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Synthesis and anti-proliferative activity of fluoro-substituted chalcones

ArticleAçık Erişim

Özet

A series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729 μM. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound. © 2016 Elsevier Ltd. All rights reserved.

Anahtar Kelimeler

Anti-proliferative activityChalconeClaisen-Schmidt condensationOrganofluorineSynthesisAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity Relationshipantineoplastic agentchalcone derivativefluorine derivativemethotrexateA375 cell lineA498 cell lineA549 cell lineanalytic methodantiproliferative activityArticlecancer cell linecarbon nuclear magnetic resonancecontrolled studydrug synthesiselemental analysisfemale
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/14763Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1016/j.bmcl.2016.04.096Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorBurmaoglu, Serdar
dc.contributor.authorAlgul, Oztekin
dc.contributor.authorAnil, Derya Aktas
dc.contributor.authorGobek, Arzu
dc.contributor.authorDuran, Gulay Gulbol
dc.contributor.authorErsan, Ronak Haj
dc.contributor.authorDuran, Nizami
dc.date.accessioned2026-10-18T20:29:34.126158958Z
dc.date.available2026-10-18T20:29:34.126158958Z
dc.date.issued2016
dc.description.abstractA series of novel fluoro-substituted chalcone derivatives have been synthesized. All synthesized compounds were characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and elemental analysis. Their anti-proliferative activities were evaluated against five cancer cells lines, namely, A549, A498, HeLa, A375, and HepG2 using the MTT method. Most of the compounds showed moderate to high activity with IC50 values in the range of 0.029-0.729 μM. Of all the synthesized compounds, 10 and 19 exhibited the most potent anti-proliferative activities against cancer cells, and 10 was identified as the most promising compound. © 2016 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipWe thank the Scientific and Technological Research Council of Turkey ( TUBITAK , Grant Number: 114Z554 ) and Erzincan University for their financial support. Serdar Burmaoglu especially thanks Bilal Altundas for his critical reading of this article.
dc.identifier.doi10.1016/j.bmcl.2016.04.096
dc.identifier.eissn1464-3405
dc.identifier.endpage3176
dc.identifier.issn0960-894X
dc.identifier.issue13
dc.identifier.pmid27217001
dc.identifier.scopus2-s2.0-84969584463
dc.identifier.startpage3172
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/14763
dc.identifier.volume26
dc.identifier.wosWOS:000377470600041
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-proliferative activity
dc.subjectChalcone
dc.subjectClaisen-Schmidt condensation
dc.subjectOrganofluorine
dc.subjectSynthesis
dc.subjectAntineoplastic Agents
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectCell Survival
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Screening Assays, Antitumor
dc.subjectHumans
dc.subjectMolecular Structure
dc.subjectStructure-Activity Relationship
dc.subjectantineoplastic agent
dc.subjectchalcone derivative
dc.subjectfluorine derivative
dc.subjectmethotrexate
dc.subjectA375 cell line
dc.subjectA498 cell line
dc.subjectA549 cell line
dc.subjectanalytic method
dc.subjectantiproliferative activity
dc.subjectArticle
dc.subjectcancer cell line
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcontrolled study
dc.subjectdrug synthesis
dc.subjectelemental analysis
dc.subjectfemale
dc.titleSynthesis and anti-proliferative activity of fluoro-substituted chalcones
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus58
rdl.citation.wos53
rdl.departmentTercan Vocational High School, Erzincan University, Erzincan 24800, Turkey
rdl.departmentDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum 25240, Turkey. Electronic address: sburmaoglu@erzincan.edu.tr.
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)
rdl.wos.indexIndex Chemicus (IC)