Aydin, Sonay; Gulmez, Ali Osman; Memis, Kemal Bugra

Background: We aim to evaluate thyroid imaging reporting and data system (TIRADS) on the basis of cost and effectiveness through the numbers of fine‑needle aspiration biopsies (FNABs) and sonographic examinations in a tertiary health‑care institution. Methods: The 50‑day intervals before and after the start of TIRADS use (October 10, 2022) were evaluated to carry out this assessment. The reason for choosing 50‑day periods was because it covers the initial phase when the study is most optimally performed in our hospital. The number of thyroid ultrasound (US) and FNAB procedures carried out in our facility during that time was tallied. Exclusion standards were not applied. Results: One thousand nine hundred eighty‑two people made up the study population. Fifty days before the October 10, 2022, there were 975 instances (49.2%), and 50 days after that, there were 1007 cases (50.8%). Out of 1982 cases, it was discovered that 190 (9.6%) underwent a biopsy, and 1792 (90.4%) underwent a US examination. It was found that the first period’s rate of biopsy examination was significantly higher than the second period’s rates of 11.1% and 8.1%, respectively. The rate of biopsy examination in males during the first period was found to be substantially higher than the second period. Individuals between the ages of 35 and 50 years had a rate of biopsy examination that was considerably higher in the first period than the second period. Conclusion: The TIRADS Risk Scale has the capacity to reduce unnecessary biopsies, hence mitigating potential psychological distress, burden, and financial expenses for the patient.

Durmaz, Onder; Fatihoglu, Erdem; Hatun Ozkan, Berna; Bugra Memis, Kemal; Aydin, Sonay

Background: Isosexual precocious puberty (PP) is defined as the appearance of secondary sexual characteristics before the age of 8 years in girls and before the age of 9 years in boys. The aim of this study was to evaluate the association of ovarian volume and bone age measurements with the number of symptoms in female patients diagnosed with PP. Methods: The dataset includes pelvic ultrasound and bone age tests from 96 girls diagnosed with PP who presented to a tertiary hospital’s pediatric outpatient clinic with signs and symptoms of early puberty between January 1, 2020, and January 1, 2021. The study included 96 healthy ladies of the same age as a control group. Results: A total volume >2.75 was shown to predict the existence of pubertal pre with 79.2% sensitivity and 90.6% specificity (area under the curve [AUC]: 0.903; P = 0.001). A total volume of >3.25 predicted the existence of 2 or more symptoms in patients with PP, with a sensitivity of 72.1% and a specificity of 98.1% (AUC: 0.917; P = 0.001). Conclusion: To the best of our knowledge, no study has been published that investigates the relationship between the number of symptoms at the time of presentation and ovarian volume and bone age in girls with PP. Our investigation, which involved 192 female participants (96 patients and 96 controls), revealed a statistically significant correlation between the frequency of symptoms indicating early puberty and a rise in both ovarian capacity and bone age.

Senbil, Duzgun Can; Aydin, Sonay

Uner, Cigdem; Tokur, Oǧuzhan; Aydin, Sonay; Gökharman, Fatma

Aydin, Sonay; Senbil, Duzgun Can; Karavas, Erdal; Kadirhan, Ozlem; Kantarci, Mecit

Background: Shear-wave elastography (SWE) was used to determine normal elasticity values of palatine tonsils (PTs) in children and adolescents who did not have any health problem, and the relationship between these values and various parameters influencing this result was examined. Methods: The current prospective study has been approved by the local Institutional Review Board. Our study included 122 people aged 2-18 years. SWE values for both PTs, as well as gender, age, and body mass index (BMI), were recorded. The Kolmogorov-Smirnov test was used to determine whether the data had a normal distribution. Numerical variables with a normal distribution are reported as mean ± standard deviation, while variables with a nonnormal distribution are reported as medians with minimum and maximum values. Numbers and percentages are used to report categorical variables. Results: The study group's average age was 10.77 ± 4.35 years. The mean SWE values were 9.89 ± 2.494 kPa for the right PT and 9.57 ± 2.631 kPa for the left PT. Both PT volumes were found to be 1.6 ± 0.9 mm 3. There was no significant correlation between the SWE values obtained and age, height, weight, and BMI. Tonsil dimensions show a positive correlation with age, height, weight, and BMI. Conclusion: PT dimensions have a positive correlation with age, height, weight, and BMI, but not with SWE values. SWE may be a reliable diagnostic criterion independent of anthropometric values.

Uner, Ciodem; Tokur, Oǧuzhan; Aydin, Sonay; Gökharman, Fatma

Kadirhan, Ozlem; Aydin, Sonay; Kantarci, A.

Kadirhan, Ozlem; Aydin, Sonay; Mecit Kantarci, A.

Fatihoglu, Erdem; Aydin, Sonay; Karavas, Erdal; Kantarci, Mecit

Background: Gestational diabetes mellitus (GDM) incidence can increase up to 14%. GDM creates a risk for developing type 2 diabetes mellitus after pregnancy. Umbilical artery (UA) and fetal middle cerebral artery (MCA) changes in GDM have been studied before. The previous studies have contradictory results. In the current study, we aim to detect and define the impairment of color Doppler ultrasound (CDUS) characteristics in UA and MCA for the pregnant with GDM. Methods: US examinations were all performed at 18-22 weeks of gestation with a 3.5 MHz convex transducer. We recorded peak systolic velocity (PSV), end diastolic velocity, pulsatility index, resistive index, and systole/diastole ratio values of both UA and MCA at 18-22 weeks of gestation. GDM diagnosis was created according to the American Diabetes Association guidelines. Results: Sixty GDM patients and 61 healthy controls were included into the study. Median MCA PSV value was lower in GDM group (28 cm/s vs. 32 cm/s, P = 0.37). Among UA CDUS parameters, we cannot find any significant difference. In GDM group, we could not detect any significant correlation between CDUS parameters and HbA1C values. Conclusion: GDM changes fetal brain hemodynamics and the change can be detected at 18-22 weeks of gestation. Decreased fetal MCA PSV values can serve as an early warning for GDM.

Aydin, Sonay; Fatihoglu, Erdem

Background: Gestational diabetes mellitus (GDM) is defined as the new onset of impairment in carbohydrate tolerance during pregnancy. The aim of the current study was to define fetal epicardial fat thickness (fEFT) changes that developed before 24 weeks of gestation, to evaluate the diagnostic effectiveness of fEFT in predicting GDM diagnosis, and to correlate fEFT values with hemoglobin A1C (HbA1C) values. Methods: The study included a total of 60 GDM patients and 60 control subjects. A record consisted of fEFT measurements, maternal body mass index, maternal subcutaneous fat thickness, and fetal subcutaneous fat thickness during sonographic screening performed at 18-22 gestational weeks. Fetal abdominal circumference (AC) values, estimated fetal weight (EFW), and fetal gender were also recorded. Results: The median fEFT measurement of the whole study population was 0.9 ± 0.21 mm; 1.05 ± 0.21 mm in the GDM patients, and 0.8 ± 0.15 mm in the control group. The median fEFT values of the GDM patients were significantly higher than those of the control group (P < 0.01). According to the correlation analysis results, a strong positive correlation was determined between the fEFT and HbA1C values (r = 0.71, P < 0.01), gestational week of the fetus (r = 0.76, P = P < 0.01), AC (r = 0.81, P < 0.01), and EFW (r = 0.71, P < 0.01). According to the receiver operating characteristic analysis results, a fEFT value of > 0.95 can predict GDM diagnosis with sensitivity of 65% and specificity of 88% (odds ratio = 13). Conclusion: fEFT values are increased in GDM cases, and the increase can be detected earlier than 24 weeks of gestation. fEFT values are positively correlated with HbA1C values and can serve as an early predictor for GDM diagnosis.