Erzincan Binali Yıldırım ÜniversitesiErzincan Binali Yıldırım ÜniversitesiAçık Erişim Arşivi · RDL Open

A metabolomics study: Could plasma metabolites be a guide for the prevention of tamsulosin side effects?; [Une étude métabolomique: les métabolites plasmatiques pourraient-ils être un guide pour la prévention des effets secondaires de la tamsulosine ?]

ArticleAçık Erişim

Özet

Background: The understanding of precision medicine, which aims for high efficacy and low toxicity in treatments, has gained more importance with omics technologies. In this study, it was aimed to reach new suggestions for low-toxicity treatment by clarifying the relationship between tamsulosin side effects and metabolome profiles. Materials and methods: Plasma samples of control and tamsulosin-treated rats were analyzed by LC-Q-TOF/MS/MS. MS/MS data was processed in XCMS software for the identification of metabolite and metabolic pathway analysis. Data were classified with MATLAB 2019b for multivariate data analysis. 34 m/z values were found to be significantly different between the drug and control groups (P ≤ 0.01 and fold analysis ≥ 1.5) and identified by comparing METLIN and HMDB databases. Results: According to multivariate data analysis, α-Linolenic Acid, Thiamine, Retinoic acid, 1.25-Dihydroxyvitamin D3-26.23-Lactone, L-Glutamine, L-Serine, Retinaldehyde, Sphingosine 1-phosphate, L-Lysine, 23S.25-Dihydroxyvitamin D3, Sphinganine, L-Cysteine, Uridine 5’-diphosphate, Calcidiol, L-Tryptophan, L-Alanine levels changed significantly compared to the control group. Differences in the metabolisms of Retinol, Sphingolipid, Alanine-Aspartate-Glutamate, Glutathione, Fatty Acid, Tryptophan, and biosynthesis of Aminoacyl-tRNA, and Unsaturated Fatty Acid have been successfully demonstrated by metabolic pathway analysis. According to our study, vitamin A and D supplements can be recommended to prevent side effects such as asthenia, rhinitis, nasal congestion, dizziness and IFIS in the treatment of tamsulosin. Alteration of aminoacyl-tRNA biosynthesis and sphingolipid metabolism pathways during tamsulosin treatment is effective in the occurrence of nasal congestion. Conclusions: Our study provides important information for tamsulosin therapy with high efficacy and low side effects in precision medicine. © 2022 Académie Nationale de Pharmacie

Anahtar Kelimeler

LC-Q-TOF/MS/MSMetabolomicsPrecision medicineSide effectsTamsulosinAnimalsBiomarkersChromatography, High Pressure LiquidIatrogenic DiseaseRatsRNA, TransferSphingolipidsTandem Mass Spectrometry25 dihydroxyvitamin d3alanineaminoacyl transfer RNAaspartic acidcalcidiolcalcitriol 26,23 lactonecysteinedihydroxycolecalciferolfatty acidglutamic acidglutamineglutathionelinolenic acidlysineretinalretinoic acidretinol
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Tam Kayıt
AlanDeğerDil
dc.contributor.authorAkman, T.C.
dc.contributor.authorKadioglu, Y.
dc.contributor.authorSenol, O.
dc.contributor.authorErkayman, B.
dc.date.accessioned2026-10-18T20:27:01.995793518Z
dc.date.available2026-10-18T20:27:01.995793518Z
dc.date.issued2023
dc.description.abstractBackground: The understanding of precision medicine, which aims for high efficacy and low toxicity in treatments, has gained more importance with omics technologies. In this study, it was aimed to reach new suggestions for low-toxicity treatment by clarifying the relationship between tamsulosin side effects and metabolome profiles. Materials and methods: Plasma samples of control and tamsulosin-treated rats were analyzed by LC-Q-TOF/MS/MS. MS/MS data was processed in XCMS software for the identification of metabolite and metabolic pathway analysis. Data were classified with MATLAB 2019b for multivariate data analysis. 34 m/z values were found to be significantly different between the drug and control groups (P ≤ 0.01 and fold analysis ≥ 1.5) and identified by comparing METLIN and HMDB databases. Results: According to multivariate data analysis, α-Linolenic Acid, Thiamine, Retinoic acid, 1.25-Dihydroxyvitamin D3-26.23-Lactone, L-Glutamine, L-Serine, Retinaldehyde, Sphingosine 1-phosphate, L-Lysine, 23S.25-Dihydroxyvitamin D3, Sphinganine, L-Cysteine, Uridine 5’-diphosphate, Calcidiol, L-Tryptophan, L-Alanine levels changed significantly compared to the control group. Differences in the metabolisms of Retinol, Sphingolipid, Alanine-Aspartate-Glutamate, Glutathione, Fatty Acid, Tryptophan, and biosynthesis of Aminoacyl-tRNA, and Unsaturated Fatty Acid have been successfully demonstrated by metabolic pathway analysis. According to our study, vitamin A and D supplements can be recommended to prevent side effects such as asthenia, rhinitis, nasal congestion, dizziness and IFIS in the treatment of tamsulosin. Alteration of aminoacyl-tRNA biosynthesis and sphingolipid metabolism pathways during tamsulosin treatment is effective in the occurrence of nasal congestion. Conclusions: Our study provides important information for tamsulosin therapy with high efficacy and low side effects in precision medicine. © 2022 Académie Nationale de Pharmacie
dc.description.sponsorshipThis study is a part of PhD thesis of R.A. Tugrul Çağrı Akman. The authors are grateful to Atatürk University [BAP-2019; Proje K: TDK-2019-7256] for financial support of this study.
dc.identifier.doi10.1016/j.pharma.2022.09.004
dc.identifier.endpage232
dc.identifier.issn0003-4509
dc.identifier.issue2
dc.identifier.pmid36126750
dc.identifier.scopus2-s2.0-85138993690
dc.identifier.startpage220
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/12082
dc.identifier.volume81
dc.identifier.wosWOS:000990502100001
dc.language.isoen
dc.publisherElsevier Masson s.r.l.
dc.relation.ispartofAnnales Pharmaceutiques Francaises
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLC-Q-TOF/MS/MS
dc.subjectMetabolomics
dc.subjectPrecision medicine
dc.subjectSide effects
dc.subjectTamsulosin
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectChromatography, High Pressure Liquid
dc.subjectIatrogenic Disease
dc.subjectRats
dc.subjectRNA, Transfer
dc.subjectSphingolipids
dc.subjectTandem Mass Spectrometry
dc.subject25 dihydroxyvitamin d3
dc.subjectalanine
dc.subjectaminoacyl transfer RNA
dc.subjectaspartic acid
dc.subjectcalcidiol
dc.subjectcalcitriol 26,23 lactone
dc.subjectcysteine
dc.subjectdihydroxycolecalciferol
dc.subjectfatty acid
dc.subjectglutamic acid
dc.subjectglutamine
dc.subjectglutathione
dc.subjectlinolenic acid
dc.subjectlysine
dc.subjectretinal
dc.subjectretinoic acid
dc.subjectretinol
dc.titleA metabolomics study: Could plasma metabolites be a guide for the prevention of tamsulosin side effects?; [Une étude métabolomique: les métabolites plasmatiques pourraient-ils être un guide pour la prévention des effets secondaires de la tamsulosine ?]
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus0
rdl.citation.wos0
rdl.departmentDepartment of Analytical Chemistry, Faculty of Pharmacy, Erzincan Binali Yildirim University, 24100 Erzincan, Turkey. Electronic address: eczcagri87@gmail.com.
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexEmerging Sources Citation Index (ESCI)