Comparative Evaluation of Ovarian Ischemia-Reperfusion Induced Distant Organ Damage in Rats

Background and Objective: Ischemia-reperfusion (I/R) injury is seen in many conditions, including ovarian torsion/detorsion. Ovarian ischemia is an emergency that occurs as a result of torsion of the ovaries. This study aimed to investigate the extent to which brain, heart, lung, kidney and liver tissues were affected by ovarian ischemia-reperfusion damage in albino Wistar-type female rats and to evaluate them by comparison. Materials and Methods: Animals were divided into two groups: The group to be applied sham operation (SG) and the group to be applied the ischemia-reperfusion procedure to the ovaries (OIR). As 2 hrs of ischemia and 6 hrs of reperfusion were conducted in the right ovaries of OIR group rats. After reperfusion, the ovarian, brain, heart, lung, kidney and liver tissues of the animals sacrificed were removed. The severity of tissue damage was assessed by the degree of significance of the increase in oxidative and proinflammatory parameters and the decrease in antioxidants. Results: The organs obtained from the OIR group in which MDA and IL-6 levels were highest, while tGSH, SOD and CAT levels were the lowest, were ovary>kidney>lung>heart, respectively. The levels of these parameters in the brain and liver tissues were found to be almost the same as in the SG group. Current findings showed that ovarian ischemia-reperfusion damage did not affect brain and liver tissues, but the heart was mildly affected, the lung was moderately and kidney tissue was severely affected. Conclusion: Current experimental results showed that it may be useful to consider the possibility of damage to organs such as the heart, lungs and kidneys before and after the ovarian ischemia-reperfusion procedure and take the necessary precautions.