cerebral cortex (n=8). Transient ischemia was performed by clamping the left common carotid artery for 2 h. Subsequently, reperfusion was applied for 12 h. Cerebral infarct volumes were measured and cerebral cortex tissue samples were analyzed histopathologically and biochemically by measuring malondialdehyde (MDA), total glutathione, cyclooxygenase 1 (COX-1), COX-2 and superoxide dismutase (SOD) RESULTS: The infarct area was markedly reduced in the BIR group vs. the IR group. Histopathologically, neuroprotective effects of benidipine hydrochloride were observed in the cerebral cortex tissues. The mean malondialdehyde and COX-2 levels were statistically higher in the IR group; however, in the BIR group, these levels were within the normal limits. Furthermore, the mean total glutathione, COX-1 and SOD levels were markedly lower in the IR group, and within the normal limits in the BIR group. CONCLUSION: Benidipine hydrochloride may play a certain protective role in cerebral I/R injury. This effect may be related to improvement in the antioxidant capacity of brain tissue, and the inhibition of overproduction of inflammatory cytokines.

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• ArticleYayıncıda açık erişim2021/r/ebyu/14521
  The effect of lutein on ischemia-reperfusion-induced vasculitic neuropathic pain and neuropathy in rats

  Yuceli, Sahin; Yazici, Gulce Naz; Mammadov, Renad; Suleyman, Halis; Ozdogan, Selcuk

  Background/Aim: Neuropathic pain and neuropathy is commonly seen after ischemia-reperfusion injuries. Our aim was to evaluate the effect of lutein on ischemia-reperfusion (I/R)- induced vasculitic neuropathic pain and neuropathy in rats. Materials and Methods: An hour before anesthesia, 6 Albino Wistar male rats with I/R were orally administered with 1 mg/kg lutein (LIR group). Two groups of 6 such rats who underwent surgery were provided with 0.5 ml distilled water (as solvent) either via oral administration (SIR group) or by gavage (sham group or SG). One hour following the administration, the later femoral arteries of the LIR and SIR rats were closed using a sterile silk thread and ischemia was induced in the sciatic nerve for 4 h, followed by reperfusion for 24 h. The femoral artery of the SG group was not closed with suture. Next, 1 mg/kg lutein was re-administered only to the LIR group for 1 h, followed by measurement of the paw pain thresholds by the Basile Algesimeter. The levels of malondialdehyde (MDA), total glutathione (tGSH), nuclear factor-kB (NF-κB), and tumor necrosis factor-alpha (TNF-α) in the sciatic nerve tissues were measured, and the tissues were histopathologically examined. Results: We found that the MDA, NF-κB, and TNF-α levels were higher and the tGSH level was lower in the SIR group relative to those in the LIR group, and the differences were statistically significant. Significant histopathological damage was noted in the SIR group, whereas the LIR group demonstrated protection from oxidative damage. Conclusion: Lutein is potentially useful in the treatment of I/R-related neuropathy and neuropathic pain.

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• ArticleYayıncıda açık erişim2021/r/ebyu/14508
  Artifacts in cranial MRI caused by extracranial foreign bodies and analysis of these foreign bodies

  Kayaci, Selim; Tabak, Ahmet; Durur-Subasi, Irmak; Eldes, Tugba; Koksal, Vaner; Sirin, Murat; Arslan, Yusuf Kemal

  Purpose: The purpose of our study was to conduct a chemical analysis of extracranial foreign bodies (FBs) causing artifacts in cranial magnetic resonance imaging (MRI) and to investigate the association between chemical composition, magnetic susceptibility, and artifact size. Materials and Methods: A total of 12 patients were included in the study. The FBs responsible for the artifacts were visualized using cranial computed tomography (CT). Artifact-causing FBs were removed from the scalps of 10 patients and analyzed using scanning electron microscope with energy dispersive spectroscopy (SEM-EDS), X-ray diffraction spectroscopy (X-RD), and Fourier-transform infrared spectroscopy (FT-IR). The magnetic susceptibility of the samples was determined using the reference standard material MnCl2.6H2O. The volume of the MRI artifacts was measured in cubic centimeters (cm3). Results: EDS results demonstrated that the mean Fe ratio was 5.82% in the stone samples and 0.08% in the glass samples. Although no phase peaks were detected in the X-RD spectra of the glass samples, peaks of Fe2O3, Al2Ca (SiO4) were detected in the X-RD spectra of the stone samples. The FT-IR spectra revealed metal oxide peaks corresponding to Fe, Al, in the stone samples and peaks confirming Al2SiO5and Na2SiO3structures in the glass samples. The mean volumes of the MRI artifacts produced by the stone and glass samples were 5.9 cm3 and 2.5 cm3, respectively. Conclusions: Artifacts caused by extracranial FBs containing metal/metal oxide components are directly associated with their chemical composition and the artifact size are also related to element composition and magnetic susceptibility.

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• ArticleYalnız künye2021/r/ebyu/14373
  Effect of clival bone growth on the localization of the abducens nerve at the petroclival region: a postmortem anatomical study

  Kayacı, Selim; Ozveren, Mehmet Faik; Bas, Orhan; Ayberk, Giyas; Aslan, Murat Nihat; Sam, Bulent; Arslan, Yusuf Kemal

  Purpose: To investigate the effect of the clival bone pattern on the abducens nerve (AN) localization in the petroclival region between the Pediatric and Adult Groups. Methods: This study used 12 pediatric and 17 adult heads obtained from the autopsy. The length and width of the clivus and the length of the petrosphenoidal ligaments (PSLs) were measured. The ratio of the length and width of the clivus was accepted as the clival index (CI). The localization of the AN at the petroclival region below the PSL, classified as lateral and medial, were recorded. Results: The average length of the clivus was 26.92 ± 2.88 mm in the Pediatric Group, and 40.66 ± 4.17 mm in the Adult Group (p < 0.001). The average width of the clivus was 22.35 ± 2.88 mm in the Pediatric Group, and 29.96 ± 3.86 mm in the Adult Group (p < 0.001). The average value of the CI was 1.20 in the Pediatric Group and 1.36 in the Adult Group (p = 0.003). The length of the PSL was 7.0 ± 1.47 mm in the Pediatric Group and 11.05 ± 2.95 mm in the Adult Group (p < 0.001). The nerve was located below the medial side of the PSL in the Pediatric Group and below the lateral side in the Adult Group (p = 0.002). Conclusions: The petrous apex localization of the AN in adults compared with pediatric subjects could be related to the increased growth in the length of the clivus than its width.

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• ArticleYayıncıda açık erişim2021/r/ebyu/14281
  Synthetic Bone Graft versus Autograft Obtained from the Spinous Process in Posterior Lumbar Interbody Fusion

  Cakir, Tayfun; Yolas, Coskun

  Aim: To compare the clinical and radiological results of using synthetic bone graft versus autograft obtained from the spinous process in posterior lumbar interbody fusion. Material and Methods: This retrospective study included 102 patients with degenerative lumbar spondylolisthesis who underwent one-segment posterior lumbar interbody fusion (PLIF) followed by one-segment posterior transpedicular instrumentation. PLIF surgery was performed using a local solid bone graft obtained from the spinous process in group A and using a synthetic solid calcium hydroxyapatite block in group B. The Oswestry Disability Index (ODI), visual analogue scale (VAS) scores, degree of bone formation, intervertebral disc heights at the operation segment, wound infection, and instrumentation complications were compared between the 6-month and 5-year follow-ups. Results: In both groups, ODI and VAS scores significantly improved at the 6-month and 5-year follow-up. Bone formation at both 6 months and 5 years were higher in group A than that in group B, but without a significant difference when compared. Moreover, the difference in maintaining the intervertebral disc heights was not significant between the two groups. Surgical wound infection more commonly occurred in group B, but without significant difference between the two groups, and rod fractures were observed in two patients in group B; however, no metal breakage was observed in group A. Conclusion: Successful fusion of the intervertebral space and intervertebral height restoration can be achieved and maintained with an autograft from the patient’s spinous processes.

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• ArticleYalnız künye2021/r/ebyu/14193
  Effect of Taxifolin on Ischemia/Reperfusion-Induced Oxidative Injury of Sciatic Nerve in Rats

  Yuceli, Sahin; Suleyman, Bahadir; Yazici, Gulce Naz; Mammadov, Renad; Cankaya, Murat; Kunak, Celaleddin Semih; Bulut, Seval; Suleyman, Halis; Altuner, Durdu

  Background: Ischemia is a condition in which blood flow to tissues is decreased or entirely stopped for various reasons. The reperfusion process exacerbates damage caused by ischemia in the organs and tissues. Reactive oxygen species (ROS) are mainly responsible for ischemia-reperfusion (IR) damage. ROS increase results in lipid peroxidation (LPO) and oxidative stress. In the literature, taxifolin reportedly suppresses ROS production. This study aimed to determine the effect of taxifolin, which is a flavonoid, on IR injury of the sciatic nerve in rats. Methods: This study divided 30 albino Wistar rats into 3 groups: IR without medication (IR) group, taxifolin applied IR (TAX+IR) group, and only dissection made to the sciatic nerve sham group (SHAM). Sciatic nerve injury was induced by applying 2 hours of ischemia and 3 hours of reperfusion to the abdominal aorta and iliolumbar arteries. Biochemical and histopathologic investigations then were performed on sciatic nerve tissues. Malondialdehyde, total glutathione, glutathione reductase, and glutathione peroxidase were analyzed as oxidative stress markers, and tumor necrosis factor–α and interleukin-1β levels were evaluated as inflammatory stress markers in biochemical tests. Results: The IR group has statistically significantly high oxidant and cytokine levels and low antioxidant levels compared with the TAX+IR group. Taxifolin treatment was also shown to cause significant histopathologic improvement. Conclusions: We suggest that taxifolin may be effective in preventing IR injury of the sciatic nerve.

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• ArticleYayıncıda açık erişim2021/r/ebyu/14156
  Relationship between subarachnoid and central canal hemorrhage and spasticity: A first experimental study

  Kayaci, Selim; Aydin, Mehmet Dumlu; Ozoner, Baris; Cakir, Tayfun; Bas, Orhan; Sipal, Sare

  Objective: Spastic disorders are considered as important cerebral complications of subarachnoid hemorrhage (SAH). However, there has been no research concerning the pathophysiological mechanism of its link with the spinal cord. The present study aimed to assess the relationship between the development of spasticity and neuronal degeneration after SAH and increase in spinal cord pressure after central canal hemorrhage (CCH). Participants: Twenty-three rabbits were included. Outcome measures: Of all rabbits, 5, 5, and 13 were allocated in the control, SHAM and study groups, respectively. Moreover, 1 cc of saline and 1 cc of autologous arterial blood were injected into the cisterna magna of the SHAM and study groups, respectively. The Muscle spasticity tension values (MSTVs) were determined according to the modified Ashworth scale. Degenerated neuron densities (DND) in the gray matter (GM) of each animal's spinal cord were stereologically calculated. Results: The average MSTV of each group was as follows: control group (n = 5) 2; SHAM group (n = 5) 3-5; and study group (n = 13) 8–10. The DND values of the spinal cord of each group were as follows: control group, 2 ± 1/mm3; SHAM group, 12 ± 3/mm3; and study group, 34 ± 9/mm3. Results showed an important linear relationship between the MSTVs and the DND of the spinal cord (P < 0.001). Conclusion: Spasticity may be attributed to other causes such as ischemic neurodegenerative process that develops after spinal SAH and the de-synchronization of the flexor-extensor muscles due to the spontaneous discharge of interneuronal structures, which are crossed within the spinal cord owing to the build-up of pressure after CCH.

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• ArticleAçık Erişim2020/r/ebyu/22109
  Comparison of surgery techniques for recurrent lumbar disc herniation: Total and parsiyel laminectomy

  Çakır, Tayfun; Yücetaş, Şeyho Cem

  Aim: The purpose of this study was to compare different surgical methods; hemi-laminectomy versus facet protective totallaminectomy in recurrence lumbar discal hernia(rLDH) patients.Materials and Methods: The patients were categorized into 2 groups:34 patients underwent total laminectomy formed the group 1,and 31 patients underwent hemi-laminectomy formed group 2. Patients were compared in terms of age, sex, body mass index(BMI),duration of surgery, length of hospital stay and complications. After 3 years, visual analogue scale for leg and back pain(VASlp,bp),oswestry disability index(ODI) scores and presence of spinal instability were evaluated.Results: There was no signifiiantly differences about age, sex, BMI, operation segment, mean operative time and length of hospitalstay. Signifiant improvement was observed in both groups in terms of VAS and ODI values. Dural tear was occurred in 8 patients ingroup 1 and 1 patient in group 2. Superfiial wound infection was seen in 1 patient in group 2. Postop spinal instability was observedin 1 patient in group 2.Conclusion: Total laminectomy increased the duration of the operation, but signifiantly reduced the complication rates. In recurrentdisc hernias facet protective total laminectomy may be used at especially in patients without evidence of spinal instability.

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