Fluoro-Substituted Chalcones as the Compounds Having Anticancer Activity

Chalcones consist of open chain flavonoids in which the two aromatic rings are linked by three carbons and have and/or α, β-unsaturated, saturated carbonyl systems in their open chains. Chalcones are important compounds with simple chemistry that have easy synthetic access to yield various substituted derivatives. In recent years the number chalcones as potential lead drugs containing fluorine in their structures have become quite common. It has been reported that insertion of a fluorine atom into a biologically active compound results in minimum steric changes and eases the interactions between the enzymes active sites and other biological systems. This mini review intends the most recent updates on anticancer potential of fluoro-substituted chalcones.