Akman, Tugrul Cagri

The aim of this study is to investigate trace elements and amino acids in the root and stem of Verbascum lasianthum Boiss. ex Bentham (VL) from Erzincan and to understand the role of these compounds in adaptation to environmental stress conditions. In the study, ICP-MS and LC-MS/MS methods are used for analyses. In addition, antioxidant activities of methanol:water extracts (70:30, v:v) of these parts were investigated. The results showed that VL in Erzincan accumulates elements such as sodium and silicium to adapt to arid and stressful environmental conditions and supports these processes by synthesizing amino acids such as L-proline, L-asparagine and L-glutamine. The high amount of iron indicates that VL can be a potential iron source in the treatment of anemia. However, aluminum accumulation in plants is extremely risky due to its possible neurotoxic effect in humans and plant toxicity. Although these amino acids and trace elements contribute to the antioxidant potential of the plant, VL showed a low antioxidant activity when compared to VL species in other regions. In conclusion, this study emphasizes the importance of comprehensively analyzing phytochemical profiles such as trace elements, amino acids and phenolic compounds to evaluate the efficacy and safety of medicinal plants.

Akdemir, Ahmet Ocak; Mumcu, Gökhan; Çinar, Yasin

Examination of spaces in the field of functional analysis, especially revealing their topological and algebraic structures, is very important in terms of forming a basis for studies in the field of pure mathematics and applied sciences. In this context, topology, which was widely used only in the field of geometry at the beginning, gave a solid foundation to the fields in which it was used by causing methodological changes in all branches of mathematics over time. Frechet-Coordinate space (FK space) is a concept that has a functional role in fields such as topological sequence spaces and summability. Topological vector spaces are described as linear spaces defined by a topology that provides continuous vector space operations. If this vector space has a complete metric space structure, it is called Frechet space, and if it has a topology with continuous coordinate functions, it is called Frechet-Coordinate (FK) space. The theory of FK spaces has gained more importance in recent years and has found applications in various fields thanks to the efforts of many researchers. If the topology of an FK space can be derived from the norm, this space is called as a BK space. In this study, cs_0^λ (Δ), cs^λ (Δ), and bs^λ (Δ) difference sequence spaces are defined, and it is revealed that these spaces are BK spaces. In addition, considering the topological properties of these spaces, some spaces that are isomorphic and their duals have been determined.

Özüdoğru, Osman; Alayunt, Naci Ömer; Güneş, Sevgi

In this study, it was aimed to show the efficacy of intravenous (IV) ferric carboxymaltose treatment for iron deficiency anemia (IDA), which is a public health problem due to its high prevalence in the world and in Türkiye. Since it is the first study in the region, its importance is increasing even more. Eighty female diagnosed with IDA and treated with IV iron carboxymaltose, who applied to Siirt Training and Research Hospital Internal Diseases Polyclinics between June 2018 and September 2019, were included in the study. Biochemical data before and after treatment from the data recorded in the system of the patients who signed the consent form of Siirt University Research Hospital were included in the study retrospectively. After treatment, hemoglobin (HGB), hematocrit (HTC), mean cell volume (MCV), ferritin, iron and B12 values increased statistically (p<0.05). In addition, platelet (PLT), total iron binding capacity (TIBC) and folate values were statistically significantly lower (p<0.05). Additionally, platelet (PLT), total iron binding capacity (TIBC) and folate values were statistically significantly lower (p<0.05). The study is important in terms of revealing the female IDA profile in the region and showing the positive results of IV iron therapy data. It is thought that the study can be a guide in finding solutions to irrational drug use, prolongation of the treatment period and high expenditures while creating IDA treatment protocols.

Hacimuftuoglu, Ahmet; Genç, Sıdıka; Çıçek, Betül; Yeni, Yeşim

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Soyüt, Hakan; Ulutaş, Yakup; Koksal, Ekrem

Zoledronik asit azot içeren bir bisfosfonattır. Güçlü bir kemik rezorpsiyon inhibitörüdür.Osteoklast aktiviteyi inhibe eder. PON1 organofosfatların, aril esterlerin ve laktonların hidrolizinikatalize eder. PON1, ateroskleroz dahil olmak üzere birçok vasküler hastalıkla ilişkili olduğubilinen Düşük Yoğunluklu Lipoprotein (LDH) ve Yüksek Yoğunluklu Lipoprotein'i (HDL),oksidatif strese karşı koruyarak bir antioksidan enzim olarak görev yapar. Aslında, daha yüksekPON1 aktivitesi aterosklerozun önlenmesinde önemli bir rol oynar. Epidemiyolojik çalışmalar,düşük PON1 aktivitesinin kardiyovasküler hastalık riski ile ilişkili olduğunu göstermektedir. Bumakalede, in vitro koşullarda insan serumunda PON1 enzim aktivitesi üzerine zoledronik asitkemoterapik ilacının inhibisyon etkisini araştırdık. İlaç, PON1 enzimini güçlü bir şekilde inhibeeder. Zoledronik asit için IC50 değeri, 0,057 mM’dır. Ki sabiti ise 0,101 mM’dır. İnhibisyon türüyarışmalıdır.