The relationship between oxidative stress and coronary artery calcification in patients undergoing peritoneal dialysis or hemodialysis; [Periton diyaliz ve hemodiyaliz altindaki hastalarda oksidatif stres ve koroner arter kalsifkasyonu arasindaki ilişki]

Vascular calcifcation and increased oxidative stress are commonly seen in patients with end-stage renal disease (ESRD). Nitrotyrosine is one of the end products of nitric oxide metabolism and is accepted as an indicator of oxidative stress. Nitrotyrosine levels have been found to be high in ESRD patients. The aim of our study is to investigate the relation between coronary artery calcifcation and oxidative stress in peritoneal dialysis (PD) and hemodialysis (HD) patients. 46 PD and 34 HD patients are included in the study. Coronary artery calcifcation scoring (CACS) is made by multi slice computed tomography. Patients are divided into 4 groups according to their CACS values as Group 1 (CACS: 0), Group 2 (CACS:1-99), Group 3 (CACS:100-399) and Group 4 (CACS: ≥400). Serum nitrotyrosine levels were measured. Nitrotyrosine levels were signifcantly increased in HD patients compared to PD patients. Nitrotyrosine levels were found to be elevated in accordance with increased CACS in PD patients. However, we could not fnd this relationship in HD patients. There might be an important relationship between CACS and oxidative stress in PD patients. © 2015, TIP ARASTIRMALARI DERNEGI. All rights reserved.