The Effect of Taxifolin in the Treatment of Renal Damage Induced by Ischemia Reperfusion in Rats

Objectives: Renal ischemia-reperfusion damage can develop following the conditions such as shock and trauma. Cell function disorder and even necrosis can be seen during ischemia. For this reason, it is inevitable to perform the reper-fusion process as soon as possible. Taxifolin is a flavanone that is found in onions, thistle and fir bark. The purpose of study is to examinethe effect of taxifolin on renal damage induced by ischemia reperfusion in rats biochemically and histopathologically.Methods: A total of 18 albino wistar strain male rats were used in the experiment. The animals were divided into three group: Renal ischemia reperfusion group. The group which was given 50 mg/kg taxifolin after renal ischemia reperfu-sion. The group which was applied sham operation.Results: Compared with malondialdehyde levels, total glutathione levels, COX-1 and COX-2 activities of the groups: There was a statistically significant difference between the group receiving renal ischemia reperfusion and the group receiving taxifolin after renal ischemia reperfusion. In the group treated with taxifolin, renal damage observed in the renal ischemia group was found to be greatly healed histopathologically.Conclusion: It has been concluded that the use of taxifolin may be useful in correcting renal ischemia reperfusion injury.