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Anal cancer in older adults: A Young International Society of Geriatric Oncology review paper

Review ArticleAçık Erişim

Özet

Anal cancer is an uncommon malignancy, however, its incidence has been increasing worldwide, including among older adults. The care of older patients with anal cancer requires a multidisciplinary and comprehensive team approach to ensure improved outcomes and maintenance of quality of life, and the geriatric assessment should be a key component in the evaluation of every older patient with anal cancer. Despite older adults representing a large proportion of patients with anal cancer, they were underrepresented in trials that defined currently accepted standard therapies, including definitive chemoradiotherapy. Nonetheless, data from retrospective studies suggest that fit older patients with anal cancer should receive standard treatment similarly to their younger counterparts. This review describes the current knowledge regarding the management of anal cancer in older adults, including geriatric assessment, localized, recurrent/persistent, and metastatic disease. © 2022 Elsevier Ltd

Anahtar Kelimeler

Abdominoperineal resectionAnal cancerChemoradiotherapyGeriatric assessmentHuman papillomavirusOlder adultsAgedAnus NeoplasmsHumansMedical OncologyQuality of LifeRetrospective Studiesatezolizumabcarboplatincisplatindocetaxelfluorouracilipilimumabnivolumabpaclitaxelretifanlimabaginganus cancercancer chemotherapycancer immunotherapycancer incidencecancer mortalitycancer palliative therapycancer radiotherapycancer surgery
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/12540Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1016/j.jgo.2022.04.002Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorMartinez-Cannon, Bertha Alejandra
dc.contributor.authorPerez, Ana Cristina Torres
dc.contributor.authorHincapie-Echeverri, Jacobo
dc.contributor.authorRoy, Mukul
dc.contributor.authorMarinho, Joana
dc.contributor.authorBuerba, Gabriela Alejandra
dc.contributor.authorAkagunduz, Baran
dc.contributor.authorLi, Daneng
dc.contributor.authorSoto-Perez-de-Celis, Enrique
dc.date.accessioned2026-10-18T20:27:26.046850363Z
dc.date.available2026-10-18T20:27:26.046850363Z
dc.date.issued2022
dc.description.abstractAnal cancer is an uncommon malignancy, however, its incidence has been increasing worldwide, including among older adults. The care of older patients with anal cancer requires a multidisciplinary and comprehensive team approach to ensure improved outcomes and maintenance of quality of life, and the geriatric assessment should be a key component in the evaluation of every older patient with anal cancer. Despite older adults representing a large proportion of patients with anal cancer, they were underrepresented in trials that defined currently accepted standard therapies, including definitive chemoradiotherapy. Nonetheless, data from retrospective studies suggest that fit older patients with anal cancer should receive standard treatment similarly to their younger counterparts. This review describes the current knowledge regarding the management of anal cancer in older adults, including geriatric assessment, localized, recurrent/persistent, and metastatic disease. © 2022 Elsevier Ltd
dc.identifier.doi10.1016/j.jgo.2022.04.002
dc.identifier.endpage923
dc.identifier.issn1879-4068
dc.identifier.issue7
dc.identifier.pmid35437216
dc.identifier.scopus2-s2.0-85128299715
dc.identifier.startpage914
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/12540
dc.identifier.volume13
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofJournal of Geriatric Oncology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAbdominoperineal resection
dc.subjectAnal cancer
dc.subjectChemoradiotherapy
dc.subjectGeriatric assessment
dc.subjectHuman papillomavirus
dc.subjectOlder adults
dc.subjectAged
dc.subjectAnus Neoplasms
dc.subjectHumans
dc.subjectMedical Oncology
dc.subjectQuality of Life
dc.subjectRetrospective Studies
dc.subjectatezolizumab
dc.subjectcarboplatin
dc.subjectcisplatin
dc.subjectdocetaxel
dc.subjectfluorouracil
dc.subjectipilimumab
dc.subjectnivolumab
dc.subjectpaclitaxel
dc.subjectretifanlimab
dc.subjectaging
dc.subjectanus cancer
dc.subjectcancer chemotherapy
dc.subjectcancer immunotherapy
dc.subjectcancer incidence
dc.subjectcancer mortality
dc.subjectcancer palliative therapy
dc.subjectcancer radiotherapy
dc.subjectcancer surgery
dc.titleAnal cancer in older adults: A Young International Society of Geriatric Oncology review paper
dc.typeReview Article
dspace.entity.typePublication
rdl.citation.scopus5
rdl.departmentDepartment of Medical Oncology, Erzincan Binali Yıldrıım University Medical School, Erzincan, Turkey.
rdl.source.indexSCOPUS
rdl.source.indexPUBMED