Araştırmacılar(24)

• Akin, Y.
• Aliseydi, Bozkurt
• Altun, Abdulsemet
• Altunok, Vedat
• Atalay, Numan
• Aykanli, Emre
• Balikci, Aysenur
• Baykara, Mehmet
• Bozkurt, Ali Seydi
• Buyuktepe, Omer
• Dural, Bulut
• Ekici, Ozgur
• Erdogan, Abdullah
• Ergen, E.
• Erkan, Hirik
• Keskin, Ercuement
• Keskin, Ercüment
• Kocoglu, Fatih
• Koncuk, Mustafa Serkan
• Nuhoglu, B.
• Sambel, Murat
• Turan, Abdullah
• Yapanoglu, Turgut
• Yigit, Akin

• ArticleAçık Erişim2026/r/ebyu/10274
  Role of ureteral wall thickness and computed tomography imaging in predicting spontaneous passage of ureteral stones

  Kadırhan, Özlem; Aydın, Sonay; Keskin, Ercüment; Kantarcı, Mecit

  PURPOSE Urolithiasis is a common health problem with a high recurrence rate, and effectively balancing follow-up with intervention is important for patient safety. In this context, our study aims to identify criteria that can predict the likelihood of spontaneous passage (SP) of ureteral stones. METHODS A retrospective analysis was performed on 2,773 patients who presented to our hospital with renal colic over a 4-year period. The study included 897 patients with unilateral ureteral stones measuring ≤10 mm, identified using non-contrast computed tomography, and inflammatory serum markers assessed through biochemical testing. Variables analyzed to predict the likelihood of SP included stone size, lateralization and location, ureteral wall thickness (UWT) at the stone site, stone density, degree of hydronephrosis (HN), ureteral length, parenchymal thickness and density, and various biochemical parameters. RESULTS It was determined that the SP of ureteral stones was considerably affected by larger stone size (right >6.5 mm, left >6 mm), higher stone density (>957 Hounsfield units), increased UWT (>1.7 mm), presence of high-grade HN (grade ≥2), and elevated neutrophil-lymphocyte ratio (NLR) (>2.15) and platelet-lymphocyte ratio (PLR) (>10.28) values in blood. No statistically significant relationship was observed between SP and ureteral length, renal parenchymal thickness, or renal parenchymal density. It was found that when the UWT at the level of the ureteral stone exceeded 1.7 mm, the risk of the stone not passing spontaneously increased by 706.5 times in univariate logistic regression (LR) analysis and by 337.9 times in multivariate LR analysis compared with individuals with a wall thickness below this threshold. CONCLUSION Our study demonstrated that, in addition to stone size and location, increased UWT at the stone level, higher stone density, the presence of concomitant high-grade HN, and elevated NLR and PLR values in the blood could be used as criteria to determine the likelihood of SP of ureteral stones. According to our results, UWT was shown to be a stronger risk factor for failure of SP than stone size. CLINICAL SIGNIFICANCE The findings indicate that wall thickness around ureteral stones is a risk factor with a higher negative predictive value for SP than the stone size and location. Copyright @ 2026 Author(s)

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2025/r/ebyu/19580
  Port Site Metastases After Incidental Upper Urinary Tract Urothelial Carcinoma: A Case Report

  Ekici, Ozgur; Emre; Altunok, Vedat; Balıkçı, Ayşenur; Büyüktepe, Ömer; Koçoğlu, Fatih

  Upper urinary tract urothelial tumors are rarely seen. Only 5% of all transitional cell carcinomas (TCCs) originate from the upper urinary tract. Although skin metastases in urinary tumors are quite rare, the incidence of skin metastases in upper urinary tract TCCs is not exactly known due to the lack of published research on this subject. In this article, we aimed to present a lesion consistent with TCC metastasis in the left inguinal region of a patient who was operated on for a renal pelvic mass. A 61-year-old male patient underwent left laparoscopic nephrectomy because of a mass reported as renal cell carcinoma (RCC) in the upper pole of the left kidney. After the pathology result reported the presence of left renal TCC, the patient underwent left ureterectomy plus cuff resection in an another medical center. After this second operation, the skin lesion developing at the trocar entry site on the left inguinal region of the patient was reported as an abscess on imaging. The histopathology of the excised abscess was reported as TCC metastasis. There is no consensus on the treatment regimen for skin metastases of urothelial carcinomas, and these metastases have a relatively poor prognosis. One -year survival rate is generally 35%. The patient in our case received gemcitabine and cisplatin treatment and has been under oncology follow-up for twelve months.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2025/r/ebyu/11942
  Intravesical BCG: A Double-Edged Sword? The Untold Story of Infection Risks

  Barkay, Orçun; Keskin, Ercüment

  Background and Objectives: Intravesical Bacillus Calmette-Guérin (BCG) therapy remains a cornerstone in the treatment of non-muscle-invasive bladder carcinoma due to its efficacy in reducing recurrence and progression rates. However, its use is associated with various complications—including urinary tract infections (UTIs)—which necessitates further exploration. This study aims to analyze UTIs occurring during intravesical BCG treatment, emphasizing the microbial spectrum, resistance patterns, and risk factors from an infectious diseases and clinical microbiology perspective. Materials and Methods: A retrospective analysis was conducted on 240 patients diagnosed with non-muscle-invasive bladder carcinoma who received intravesical BCG therapy between 2010 and 2021. Data were collected from hospital records, including demographic characteristics, comorbidities, number of intravesical BCG cycles, and microbiological findings. UTIs were classified based on susceptibility patterns, and statistical analyses were performed to determine associations between clinical variables and UTI risk. Results: UTIs developed in 39.1% (n = 94) of patients, with 25.8% (n = 62) caused by susceptible pathogens and 13.3% (n = 32) by resistant pathogens. The most common causative agent was Escherichia coli (80.7% in susceptible UTIs, 43.8% in resistant UTIs), followed by Pseudomonas aeruginosa and Klebsiella pneumoniae. The presence of diabetes mellitus and chronic kidney disease significantly increased the risk of developing a UTI (p < 0.05). A higher number of intravesical BCG cycles correlated with increased UTI occurrence (p < 0.001). Serum C-reactive protein (CRP) levels were significantly elevated in patients with resistant UTIs, while procalcitonin levels were not a reliable predictor of UTI occurrence. Conclusions: Intravesical BCG therapy is associated with a significant incidence of UTIs, particularly among patients with predisposing comorbidities. The increasing prevalence of antibiotic-resistant infections underscores the need for careful monitoring and targeted antimicrobial stewardship strategies. CRP may serve as a useful adjunctive marker for UTI diagnosis in this setting. Future studies should focus on optimizing infection control measures and refining diagnostic criteria to differentiate between BCG-related inflammation and infectious complications.

  RDL Kalıcı Kaydıİncele
• ArticleAçık Erişim2025/r/ebyu/11876
  Investigation of genetic causes in non-obstructive azoospermic patients

  Dural, Bulut; Gecit, Ilhan; Aykanli, Emre; Ekici, Cemal; Oguz, Fatih; Koc, Ahmet

  Background: Male factor infertility is a health problem that affects millions of couples around the world. Male factor infertility is responsible for approximately more than half of all cases of infertility. About 15% of men and 10% of women with infertility may have genetic abnormalities, including chromosomal abnormalities and single gene mutations. In this study, results of genetic analys is of the infertile male patients who underwent testicular sperm extraction (TESE) with the diagnosis of non-obstructive azoospermia were evaluated in order to reveal genetic defects that impair or prevent spermatogenesis in male infertility. Methods: We compared the results of peripheral blood chromosome analysis, molecular karyotyping, male infertility genetic panel, and also testosterone, prolactin, follicular stimulating hormone and luteinizing hormone levels in non-obstructive azoospermic infertile patients aged 26–44 years, and investigated the relationship between these parameters and genetic mutations. Results: As a result of this research, among 26 patients, INSL3 (insulin-like peptide 3) gene mutation, which is considered pathogenic according to the criteria published by the American College of Medical Genetics and Genomics (ACMG) was detected in 1, FSHR (follicle stimulating hormone receptor) gene polymorphism in 17, CFTR (cystic fibrosis transmembrane conductance regulator) mutations in 5, CATSPER1 (cation channel sperm associated 1) and TEX101 (testis expressed 101) in 1, LHCGR (luteinizing hormone/choriogonadotropin receptor) in 1, ZMYND15 (zinc finger mynd-type containing 15) in 1, DNAH5 (dynein axonemal heavy chain 5) in 2, and DNAH11 (dynein axonemal heavy chain 11) changes in 1 patient. In the chromosome analysis, 47XXY Klinefelter syndrome was observed in 6 patients. Conclusions: The results have shown that non-obstructivea zoospermic patients with complaints of infertility may have other genetic abnormalities leading to infertility, despite the results of chromosomal analysis of the peripheral blood samples were within normal reference limits. Investigating these underlying genetic disorders helped us find the cause of infertility in ourpatient population.

  RDL Kalıcı Kaydıİncele
• ArticleYalnız künye2025/r/ebyu/11850
  Does Voiding in a Standing Position Cause Benign Prostate Hyperplasia?

  Aykanli, Emre; Yavuzsan, Abdullah Hizir; Buyuktepe, Omer; Altunok, Vedat; Balikci, Aysenur; Kocoglu, Fatih; Koncuk, Mustafa Serkan; Atalay, Numan; Turkmen, Nihat

  Background: Benign prostate hyperplasia (BPH) is a common health problem amongst men worldwide. It has a multifactorial ethiology, and in some societies, urinating in a standing position is believed to cause BPH. Although the effect of urination position on voiding parameters has been extensively investigated, whether they have a role in the aetiology of BPH is not known. Material and Methods: The patients who had (n = 89) and had not ever used (n = 213) alpha-blockers were included in the study. All patients were divided into four groups in accordance with their past urination habits: Group 1 (I always pee in a standing position), group 2 (I mostly pee in a standing position), group 3 (I mostly pee in a sitting position) and group 4 (I always pee in a sitting position). The current uroflowmetry results, prostate volumes (PVs) and International Prostate Symptom Score (IPSS) of the groups were compared. Results: The IPSSs of groups 1–4 (total n = 213) who had not used alpha-blockers before were 10 (9–16), 10 (7–14), 10 (7–14) and 10 (8–13) points, respectively; Their median PVs were 40, 35, 40 and 40 mL, respectively; And their average maximum urinary flow rate (Qmax) values were 17 (12.7–20.5), 1.46 (11.1–20), 15 (12.4–18.9) and 15.6 (11.7–19.5) mL/s, respectively. No statistical difference was observed between the groups. Alpha-blockers were started in 104 patients who had not used alpha-blockers before in accordance with their clinical results. When these 104 patients who were started on alpha-blockers for the first time and 89 patients who were started on alpha-blockers before were examined together, the average ages of starting alpha-blockers were 59.9 ± 7.1, 60.5 ± 6.7, 59.6 ± 6.5 and 60.8 ± 6.7 years. No statistical difference was observed between the groups. Patients with and without clinical BPH were compared in terms of past urination habits. In both groups, the rates of patients who always or mostly urinated whilst sitting (60%–61%) and those of patients who always or mostly urinated whilst standing (39%–40%) were similar. Conclusions: This retrospective study showed that positional urination habits do not have a role in the aetiology of BPH. However, multicentre prospective studies with a larger patient population are needed.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2025/r/ebyu/11562
  A New Emerging Threat in Critical Care: Myroides odoratimimus Outbreak in a Tertiary Hospital

  Savci, Unsal; Eser, Baris; Sungur, Mustafa; Yildiz, Serap S.; Akdogan, Ozlem; Caliskan, Selahattin; Sahin, Mustafa

  Aims and background:Myroides spp. is an environmental pathogen and causes disease in immunocompromised patients. In this study, we report an outbreak of urinary tract infections (UTIs) caused by Myroides odoratimimus (M. odoratimimus) in a university hospital in Turkey. Methods: A total of 25 M. odoratimimus strains isolated from the clinical samples of 20 patients in our intensive care units and clinics were included in the study. Phenotypic and genotypic identification of isolates was performed using conventional methods, VITEK®-2 automated identification system, Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry, and 16S-RNA Microbial Diagnosis methods. In addition, the repetitive extragenic palindromic (REP) elements polymerase chain reaction (PCR) assay method was applied for molecular epidemiological analysis. Results: All cases were diagnosed with nosocomial UTI, except for one case diagnosed with nosocomial bacteremia. One of the M. odoratimimus isolates was sensitive to piperacillin/tazobactam (MIC: ≤4 µg/mL), and one isolate was moderately sensitive to cefepime (MIC: 16 µg/mL). Other all M. odoratimimus isolates were resistant to the tested antibiotics beta-lactams, monobactams, carbapenems, aminoglycosides, fluoroquinolones, and sulphonamides. When 10 isolates were evaluated with the REP PCR method, DNA fingerprint similarities were visually determined, and there was a similar DNA pattern among them. The source of Myroides infection could not be identified from the environmental samples. Conclusions: The increasing population of immunosuppressed patients suggests that M. odoratimimus and other opportunistic multi-drug resistant pathogens with resistance to broad-spectrum antibiotics may be encountered more frequently in critical units in future. In order to choose the optimal antibiotic regimen, awareness and an index of suspicion regarding this atypical pathogen are important for rapid identification and appropriate susceptibility testing. Clinical significance: It has been observed that the pathogenicity of M. odoratimimus bacteria has increased recently, and it can not only cause UTIs but more serious manifestations such as sepsis with bacteremia, which can be life-threatening.

  RDL Kalıcı Kaydıİncele
• ArticleYalnız künye2025/r/ebyu/11406
  Comparative study of the protective effects of coenzyme Q10 and cinnamon extract on possible kidney damage and dysfunction of amiodarone in rats

  Ekici, Ozgur; Gul, Abdullah; Keskin, Ercument; Bulut, Seval; Suleyman, Bahadir; Mammadov, Renad; Cicek, Betul; Demir, Ozlem; Gunay, Murat; Suleyman, Halis

  Background: An increase in free oxygen radicals and proinflammatory cytokines and decrease in intracellular adenosine triphosphate account for the nephrotoxic effect of amiodarone. This study investigated the protective effects of Coenzyme Q10 (CoQ10), cinnamon extract (CE) and the combination of the two (CoCE) on possible amiodarone-induced renal injury in rats. Methods: Thirty male albino Wistar rats were cetegorized into healthy (HG), amiodarone (ADG), CoQ10 + amiodarone (CoQA), CE + amiodarone (CEA), and CoCE + amiodarone (CoCEA) groups. First, CoQ10 (10 mg/kg) and CE (100 mg/kg) were orally given. After 1 h, 50 mg/kg amiodarone was orally given to all groups except for HG. Amiodarone, CoQ10, and CE administration was continued orally at the indicated doses once daily for 10 days.Then, blood samples were collected from all groups to determine creatinine, blood urea nitrogen (BUN), and kidney injury molecule (KIM-1) levels, followed by euthanasia and removal of kidney tissues. Oxidative stress and inflammatory parameters were analysed in the tissue samples. Histopathological examination was also performed on the tissues. Results: Amiodarone increased malondialdehyde levels and decreased total glutathione, superoxide dismutase, and catalase levels (p < 0.001). Amiodarone increased the expression and tissue levels of tissue nuclear factor kappa B, tumor necrosis factor-alpha, interleukin-1β and interleukin-6, and led to increases in serum creatinine and BUN and KIM-1 levels (p < 0.001). Amiodarone also caused histopathological damage (p < 0.001).CoQ10, CE and especially CoCE inhibited biochemical changes and tissue damage (p < 0.001). Conclusion: Although CoQ10, CE, and CoCE effectively prevent amiodarone-induced oxidative and inflammatory nephrotoxicity, CoCE appears to be superior.

  RDL Kalıcı Kaydıİncele
• ArticleAçık Erişim2025/r/ebyu/11132
  The Andrology Working Group of the Society of Urological Surgery in Turkiye: Bridging Academic Gaps and Advancing Male Reproductive or Sexual Health

  Çeker, Gökhan; Deliktaş, Hasan; Gül, Ümit; Turunç, Tahsin; Tepeler, Abdülkadir; Çırakoğlu, Abdullah; Yavuz, Abdulmecit; Altunkol, Adem; Esen, Ahmet Adil; Göçener, Ahmet Anıl

  The Andrology Working Group of the Society of Urological Surgery in Turkiye was established to address the lack of a formal andrology subspecialty in Turkiye and to advance male reproductive and sexual health. With a youth-driven approach-where young professionals play a leading role in organizing educational programs, conducting research, and contributing to advancements in clinical practice-the group fosters collaboration in key subspecialties, including male infertility, erectile dysfunction, and ejaculation disorders. By bridging academic gaps and supporting young professionals, the group plays a pivotal role in shaping the future of andrology in Turkiye. Notably, the group has facilitated over 25 national and international training programs and contributed 14 peer-reviewed publications, directly impacting andrology education and clinical practice in the region.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2024/r/ebyu/19735
  The Effect of Voiding in Sitting and Standing Positions on Uroflowmeter Parameters: Descriptive Research

  Türkmen, Nihat; Aykanli, Emre

  Objective: Uroflowmetry is one of the most commonly used assessment tools in patients with lower urinary tract symptoms (LUTS). However, uroflowmetric parameters can be affected by various factors. In this study, we aimed to examine the effects of different voiding positions on uroflowmeter parameters. Material and Methods: 105 patients aged 40-80 years who applied to the urology outpatient clinic with the complaint of LUTS were included in the Our Prospective study. Uroflowmetry measurements were performed on each of the participants in standing and sitting positions, one day apart. After uroflowmetry, residual urine was measured by transab- dominal ultrasound in each patient. Qmax, Qave, voiding volume, voiding time and residual urine volumes of the patients in standing and sitting positions were compared. Results: The mean Qmax-Qave-voiding volume values of the patients were measured as 13. 8 mL/s-7 mL/s-336 mL in the sitting position and 11. 6 mL/s-6 mL/s-304 mL in the standing position respectivly. Q max, Qave values and voiding volume values were significantly higher in patients who voided in the sitting position (p<0.001). The residual urine amount of the patients after voiding was measured as 20 mL in the sitting position and 40 mL in the standing position, and it was observed that the amount of residual urine in the patients who voided while sitting position was significantly less (p<0.001). Conclusion: In our study, it was observed that voiding position had an effect on uroflowmetry parameters. Urinating, especially in a sitting position, has a positive effect on uroflowmetry parameters.

  RDL Kalıcı Kaydıİncele
• ArticleYayıncıda açık erişim2024/r/ebyu/19697
  Investigation of the Knowledge Levels of Physicians Working in the Emergency Department About Testicular Torsion: Observational Study

  Keskin, Ercüment; Gul, Abdullah; Bozkurt, Aliseydi; Ekici, Ozgur; Emre; Doğan, Muhammet Emin; Balıkçı, Ayşenur

  Objective: The aim of the study is to investigate the level of knowledge of emergency physicians about the clinical approach to testicular torsion. Material and Methods: A questionnaire with 10 questions was prepared to determine the level of knowledge about acute scrotum. 4 questions consisted of demographic data and 10 questions consisted of questions about clinical knowledge. Four of these questions were specifically measuring physical examination (PE) knowledge. The total scores of the answers given and the answers to the questions measuring PE knowledge were recorded separately, each question being one score. Total scores were compared according to gender, institution and degree. Results: A total of 99 emergency physicians were reached for the study. Mean age 27.6±4.6 years; male/female ratio was 55/44. The mean total score of all physicians was 6.13±1.63; The mean total score of the 4-question PE was 2.29±1.07. Physicians participating in the survey were separated according to their gender, institution, and degree, and their total scores were compared. No statistically significant difference was observed between the groups. While no statistically significant difference was observed in PE scores according to gender and the institutions they work at, there was a statistically significant difference between specialist physicians (3.09±1.04) and general practitioners (1.94±0.95) when compared according to their degrees (p: 0.009). Conclusion: It is important to increase the PE knowledge of the physicians working in the emergency department about testicular torsion through continuous education after graduation in order to prevent organ losses.

  RDL Kalıcı Kaydıİncele