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- ArticleYalnız künye2017Association between Newly Diagnosed Essential Hypertension, Smoking, Assymetric Dimethylarginine and ischemia-Modified Albumin
Bengü, Aydın Şükrü; Mertoglu, Cuma; Çiftçi, Çavlan; Dalar, Levent; Kiraz, Zeynep Küskü; Altuntaş, Emine; Usalp, Songül
Objective: This study aimed to investigate the relationship between increasing levels of assymetric dimethylarginine (ADMA)and ischemia- modified albumin (IMA) in people with early diagnosis of hypertension (HT) and smoking history. Methods: The study included 95 outpatients who visited our hospital. Patients were classified into three groups: group 1, healthy and non- smokers (n=25); group 2, no smoker patients with newly diagnosed essential HT with LVH (left ventricle hypertrophia) (n=35); group 3, smoking patients with a LVH accompanying newly diagnosed essential HT (n=35). 51% of patients are females; 49% of them are males.The trial was approved by the local ethics committee. Blood samples were analyzed, which were taken after 8 h of fasting. Biochemical param- eters such as, C reactive protein (CRP), ADMA, IMA values were recorded. Using echocardiography, cardiac values were recorded. Results: In this study, the first group consisted of 25 patients and sec- ond and third group of 35 patients. There were 49 females and 46 males; 70 patients were hypertensive and 6 diabetic. Comparing groups 1 and 2, a significant increase in ADMA was found in group 2. A signifi- cant difference was available regarding red cell distribution widht(RDW) and neutrophil lymphocyte ratio (N/L) ratio. Both parameters have in- creased. Significant differences were found between groups 2 and 3 in terms of ADMA, arginine, albumin, and WBC. While ADMA, white blood cell(WBC), and albumin increased and arginine decreases in group 3. Conclusion: There is an association between ADMA level, smoking, and HT. Patients with HT and smoking history showed increased ADMA level compared with normal. Hypertension and smoking are the causes of increased ADMA, but decreased NO level.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2017Neutrophil-Lymphocyte ratio and Platelet-Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus
Mertoglu, Cuma; Gunay, Murat
Aims Chronic inflammation plays a central role in the development and progression of diabetes, and in the pathogenesis of its complications. The neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are indicators of subclinical inflammation. Mean platelet volume (MPV) is one of the platelet function indices. We investigated the association of NLR, PLR and MPV with prediabetes and type 2 diabetes mellitus and determine whether or not these are reliable markers for diagnosis. Materials and methods Participants were divided into four groups; 1: normal glucose tolerance, 2: impaired glucose tolerance (prediabetic), 3: newly diagnosed diabetic by OGTT. 4: group is previously diagnosed diabetic without complication. Outcomes were compared between groups. Results There are significant differences between all groups in NLR (p = 0.004) and PLR (p = 0.021) values. NLR values are significantly higher in prediabetic (1.60 ± 0.85), firstly diagnosed diabetic (1.58 ± 0.78) and clear diabetic (2.07 ± 0.95) groups compared to normal group (1.37 ± 0.69) (mean, SD). PLR values are significantly lower in prediabetic (90.35 ± 44.34) and firstly diagnosed diabetic (86.38 ± 45.24) groups compared to normal group (100.55 ± 48.14) but significantly higher in clear diabetic group (122.45 ± 37.43). There are no significant differences between all groups in MPV values. Conclusion Inflammation marker NLR significantly increases in prediabetic and diabetic patients. PLR significantly decreases in prediabetes and early stages of diabetes but increases in later stages. NLR and PLR values may be reliable predictive markers in prediabetes and diabetes mellitus.
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