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- ArticleAçık Erişim2022INTERNALIZED STIGMA, PERCEIVED SOCIAL SUPPORT, AND LIFE QUALITY IN PATIENTS ADMITTED TO A FORENSIC PSYCHIATRY UNIT; [ADLİ PSİKİYATRİ SERVİSİNDE TEDAVİ GÖREN HASTALARDA İÇSELLEŞTİRİLMİŞ DAMGALANMA, ALGILANAN SOSYAL DESTEK VE YAŞAM KALİTESİ]
Kazgan Kiliçaslan, Aslı; Yildiz, Sevler; Sirlier Emir, Burcu; Kurt, Osman
Objective: This study aimed to examine internalized stigma, perceived social support, and the quality of life and its associations among patients admitted to a forensic psychiatry unit. Material and Method: A total of 97 patients treated at a High Security Forensic Psychiatry Unit were included. A Sociodemographic Data Form, the Multi-Dimensional Scale of Perceived Social Support (MSPSS), the Internalized Stigma of Mental Illness (ISMI), and the World Health Organization Quality of Life Short Form (WHOQOL) were administered to all patients. Results: The mean ISMI, MSPSS, and WHOQL scores were 74.3±8.4, 38.3±8.4, and 75.9±10.5, respectively. A negative correlation between the total MSPSS and total ISMI scores as well as between total the ISMI and total WHOQOL scores was found; on the other hand, a positive and significant association was determined between the total MSPSS and total WHOQOL scores (p<0.001, r=-0.367; p<0.001, r=-0.550; p<0.001, and r=0.496, respectively). The MSPSS total and sub-scale scores, age, alienation, stereotype endorsement, and perceived discrimination predicted the total WHOQOL score (R2=0.613; Model F=12.242; p<0.001). Conclusion: Forensic psychiatry patients experience internalized stigma and reduced social support. Increasing levels of internalized stigma were associated with progressively lower levels of perceived social support and life quality. Predictors of the quality of life include the perceived social support, stereotype endorsement, discrimination, and alienation. This study sheds some light on factors affecting the quality of life in this relatively under examined group of forensic psychiatry patients.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2021The Relationship Between Impulsivity Level and Neutrophil / Lymphocyte Ratio, Platelet/ Lymphocyte Ratio and Mean Platelet Volume in Individuals Diagnosed with Gambling Disorder
Yildiz, Sevler; Atmaca, Murad; Kılıçaslan, Aslı Kazğan; Tabara, Muhammed Fatih
Aim: Gambling disorder (GD) is a mental illness with an increasing frequency in society that characterized by the urge to gamble despite negative consequences and desire to quit. In this study, we aimed to examine the mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and the relationship between these values and impulsivity in patients with GD.Material and Method: 42 patients diagnosed with gambling disorder and 42 healthy controls were included in this study. Sociodemographic data form, Barratt Impulsivity Scale Short Form (BIS-11-SF) were administered to all participants, and then a complete blood count was requested from these individuals. NLR, PLR and MPV were measured according to complete blood count.Results: The mean BSI-11-SF total score of the patient group was found to be statistically significantly higher than the control group (p <0.05). It was found that while the motor impulsivity scores of GD patients increased, the MPV values significantly decreased (r=-0.33, p = 0.03). There was no significant difference between the patient and control groups in terms of NLR (p = 0.288), PLR (p = 0.377) and MPV (p = 0.883) values. In addition, in the patient group, there was a weak negative correlation between age and motor impulsivity score and a weak negative correlation between motor impulsivity score and MPV (r=-0.33, p=0.03), (r=-0.31, p=0.04).Conclusion: It was concluded that an individual’s diagnosis with gambling disorder had a high level of impulsivity, but there was no relationship between gambling and complete blood count parameters. Further studies are needed to explain the etiopathogenesis of gambling disorder.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Type D personality and self-esteem in conversion disorder: a case-control study
Yildiz, Sevler; Kurt, Osman; Korkmaz, Sevda; Kılıçaslan, Aslı Kazğan
Aim: In the present study, we aimed to investigate the differences in type D personality and self-esteem between patients with conversion disorder (CD) and the control group. Material and Method: We carried out the study with 100 patients diagnosed with CD and 100 matching healthy individuals. We used a sociodemographic information form, the Type D Personality Scale (DS-14), and the Rosenberg Self-Esteem Scale (RSES) as the data collection tools. Considering that the scales should have high discriminative powers, we calculated the cut- off points on each scale performing the ROC analysis. Results: The results showed that the patients with CD had significantly higher negative affectivity (NA), social inhibition (SI), and DS-14 total scores than the control group (p<0.001). Also, the patient group obtained significantly higher scores on the RSES than the control group, indicating lower self-esteem among the patients (p<0.001). Finally, we concluded significant positive correlations between the RSES scores and NA (r=0.549 p<0.001), SI (r=0.410 p<0.001) and DS-14 total scores (r=0.521 p<0.001). Conclusion: Overall, we found that CD patients had type D personality traits and low self-esteem. As the patients had decreased self-esteem, their DS-14 scores increased. Uncovering SI and NA to be high in these patients may drive physicians to take measures to mitigate these situations and adopt a different perspective on CD. In addition, the results may contribute to better addressing patients’ conversion symptoms and personality traits compatible with CD.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Medication and symptom severity in schizophrenia patients in COVID-19 pandemic: A cross-sectional study
Yildiz, Sevler; Kurt, Osman; Korkmaz, Sevda; Kılıçaslan, Aslı Kazğan
The present study aimed to determine the possible correlation between medical treatment [oral antipsychotics (OAP), long-acting injectable antipsychotics (LAI), oral + long-acting injectable antipsychotics (OAP + LAI)] and symptom severity, and the compliance of schizophrenia patients with the medication during the COVID-19 pan- demic. The study was conducted with 100 schizophrenia patients who applied to the psychiatry outpatient clinic during the pandemic and met the study criteria. Sociode- mographic data form, Positive and Negative Symptom Scale (PANSS), and Functional Recovery Scale in Schizophrenia (FRSS) were applied to each participant. The rate of patients who quit current treatment was 19%. A statistically significant difference was determined between the patients on OAP and those on LAI, and between those on OAP and those on OAP + LAI based on the overall scale scores (p <0.001). There were significant differences between the FRSS scores of the patients who discontinued treatment, those who continued medication, and those who switched to depot antipsychotic medication (p <0.001). There was a significant difference between those who discontinued medication and those who continued medication based on the overall scale scores (p <0.001). In the present study, it was determined that the symptoms of patients on only LAI medication and those in OAP + LAI medication were lower, and their functionality scores were higher when compared to the patients on only OAP medication. It was also determined that among the schizophrenia patients who applied to psychiatry clinic during pandemic, those who were on LAI exhibited better func- tionality and lower symptom burden when compared to other treatment modalities. During the pandemic, it was observed that LAI medication protected the patients better.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Relationship Between Metabolic Syndrome and Impulsivity in Gambling Disorder
Yildiz, Sevler; Atmaca, Murad; Kılıçaslan, Aslı Kazğan; Tabara, Muhammed Fatih
Objective: The present study aims to compare Metabolic Syndrome (MetS) parameters in pathological gambling disorder (PGD) patients and healthy controls and analyze the correlation between MetS and impulsivity levels in PGD patients with MetS diagnosis. Method: The present study was conducted with 74 PGD patients and 73 healthy controls. The sociodemographic data form and the Barratt Impulsivity Scale short form (BIS-11) were applied to all participants. The MetS parameters determined for all participants were analyzed based on to the National Cholesterol Education Program (NCEP) Adult Treatment Panel II criteria. Results: The total BIS-11 and subscale scores of the patient group were statistically significantly higher when compared to the control group. MetS rate in patients was higher than the control group with 58.1%. There was a significant correlation between diastolic blood pressures of the patients and motor impulsivity and unplanned impulse scores. SBPs, DBPs, TG and fasting blood levels of the patients were found to be significantly higher than the controls, while HDL levels were found to be significantly lower. Conclusion: PGD patients had higher impulsivity levels and MetS rates in these patients were higher than healthy controls. We think that our findings emphasize the consideration of impulsivity-based approaches in PGD treatment and attention to MetS in patients with PGD.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Suicidal Behavior in Individuals with Substance Use Disorder Who Apply to the Probation Outpatient Clinic
Yildiz, Sevler; Uğur, Kerim; Tamam, Lut; Kartal, Fatma; Kılıçaslan, Aslı Kazğan; Polat, Hatice; Demirkol, Mehmet Emin
Objective: The aim of this study was to investigate the correlation between psychological pain, childhood mental trauma, alexithymia, impulsivity and psychological resilience and suicide attempts in individuals with substance use disorder (SUD) who applied to the Probation Outpatient Clinic. Method: The study was conducted with 120 individuals who applied to the probation outpatient clinic and healthy controls. Socio-Demographic Data Form, Childhood Psychological Trauma Scale (CTQ-28), Toronto Alexithymia Scale (TAS), Psychological Pain Scale (PP), Barratt Impulsiveness Scale (BIS), Psychological Resilience Scale (PRS) were applied to all participants. Results: PP, TAS, BIS, CTQ-28 scale scores of patients with suicide attempt history were higher. In the forward stepwise model designed to predict the risk of suicide attempt, PRS, TAS-A, PRS-social competence and BIS-total scores contributed significantly to the model. It was determined that the four significant variables explained 65,6% of the variance in suicide risk. Conclusion: High psychological pain, alexithymia, impulsivity and childhood trauma and low psychological resilience in individuals with substance use disorder could be a predictor of suicide risk.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Sınırda kişilik bozukluğunda serum ürik asit seviyeleri ve dürtüsellikle ilişkisi
Yildiz, Sevler; Kurt, Osman; Korkmaz, Sevda; Kılıçaslan, Aslı Kazğan
Amaç: Çalışmanın amacı ilaç kullanımı olmayan sınırda kişilik bozukluğu (SKB) tanılı hastalardaki serum ürik asit seviyelerini incelemek ve bunun dürtüsellikle olabilecek olası ilişkisini araştırmaktır. Gereç ve Yöntem: Bu çalışmaya SKB tanılı 69 hasta ve 54 sağlıklı kontrol grubu dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Barratt Dürtüsellik Ölçeği Kısa Formu (BDÖ-11) uygulanmıştır. Ardından tüm katılımcılardan açlık venöz kan örnekleri alınarak serum ürik asit düzeyleri çalışılmıştır. Bulgular: SKB tanılı hastalarda serum ürik asit seviyeleri, BDÖ-11 alt boyut ve toplam puanları ve BDÖ toplam puanı kontrol grubundan anlamlı şekilde yüksek bulunmuştur. Serum ürik asit seviyeleri ile BDÖ-11 ölçek puanı arasında pozitif yönde anlamlı bir korelasyon olduğu görülmüştür. Sonuç: Bu çalışmada, ilaç kullanımı olmayan sınırda kişilik bozukluğu tanılı hastalarda kontrol grubuna göre daha yüksek serum ürik asit seviyelerini bildirilmiştir. Çalışmanın bulguları SKB tanılı hastalardaki dürtüselliğin biyolojik temellere dayandırılması açısından örnek oluşturabilir. SKB hastalarında ürik asit seviyeleri ile ilgili ileride yapılacak olan uzunlamasına ve deneysel çalışmalar bizlere bu hastalardaki dürtüselliğin tanı ve tedavisi açısından alternatif bir yol gösterecektir.
RDL Kalıcı Kaydıİncele - Conference ObjectYalnız künye2021Obsesif kompulsif bozukluk tanılı\rhastalarda tp-e ınterval, tp-e/qt oranı\rve fragmante qrs parametrelerinin\rincelenmesi
Yildiz, Sevler; Keleş, Fikret; Kazgan Kılıçaslan, Aslı; Keleş, Denizhan Danacı
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RDL Kalıcı Kaydıİncele - Conference ObjectYalnız künye2021Sağlık çalışanlarında COVID-19 aşısının\r(sinovac) depresyon, anksiyete, stres ve\rsağlık anksiyetesi üzerine etkisi
Yildiz, Sevler; Akkus, Mustafa; Kefeli, Mehmet Celal; Şimşek, Meltem Hazel
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RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Evaluation of depression, self-esteem and hopelessness in patients admitted to psychiatry outpatient clinic in geriatric population during COVID-19 outbreak
Yildiz, Sevler; Uğur, Kerim; Kurt, Osman; Kılıçaslan, Aslı Kazğan
Infection control measures taken to ensure social isolation during the COVID-19 pandemic process seem to negatively affect the mental health of elderly individuals. In this study, it is aimed to examine the effects of pandemic on the mental health of the elderly. 150 patients over the age of 65 who were admitted to the psychiatry outpatient clinic for the first time during the pandemic period were included in the study. Socio demographic data form, Geriatric Depression Scale (GDS), Beck Hopelessness Scale (BHS), Rosenberg Self Esteem Scale (RSE) were applied to all cases after the psychiatric interview conducted by us. In the geriatric population, it was observed that there was a significant negative correlation between BHS and RSE (r = -0.241 p = 0.003), and a positive significant relationship between BHS and GDS (r = 0.478 p <0.001). There was no significant correlation between RSE and GHS (r = -0.042 p = 0.614). During the COVID-19 pandemic, it is understood that the hope level and self-esteem of the geriatric population are low, and their mood is depressive. Among the measures to be taken during infection control, we think that elderly people should be given psychosocial support, and thus a healthier environment can be offered to these individuals in terms of physical and mental aspects.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Personality characteristics, anxiety sensitivity, anxiety and depression levels of patients with premenstrual dysphoric disorder
Yildiz, Sevler; Kiliçaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Atmaca, Murad
Purpose: The aim of this study was to evaluate the personality traits, anxiety sensitivity, anxiety and depression levels of patients with Premenstrual dysphoric disorder (PMDD). Materials and Methods: Forty PMDD patients with no psychiatric treatment history and 40 healthy women with similar sociodemographic characteristics and no history of systemic or psychiatric disease were included in the study. Anxiety-Sensitivity-Index-3 (ASI-3), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and the Eysenck Personality Questionnaire-Revised Abbreviated (EPQR-S) were administered to all participants. Results: The patient group's EPQR-S neuroticism, psychoticism, lying subscales and total scores were significantly higher than the control group's scores. The ASI-3 physical, cognitive, social sub-dimensions and total score of the patient group were found to be significantly higher than the control group's score. The BDI and BAI scale scores of the patient group were found to be significantly higher than the scores of the control group. Conclusion: In women with high anxiety sensitivity, psychotic and neurotic personality traits, this may affect the development of PMDD or the course of the disease.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2021Evaluation of perceived family burden, care burden and quality of life of caregivers during the pandemic period
Yildiz, Sevler; Kazgan, Asli; Kurt, Osman; Korkmaz, Sevda
Aim: In this study, we aimed to evaluate the perceived family burden, caregiving burden and the quality of life of people who have to spend most of their time at home with their patients during the pandemic period and who provide home care for patients diagnosed with psychotic disorder. Material and Methods: The study included caregivers of 91 patients with a diagnosis of psychotic who admitted to the psychiatry outpatient clinic during the pandemic period and met the study criteria. All participants were applied the World Health Organization Quality of Life Form (WHOQOL-BREF-TR), Perceived family burden scale (PFBS), and the Zarit Caregiver Burden Scale (ZBS). Results: Participants' mean PFBS score was 65.6 +/- 19.1 and their ZBS mean score was 56.2 +/- 14.8. A positive correlation was found between PFBS score and ZBS score (p=0,00, r=0,763). Also, a significant negative correlation was found between PFBS score and WHOQOL-BREF-TR scale sub-scales and the ZBS score and the WHOQOL-BREF-TR scale sub-scales. Discussion: The pandemic period negatively affected caregivers of patients diagnosed with psychosis.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2021Molecular Mechanism of the Protective Effect of Tianeptine Against Ketamine-Induced Cardiac Injury in Rats
Yildiz, Sevler; Ugur, Kerim; Tas, Hakan G.; Ozcicek, Fatih; Kuyrukluyildiz, Ufuk; Mendil, Ali S.; Cankaya, Murat; Mamedov, Renad; Suleyman, Halis
Ketamine is a short-acting anesthetic drug that is derived from phencyclidine. Ketamine is used to treat depression and chronic pain disorders, as well as for anesthesia, analgesia, and sedation. Ketamine’s sympathomimetic characteristic causes cardiotoxicity. The pathophysiology of ketamine’s harmful impact has been linked to reactive oxygen species (ROS) and proinflammatory cytokines such as interleukin 1 beta (IL-1), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). Tianeptine is an antidepressant that works similarly to tricyclic antidepressants. According to studies, tianeptine reduces the production of proinflammatory cytokines such as ROS, IL-1, IL-6, and TNF-α. Tianeptine has a sympatholytic action as well. All of this evidence suggests that tianeptine might help to reduce ketamine cardiotoxicity. The goal of our research is to use biochemical and histological techniques to see how tianeptine affects ketamine-induced cardiotoxicity in rats.
RDL Kalıcı Kaydıİncele - Review ArticleAçık Erişim2021The relationship between anxiety and serum Urotensin-II and S100B levels in patients with essential hypertension; [Esansiyel hipertansiyonlu hastalarda anksiyete ile serum ürotensin-II ve S100B seviyeleri arasındaki ilişki]
Kazğan, Aslı; Korkmaz, Sevda; Yildiz, Sevler; Korkmaz, Hasan; Telo, Selda; Atmaca, Murad
Objective: In hypertensive people, some biochemical parameters that are associated with oxidative stress and endothelial functions may play a role in the manifestation of anxiety symptoms, and even in the intensification of clinical symptoms of the disease. The purpose of our correlative study is to examine the association between anxiety severity and levels of oxidative stress parameters of Urotensin-II and S100B protein in patients with essential hypertension. Method: A total of 153 patients, who have applied Sociodemographic and Clinical Data Form, Beck Anxiety Inventory (BAI), Beck Depression Inventory and venous blood samples were taken after blood pressure measurement. S100B and Urotensin-II levels were measured with Enzyme-Linked Immunosorbent Assay method. Results: A positive correlation was determined between depression and anxiety scores, and systolic blood pressure (p=0.049, r= 0.160; p<0.01, r=0.292). There was a positive relation between BAI scores and Urotensin-II levels (p= 0.043, r= 0.164). A positive correlation was determined between Urotensin-II levels and S100B levels (p<0.01, r= 0.711). A statistically significant difference was observed in serum Urotensin-II levels between depression group and no depression group (p=0.017). Discussion: It was determined in our study that Urotensin-II level increased with increasing anxiety level in essential hypertension patients. It was also determined that Urotensin-II level was higher in hypertensive patients with depression compared to patients who don't have depression. Our study will shed light on new studies that will investigate the contribution of Urotensin- II and S100B in the etiology of patients diagnosed with essential hypertension, which is very commonly accompanied by anxiety and depressive symptoms.
RDL Kalıcı Kaydıİncele - LetterAçık Erişim2021Angioedema induced by valproic acid
Yildiz, Sevler; Kazgan, Asli
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2020Evaluation of temperament/personality traits, alexithymia, psychiatric symptoms, and quality of life in female patients diagnosed with infertility
Yildiz, Sevler; Ugur, Kerim; Sandogan, Erdinc; Yagin, Fatma Hilal; Akkus, Mustafa
Purpose: The aim of this study was to compare the temperament/personality characteristics, alexithymia, psychiatric symptoms, and quality of life of a group of infertile women with the healthy control group, and thus to provide a basis for assessing the possible causal relationship between the phenomenon of infertility and these characteristics. Materials and Methods: Seventy-five women between 18-49 years of age who were diagnosed with infertility in the obstetrics outpatient clinic were included in the patient group and 75 healthy female individuals in the control group. Beck Depression Inventory, State Trait Anxiety Scale (STAI I-II), Quality of Life Scale, TEMPS Temperament Scale, and Toronto Alexithymia Scale were administered to all participants, and a semi-structured interview form was employed to question the clinical-sociodemographic characteristics. Results: Depression and anxiety scores of the patient group were higher than the control group's scores and the differences were statistically significant. The quality of life scale scores of the patient group were found to be lower in each sub-scale, and the differences were statistically significant. TheTemps-A sub-scales scores of the patient group were higher with statistically significant differences. Conclusion: Our findings support the need to investigate the possible accompanying psychosocial disorders in women receiving infertility treatment. The psychological support will be important for this group of women in terms of positively affecting the outcome during the treatment process
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