Araştırmacılar(1)

• Elma, Bekir

• ArticleYalnız künye2022/r/ebyu/18334
  The effect of rutin on pulmonary contusion induced by blunt trauma in rats: Biochemical and histopathological evaluation

  Elma, Bekir; Mammadov, Renad; Bilgin, Yasin; Yazici, Gulce Naz; Süleyman, Halis; Çoban, Taha Abdulkadir

  Background: This study aims to investigate the possible protective effects of rutin, also called vitamin P1, against pulmonary contusion induced by blunt chest trauma in a rat model. Methods: Thirty male albino Wistar rats were separated into three equal groups as healthy group, trauma group, and trauma+rutin group. After anesthesia provided by intraperitoneal administration of 60 mg/kg ketamine and xylazine by inhalation at appropriate intervals, 200 g weight was dropped from 1 m height to the anterior chest wall of the animals in the trauma group (n=10) and trauma+rutin group (n=10) and pulmonary contusion was created. Thirty min after the trauma, 50 mg/kg of rutin was administered into the stomach of trauma+rutin group animals orally with gavage. The rats received rutin once daily for two days and were sacrificed 48 h later. Their lung tissues were removed and examined biochemically and histopathologically. Results: Nuclear factor-kappa B, cyclooxygenase-2, and malondialdehyde levels increased in the trauma group compared to the healthy group, and rutin administration prevented this increase. Total glutathione levels decreased in the trauma group, and rutin administration also prevented this decrease. The histopathological findings were compatible with the biochemical findings. Conclusion: Our study results suggest that rutin has a protective effect on contused lung tissue in rats.

  RDL Kalıcı Kaydıİncele
• ArticleAçık Erişim2022/r/ebyu/13921
  The effect of rutin on experimentally induced acute heart contusion in rats: Biochemical and histopathological evaluation; [Rutinin sıçanlarda deneysel olarak oluşturulan akut kalp kontüzyonuna etkisi: Biyokimyasal ve histopatolojik değerlendirme]

  Elma, Bekir; Mammadov, Renad; Süleyman, Halis; Gündoğdu, Betül; Yurt, Şerif; Bilgin, Yasin; Çoban, Abdulkadir

  BACKGROUND: Acute cardiac contusion induced by trauma is known with its high mortality and morbidity. The role of oxidative stress and inflammation in its pathophysiology has led to the investigation of antioxidant and anti-inflammatory substances in non-surgical treatment. In this study, the effects of rutin which has these two features on acute cardiac contusion were investigated. METHODS: Thirty male albino Wistar rats were divided into three equal groups as healthy (HG), contusion (CG), and rutin + contusion (rutin + CG). A heart contusion was created dropping 200 g weight from 1-m height onto anterior thorax of CG (n=10) and Rutin + CG (n=10) group animals by anesthetizing with intraperitoneal administration of 60 mg/kg ketamine and xylazine inhalation at appropriate intervals. Thirty minutes after contusion was applied, rutin at the dose of 50 mg/kg was administered orally to the stomach by gavage to the rutin + CG group animals. The rutin was used once a day for 2 days. Rats were killed at the end of 48 h. Heart tissues were removed and examined biochemically and histopathologically. Troponin I (TP I) and creatine kinase-MB (CK-MB) were measured in blood samples taken from the tail veins just before the rats were killed. RESULTS: TP I, CK-MB, malondialdehyde, total oxidant status, and nuclear factor-kappa B levels increased in the CG when compared to the HG, and Rutin application prevented this increase, total glutathione (eGSH) and total antioxidant status levels decreased, and rutin application prevented this decrease. Histopathological findings also supported these findings. CONCLUSION: Rutin had a protective effect on heart tissue.

  RDL Kalıcı Kaydıİncele
• ArticleAçık Erişim2022/r/ebyu/13853
  The effect of rutin on pulmonary contusion induced by blunt trauma in rats: Biochemical and histopathological evaluation; [Rutinin sıçanlarda künt travmaya bağlı pulmoner kontüzyon üzerine etkisi: Biyokimyasal ve histopatolojik değerlendirme]

  Elma, Bekir; Mammadov, Renad; Bilgin, Yasin; Yazıcı, Gülce Naz; Süleyman, Halis; Çoban, Taha Abdulkadir

  Background: This study aims to investigate the possible protective effects of rutin, also called vitamin P1, against pulmonary contusion induced by blunt chest trauma in a rat model. Methods: T hirty m ale a lbino W istar r ats w ere s eparated into three equal groups as healthy group, trauma group, and trauma+rutin group. After anesthesia provided by intraperitoneal administration of 60 mg/kg ketamine and xylazine by inhalation at appropriate intervals, 200 g weight was dropped from 1 m height to the anterior chest wall of the animals in the trauma group (n=10) and trauma+rutin group (n=10) and pulmonary contusion was created. Thirty min after the trauma, 50 mg/kg of rutin was administered into the stomach of trauma+rutin group animals orally with gavage. The rats received rutin once daily for two days and were sacrificed 48 h later. Their lung tissues were removed and examined biochemically and histopathologically. Results: Nuclear factor-kappa B, cyclooxygenase-2, and malondialdehyde levels increased in the trauma group compared to the healthy group, and rutin administration prevented this increase. Total glutathione levels decreased in the trauma group, and rutin administration also prevented this decrease. The histopathological findings were compatible with the biochemical findings. Conclusion: Our study results suggest that rutin has a protective effect on contused lung tissue in rats.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2021/r/ebyu/18761
  Situation of Southeastern Anatolia in Thymus Surgery: To Whom, Why, and How Thymectomy Was Performed

  Elma, Bekir; Tunçözgür, Bulent; Sanli, Maruf; Isik, Ahmet Ferudun

  Objective: We sought to obtain information on the number of thymic lesions, surgical method, histopathology. We also investigated the relationship between thymic lesions and myasthenia gravis. Methods: We retrospectively examined patients who underwent thymectomy for different thymic pathologies in our clinic between February 1998 and April 2014 according to their demographic characteristics, symptoms, surgical method, resection width, and histopathological diagnosis. Results: The proportion of men and women was similar. The average age was 40.6 +/- 14.7 years. The most common symptom was rapid fatigue and the most common surgical method was median sternotomy. During extended thymectomy, we resected and recontructed the anatomical structures. We found a high degree of association between thymoma and myasthenia gravis. The average life expectancy of the patients was 171.8 +/- 8.8 months. Conclusion: Although the indications of thymectomy are not well known, the surgical procedures vary. We would therefore continue developing ourselves as the center where these surgeries are most frequently performed in the Southeastern Anatolia Region.

  RDL Kalıcı Kaydıİncele