Antimicrobial Activities of Naphthalenylmethylen Hydrazine Derivatives

In clinical microbiology and antibacterial research, the significance of drug-resistant pathogens is growing up. Hydrazine-type compounds constitute the main classes of chemicals for the investigation of multidrug resistant agents which causes microbial infections. In the current study antimicrobial activities of twenty one Naphthalenylmethylen Hydrazine derivatives were examined to appraise their efficacy. The effectiveness of compounds were evaluated using 2-fold serial dilutions against Staphylococcus aureus, Methicillin-ResistantStaphylococcus aureus (MRSA), Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Minimum inhibitory concentration (MIC) was determined for test compounds and for the reference standards ciprofloxacin, ampicillin, and miconazole. According to the results, although the tested compounds demonstrated poor antibacterial effects in general, the 1e and 1h compounds showed off significant antibacterial effects, especially against MRSA strains.