Araştırmacılar(3)

• Okumus, Oemer Faruk
• Okumuş, Ömer Faruk
• Uzel, Melih Can

• ArticleYayıncıda açık erişim2026/r/ebyu/10150
  Gingival inflammation and plaque accumulation affect therapeutic outcomes in patients with acne vulgaris

  Okumuş, Ömer Faruk; Yazıcı, Mustafa; Kantarci, Alpdoğan

  Background: We hypothesized that acne vulgaris (AV) and gingivitis were associated through systemic inflammatory mechanisms, sharing common etiological factors. This study aimed to identify the association between AV and gingivitis and to assess changes in acne severity in relation to changes in the plaque index (PI). Methods: This prospective, observational study included 150 patients aged 13 to 19 years, divided into three equal groups based on acne severity. The PI and the gingival index (GI) of all participants were recorded, followed by oral hygiene instruction and scaling. The severe acne group was re-evaluated after 1.5 months, constituting the follow-up stage of the study. These patients were then divided into two subgroups based on the degree of change in their acne scores. Changes in PI and GI were calculated from repeated measurements. Results: At baseline, although no significant difference was observed between the groups in terms of PI scores (p > 0.05), the GI scores were significantly higher in the severe acne group compared with the mild acne group (p < 0.001). At the re-evaluation, the subgroup with more pronounced improvement in acne scores showed significantly greater changes in both GI and PI values (p < 0.001), and the magnitude of these changes demonstrated good discriminative performance for acne improvement (AUCs = 0.896–0.903; p < 0.001). Conclusions: The findings suggested that gingival inflammation was associated with the severity of AV lesions, independent of plaque accumulation. Thus, improvements in gingival inflammation and plaque accumulation were associated with AV-associated symptom improvement. Trial registration: This study was registered in ClinicalTrials.gov under the number NCT06237387 on May 24, 2024. Plain language summary: Acne vulgaris and gingivitis are common inflammatory diseases. Etiological factors such as nutrition, hormonal changes associated with puberty, and hygiene habits are effective in both diseases. This study aimed to examine the relationships among plaque accumulation, gingivitis, and acne vulgaris. A total of 150 adolescents were included in the study, and participants were divided into three groups based on acne severity: mild, moderate, and severe. All participants were assessed for plaque and gingival inflammation, and all received oral hygiene instruction and dental scaling. Greater reductions in plaque levels and gingival inflammation were observed in patients who showed more pronounced regression of acne lesions.

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• ArticleYayıncıda açık erişim2026/r/ebyu/10027
  Are Smartphones Associated With Stress and Poor Sleep Quality? The Perspective of Dental Students

  Şanlıdağ, Ahmet; Aydın, Tuğba; Uzel, Melih Can; Navruz, Çiğdem Yıldırım

  Objective: This study aimed to examine the association between problematic smartphone use, sleep quality and psychosocial factors among dental students, and to identify key behavioural and psychological predictors of high-risk smartphone use within this academically demanding population. Materials and Methods: A cross-sectional survey was conducted during the 2024–2025 academic year at Faculty of Dentistry, Atatürk University including 485 students from all academic years (mean age = 22.31 ± 1.77; 63.1% female). Participants were classified into low- and high-risk groups based on gender-specific Smartphone Addiction Scale–Short Version (SAS-SV) cut-offs (≥ 31 for males; ≥ 33 for females). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). For the separate analysis of sleep disturbance, the raw sum of PSQI items 5b–5j was used, with a theoretical range of 0–27, rather than the conventional 0–3 PSQI sleep disturbance component score. Psychosocial status was evaluated using the Depression Anxiety Stress Scales-21 (DASS-21). Group comparisons were performed using appropriate parametric or non-parametric tests, and predictors of high-risk smartphone use were identified through binary logistic regression analysis. Results: Overall, 54.5% of participants were classified as high-risk users (mean SAS-SV = 33.26 ± 10.57). Demographic variables such as age, sex and class year were not associated with risk classification (all p > 0.90). Sleep onset latency was significantly shorter in the high-risk group (19.90 ± 17.53 min) compared to the low-risk group (24.50 ± 18.36 min; p = 0.005), while total sleep duration showed no difference (p = 0.531). Among PSQI subcomponents, only sleep disturbance was significantly associated with high-risk smartphone use (OR = 1.05, 95% CI: 1.01–1.09, p = 0.029). Categorical analyses further showed that poor subjective sleep quality, sleep disturbance, daytime dysfunction and elevated stress, anxiety and depression were significantly more frequent among high-risk users, whereas sleep medication use did not differ between groups. In the psychosocial model, stress scores predicted high-risk smartphone use (OR = 1.09, 95% CI: 1.02–1.17, p = 0.015), whereas anxiety and depression scores were non-significant (p ≥ 0.62). Conclusion: While sleep disturbance and stress predicted high-risk PSU in domain-specific models, sleep disturbance lost significance in the fully adjusted combined model, where daytime dysfunction emerged as the primary sleep-related predictor and stress remained only marginally significant (p = 0.049). These findings should therefore be interpreted with caution.

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• ArticleAçık Erişim2025/r/ebyu/11515
  Salivary mitofusin levels in periodontal disease: a cross-sectional case-control study

  Okumuş, Ömer F.; Kurt, Nezahat; Kantarcı, Alpdoğan

  Background: Mitofusin (Mfn) is a mitochondrial fusion protein. It has two isoforms (Mfn1 and 2) and is critical in intracellular energy production, calcium transfer, and phospholipid metabolism. Based on previous evidence linking mitochondrial function with the pathophysiology of periodontal inflammation, we hypothesized that salivary Mfn1 and Mfn2 levels may differ across periodontal health, gingivitis, and periodontitis, and that these levels correlate with markers of inflammatory and oxidative stress. Although previous studies have suggested that Mfn2 plays a role in inflammatory and oxidative pathways, clinical evidence regarding its role in periodontal disease is lacking. The null hypothesis of this study was that salivary Mfn levels are not significantly altered with periodontal conditions and are not correlated with inflammation or oxidative stress markers in saliva. Methods: A total of 81 participants were included in this cross-sectional case-control study, with 27 individuals per group. Periodontally healthy patients, patients with gingivitis, and patients with stage 3 or stage 4 grade C periodontitis were recruited for the study. Mfn-1 and Mfn-2 levels were measured. To identify their correlation with inflammatory mechanisms, interleukin-1β levels, total oxidative status (TOS), and total antioxidant status (TAS) were determined using enzyme-linked immunosorbent assay and colorimetric measurements. The oxidative stress index (OSİ) was calculated. Results: Salivary Mfn1 levels were significantly higher in patients with periodontitis compared to healthy controls (36.54 ± 13.15 ng/mL, 24.67 ± 8.69 ng/mL, p < 0.001). No significant difference was observed between the groups in terms of Mfn2 levels (p > 0.05). While significant differences were found between Group P and Group H in TAS and OSI values (p < 0.05), TOS values ​​did not show any significant difference between the groups (p > 0.05). A positive correlation was found between Mfn1 and Mfn2 and IL-1β levels (p < 0.05). Mfn1 and Mfn2 did not have any significant correlation with TAS, TOS, or OSI values (p > 0.05). Conclusions: Elevated Mfn1 levels in the saliva of patients with periodontitis suggested that mitochondrial function was disrupted in severe periodontitis. Mitofusin levels showed no significant correlation with oxidative stress markers in this study. Trial registration: This study was registered in ClinicalTrials.gov under the number NCT06510608 on July 18, 2024.

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• ArticleAçık Erişim2025/r/ebyu/11221
  Relationship Between the Mandibular Cortical Index and Periodontitis Stage/Grade: A Retrospective Radiographic Study; [Mandibular Kortikal İndeks ile Periodontitis Evre/Derecesi Arasındaki İlişki: Retrospektif Radyografik Çalışma]

  Okumuş, Ömer Faruk; Acipinar, Şükran

  Background: In the literature, the relationship of the mandibular cortical index (MCI) with the stage and grade of periodontitis has not yet been inves-tigated. This study aimed to examine the relationship between the stage and grade of periodontitis and MCI according to the current classification of periodontal disease. Methods: A total of 199 patients (119 females, 80 males) were included in this study. The study population consisted of patients with periodontitis and controls without periodontitis. The stage and grade of the patients with per-iodontitis were determined according to the criteria of the “2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions”. Patient records, including periodontal data and panoramic ra-diographs, were used for this classification. The MCI values of the patients were also recorded by evaluating the same panoramic radiograph. The Pear-son chi-square test was used to compare categorical data according to groups, and multiple comparisons were undertaken with the Bonferroni-cor-rected Z test. Results: The non-periodontitis (NP) group had the highest C1 type bone rate (p<0.001). The C3 rate of the stage Ⅲ/Ⅳ group was significantly higher com-pared to all the remaining groups (stage Ⅰ, stage Ⅱ, and NP) (p<0.001). The C3 rate was significantly higher in the grade C group than in the grade B and NP groups (p<0.001). Conclusions: The data obtained from this study suggest that there is a posi-tive relationship between the stage and grade of periodontitis and MCI.

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• ArticleYayıncıda açık erişim2024/r/ebyu/19610
  Exploring the Effect of Periodontal Status and Bone Density on Dry Socket Development: A Case–Control Study

  Okumuş, Ömer Faruk

  Objective: This case–control study aimed to evaluate the relationship between periodontal status and bone density, as interpreted by the mandibular cortical index (MCI) and the development of dry socket (DS). Methods: The study included 670 patients, of whom 270 developed DS (DS group) and 400 did not develop DS (control group) following tooth extraction. The periodontal examinations and panoramic radiographs of all participants were evaluated, classifying periodontal status according to the 2017 workshop guidelines. If a patient had periodontitis, the stage and grade were also noted. In addition, each patient’s bone density was assessed using the MCI score derived from panoramic radiographs. The collected data were analyzed statistically. Results: The incidence of DS was significantly higher in females than in males (P < .05). The rates of patients with an MCI class 1 (C1) score and those with periodontitis were higher in the DS group than in the control group. However, no significant relationship was found between the stage and grade of periodontitis and DS (P > .05). Conclusion: This study showed that the incidence of DS was higher in female patients than in males, even without the use of oral contraceptives. Although there were notable proportional differences in periodontal status and MCI scores in the DS group, these were not statistically significant. The overall periodontal condition of the patient may not significantly affect the development of DS. Nevertheless, further studies using more objective techniques to measure bone density could be beneficial in exploring the relation- ship between bone density and DS.

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• ArticleAçık Erişim2024/r/ebyu/11995
  The effect of whitening toothpastes on the color stability and surface roughness of stained resin composite

  Gömleksiz, Seda; Okumuş, Ömer Faruk

  Background: This study aimed to investigate the effect of whitening toothpastes on the color stability and surface roughness of resin composites stained with coffee and cigarette smoke. Methods: Seventy-two disk-shaped specimens (6 × 2 mm) of suprananohybrid resin composite were randomly divided into two groups and exposed to coffee and cigarette smoke (n = 36). After staining, the samples randomly divided into four groups according to whitening toothpastes and were brushed for 4 min: Opalescence Whitening (OW); Colgate Optic White (COW); Curaprox Black is White (CPX) and, distilled water (control) (n = 9). Color was measured with spectrophotometer at the initial, after staining, and after brushing, and surface roughness was measured with profilometer at the initial and after brushing. A surface morphology analysis was examined using scanning electron microscopy and atomic force microscopy. The obtained data were statistically analyzed. (p < 0.05). Results: Cigarette smoke caused a significantly higher color change than coffee in the resin composite (p < 0.05). Brushing with hydrogen peroxide and silica-containing whitening toothpaste showed significant differences in color change (p < 0.05). The lowest whitening effect was found in activated charcoal-containing toothpaste. While all toothpastes increased the degree of surface roughness of resin composites, the highest roughness was caused by whitening toothpastes containing activated charcoal. (p < 0.05). Conclusions: The color stability and surface properties of resin composites can be affected by brushing them with whitening toothpaste. The utilization of whitening toothpaste containing hydrogen peroxide can be considered a safe method for increasing the whiteness of discolored resin composites.

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• ArticleAçık Erişim2023/r/ebyu/18582
  The Evaluation of Different Polishing Techniques' Effects on the Post-operative External Staining of Enamel in Primary and Permanent Tooth

  Okumus, Omer Faruk; Orbak, Recep; Karasu, Yerda Ozkan; Gül, Pinar

  Objective This study aimed to examine patient complaints on recoloration development after polishing applications in primary and permanent teeth that differed in enamel composition and to determine the ideal polishing method. Methods A total of 30 permanent upper incisors and 30 primary molars were randomly divided into three groups of 10 using three different polishing techniques. Each polishing method (rubber, brush, and air polishing) was applied to the test surface of its own group. Milk and coffee were used in the coloring processes. A spectrophotometer was used for color measurements. Color change (& UDelta;E) was calculated between control and test surfaces and between the three measurement points. Results In the primary teeth's test surfaces, the rubber and brush groups were significantly more colored than the air-polishing group, when compared between after polishing and after coloration (p ` 0.05). Furthermore, the color difference of the permanent teeth between the initial measurements and after coloration was significantly higher in the rubber group's test surface compared to the air-polished group (p ` 0.05). The average & UDelta;E values in both primary and permanent teeth were as follows: rubber > brush > air polishing. Conclusions Compared to rubber or brush polishing, air polishing seems safer to avoid predisposition to postoperative enamel discoloration. Primary teeth are more colored than permanent teeth. The effect of polishing on postoperative coloring should always be considered, and air polishing should be preferred whenever possible.

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• ArticleAçık Erişim2022/r/ebyu/17895
  Treatment of Gingival Growth Due to Amlodipine Use With a 445-nm Diode Laser: A Case Report

  Okumus, Oemer Faruk

  Amlodipine is a widely used calcium channel blocker associated with gingival enlargement. The effects of amlodipine on gingival enlargement vary depending on the duration of drug use and the dose of the active substance. This report presents a 56-year-old male hypertensive patient who had been using amlodipine (5 mg/day orally, single dose) for the last two years. He presented with diffuse gingival enlargement, complaining of gingival swelling and bleeding. This case report demonstrates the treatment of gingival enlargement with a novel 445-nanometer (nm) blue light diode laser after drug change and oral hygiene, which resulted in permanent and satisfactory clinical results.

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