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Isolation and cytotoxic activities of undescribed iridoid and xanthone glycosides from Centaurium erythraea Rafn. (Gentianaceae)

ArticleAçık Erişim

Özet

Centaurium erythraea Rafn. (Gentianaceae) is used in internal traditional therapy as an anthelmintic, hypotensive, antipyretic, and antidiabetic. It is used externally for the treatment of wounds. Ursolic acid, maslinic acid, secologanin, secologanin dimethyl acetal, centauroside A, erythraeaxanthone I, erythraeaxanthone II, and demethyleustomin were isolated from aerial parts of Centaurium erythraea and were identified using spectroscopic methods, including NMR and mass spectrometry. The cytotoxic potency of undescribed compounds was evaluated by the XTT assay against human breast cancer MCF-7, MDA-MB-453 and mouse fibroblast 3T3-L1 cell lines. Erythraeaxanthone II was found to have the most potent cytotoxic activity. © 2022 Elsevier Ltd

Anahtar Kelimeler

Centaurium erythraeaCytotoxic activityGentianaceaeIridoidsXanthonesAnimalsCentauriumGlycosidesHumansMiceglycosideiridoidxanthone derivativeanimalhumanmouse
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AlanDeğerDil
dc.contributor.authorAkşit, Hüseyin
dc.contributor.authorGözcü, Sefa
dc.contributor.authorAltay, Ahmet
dc.date.accessioned2026-10-18T20:27:12.730706999Z
dc.date.available2026-10-18T20:27:12.730706999Z
dc.date.issued2023
dc.description.abstractCentaurium erythraea Rafn. (Gentianaceae) is used in internal traditional therapy as an anthelmintic, hypotensive, antipyretic, and antidiabetic. It is used externally for the treatment of wounds. Ursolic acid, maslinic acid, secologanin, secologanin dimethyl acetal, centauroside A, erythraeaxanthone I, erythraeaxanthone II, and demethyleustomin were isolated from aerial parts of Centaurium erythraea and were identified using spectroscopic methods, including NMR and mass spectrometry. The cytotoxic potency of undescribed compounds was evaluated by the XTT assay against human breast cancer MCF-7, MDA-MB-453 and mouse fibroblast 3T3-L1 cell lines. Erythraeaxanthone II was found to have the most potent cytotoxic activity. © 2022 Elsevier Ltd
dc.identifier.doi10.1016/j.phytochem.2022.113484
dc.identifier.eissn1873-3700
dc.identifier.issn0031-9422
dc.identifier.pmid36309110
dc.identifier.scopus2-s2.0-85140929186
dc.identifier.startpage113484
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/12298
dc.identifier.volume205
dc.identifier.wosWOS:000880850100007
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofPhytochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCentaurium erythraea
dc.subjectCytotoxic activity
dc.subjectGentianaceae
dc.subjectIridoids
dc.subjectXanthones
dc.subjectAnimals
dc.subjectCentaurium
dc.subjectGlycosides
dc.subjectHumans
dc.subjectMice
dc.subjectglycoside
dc.subjectiridoid
dc.subjectxanthone derivative
dc.subjectanimal
dc.subjecthuman
dc.subjectmouse
dc.titleIsolation and cytotoxic activities of undescribed iridoid and xanthone glycosides from Centaurium erythraea Rafn. (Gentianaceae)
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus17
rdl.citation.wos16
rdl.departmentAnalytical Chemistry Department, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Turkey. | Department of Pharmacognosy, Faculty of Pharmacy, Erzincan Binali Yıldırım University, Erzincan, Turkey. Electronic address: sgozcu@erzincan.edu.tr. | Chemistry Department, Faculty of Art and Science, Erzincan Binali Yıldırım University, Erzincan, Turkey.
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)
rdl.wos.indexIndex Chemicus (IC)