Kars, Ayhan; Atalay, Fatma; Topal, Kubra; Anbar, Sezai Sacid; Akyel, Fatma; Kiliç, Korhan

Purpose: This research was conducted to assess cervical vestibular evoked myogenic potential (cVEMP) test responses in patients with primary hypothyroidism without vestibular symptoms. Materials and Methods: Thirty-one patients diagnosed with primary hypothyroidism and who had not yet started on hormone replacement therapy, together with a 26-member control group, were enrolled in the research. All participants underwent detailed otorhinolaryngological examinations and thyroid function, cVEMP, and audiological tests. cVEMP records were compared between the groups. Results: Thirty-one patients aged between 21 and 57 years (38.5 +/- 9.7) and a control group of 26 healthy volunteers aged between 20 and 52 years (36.1 +/- 8.8) were included in the study. Absent VEMP responses were observed in 12 members of the patient group and in three of the control group. Interpeak amplitudes (IPAs) in both ears were significantly lower in the patient group than in the controls. While no significant difference was found between the groups' VEMP threshold values, asymmetry rates in both ears were significantly higher in the patient group. Conclusion: cVEMP can be usefully employed in the detection of subclinical vestibular dysfunction in hypothyroid patients.

Öztürk, Mehmet Eren; Kahraman, Sevket; Yalçin, Ahmet; Sunar, Mukadder

Purpose: The aim of this study is to determine the prevalence of mesenteric panniculitis in patients with urinary system calculi and identify factors, such as hydronephrosis and calculus location, that might be associated with the presence of mesenteric panniculitis. Materials and Methods: In this retrospective observational study, the prevalence of mesenteric panniculitis was determined in 692 patients with urolithiasis using non-contrast-enhanced computed tomography imaging between 2017 and 2020. The grade of hydronephrosis and the level of urinary calculi were recorded for each patient, and statistical analysis was performed to assess the link between these features and mesenteric panniculitis. Results: The prevalence of mesenteric panniculitis in patients with urolithiasis was 6.35% and it was associated with the presence of hydronephrosis. It was more common in patients who had both ureterolithiasis and nephrolithiasis with no statistically significant difference regarding in age, gender, or the presence of either only nephrolithiasis or only ureterolithiasis. Conclusion: Mesenteric panniculitis is more common in patients with both ureterolithiasis and nephrolithiasis and can be easily diagnosed with non-contrast computed tomography imaging. Because the mesentery and urinary system share a common lymphatic drainage system, increased lymphatic drainage due to hydronephrosis has been shown to contribute to the development of mesenteric panniculitis.

Yildiz, Sevler; Uğur, Kerim; Kurt, Osman; Kılıçaslan, Aslı Kazğan; Kılıçarslan, Gülhan

Purpose: Generalized anxiety disorder (GAD) is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness (IMT) and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.

Kara, Ilknur Sueruecue; Caki, Tayfun

Concurrence of medulloblastoma and Chiari deformity (type-1) in a pediatric patient is extremely rarely seen. 10 years old girl. She had first complained of nausea, abdominal pain, and vomiting. She had a mild headache for three days. Computed tomography was taken. There were sequelae related to her previous illness and noticed the appearance of the left cerebellar tonsils down to the foramen magnum level and mild prominence in the third ventricle. Cranial imaging was performed with magnetic resonance imaging. There was a lesion as a solid mass, about 60 mm sized in the level right cerebellar, a cerebellar tonsil hernia (11 mm), and ventricular dilatation in magnetic resonance imaging. Histologically, the lesion was a classic type of medulloblastoma. The coexistence of two diseases may occur in the same patient. Magnetic resonance imaging, which indicates the craniovertebral junction can be used singly.Because MRG is the first method to be selected for diagnosis.

Toktay, Erdem; Gürbüz, Muhammet Ali; Bal, Tugba; Özgül, Ozlem; Erba, Elif; Ugan, Rustem Anil; Sell, Jale

Purpose: In this study, our aim was to investigate the potential effects of strong antioxidant daidzein (DZ) on ovarian ischemia and reperfusion injury. Materials and Methods: A total of 42 female Sprague-Dawley rats were randomly divided into seven groups. For the experimental model, the clamps were removed after 3 hours of ischemia, and blood flow was provided again. Then, reperfusion process was terminated for 3 hours. Daidzein was orally administered to animals at doses of 35 and 70 mg/kg 30 minutes before ischemia (I) and ischemia and reperfusion (I/R) procedures. Results: Severe immunoreactivity of the IL-1 beta, IL-6 and Caspase-3 were detected in I and I/R groups. Moderate immunoreactivity of IL-1 beta, IL-6 and Caspase-3 was detected in I+DZ35 and I/R+DZ35 groups, and slightly positivity was detected in I+DZ70 and I/R+DZ70 groups. The SOD activity level increased in the groups treated with Daidzein, while MDA levels decreased. In addition, hemorrhage areas and inflammatory cell migration decreased in I/R+DZ70 and I/R+DZ35 groups, when compared to I/R group in a dose dependent manner. Conclusion: Daidzein has a strong protective role in the treatment of ovarian ischemia-reperfusion injury and can be used as a therapeutic agent.

Dincer, Busra; Atalay, Fatma; Tatar, Arzu

Purpose: This study explores the biochemical and functional effects of famesene, which has potent free radical scavenging and antioxidant properties, on paclitaxel-induced ototoxicity. Materials and Methods: Eighteen male Wistar albino rats were allocated into three groups of six rats at random. No paclitaxel or famesene was given to the control group throughout the research. Paclitaxel was given four times intraperitoneally at a dose of 5 mg/kg (1st, 7th, 14th & 21st days) in the paclitaxel group. In the Famesene + Paclitaxel group, 5 mg/kg paclitaxel was given first, followed by 4 times 50 mg/kg famesene intraperitoneally 30 minutes later (1st, 7th, 14th & 21st days). Otoacoustic emission measurement was taken on days 0 and 21 in all rats. After that, the animals were sacrificed, and their cochleas were extracted for biochemical testing. Results: Paclitaxel caused oxidative stress in the cochlea, which considerably elevated malondialdehyde levels and lowered glutathione levels in cochlear tissues. Furthermore, the paclitaxel group's distortion product otoacoustic emission values were significantly lower than the other groups. Improvements in the damage produced by paclitaxel in various biochemical and functional parameters were observed in the Famesene+Paclitaxel group. Conclusion: The study findings imply that famesene, a natural antioxidant, reduced paclitaxel-induced hearing loss in rats, and a combination of famesene and paclitaxel therapy may have protected from paclitaxel-induced ototoxicity for future clinical use.

Yilmaz, Sevil Karahan; Özçiçek, Fatih; Mertoglu, Cuma

Purpose: The aim of this study was to evaluate the traditional and novel obesity-related indices in the determination of metabolic syndrome in adults and to determine which marker is the better predictor. Materials and Methods: A total of 419 adults between the ages of 18-65 were included in this study. Body weight, height, waist, hip and waist circumference, and blood pressure were measured; fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol values were analyzed. Metabolic syndrome (MetS) was defined using the International Diabetes Federation criteria. The values of 23 obesity-related indices were calculated. Results: The prevalence of metabolic syndrome is 58.7% (male 41.2%; female 67.7%). The triglyceride glucose (TyG) index has the largest area under the curve (AUC) in both men (AUC = 0.894, cutoff = 3.9) and women (AUC = 0.901, cutoff = 3.9). In men, lipid accumulation product (LAP) had the second highest determination for MetS (AUC = 0.880, cut-off = 51.1), followed by TyG-waist/hip (AUC = 0.876, cut-off = 3.7). Cardiometabolic index (CMI) (AUC = 0.872, cut-off value = 1.3) and visceral adiposity index VAI (AUC = 0.868, cut-off value = 4.1) had the second and third largest AUCs, respectively, in women. Conclusion: TyG index is the best predictor of MetS. Waist circumference could be an alternative index in large epidemiology survey due to its convenient and cost-efective characteristics.

Kara, Ilknur Surucu; Özdamar, Mustafa Yasar; Kolkiran, Abdulkerim; Peker, Necla Aydin; Topal, Ismail

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Yildiz, Sevler; Kurt, Osman; Korkmaz, Sevda; Kılıçaslan, Aslı Kazğan

Amaç: Çalışmanın amacı ilaç kullanımı olmayan sınırda kişilik bozukluğu (SKB) tanılı hastalardaki serum ürik asit seviyelerini incelemek ve bunun dürtüsellikle olabilecek olası ilişkisini araştırmaktır. Gereç ve Yöntem: Bu çalışmaya SKB tanılı 69 hasta ve 54 sağlıklı kontrol grubu dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Barratt Dürtüsellik Ölçeği Kısa Formu (BDÖ-11) uygulanmıştır. Ardından tüm katılımcılardan açlık venöz kan örnekleri alınarak serum ürik asit düzeyleri çalışılmıştır. Bulgular: SKB tanılı hastalarda serum ürik asit seviyeleri, BDÖ-11 alt boyut ve toplam puanları ve BDÖ toplam puanı kontrol grubundan anlamlı şekilde yüksek bulunmuştur. Serum ürik asit seviyeleri ile BDÖ-11 ölçek puanı arasında pozitif yönde anlamlı bir korelasyon olduğu görülmüştür. Sonuç: Bu çalışmada, ilaç kullanımı olmayan sınırda kişilik bozukluğu tanılı hastalarda kontrol grubuna göre daha yüksek serum ürik asit seviyelerini bildirilmiştir. Çalışmanın bulguları SKB tanılı hastalardaki dürtüselliğin biyolojik temellere dayandırılması açısından örnek oluşturabilir. SKB hastalarında ürik asit seviyeleri ile ilgili ileride yapılacak olan uzunlamasına ve deneysel çalışmalar bizlere bu hastalardaki dürtüselliğin tanı ve tedavisi açısından alternatif bir yol gösterecektir.

Yildiz, Sevler; Kiliçaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Atmaca, Murad

Purpose: The aim of this study was to evaluate the personality traits, anxiety sensitivity, anxiety and depression levels of patients with Premenstrual dysphoric disorder (PMDD). Materials and Methods: Forty PMDD patients with no psychiatric treatment history and 40 healthy women with similar sociodemographic characteristics and no history of systemic or psychiatric disease were included in the study. Anxiety-Sensitivity-Index-3 (ASI-3), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and the Eysenck Personality Questionnaire-Revised Abbreviated (EPQR-S) were administered to all participants. Results: The patient group's EPQR-S neuroticism, psychoticism, lying subscales and total scores were significantly higher than the control group's scores. The ASI-3 physical, cognitive, social sub-dimensions and total score of the patient group were found to be significantly higher than the control group's score. The BDI and BAI scale scores of the patient group were found to be significantly higher than the scores of the control group. Conclusion: In women with high anxiety sensitivity, psychotic and neurotic personality traits, this may affect the development of PMDD or the course of the disease.