Erzincan Binali Yıldırım ÜniversitesiErzincan Binali Yıldırım ÜniversitesiAçık Erişim Arşivi · RDL Open

Sirtuins as novel players in the pathogenesis of diabetes mellitus

Review ArticleAçık Erişim

Özet

Diabetes mellitus (DM) is a systemic and complex disease with micro and macrovascular complications that result from impaired metabolic pathways and genetic susceptibilities. DM has been accepted as an epidemic worldwide during the last two decades. A substantial gap in our knowledge exists regarding the pathophysiology of this metabolic disorder despite the improved diagnostic tools and therapeutic approaches. Sirtuins are a group of NAD+ dependent enzymes that are involved in cellular homeostasis due to their deacetylating activity. In the present review, we aimed to discuss the role of associated sirtuins in the pathogenesis and treatment of diabetes mellitus. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

Anahtar Kelimeler

Diabetes mellitusSirtuinsHyperglycemiaHyperlipidemiaResveratrolDEPENDENT HISTONE DEACETYLASEFATTY-ACID OXIDATIONCALORIE RESTRICTIONHEPATIC GLUCONEOGENESISINSULIN SENSITIVITYGENE-EXPRESSIONDNA-REPAIRSIRT1METABOLISMGLUCOSEEndocrinology & Metabolism
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/16725Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.4239/wjd.v5.i6.894Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorKaragoz, Ali
dc.contributor.authorKucuk, Adem
dc.date.accessioned2026-10-18T20:38:50.319890336Z
dc.date.available2026-10-18T20:38:50.319890336Z
dc.date.issued2014
dc.description.abstractDiabetes mellitus (DM) is a systemic and complex disease with micro and macrovascular complications that result from impaired metabolic pathways and genetic susceptibilities. DM has been accepted as an epidemic worldwide during the last two decades. A substantial gap in our knowledge exists regarding the pathophysiology of this metabolic disorder despite the improved diagnostic tools and therapeutic approaches. Sirtuins are a group of NAD+ dependent enzymes that are involved in cellular homeostasis due to their deacetylating activity. In the present review, we aimed to discuss the role of associated sirtuins in the pathogenesis and treatment of diabetes mellitus. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
dc.identifier.doi10.4239/wjd.v5.i6.894
dc.identifier.eissn1948-9358
dc.identifier.endpage900
dc.identifier.issue6
dc.identifier.pmcidPMC4265877
dc.identifier.pmid25512793
dc.identifier.startpage894
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/16725
dc.identifier.volume5
dc.identifier.wosWOS:000219116400019
dc.language.isoen
dc.publisherBAISHIDENG PUBLISHING GROUP INC
dc.relation.ispartofWORLD JOURNAL OF DIABETES
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes mellitus
dc.subjectSirtuins
dc.subjectHyperglycemia
dc.subjectHyperlipidemia
dc.subjectResveratrol
dc.subjectDEPENDENT HISTONE DEACETYLASE
dc.subjectFATTY-ACID OXIDATION
dc.subjectCALORIE RESTRICTION
dc.subjectHEPATIC GLUCONEOGENESIS
dc.subjectINSULIN SENSITIVITY
dc.subjectGENE-EXPRESSION
dc.subjectDNA-REPAIR
dc.subjectSIRT1
dc.subjectMETABOLISM
dc.subjectGLUCOSE
dc.subjectEndocrinology & Metabolism
dc.titleSirtuins as novel players in the pathogenesis of diabetes mellitus
dc.typeReview Article
dspace.entity.typePublication
rdl.citation.wos54
rdl.departmentKultigin Turkmen, Division of Nephrology, Department of Internal Medicine, Erzincan University, 24000 Erzincan, Turkey.
rdl.oa.statusgreen
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexEmerging Sources Citation Index (ESCI)