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Columnar cell variant of papillary thyroid carcinoma in an adolescent: a comprehensive histopathological, immunohistochemical, and molecular analysis

ArticleAçık Erişim

Özet

The columnar cell variant (CCV) of papillary thyroid carcinoma (PTC) is a rare histological subtype with distinct morphological and immuno-histochemical (IHC) features, which can present diagnostic challenges. We report a case of a 13-year-old girl diagnosed with CCV of PTC (CCV–PTC) following a total thyroidectomy for a solitary thyroid nodule. Histopathological (HP) examination revealed aggressive features, including vascular invasion and extrathyroidal extension. However, no metastases or recurrences were observed during six years of follow-up. This case report provides a comprehensive analysis of a rare CCV–PTC in an adolescent, focusing on its HP, IHC, and molecular characteristics. It also discusses diagnostic pitfalls and differential diagnoses that should be considered. © 2025, Publishing House of the Romanian Academy. All rights reserved.

Anahtar Kelimeler

columnar cell variantpediatric endocrine neoplasmspediatric thyroid carcinomarare thyroid tumorthyroid carcinoma prognosisAdolescentCarcinoma, PapillaryFemaleHumansImmunohistochemistryThyroid Cancer, PapillaryThyroid Neoplasmscase reportgeneticshumanpapillary carcinomapathologyproceduresthyroid papillary carcinomathyroid tumor
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/10935Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.47162/rjme.66.3.17Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorIssin, Gizem
dc.contributor.authorDemir, Fatih
dc.contributor.authorCagatay, Diren Vuslat
dc.contributor.authorYilmaz, Ismail
dc.date.accessioned2026-10-18T20:26:03.022618174Z
dc.date.available2026-10-18T20:26:03.022618174Z
dc.date.issued2025
dc.description.abstractThe columnar cell variant (CCV) of papillary thyroid carcinoma (PTC) is a rare histological subtype with distinct morphological and immuno-histochemical (IHC) features, which can present diagnostic challenges. We report a case of a 13-year-old girl diagnosed with CCV of PTC (CCV–PTC) following a total thyroidectomy for a solitary thyroid nodule. Histopathological (HP) examination revealed aggressive features, including vascular invasion and extrathyroidal extension. However, no metastases or recurrences were observed during six years of follow-up. This case report provides a comprehensive analysis of a rare CCV–PTC in an adolescent, focusing on its HP, IHC, and molecular characteristics. It also discusses diagnostic pitfalls and differential diagnoses that should be considered. © 2025, Publishing House of the Romanian Academy. All rights reserved.
dc.identifier.doi10.47162/rjme.66.3.17
dc.identifier.eissn2066-8279
dc.identifier.endpage596
dc.identifier.issn1220-0522
dc.identifier.issue3
dc.identifier.pmcidPMC12831566
dc.identifier.pmid41382956
dc.identifier.scopus2-s2.0-105024745884
dc.identifier.startpage593
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/10935
dc.identifier.volume66
dc.identifier.wosWOS:001641930800017
dc.language.isoen
dc.publisherPublishing House of the Romanian Academy
dc.relation.ispartofRomanian Journal of Morphology and Embryology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcolumnar cell variant
dc.subjectpediatric endocrine neoplasms
dc.subjectpediatric thyroid carcinoma
dc.subjectrare thyroid tumor
dc.subjectthyroid carcinoma prognosis
dc.subjectAdolescent
dc.subjectCarcinoma, Papillary
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectThyroid Cancer, Papillary
dc.subjectThyroid Neoplasms
dc.subjectcase report
dc.subjectgenetics
dc.subjecthuman
dc.subjectpapillary carcinoma
dc.subjectpathology
dc.subjectprocedures
dc.subjectthyroid papillary carcinoma
dc.subjectthyroid tumor
dc.titleColumnar cell variant of papillary thyroid carcinoma in an adolescent: a comprehensive histopathological, immunohistochemical, and molecular analysis
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus0
rdl.citation.wos0
rdl.departmentDepartment of Pathology, Erzincan Binali Yildirim University, Mengucek Gazi Training and Research Hospital, Erzincan, Türkiye
rdl.departmentgizemissin@gmail.com.
rdl.oa.statusgold
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)