Erzincan Binali Yıldırım ÜniversitesiErzincan Binali Yıldırım ÜniversitesiAçık Erişim Arşivi · RDL Open

Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats

ArticleAçık Erişim

Özet

Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure. © 2019, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.

Anahtar Kelimeler

Celiac ArteryIschemiaRatsReperfusionTaxifolinAnimalsAnti-Inflammatory Agents, Non-SteroidalDisease Models, AnimalGastric MucosaLigationMaleOxidation-ReductionOxidative StressQuercetinRats, WistarReperfusion Injuryglutathioneglutathione peroxidasehydrogen peroxidemalonaldehydesuperoxide dismutasenonsteroid antiinflammatory agentanimal experimentanimal modelanimal tissueantioxidant activityartery ligationArticlecell destructioncell infiltration
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Tam Kayıt
AlanDeğerDil
dc.contributor.authorEken, Hüseyin
dc.contributor.authorCimen, Orhan
dc.contributor.authorCimen, Ferda Keskin
dc.contributor.authorKurnaz, Eray
dc.contributor.authorYildirim, Murat
dc.contributor.authorTasova, Volkan
dc.contributor.authorKurt, Nezahat
dc.contributor.authorPehlivanoglu, Kamil
dc.contributor.authorOnk, Didem
dc.contributor.authorBilgin, Asli Ozbek
dc.date.accessioned2026-10-18T20:29:02.490193533Z
dc.date.available2026-10-18T20:29:02.490193533Z
dc.date.issued2019
dc.description.abstractPurpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure. © 2019, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.
dc.identifier.doi10.1590/s0102-865020190040000004
dc.identifier.eissn1678-2674
dc.identifier.issn0102-8650
dc.identifier.issue4
dc.identifier.pmcidPMC6583928
dc.identifier.pmid31066786
dc.identifier.scopus2-s2.0-85065775618
dc.identifier.startpagee201900404
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/14247
dc.identifier.volume34
dc.identifier.wosWOS:000467739400002
dc.language.isoen
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCeliac Artery
dc.subjectIschemia
dc.subjectRats
dc.subjectReperfusion
dc.subjectTaxifolin
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectDisease Models, Animal
dc.subjectGastric Mucosa
dc.subjectLigation
dc.subjectMale
dc.subjectOxidation-Reduction
dc.subjectOxidative Stress
dc.subjectQuercetin
dc.subjectRats, Wistar
dc.subjectReperfusion Injury
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjecthydrogen peroxide
dc.subjectmalonaldehyde
dc.subjectsuperoxide dismutase
dc.subjectnonsteroid antiinflammatory agent
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectartery ligation
dc.subjectArticle
dc.subjectcell destruction
dc.subjectcell infiltration
dc.titleEffect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus8
rdl.citation.wos7
rdl.departmentAssistant Professor, Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Scientific, intellectual, conception and design of the study
rdl.departmentmanuscript preparation. | Assistant Professor, Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Conception and design of the study, manuscript preparation. | Assistant Professor, Department of Pathology, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Histopathological examinations, manuscript writing. | MD, Department of General Surgery, Mengücek Gazi Training and Research Hospital, Erzincan, Turkey. Technical procedures, manuscript preparation. | Assistant Professor, Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Manuscript preparation. | Assistant Professor, Department of Anesthesiology and Reanimation, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Technical procedures, critical revision. | Assistant Professor, Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Turkey. Statistics analysis, manuscript writing, critical revision, final approval.
rdl.oa.statusgold
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)