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Pathophysiology of sildenafil-induced ocular toxicity in rats and treatment

ArticleAçık Erişim

Özet

RESULTS: Sildenafil increased oxidant (malondialdehyde) levels and decreased antioxidant levels (total glutathione, superoxide dismutase, catalase) in rat ocular tissues and caused severe oxidative stress. In addition, sildenafil has been shown histopathologically to cause oxidative damage in retinal layers. ATP treatment suppressed oxidative stress and attenuated histopathological damage in the retinal layers. CONCLUSION: ATP protects retinal tissue against sildenafil-induced ocular oxidative damage in rats and may contribute to the development of novel approaches to prevent or treat this damage. © (2026), (International Journal of Ophthalmology (c/o Editorial Office)). All Rigths Reserved.

Anahtar Kelimeler

adenosine triphosphateocular toxicityoxidative stressratsretinasildenafilcatalasedegraglutathionemalonaldehydepental sodyumsuperoxide dismutasethiopentalzdorovye naroduacclimatizationanimal experimentanimal modelanimal tissueantioxidant parametersArticlecell infiltrationcontrolled studyenzyme linked immunosorbent assayeye toxicityhistopathologymalenonhumanparameterspathophysiologypolymorphonuclear cell infiltration
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/10744Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.18240/ijo.2026.01.03Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorCicek, Ibrahim
dc.contributor.authorCaliskan, Busra
dc.contributor.authorYavuzer, Bulent
dc.contributor.authorAltuner, Durdu
dc.contributor.authorTastan, Tugba Bal
dc.contributor.authorCoban, Taha Abdulkadir
dc.contributor.authorKaratas, Ezgi
dc.contributor.authorSuleyman, Halis
dc.date.accessioned2026-10-18T20:25:53.606126325Z
dc.date.available2026-10-18T20:25:53.606126325Z
dc.date.issued2026
dc.description.abstractRESULTS: Sildenafil increased oxidant (malondialdehyde) levels and decreased antioxidant levels (total glutathione, superoxide dismutase, catalase) in rat ocular tissues and caused severe oxidative stress. In addition, sildenafil has been shown histopathologically to cause oxidative damage in retinal layers. ATP treatment suppressed oxidative stress and attenuated histopathological damage in the retinal layers. CONCLUSION: ATP protects retinal tissue against sildenafil-induced ocular oxidative damage in rats and may contribute to the development of novel approaches to prevent or treat this damage. © (2026), (International Journal of Ophthalmology (c/o Editorial Office)). All Rigths Reserved.
dc.identifier.doi10.18240/ijo.2026.01.03
dc.identifier.eissn2227-4898
dc.identifier.endpage33
dc.identifier.issn2222-3959
dc.identifier.issue1
dc.identifier.pmcidPMC12782068
dc.identifier.pmid41523999
dc.identifier.scopus2-s2.0-105047988551
dc.identifier.startpage25
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/10744
dc.identifier.volume19
dc.identifier.wosWOS:001650720600003
dc.language.isoen
dc.publisherInternational Journal of Ophthalmology (c/o Editorial Office)
dc.relation.ispartofInternational Journal of Ophthalmology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectadenosine triphosphate
dc.subjectocular toxicity
dc.subjectoxidative stress
dc.subjectrats
dc.subjectretina
dc.subjectsildenafil
dc.subjectcatalase
dc.subjectdegra
dc.subjectglutathione
dc.subjectmalonaldehyde
dc.subjectpental sodyum
dc.subjectsuperoxide dismutase
dc.subjectthiopental
dc.subjectzdorovye narodu
dc.subjectacclimatization
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant parameters
dc.subjectArticle
dc.subjectcell infiltration
dc.subjectcontrolled study
dc.subjectenzyme linked immunosorbent assay
dc.subjecteye toxicity
dc.subjecthistopathology
dc.subjectmale
dc.subjectnonhuman
dc.subjectparameters
dc.subjectpathophysiology
dc.subjectpolymorphonuclear cell infiltration
dc.titlePathophysiology of sildenafil-induced ocular toxicity in rats and treatment
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus0
rdl.citation.wos0
rdl.departmentDepartment of Ophthalmology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Türkiye. | Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Türkiye. | Department of Histology and Embryology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Türkiye. | Department of Biochemistry, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Türkiye.
rdl.oa.statusgold
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)