Sürdürülebilir Kalkınma Amaçları
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- ArticleAçık Erişim2025The Nutritional Parameters in Children with Delays in Speech
Mertoglu, Cuma; Kara, İlknur Sürücü; Dolğun, Ilke
Objective: This study aimed to examine and compare the data on nutritional parameters in children with specific language impairments. Methods: Children under 5 years of age who presented to the outpatient clinic with isolated speech delay and were diagnosed with a specific language disorder, along with a healthy control group, were evaluated. The hemoglobin, iron, vitamin B12, and vitamin D levels of the patients were recorded after normal values and deficiency limits were determined for each age group. Results: Of the 188 children, 94 were in the control group and 94 were in the patient group. The control group was the same age and gender as the patients. Seventy-one (75.5%) of the patients were male and 23 (24.5%) were female. The mean age was 2.70 ± 0.65; the median age was 2.66 (min-max: 1.50-3.92) years. The mean serum iron levels in the patient group (67.95 ± 41.86 μg/dL) were significantly lower than in the control group (81.59 ± 37.34 μg/dL) (P = .008). B12 deficiency was significantly higher in the patient group (30%) than in the control group (16%) (P = .037). Other nutritional parameters of the patient and control groups were similar Conclusion: Low iron levels and vitamin B12 deficiency may be effective factors in speech delay. It is impor- tant to the nutritional parameters for speech delay and to treat vitamin deficiencies if present.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2025Anemia, inflammation, circadian rhythm and season effects in febrile convulsions
Surucu Kara, Ilknur; Aydin Peker, Necla; Arslan, Yusuf Kemal; Mertoglu, Cuma
OBJECTIVE: Our aim in the study is to investigate circadian rhythm, season, age, gender, and hemogram parameters in children diagnosed with febrile convulsions. METHODS: The data of a total of 478 children, consisting of 160 patients with febrile convulsions (90 male/70 female) and 318 control groups (healthy, convulsiyon free-febrile), were compared. RESULTS: The average age of all patients was 25.7±14.7 (minimum 6-maximum 60) months, and the most common convulsion age was 13-18 months. Circadian rhythm was similar, application seasons were similar. The male/female ratio was 1.3. MPV in winter was lower than other seasons (p=0.002). At younger ages, lymphocyte count was higher (p=0.048) and NLR was lower (p=0.036). NLR was lower in patients with febrile convulsions with anemia than in patients with febrile convulsions without anemia (p=0.029). NLR was lower in patients with febrile convulsions with anemia than in the convulsion-free febrile control group with anemia (p=0.001). In patients with febrile convulsions, MPV was lower (p=0.033) and NLR was higher (p=0.001) than in the convulsion-free febrile control group. One third of the patients had hypocapnia. CONCLUSION: Young age, anemia, inflammation, and hypocapnia may facilitate the occurrence of febrile convulsions. MPV and NLO, which are hemogram parameters, can guide us about inflammation. Blood gases may provide information regarding hypocapnia. These rapid examinations may help elucidate the etiology. Prospective studies are needed for circadian rhythm in febrile convulsions.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2025The relationship between rheumatoid arthritis and epicardial fat thickness, and serum levels of chemerin, adropin, and betatrophin
Ekinci, Bilge; Mertoglu, Cuma; Coskun, Resit; Arslan, Yusuf Kemal; Coban, Taha Abdulkadir; Ozcicek, Fatih
Background. Cardiovascular diseases (CVDs) are highly prevalent among patients with rheumatoid arthritis (RA). Epicardial adipose tissue, serum betatrophin, chemerin, and adropin levels are factors associated with atherosclerosis and cardiovascular involvement. Objectives. This study aimed to investigate the relationship between RA and epicardial fat thickness (EFT), as well as serum betatrophin, chemerin and adropin levels. Materials and methods. This cross-sectional study included 80 patients (62 women and 18 men) diagnosed with RA according to the American College of Rheumatology/The European Alliance of Associations for Rheumatology (ACR/EULAR) 2010 RA classification criteria and 80 healthy controls (64 women and 16 men). Exclusion criteria comprised other autoimmune diseases, CVDs, diabetes mellitus, other endocrine disorders, acute or chronic pancreatic disorders, malignancy, pregnancy, breastfeeding, or antihyperlipidemic drug usage. Serum betatrophin, chemerin and adropin concentrations were measured. Epicardial fat thickness was evaluated with transthoracic echocardiography. Results. Adropin levels were significantly lower in the RA group compared to the control group (p < 0.001). Chemerin levels and EFT were significantly higher in the RA group than in the control group (p = 0.016, p < 0.001, respectively). When assessing the relationship between biomarkers and EFT in RA patients, a strong positive correlation was observed between chemerin and EFT (r = 0.73, p = 0.046) in patients with high disease activity. Conclusions. Epicardial fat thickness, as an indicator of cardiovascular involvement, is higher in patients with RA. Moreover, high chemerin levels and low adropin levels in these patients may be indicative of cardiovascular involvement. Copyright by Author(s)
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024The relationship between serum adropin levels and erectile dysfunction
Keskin, Ercument; Ekici, Ozgur; Erdogan, Abdullah; Bozkurt, Aliseydi; Sambel, Murat; Karabakan, Mehmet; Mertoglu, Cuma
Erectile dysfunction (ED) is associated with endothelial damage, especially atheroscle-rosis. The search for biomarkers that can predict ED still continues. Adropin is known to affect nitric oxide (NO) bioavailability and energy homeostasis. In our study, we have aimed to investigate the relationship between serum adropin levels and ED. Male patients with and without ED between 40–60 years of age, who presented to the outpatient clinics of urology between November 2019–February 2020, were prospectively included in the study. Biochemical values measured at the time of admission to the outpatient clinic. According to the International Index of Erectile Function-5 (IIEF-5) scores which range between 5 and 25 points, patients with a score ≤21 were considered to have ED. The patients were divided into two groups: as ED and non-ED control groups. Laboratory values obtained at admission to outpatient clinics of urology were compared between groups. Patients with (n: 40), and without (n: 40) ED were included in the study. The mean age (50.2 ± 5.7 years), average body mass index (BMI) (29.7 ± 2.5 kg/m2 ), IIEF score (15.8 ± 6 pts), serum adropin (584.8 ± 172 pg/mL), and total testosterone (396.4 ± 91.7 ng/dL) levels were recorded. Serum adropin and testosterone levels were statistically significantly higher in the non-ED group than in the ED group (712.3 ± 222 pg/mL vs. 511.1 ± 145 pg/mL, p < 0.001 and 420.5 ± 56 ng/dL vs. 374.3 ± 98 ng/dL, respectively p = 0.032). Whereas fasting blood glucose (FBG) values were found to be statistically significantly higher in the ED group (100.2 ± 14 mg/dL vs. 143.8 ± 78 mg/dL, p = 0.001). According to the results of our study, serum levels of adropin which improves endothelial functions were comparatively lower in ED patients, as expected.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects
Akman, Tugrul Cagri; Yazici, Mustafa; Atila, Alptug; Mertoglu, Cuma
Isotretinoin is an effective treatment against acne vulgaris, but it also causes many side effects during and after the treatment. The relationship between the changes in the levels of plasma trace elements of patients with AV after 3 months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma–Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, and zinc in plasma increased statistically, while the level of potassium decreased (p < 0.05). The treatment had differing effects on zinc levels based on the gender of the individuals. With treatment, the levels of zinc in the plasma of men showed a greater increase compared to women (p = 7.3e-04). Additionally, the correlation matrix analysis revealed a strong correlation (R > 0.8) between magnesium and calcium. According to the study results, the change in phosphorus and potassium levels shows that isotretinoin affects kidney functions. The results suggest that phosphorus, potassium, magnesium, and zinc are associated with fatigue, dry skin and chapped lips, hair loss, and sebum secretion, respectively. Consequently, the study emphasizes the need for a comprehensive pre-treatment assessment, including monitoring of liver and kidney function as well as the levels of phosphorus and potassium in patients.
RDL Kalıcı Kaydıİncele - CorrectionAçık Erişim2023COVID-19 Hastalarında Oksihemoglobin Disosiasyon Eğrisi
Mertoglu, Cuma; Huyut, Mehmet Tahir; Ustundag, Hilal
Amaç: Koronavirüs hastalığı-2019 (COVID-19), hipoksemi ve bazı hastalarda ciddi derecede solunum sıkıntısı ile seyredebilen bir hastalıktır. Oksihemoglobin disosiasyon eğrisi (ODC), O2 değişiminin etkilerini anlamak için çok önemlidir. Bu çalışmanın amacı; COVID-19 hastalarında ODC ve hemoglobin (Hb) arasındaki oksijen taşıma kapasitesi ilişkisini değerlendirmektir. Gereç ve Yöntemler: Çalışmada, yoğun bakım ünitesi (YBÜ) COVID-19, yoğun bakım dışı (non-YBÜ) COVID-19 ve COVID-19 olmayan diğer solunum sıkıntılı toplam 686 hastanın arter kan gazından elde edilen veriler retrospektif olarak incelenerek oksihemoglobin eğrileri oluşturuldu. Bulgular: COVID-19 tanılı ve diğer solunum sıkıntılı hastaların ODC’lerinin standart eğriye göre hafif sağa eğilim gösterdiği belirlendi. YBÜ grubunun P50 değeri, diğer gruplara kıyasla daha yüksekti (ortalama: 30,74 mmHg, n=131, p=0,047). Kontrole kıyasla nonYBÜ grubunun; oksihemoglobin yüzdesi (ortalama: %65,44 vs %69,81, p=0,015), PO2 ’ı (46,98 mmHg vs 48,98 mmHg, p=0,001), glikoz miktarı (ortalama: 163,39 mg/dL vs 195,36 mg/dL, p=0,002) ve pH’sı (medyan: 7,38 vs 7,41, p=0,007) daha yüksek iken karboksihemoglobin yüzdesi (ortalama: %1,66 vs %1,13, p=0,000), PCO2 ’ı (42,02 mmHg vs 39,44 mmHg, p=0,015), potasyum (ortalama: 4,33 mmol/L vs 4,04, p=0,026) ve sodyum (ortalama: 138,10 mmol/L vs 135,80 mmol/L, p=0,000) seviyesi daha düşüktü. YBÜ grubunun methemoglobin yüzdesi ise diğer gruplara kıyasla daha düşüktü (p=0,000). Sonuç: COVID-19 ve diğer solunum sıkıntılı hastaların ODC’si hafif sağa kaymaktadır, bu sonuç hastaların kısmen solunum güçlüğü çektiğini göstermektedir.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2023Oxyhemoglobin Dissociation Curve in COVID-19 Patients
Ustundag, Hilal; Mertoglu, Cuma; Huyut, Mehmet Tahir
Objective: Coronavirus disease-2019 (COVID-19) is a disease that can progress with hypoxemia and severe respiratory distress in some patients. The oxyhemoglobin dissociation curve (ODC) is critical to understanding the effects of O2 exchange. This study aimed to evaluate the relationship between the ODC and oxygen-carrying capacity of hemoglobin (Hb) in COVID-19 patients.Materials and Methods: In the study, ODCs were created by examining the data obtained from the arterial blood gas analyses of 686 intensive care unit (ICU) and non-ICU COVID-19 patients retrospectively.Results: It was concluded that patients with COVID-19 and other respiratory distress patients had a slight right-leaning trend in the ODC compared with the standard curve. The P50 value of the ICU group was higher than the other groups (mean: 30.74 mmHg, n=131, p=0.047). While the percentage of oxyhemoglobin (mean: 65.44% vs 69.81%, p=0.015), the amount of glucose (mean: 163.39 mg/dL vs 195.36 mg/dL, p=0.002) and pH (median: 7.38 vs 7.41, p=0.007) in the non-ICU group was higher compared with the control group, the carboxyhemoglobin percentage (mean: 1.66% vs 1.13%, p=0.000), PCO2 (42.02 mmHg vs 39.44 mmHg, p=0.015), potassium (mean: 4.33 mmol/L vs 4.04, p=0.026), and sodium (mean: 138.10 mmol/L vs 135.80 mmol/L, p=0.000) were lower. The methemoglobin percentage of the ICU group was lower (p=0.000) than the other groups.Conclusion: The ODC of COVID-19 and other respiratory distress patients shifts slightly to the right, indicating that patients have partial respiratory difficulties.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2023The Relationship Between Vitamin-D Deficiency and Protein Oxidation Among Obese Children
Surucu Kara, Ilknur; Mertoglu, Cuma; Siranli, Gülsah; Arslan, Yusuf Kemal; Gok, Gamze; Erel, Ozcan
Aim: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. Methods: Thiol-disulfide homeostasis, Vitamin-D, ischemia modified albumin, insulin, and lipid levels were compared among obese, pre-obese and normal-weight healthy children. Results: A total of 136 children (69 boys and 67 girls) were included in the study. The vitamin-D levels of obese children were lower than those of pre-obese and normal weight (p < 0.05). In the normal weight group, total thiol and native thiol were lower in the pubertal period than in adolescence; were higher in those with sufficient Vitamin-D level than those with insufficient and deficient Vitamin-D (p < 0.05). Vitamin-D level was lower in pre-obese girls than boys (p < 0.05). Those with high triglycerides had high disulfide/total thiol, disulfide, and disulfide/native thiol and low native thiol/total thiol (p < 0.05). Conclusion: Thiol-disulfide homeostasis is negatively affected by low vitamin D levels, pubertal period and high triglyceride levels.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022Evaluation of epicardial adipose tissue thickness and inflammatory parameters in smokers and non-smokers
Arslan, Yusuf Kemal; Mertoglu, Cuma; Ozcicek, Adalet; Ozcicek, Fatih; Soylu, Yasin Emrah; Çoşkun, Reşit
Smoking is the leading cause of preventable death. Epicardial adipose tissue (EAT) surrounds the heart surface and creates local and systemic effects secreting the hormones, cytokines, inflammatory mediators. Previous studies demonstrated that both smoking and EAT have a strong association with inflammation and atherosclerosis.Our study aimed to determine the relationship of smoking with EAT thickness and inflammation by evaluating smokers and non-smokers. A total of 259 healthy male and female participants between the ages of 18-65, without a history of chronic disease and with a body mass index within normal limits, were included in a study. EAT thickness measurements were made by transthoracic echocardiography and EAT thicknesses of smokers and non-smokers were compared. In addition, the effects of smoking and EAT thickness on different inflammatory parameters were evaluated. When the EAT thicknesses were compared between smokers and non-smokers (2.60±1.2), a statistically significant difference was found in favor of smokers (3.84±1.84) (p<0.001). A moderate positive correlation was found among age, body mass index, smoking duration in years, pack/year and EAT thickness. The difference among waist circumference, the number of cigarettes smoked daily, diastolic blood pressure, fasting blood glucose, ALT, AST, total cholesterol, triglyceride, LDL-cholesterol, CRP, uric acid, platelet count, MPV values, platelet/lymphocyte ratio and EAT thickness were found meaningful, but the weak correlation in different ratios were determined. Smoking was found to be the most important determinant of EAT thickness. Other determinants of EAT thickness were age, body mass index, CRP and female gender. The significant statistical relationship between smoking and EAT thickness suggests that smoking increases EAT thickness and inflammatory parameters. Co-assessment of the EAT and blood inflammatory parameters in smokers may guide the initiation of medical treatment in primary prevention or other therapies.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022Platelet Activity Increases in Patients with Diabetic Retinopathy
Mertoglu, Cuma; Ozcicek, Adalet; Çoban, T. Abdulkadir; Karakurt, Yucel; Şiranlı, Gülşah; Ersoy, Alevtina
Objective: The role of new inflammatory markers such as neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, mean platelet volume, and platelet distribution width in diabetic microvascular complications was investigated. Methods: A total of 266 (172 female, 94 male) individuals were divided into 5 groups: group 1, who have diabetes without any complications for at least 10 years; group 2, only diabetic nephropathy; group 3, only diabetic neuropathy; group 4, only diabetic retinopathy; and group 5, control group. Results: Glucose and HbA1c were higher in retinopathy, neuropa thy, and nephropathy groups than in the control group (P < .001). Neutrophil-lymphocyte ratio in the neuropathy group was higher in the retinopathy and uncomplicated diabetic groups (mean ± SD; 2.4 ± 2.9, 1.6 ± 0.5, 1.5 ± 0.5, P = .018, P = .001, respectively), and platelet-lymphocyte ratio was higher only in the retinopa thy group (mean ± SD; 133.8 ± 59, 105.5 ± 34, P = .001). In the retinopathy group, mean platelet volume and platelet distribution width were higher than the control group and the uncomplicated diabetic group (mean platelet volume mean ± SD; 10.6 ± 1.0, 10.0 ± 0.6, 9.7 ± 1.9, P = .009, P = .003, platelet distribution width mean ± SD; 13.0 ± 2.3, 11.4 ± 1.2, 11.7 ± 1.6, P < .001, P = .003, respec tively). Conclusions: Patients with diabetic neuropathy have sub clinical inflammation, and patients with retinopathy have platelet activation. However, further studies are needed to investigate the mechanism of this increased inflammation and platelet reactivity in the development of these complications.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022Serviks Dokularında HPV DNA Pozitifliği ve Osteopontin Düzeyi Arasındaki İlişkinin Araştırılması
Arslan, Yusuf Kemal; Mertoglu, Cuma; Sayar, Ilyas; Aydın, Merve; Çıkman, Aytekin; Kulhan, Mehmet; Gülhan, Barış; Demir, Esra Tuba; Kulhan, Nur Gözde
Amaç: Çalışmamızda, HPV pozitif ve HPV negatif serviks dokularında osteopontin düzeyinin araştırılması, prognostik bir biyobelirteç olarak tanıda klinik öneminin değerlendirilmesi amaçlandı. Yöntem: Haziran 2015-Nisan 2017 tarihleri arasında Erzincan Binali Yıldırım Üniversitesi, Mengücek Gazi Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Polikliniği’ne başvuran ve serviks kanseri taramasına katılan 82 kişi çalışmaya alındı. Servikovajinal sürüntü örnekleri, standart işlem prosedürüne göre toplandı. Geleneksel Pap sitolojisi için slayt hazırlanarak, standart protokollere göre boyandı ve sonuçlar 2004 Bethesda sınıflandırma sistemine göre derecelendirildi. Digene konik fırça örnekleyicisi ile serviksten örnek alındı. Tüm servikal örnekler, Digene® HC2 High-Risk HPV DNA Kiti ile analiz edildi. HPV DNA pozitifliği saptanan örneklere CLART kit ile genotipleme yapıldı. 41 HPV pozitif hasta ve 41 HPV negatif kontrolün doku örneklerinde osteopontin düzeyleri ELISA kiti ile araştırıldı. Bulgular: Osteopontin düzeyleri hasta grubunda 31.55±7.11 ng/ml, kontrol grubunda ise 28.81±5.44 ng/ml olarak saptandı. Hasta grubu ile kontrol grubu arasında istatistiksel olarak anlamlı fark saptandı (p=0.048). Osteopontin düzeyi ile yaş, doğum şekli, hastalık öyküsü, operasyon yöntemi, HPV tipi, preoperatif ve postoperatif patoloji, gravida ve parite arasında istatistiksel olarak anlamlı bir fark bulunmadı (p>0.05). Sonuç: Çalışmamızda, HPV pozitif 41 hastadan yalnızca 5’inde servikal intraepitelyal neoplazi saptanması çalışmamızın kısıtlayıcı yanını oluşturmaktadır. Osteopontin düzeyi, HPV pozitif hastalarda yüksek bulunmasına rağmen, daha geniş sayıda servikal intraepitelyal neoplazi olguları üzerinde yapılacak olan çalışmalara gereksinim olduğunu düşünmekteyiz.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?
Huyut, Mehmet Tahir; Huyut, Zubeyir; Ilkbahar, Fatih; Mertoglu, Cuma
It remains important to investigate the changing and impact of routine blood values (RBVs) in order to predict mortality and follow an appropriate treatment in COVID-19 patients. In the study, the importance of RBVs in the mortality of patients with COVID-19 was investigated. The changes in the biochemical, hematological, and immunological parameters of patients who recovered (n = 4364) and died (n = 233) from COVID-19 over time and their relationship with the mortality of the disease were evaluated retrospectively. Odds ratios of the parameters affecting one-month mortality were calculated by running multiple-logistic-regression analysis. The cut off values and diagnostic efficiencies of the parameters that posed a risk for mortality were obtained via receiver operating curve analysis. It was determined that the C-reactive protein (CRP), D-dimer, procalcitonin, erythrocyte-sedimentation-rate (ESR), troponin values were at abnormal levels until death occurred in the patients who died. In addition, the procalcitonin levels were consistently high in patients who died. The patients who died generally had a sustained increase in their leukocyte and neutrophil levels and biochemical variables, and an ongoing decrease in lymphopenia and eosinopenia levels. Although significant changes were observed in liver function tests, cardiac troponin, hemogram values, kidney function tests and parameters related to inflammation in deceased patients, high ESR, international-normalized-ratio (INR), prothrombin-time (PT), CRP, D-dimer, ferritin and red-cell-distribution width (RDW) values, respectively, were the most effective predictive mortality risk biomarkers of COVID-19. In addition, neutrophilia, leukocytosis, thrombocytopenia, erythrocytopenia were other risk predictors of mortality. Indicators was found in this study can be successfully used to predict mortality from COVID-19.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022Comparison of traditional and novel obesity-related indices for identification of metabolic syndrome in adults
Yilmaz, Sevil Karahan; Özçiçek, Fatih; Mertoglu, Cuma
Purpose: The aim of this study was to evaluate the traditional and novel obesity-related indices in the determination of metabolic syndrome in adults and to determine which marker is the better predictor. Materials and Methods: A total of 419 adults between the ages of 18-65 were included in this study. Body weight, height, waist, hip and waist circumference, and blood pressure were measured; fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol values were analyzed. Metabolic syndrome (MetS) was defined using the International Diabetes Federation criteria. The values of 23 obesity-related indices were calculated. Results: The prevalence of metabolic syndrome is 58.7% (male 41.2%; female 67.7%). The triglyceride glucose (TyG) index has the largest area under the curve (AUC) in both men (AUC = 0.894, cutoff = 3.9) and women (AUC = 0.901, cutoff = 3.9). In men, lipid accumulation product (LAP) had the second highest determination for MetS (AUC = 0.880, cut-off = 51.1), followed by TyG-waist/hip (AUC = 0.876, cut-off = 3.7). Cardiometabolic index (CMI) (AUC = 0.872, cut-off value = 1.3) and visceral adiposity index VAI (AUC = 0.868, cut-off value = 4.1) had the second and third largest AUCs, respectively, in women. Conclusion: TyG index is the best predictor of MetS. Waist circumference could be an alternative index in large epidemiology survey due to its convenient and cost-efective characteristics.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022COVID-19 is more dangerous for older people and its severity is increasing: a case-control study
Mertoglu, Cuma; Huyut, Mehmet; Olmez, Hasan; Tosun, Mustafa; Kantarci, Mecit; Coban, Taha
Coronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn. In the non-ICU group, lymphocyte to monocyte ratio was lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn; and eosinophil, hematocrit, hemoglobin, lymphocyte, and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn, while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher in autumn than summer. The changes in routine blood biomarkers in COVID-19 varied from the emergence of the disease until now. Also, the timely changes of blood biomarkers were mostly more negative, indicating that the disease progresses severely. The study was approved by the Erzincan Binali Yildirim University Non-interventional Clinical Trials Ethic Committee (approval No. 86041) on June 21, 2021.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2022Assessing the nitric oxide and asymmetric dimethylarginine levels in lifelong premature ejaculation: A prospective study; [Evaluación de los niveles de óxido nítrico y dimetilarginina asimétrica en la eyaculación precoz de por vida, un estudio prospectivo]
Erdogan, Abdullah; Keskin, Ercument; Sambel, Murat; Mertoglu, Cuma
Objective: To evaluate nitric oxide (NO) and asymmetric dimethylarginine (ADMA) levels in men with premature ejaculation (PE), which is a common condition that adversely affects quality of life. Material and method: Of the 20–50-year old men presenting to the urology clinic, who were married or had regular sexual intercourse, 40 that were diagnosed with lifelong PE according to the Premature Ejaculation Diagnostic Tool (PEDT) and intravaginal ejaculation latency time (IELT) measured by a stopwatch were included in the study. The results of the PE group were compared to those of the control group formed with 40 healthy hospital personnel. Venous blood samples were centrifuged and stored at −80 °C. The NO and ADMA values were compared between the individuals with and without PE. Results: There was no statistically significant difference between the groups in terms of age, body mass index (BMI), and The International Erectile Dysfunction Index-5 (IIEF-5) questionnaire scores. The NO and ADMA values were significantly lower in the PE group than in the control group (29.76 ±13.26 μmol/L vs. 48.27 ± 22.71 μmol/L; p < 0.001 and 1.01 ± 0.49 nmol/ml vs. 1.83 ± 1.06 nmol/ml; p < 0.001, respectively). There was a significant correlation between IELT and NO levels (r = 0.407, p = 0.001). Conclusion: Our study can contribute to the explanation of the pathophysiology of PE having unclear etiology and treatment. Further studies on these molecules with larger case series are required for the diagnosis and treatment of PE.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2021Is there a role of antisperm antibodies in women with unexplained infertility - a Turkish pilot cross sectional case control study
Mertoglu, Cuma; Turkler, Can; Ulug, Pasa; Ata, Nahit
Aim: Although some studies indicate that the presence of antisperm antibody (ASA) is important in the etiology of female infertility, this remains a controversial issue. The aim of this study was to determine whether the presence of ASA was important or not in primary and secondary unexplained infertility patients. Materials and Methods: Female patients (n = 90) were divided into three groups as follows: the primary infertility group (n = 30), the secondary infertility group (n = 28) and a control group (n = 32). In addition to laparoscopic evaluations, the presence of ASA in the study groups was also examined in serum and peritoneal washing liquid. The ASA - immunoglobulin G was measured using the Enzyme-Linked ImmunoSorbent Assay (ELISA) method with a qualitative measurement kit. Results: When the demographic data were analyzed, it was observed that the study groups were homogeneous in terms of age and period of infertility. The results of the study demonstrated that, when compared to the secondary infertility and control groups, the ASA positivity in the serum in the primary infertility group was significant (p < 0.05). However, when the groups were compared, there was no difference in terms of ASA positivity in peritoneal washing fluid (p > 0.05). Conclusion: This study showed that the presence of ASA in serum may be an impact on the etiology of unexplained primary infertility
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021The role of protein oxidation in the development of diabetic microvascular complications
Mertoglu, Cuma; Siranli, Gulsah; Coban, T. Abdulkadir; Karakurt, Yucel; Ersoy, Alevtina; Ozcicek, Adalet; Arslan, Yusuf; Gok, Gamze; Erel, Ozcan
OBJECTIVE: The role of protein oxidation in the development of diabetic microvascular complications was investigated. METHODS: In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. RESULTS: Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). CONCLUSION: Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Assessment of Relationship Between Serum Vitamin D Levels and Metabolic Syndrome Components in Hemodialysis Patients
Yilmaz, Sevil Karahan; Mertoglu, Cuma; Ayaz, Aylin
Aim: This study is aimed to evaluate the relationship between serum vitamin D levels and metabolic syndrome in hemodialysis patients. Materials and Methods: This study was conducted with participation of 80 patients undergoing hemodialysis for more than 6 months three times a week, aged > 18 years. Their height, dry weight, waist circumference were measured. Biochemical parameters such as serum 25-hydroxyvitamin D, lipid profile, and fasting blood glucose were analyzed. Metabolic syndrome was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Severe vitamin D deficiency, 25 (OH) vitamin D < 5 ng/ml; mild vitamin D deficiency, 25 (OH) vitamin D 5-15 ng/ml; vitamin D insufficiency, 25 (OH) vitamin D 16-30 ng/ml, and vitamin D sufficiency, 25 (OH) vitamin D > 30 ng/ml were categorized. Statistical analysis of the data was performed with the use of SPSS version 21.0. Results: 48.4% of hemodialysis patients were identified to have metabolic syndrome. According to the serum levels of vitamin D; 35.0% of patients had severe vitamin D deficiency, 37.4% of patients had mild vitamin D deficiency, 18.8% of patients had vitamin D insufficiency and 8.8% of patients had vitamin D sufficiency (> 30 ng/ml). Vitamin D insufficiency was significantly associated with metabolic syndrome and central obesity. Conclusions: Deficiency/insufficiency is observed in serum 25-hydroxyvitamin D levels in hemodialysis patients. Vitamin D insufficiency is associated with metabolic syndrome.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Effect of different protein diets on weight loss, inflammatory markers, and cardiometabolic risk factors in obese women
Yilmaz, Sevil; Eskici, Günay; Mertoglu, Cuma; Ayaz, Aylin
Background: Reducing and maintaining body weight has become more important than ever as obesity is becoming increasingly common worldwide. This study was aimed to investigate the effects of diets with different protein contents administered to obese women on anthropometric measurements, inflammatory markers, and cardiometabolic risk factors. Materials and Methods: This randomized controlled trial was conducted with sixty volunteering obese women aged between 20 and 45 years. The subjects were divided into two groups in equal numbers. The high-protein (HP) group (n = 30) was administered an iso-caloric HP diet (25% protein, 30% fat, and 45% carbohydrate), and the control group (n = 30) an isocaloric low-protein diet (15% protein, 30% fat, and 55% carbohydrate), and both groups were followed up for 8 weeks. The subjects' descriptive data, anthropometric measurements, homeostatic model assessment-insulin resistance (HOMA-IR), lipid profiles, and high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-), and interleukin-6 (IL-6) levels were analyzed. Results: There was no significant difference at baseline (except for low-density lipoprotein cholesterol [LDL-C]), and end-of-study (except for IL-6, systolic blood pressure [SBP], and diastolic blood pressure) values of parameters between the two groups; after adjusted for baseline measurements, a significant difference was observed between the groups for body weight, body mass index, waist circumference, HOMA-IR, LDL-C, hs-CRP, TNF-, IL-6, and SBP (P = 0.004, P = 0.001, P = 0.003, P = 0.029, P = 0.004, P = 0.016, P = 0.004, P = 0.010, and P = 0.000, respectively) and were greater in the HP group than in the control group (P < 0.05). Conclusion: The HP diet was effective on improvement in HOMA-IR, SBP, LDL-C, hs-CRP, TNF-, IL-6, and resulted in body weight loss.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2021How do routine laboratory tests change in coronavirus disease 2019?
Mertoglu, Cuma; Huyut, Mehmet Tahir; Arslan, Yusuf; Ceylan, Yasar; Coban, Taha Abdulkadir
How the routine laboratory tests change in terms of coronavirus disease 2019 (COVID-19) was retrospectively analyzed in a large group of patients. Biochemical, hematological and inflammatory variables of a totaly 555 (n = 532 in non-intensive care unit (non-ICU), n = 23 in ICU) patients diagnosed with COVID-19 were analyzed accessing them through the laboratory information system. White blood cell (WBC), neutrophil (NEU), platelet large cell ratio, neutrophil to lymphocyte ratio (NLR), derived NLR (d-NLR), aspartate aminotransferase, urea, creatine kinase (CK) myocardial band (CK-MB), procalcitonin (PCT) values were high whereas lymphocyte (LYM), eosinophil, red blood cells (RBC), hemoglobin, lymphocyte to monocyte ratio, estimated glomerular filtration rate values were low in the ICU group when compared with non-ICU. WBC, NEU, red cell distribution width, alanine transaminase, creatinine, urea, CK-MB, CK, direct bilirubin, lactate dehydrogenase, glucose, C-reactive protein, erythrocyte sedimentation rate, ferritin, D-dimer, PCT and international normalized ratio values increased while RBC, hemoglobin, hematocrit, mean corpuscular volume and total bilirubin values decreased in a significant proportion of patients in both groups based on the normal reference ranges. LYM count was found to be low in a significant number of patients (57.5%) especially in the ICU group and as an important risk factor and diagnostic parameter on admission to ICU (OR: 125, AUC: 0.74). Routine laboratory tests provide important information in terms of both diagnosis and severity of COVID-19. Lymphopenia is a condition that should be monitored which indicates the severity of the disease.
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