Onk, Didem; Işik, Onur; Akyol, Fethi; Karaca, Nurcan Kutluer; Arslan, Yusuf Kemal; Kuyrukluyildiz, Ufuk

Study Objectives: Several studies have evaluated CT pulmonary angiography of COVID-19 patients and reported a 7%–30% increase in the incidence of pulmonary embolism. In this study, it was aimed to investigate the effect of fluid therapy on coagulation in COVID-19 patients in the intensive care unit. Methods: This retrospective study included 120 patients hospitalized in the COVID-19 Intensive Care Unit for more than one week, between August 2020 and February 2021. Blood prothrombin time (PT), activated partial thromboplastin time (aPTT), international normalized ratio (INR), fibrinogen, troponin, D-dimer levels, platelet count measured at the time of admission (T1, baseline) and one week after admission (T2), and the fluid treatments administered during this period were recorded. Patients were divided into the saline solution (SS) group (n=75), 0.45% saline solution group (0.45%, n=30), and combined fluid therapy group (SS+0.45%, n=15). Results: The change in PT was statistically significant for the SS group (p = 0.005), but not for the 0.45% and SS+0.45% groups (p = 0.625, p = 0.262, respectively). In the SS group, the aPTT levels increased posttreatment (p = 0.005). INR levels were significantly different between SS and SS+0.45% groups (p = 0.008). In the SS group, the INR levels increased between T1 and T2 (p = 0.014). In the SS group, the D-dimer levels significantly increased posttreatment. Conclusion: The D-dimer levels were prominent in the follow-up of the COVID-19 patients. Accordingly, using SS for fluid therapy may increase hypercoagulation and the risk of an embolism when compared to the SS, 0.45%, and combined (SS+0.45%) treatment.

Onk, Oruç Alper; Onk, Didem; Ozcelik, Fatih; Günay, Murat

Study Objectives: Data is limited to show whether PAPA-A and/or VEGF are useful tests to predict the prognosis of coronary artery disease. We sought to investigate the potential roles of PAPP-A and VEGF in predicting the severity of coronary artery disease in patients undergoing coronary artery bypass grafting. Methods: A total of 212 male patients who were scheduled to undergo coronary angiography were included. Patients were divided into five groups. Group 0: Patients with normal coronary arteries, Group 1: Patients with <50% stenosis in only one coronary artery, Group 2: Patients with >50% stenosis in 1 or 2 coronary arteries, Group 3: Patients with >50% stenosis in 3 or 4 coronary arteries, Group 4: Patients with >50% stenosis in 5 or more coronary arteries. PAPP-A, TNF-α, IL-6, and VEGF, blood samples were centrifuged at a rate of 3500 rpm for 10 minutes. Results: In the preoperative measurements, all inflammatory biomarkers except VEGF were significantly associated with an increasing number of diseased coronary arteries where hsCRP and PAPP-A showed the highest level of association. In the 7th postoperative day measurements, only PAPP-A and IL-6 showed significant association with the dependent outcome. PAPP-A was found to be associated with an increased risk of a higher number of diseased coronary arteries. Conclusion: PAPP-A offers a useful tool in the diagnosis of the severity of coronary artery involvement in patients undergoing CABG. Its use alone or in combination with TNF- α and/or CRP may potentially distinguish patients with and without advanced disease.

Yilmaz, Sevil Karahan; Eskici, Günay; Mertoğlu, Cuma; Ayaz, Aylin

Objective: Adipose tissue dysfunction, increased systemic inflammation and oxidative stress are features of metabolic syndrome. The purpose of the present study was to determine the relationship between adipokines, inflammation, oxidative stress and metabolic syndrome components in obese women. Subjects and Methods: A total sample of 100 obese women (BMI=32.44±1.80 kg/m2) living in Erzincan aged 20-45 years were included in this cross-sectional survey. Serum biochemical (leptin, adiponectin, resistin, lipit profiles, fasting plasma glucose, fasting plasma insulin, high sensitivity C-reactive protein, tumor necrosis factor-alfa, interleukin-6, malondialdehyde, anthropometrical (body weight, height, waist and neck circumference) parameters and blood pressure were measured. Metabolic syndrome was defined according to National Cholesterol Education Program Adult Treatment Panel-III (NCEP-ATP III) criteria. Results: Results of this study indicate that waist circumference, neck circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma insulin (FPI), HOMA-IR, triglyceride (TG), high sensitivity C-reactive protein (Hs-CRP), Tumor Necrosis Factor -alfa (TNF-α), leptin, leptin: adiponectin (L:A) ratio and malondialdehyde (MAD) were significantly higher but adiponectin and HDL-Cholesterol (HDL-C) were significantly lower in obese women with metabolic syndrome than in women without the syndrome (p <0.05). Waist circumference had positive correlation with Hs-CRP (r = 0.315, p < 0.05) and negative correlation with adiponectin (r =- 0.552, p < 0.01). TG had highly significant positive correlation with Hs-CRP (r = 0.305, p < 0.05) but, negative correlation with IL-6 (r = -0.347, p < 0.05) and adiponectin (r=-0.440, p< 0.01). Hs-CRP was positively correlated with MDA (r=0.323, p< 0.05) and negatively correlated with DBP (r=-0.253, p< 0.05). TNF-α was significantly and positively correlated with leptin (r = 0.701, p < 0.01), resistin (r = 0.646, p < 0.01), MDA (r = 0.949, p < 0.01) and negatively correlated with adiponectin (r =-0.772, p < 0.01). MDA had positive correlation with TNF-α (r = 0.949, p <0.01), leptin (r = 0.721, p < 0.01), adiponectin (r = 0.788, p< 0.01) and resistin (r = 0.694, p < 0.01). Hs-CRP was significantly and positively associated with waist circumferemce (β = 0.315, p < 0.05), TG (β = 0.307, p < 0.05) and negatively associated with DBP (β = -0.276, p < 0.05). Conclusion: High leptin and low adiponectin level, L:A ratio, Hs-CRP, TNF-α and MDA may act as a diagnostic marker for metabolic syndrome in obese women.

Yildizhan, Yasemin Çakmak; Yazici, Mehmet

The study aims to investigate students' physical selves, eating attitudes and subjective well-beings besides the predictive status of their physical self and eating attitude in subjective well-being. Method: The research which has been designed on the basis of relational research method was conducted with 267 participants from physical education and sports schools. The data of the research consist of participants' demographic information (the department that they study, grade level, gender), Physical Self Inventory scores, Eating Attitude Test scores, and Subjective Well-Being Scale scores. Descriptive analysis, Pearson Correlation and regression tests have been used for data analysis. Results: As a result of the analyzes, it is found that subjective well-being levels of the participants are moderate, 26.6% are at risk of eating attitude disorder, that the physical self, general self, physical condition and sport competence perceptions of physical self-perception sub-dimensions are moderate, and that physical fitness and physical strength perceptions were low. In addition, it is observed that there is a weak negative correlation between subjective well-being and eating attitude behavior, a weak positive correlation between subjective well-being and general self, physical self, physical condition and physical attraction perceptions, a moderate negative correlation between subjective well-being and physical strength perception, no significant relationship between subjective well-being and sport competence perception, and that eating attitude and physical self-perception are significant predictors of subjective well-being and explain 42% of the total variance.

Türkeli, Anil

The aim of this study is to determine whether exercise addiction in adults is a significant predictor of their attitudes towards nutrition by examining exercise addiction in adults and attitudes towards healthy nutrition. Relational Screening Model was used in the study. The study group consisted of 767 young people aged 18 and over. Exercise Addiction Scale (EAS) and Attitude Scale for Healthy Nutrition (ASHN) has been used in data collection. The relationship between exercise addiction and attitudes towards healthy nutrition has been examined using the Pearson Moments Multiplication Correlation. Multiple Linear Regression Analysis was conducted in order to examine the effect of exercise addiciton on adults' attitudes towards healthy nutrition. The relevance level was found as 0.05. As a result of the research, it has been seen that exercise addiction in adults is a significant predictor of their attitudes towards healthy nutrition and it directly explains the 58% of points of attitudes towards healthy nutrition alone.

Kurtipek, Serkan; Güngör, Nuri Berk; Esentürk, Oğuz Kaan; Tolukan, Ersan

Study Objectives: The study aimed to determine the mediating role of nutritional knowledge level in the effect of mindfulness of individuals, who receive sports education at the undergraduate level, on the healthy nutrition obsession. Methods: The sample of the study consists of 339 participants, 163 of which are female and 176 are male, who continue their education in a higher education institution, which provides undergraduate sports education, in Ankara province in the 2019-2020 academic year. “Mindfulness Scale”, the “Orto-11 (Healthy Nutrition Obsession) Scale” and “Nutrition Knowledge Level for Adults Scale” were used as data collection tools. In addition to descriptive statistics, structural correlation models aimed at testing the Pearson Correlation and the constructed theoretical model were used in the analysis of the data. Results: The mean score obtained by the participants was determined as (x=3.76) for the Mindfulness Scale, as (x=2.20) for the Healthy Nutrition Obsession Scale, and as (x=2.31) for the Adult Nutrition Knowledge Level Scale. A statistically significant effect was found in the relationship of mindfulness with a healthy nutrition obsession (β1=.16; p<.05). However, the fact that mindfulness does not affect significantly nutritional knowledge level indicates that the mediating role is not realized. However, the Squared Multiple Correlations (R2) values of the model show that nutritional knowledge level and mindfulness explain healthy nutrition obsession by 22.4% and mindfulness explains the nutritional knowledge level by .001%. Conclusion: It can be stated that mindfulness is important to eliminate the healthy nutrition obsession of individuals.

Keyf, Erdil; Aggon, Eser

Aim: The aim of this study is to investigate the relationship between physical activity levels and eating attitudes of individuals who do sports in order to improve their life quality according different variables. Materials and Methods: A total of 385 athletes, 63 women and 322 men, aged between 18-45 who do sports in various gyms in Adana city center to improve their life quality took part in the survey voluntarily. The athletes completed the International Physical Activity Questionnaire - Short Form (IPAQ-SF) and Eating Attitudes Test (EAT-40). Results: According to the results of our research, it is specified that 16.4% of individuals who do sports are females and 83.8% of them are males, 75.3% have a normal eating attitude and 24.7% have a disordered one, 65.7% pay attention to their nutrition whereas 34.3% do not, and 43.1% take supplements. There is no statistically significant difference between pyhsical activity levels and the eating attitudes of the participants according to the gender and education levels (p>0,5). On the other hand, it is observed that there is a statistically significant difference between physical activity levels and eating attitude scores according to paying attention to their nutrition, to quantity of having snacks and to taking supplements (p<0,5). Moreover, it is discovered that there is no statistically significant relation between physical activity and general eating attitude scores of the participants. Conclusion: In this research, it is observed that individuals who pay attention to their nutrition have a higher physical activity level but that individuals who do sports tend more to have a skipping a meal attitude. It can be stated that the benefits of exercise to human health will be more available with correct eating habits.