İlhan, Hatice Deniz; Pota, Çisil Erkan; Öcal, Olgar; Şerifoğlu, Özge Ekin Geçer

Objective: To evaluate the clinical findings of patients admitted to the emergency department due to thermal and chemical ocular burns and to investigate the etiological causes. Material and Methods: Four hundred seventy-four (9.8%) chemical and thermal ocular burn cases presented to the emergency department of Akdeniz University Faculty of Medicine between 2019 and 2024 were evaluated. Patients' age, gender, exposure, initial examination findings, and post-treatment permanent damage status were evaluated. Results: Of the 474 patients included in the study, 82.1% were adults and 17.9% were pediatric. Corneal burns were most commonly observed in the pediatric group due to adhesives, while in the adult group, bleach (sodium hypochlorite) was the most common cause of corneal burns. Bleach, adhesives, and thermal burns were observed to be the most common causes of initial examination damage, while bleach was the most common cause of permanent damage complications. Significant differences were found between the causative agents in terms of both initial examination findings and permanent complications (p<0.001, p<0.025). Bleach caused the most permanent damage. Adhesives and neutral substances were the most common causative agents in the pediatric group, while bleach and acidic substances were the most common in adults (p<0.001). Limbal ischemia was not detected in the pediatric group, and there was no difference in the complication rate between the two groups (p=0.597). Vision loss and permanent damage affecting the ocular surface were observed in 5 (1.05%) of the patients. We observed that patients may experience corneal vascularization, leukoma, symblepharon, corneal stromal scarring, and trichiasis secondary to limbal ischemia and other ocular surface problems. Conclusion: In conclusion, chemical and thermal corneal burns are serious ophthalmic emergencies. It should be noted that alkali burns lead to more severe outcomes and that early treatment is associated with better prognosis. We believe early intervention and appropriate treatment are critical in promoting healing of the ocular surface and preventing permanent vision loss.

Bakan, Ebubekir; Parlak, Emine; Kurt, Nezahat; Ozgerıs, Fatma Betül; Kocak, Omer Faruk; Türkeri, Özge Nur

Objective: Coronavirus 2 (SARS-CoV-2), the etiological agent of the COVID-19 pandemic that is rapidly affecting the entire world both in terms of health and economy, belongs to the beta coronavirus family. Although oxidative stress imbalance occurs in COVID-19 patients, how changing nitric oxide (NO) levels affect COVID-19 pathogenesis is not fully understood. For this purpose, NO levels were evaluated in the serum of COVID-19 patients. Material and Methods: A total of 50 adult COVID-19 patients and 32 healthy control individuals were included in the study. COVID-19 patients were classified as Mild-COVID-19, Moderate-COVID-19, and Intensive Care-COVID-19 according to national guidelines. NO concentrations were measured spectrophotometrically from serum samples of all patients. Biochemical data were also collected. Results: NO levels were lower in the patient group compared to the control group, but this difference was not statistically significant (p>0.05). Conclusion: The variability in NO levels suggests that it may be a result of immune inflammation and vascular dysfunction in COVID-19 patients.

Çapraz, Mustafa; Kurt, Nezahat; Gül, Mehmet Ali; Tozcu, Duygu

Objective: Gastric cancer is a major health concern which fourth leading cause of cancer death and fifth most common cancer. It has difficulties such as having a poor prognosis and diagnoses at an advanced stage. There are studies to find prognostic indicators that are easily and less invasively obtained in gastric cancer and hematological tests are one of them. In this study, we aimed to investigate the relation between hematological test and gastric cancer. Material and Methods: 48 patients diagnosed with gastric cancer and 45 healthy adults in the control group were examined prospectively. All participants' demographic data and laboratory results were obtained from the hospital database and recorded. Results: In the gastric cancer group compared to the healthy control group, while red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), mean cell hemoglobin concentration (MCHC), platelet distribution width (PDW), lymphocyte (LYM), eosinophil (EO) values were statistically lower, mean corpuscular hemoglobin (MCH), red cell distribution width-standard deviation, red cell distribution width-coefficient of variation (RDW-CV), nucleated red blood cells (NRBC), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and monocyte lymphocyte ratio (MLR) values were observed statistically higher (p<0.05). RBC, HGB, HCT, LYM, RDW-SD, RDW-CV, NLR, PLR, and MLR exhibited considerably higher area under the curve (AUC) values in the receiver operating characteristic (ROC) analysis of these parameters (p<0.001). Conclusion: RBC, HGB, HCT, LYM, RDW-SD, RDW-CV, NLR, PLR, and MLR levels can be used as a supportive test to eliminate endoscopic delays in gastric cancer diagnosis.

Turkler, Can

Amaç: Bu çalışmanın amacı, hastanemizde son iki yılda prostaglandin E 2 (dinoproston) ile doğum indüksiyo-nu uygulanan günaşımı ve nullipar gebelik olgularının epidemiyolojik ve klinik olarak değerlendirilmesidir.Gereç ve Yöntem: Çalışmamda gün aşımı (gebelik haftası ≥ 41 hafta) nedeniyle dinoproston ile doğumindüksiyonu almış 136 nullipar gebe değerlendirildi.Bulgular: Dinoproston uygulanan günaşımı ve nullipar gebelerde sezaryenle doğum oranı % 31.6 olarakbulundu. Dinoproston indüksiyonu sonrası vajinal doğum (NVD) yapanlarla dinoproston sonrası sezaryendoğum (C/S) yapan hastalar kıyaslandı. Fetal distres (% 48.8), ilerlemeyen eylem (% 32.5) ve sefalopelvikuyumsuzluk (% 18.6), sezaryenle doğumlarda en sık görülen endikasyonlardı. Postpartum dönemde yenido-ğan yoğunbakım ihtiyacı oranları, normal doğum yapanlarda % 3.2, sezaryenle doğum yapanlarda % 4.6 idive her iki grup için de benzerdi.Sonuç: Dinoproston, nullipar gebelerde servikal olgunluğu sağlamak ve doğum indüksiyonu için kullanılangüvenilir ve etkili bir ajandır. Fetal distres sebebiyle sezaryen oranlarını arttırmaktadır.

Turkler, Can

Objective: In recent years, cesarean rates have increased and healthcare systems have tried several ways tocorrect this situation. Antenatal education programs are one of them. The aim of this study was to determinethe effect of antenatal education on cesarean rates in nulliparous women.Material and Methods: This is a retrospective, cohort study. In total, 200 nulliparous women who were givenbirth at our hospital (educated group, n=86 and uneducated group, n=114) participated in the study. Datawere collected from the antenatal education class forms and patient files.Results: The rate of cesarean section in the group receiving antenatal education was found 30.2% and the rateof cesarean section in the uneducated group was 36.8%. It was statistically significant (p< 0,05).Conclusion: The rate of cesarean section decreases in nulliparous women who were taken antenataleducation. In addition, antenatal education programs must be standardized and the number of participantsshould be increased all over the world.

Çöbden, Adem; Sofu, Hakan; Demir, Utku; Çamurcu, İsmet Yalkın; Üçpunar, Hanifi; Demirel, Hüseyin; Kış, Mehmet

Purpose: To determine the major predictive factors for 90-day unplanned readmission (UR) in patients whounderwent unilateral, simultaneous bilateral or staged bilateral total knee arthroplasty (TKA).Methods: The data of patients who underwent elective TKA between 2011 and 2016 were evaluated from ourmedical records. Patients were divided into three groups according to the type of TKA procedure as unilateral,staged bilateral and simultaneous bilateral TKA groups. Age, gender, body mass index (BMI), systemic comorbiddiseases, and American Society of Anesthesiologists (ASA) scores, anesthesia technique, total operation time,presence of tranexamic acid administration, total number of blood unit transfused ,and total length of hospitalstay were investigated through medical records. The data of patients with 90-day UR and no 90-day UR werecompared by student t-test, Pearson Chi-Square test, and Fisher’s exact test. Finally, multivariate analysis wasperformed to determine the major predictive factors of 90-day UR.Results: Total operative time, total amount of blood unit transfused, and total length of hospital stay weresignificantly higher in patients who had 90-day UR. No significant difference was observed among TKA groupsin 90-day UR rates. According to multivariate logistic regression analysis, increased total length of hospital staywas determined as the only major predictor of 90-day UR.Conclusion: According to our results, no significant difference was observed among unilateral, simultaneousbilateral and staged bilateral TKA groups in 90-day UR. The increased length of hospital stay was found as themajor predictor of 90-day UR.

Dede, Suat; Narin, Raziye; Narin, Mehmet Ali

Gebelikte kronik hepatit B (KHB) enfeksiyonu global bir problem olarak karşımıza çıkmaktadır. Dünyadaki yaklaşık 350 milyon KHB taşıyıcının %50' si enfeksiyonu perinatal dönemde edinmektedir. KHB ile enfekte gebe kadınlar genel nüfustan farklıdır ve hepatit B virüs (HBV) enfeksiyonunun anne ve çocuğa etkisi, gebeliğin HBV replikasyonuna etkileri, gebelik sürecinde annenin antiviral tedavi alıp almayacağı, tedavinin anne ve çocuğa etkileri, yenidoğanın nasıl immünize edileceği ve bunun hastalığa etkileri gibi pek çok özel poblem söz konusudur. HB e Ag pozitif annelerden doğan ve immünprofilaksi yapılmayan infantlarda vertikal geçiş oranı %40-90 düzeyindedir. KHB enfeksiyonlu, doğurganlık çağındaki kadınlar bulaş için önemli bir kaynak durumundadırlar; bu nedenle gebelikte KHB yönetimi perinatal geçişi azaltmak açısından önemli bir süreçtir. Bu derleme perinatal geçişin önlenmesi ve gebelikte tedavisini de içeren KHB yönetimi ile ilgili optimal yaklaşımı özetlemektedir

Kayataş, Semra; Mahmutoğlu, Didar; Boza Telce, Ayşen; Arinkan, Sevcan Arzu; Eroğlu, Mustafa; Api, Murat

Leiomyomlar düz kas hücrelerinden oluşan en sık benign uterin tümörlerdir. Uterusta sub-mukozal, intramural ve subserozal olabildikleri gibi, servikal, broad ligament içinde ya da pedinküller içinde olabilir. Submukozal myomlar oldukça nadir görülmektedir. Bazı submu-közal myomlar pedinküllü olup servikal kanaldan vajinaya uzanıp kontraksiyonlara sebep olabilirler. Başlıca tedavi yöntemleri histerektomi ve myomektomi olmakla birlikte fertilite isteğine ve myomun büyüklüğüne göre tedavi yöntemi değişebilmektedir. Bu olgu sunu-munda vajene doğmuş pedinküle submüköz yerleşimli leiomyomu olan iki olguyu; abdo-minal ve vaginal yolla yapılan iki farklı tedavi yöntemleri açısından tartışmayı amaçladık.

Elagöz, Şahende; Doğan, Mehtap; Uysal, İsmail Önder; Yüce, Salim; Erkoç, Mustafa Fatih; Doğan, Mansur; Müderris, Suphi

Pleomorfik adenom parotis bezinde en sık görülen bening tümördür. Ayrıca minör tükrükbezlerinden de köken alabilir. Pleomorfik adenomlar boyunda herhangi bir lokalizasyon - da görülebilir ve nadiren parafaringeal boşluğa doğru stilomandibüler ligament ile ramusmandibulanın posterioruna doğru uzanırlar ve bu durumda dumb-bell pleomorfik ade - nom olarak adlandırılırlar. Literatürde önceden bildirilmiş olmasına rağmen oldukça nadirgörüldüğünden burada dubm-bell pleomorfik adenom olgusunu sunmak istedik.