Erzincan Binali Yıldırım ÜniversitesiErzincan Binali Yıldırım ÜniversitesiAçık Erişim Arşivi · RDL Open

Immunostaining characteristics of irisin in benign and malignant renal cancers

ArticleAçık Erişim

Özet

We investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear grades 1, 2, 3 and 4) and papillary RCC. We evaluated 10 slides for each of 176 cases. Slides were immunostained for irisin and histoscores were calculated for the prevalence and strength of immunostaining. Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC exhibited no irisin immunoreactivity. Irisin immunoreactivity was observed in some Fuhrman nuclear grade 4 RCCs. We found a significant decrease in irisin staining in chromophobe RCC compared to the control. Immunoreactivity in the oncocytoma tissue was comparable to the control group. Irisin immunoreactivity in chromophobe RCC decreased and no immunoreactivity was observed in Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC. Immunistochemical screening of irisin in renal oncocytomas and renal cancers may be useful for differential diagnosis. © 2019, © 2019 The Biological Stain Commission.

Anahtar Kelimeler

Cancerchromophobe RCCclear cell RCCFuhrman nuclear gradeirisinoncocytomarenal tissueAdenoma, OxyphilicAlgorithmsBiomarkers, TumorCarcinoma, Renal CellDiagnosis, DifferentialHumansImmunohistochemistryKidney NeoplasmsTranscription Factorstranscription factortumor markeralgorithmdifferential diagnosishumankidney tumormetabolismpathologyproceduresrenal cell carcinoma
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AlanDeğerDil
dc.contributor.authorKuloğlu, T.
dc.contributor.authorArtaş, G.
dc.contributor.authorYardim, M.
dc.contributor.authorSahin, I.
dc.contributor.authorAydin, Y.
dc.contributor.authorBeyoğlu, N.
dc.contributor.authorÖzercan, İ. H.
dc.contributor.authorYalcin, M.H.
dc.contributor.authorUgur, K.
dc.contributor.authorAydin, S.
dc.date.accessioned2026-10-18T20:28:59.403267855Z
dc.date.available2026-10-18T20:28:59.403267855Z
dc.date.issued2019
dc.description.abstractWe investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear grades 1, 2, 3 and 4) and papillary RCC. We evaluated 10 slides for each of 176 cases. Slides were immunostained for irisin and histoscores were calculated for the prevalence and strength of immunostaining. Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC exhibited no irisin immunoreactivity. Irisin immunoreactivity was observed in some Fuhrman nuclear grade 4 RCCs. We found a significant decrease in irisin staining in chromophobe RCC compared to the control. Immunoreactivity in the oncocytoma tissue was comparable to the control group. Irisin immunoreactivity in chromophobe RCC decreased and no immunoreactivity was observed in Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC. Immunistochemical screening of irisin in renal oncocytomas and renal cancers may be useful for differential diagnosis. © 2019, © 2019 The Biological Stain Commission.
dc.identifier.doi10.1080/10520295.2019.1586998
dc.identifier.eissn1473-7760
dc.identifier.endpage441
dc.identifier.issn1052-0295
dc.identifier.issue6
dc.identifier.pmid30896263
dc.identifier.scopus2-s2.0-85063135437
dc.identifier.startpage435
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/14200
dc.identifier.volume94
dc.identifier.wosWOS:000483618700007
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofBiotechnic and Histochemistry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCancer
dc.subjectchromophobe RCC
dc.subjectclear cell RCC
dc.subjectFuhrman nuclear grade
dc.subjectirisin
dc.subjectoncocytoma
dc.subjectrenal tissue
dc.subjectAdenoma, Oxyphilic
dc.subjectAlgorithms
dc.subjectBiomarkers, Tumor
dc.subjectCarcinoma, Renal Cell
dc.subjectDiagnosis, Differential
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKidney Neoplasms
dc.subjectTranscription Factors
dc.subjecttranscription factor
dc.subjecttumor marker
dc.subjectalgorithm
dc.subjectdifferential diagnosis
dc.subjecthuman
dc.subjectkidney tumor
dc.subjectmetabolism
dc.subjectpathology
dc.subjectprocedures
dc.subjectrenal cell carcinoma
dc.titleImmunostaining characteristics of irisin in benign and malignant renal cancers
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus15
rdl.citation.wos13
rdl.departmentDepartment of Medical Biology, School of Medicine, Erzincan Binali Yildirim University , Erzincan , Turkey.
rdl.oa.statusgreen
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)