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The effect of resveratrol on oxidative ovary-damage induced by methotrexate in rats (Resveratrol oxidative ovary-damage)

ArticleAçık Erişim

Özet

Methotrexate (MTX) is a commonly used folic acid antagonist for the treatment of neoplasia and some autoimmune diseases. Resveratrol has important anti-inflammatory, antioxidant and immunomodulatory properties. The aim of this study was to investigate the effects of resveratrol on MTX-induced ovary-damage and oxidative stress in rats. We hypothesized that supplement of resveratrol could counteract MTX-induced cytotoxicity in rat ovary. Albino Wistar female rats were randomly divided into three groups: Healthy control (HC), resveratrol + methotrexate (RMTX) and methotrexate (MTX) group. Their ovaries were removed. Biochemical and histopathological methods were utilized for evaluation of the oxidative ovary-damage. MDA was found to be higher but tGSH and SOD were lower in the ovarian tissue of the rat group administered MTX, but it is observed that these ratios are reversed in HC and in RMTX groups. MTX treatment induced ovary damage and especially pre-treatment with resveratrol provided protective effect against this MTX-induced ovary-damaged.

Anahtar Kelimeler

MethotrexateOxidative ovary-damageResveratrolAnimalsAntioxidantsFemaleOvaryOxidative StressRatsRats, Wistarglutathionemalonaldehydesuperoxide dismutaseantioxidantanimal experimentanimal modelanimal tissueantioxidant activityArticlebiochemistryblood vesselcontrolled studydrug cytotoxicityenzyme activityhistopathologylipid peroxidationnonhumanovary diseaseovary tissuerat
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/14436Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.4149/gpb_20190281Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorAta, Nahit
dc.contributor.authorKulhan, Nur G.
dc.contributor.authorKulhan, Mehmet
dc.contributor.authorTurkler, Can
dc.contributor.authorKiremitli, Tunay
dc.contributor.authorKiremitli, Sevil
dc.contributor.authorCimen, Ferda Keskin
dc.contributor.authorSuleyman, Halis
dc.contributor.authorToprak, Veysel
dc.date.accessioned2026-10-18T20:29:13.864214903Z
dc.date.available2026-10-18T20:29:13.864214903Z
dc.date.issued2019
dc.description.abstractMethotrexate (MTX) is a commonly used folic acid antagonist for the treatment of neoplasia and some autoimmune diseases. Resveratrol has important anti-inflammatory, antioxidant and immunomodulatory properties. The aim of this study was to investigate the effects of resveratrol on MTX-induced ovary-damage and oxidative stress in rats. We hypothesized that supplement of resveratrol could counteract MTX-induced cytotoxicity in rat ovary. Albino Wistar female rats were randomly divided into three groups: Healthy control (HC), resveratrol + methotrexate (RMTX) and methotrexate (MTX) group. Their ovaries were removed. Biochemical and histopathological methods were utilized for evaluation of the oxidative ovary-damage. MDA was found to be higher but tGSH and SOD were lower in the ovarian tissue of the rat group administered MTX, but it is observed that these ratios are reversed in HC and in RMTX groups. MTX treatment induced ovary damage and especially pre-treatment with resveratrol provided protective effect against this MTX-induced ovary-damaged.
dc.identifier.doi10.4149/gpb_20190281
dc.identifier.eissn1338-4325
dc.identifier.endpage524
dc.identifier.issn0231-5882
dc.identifier.issue6
dc.identifier.pmid31829309
dc.identifier.scopus2-s2.0-85076470144
dc.identifier.startpage519
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/14436
dc.identifier.volume38
dc.identifier.wosWOS:000514074900007
dc.language.isoen
dc.publisherSlovak Academy of Sciences
dc.relation.ispartofGeneral Physiology and Biophysics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMethotrexate
dc.subjectOxidative ovary-damage
dc.subjectResveratrol
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectFemale
dc.subjectOvary
dc.subjectOxidative Stress
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectglutathione
dc.subjectmalonaldehyde
dc.subjectsuperoxide dismutase
dc.subjectantioxidant
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectArticle
dc.subjectbiochemistry
dc.subjectblood vessel
dc.subjectcontrolled study
dc.subjectdrug cytotoxicity
dc.subjectenzyme activity
dc.subjecthistopathology
dc.subjectlipid peroxidation
dc.subjectnonhuman
dc.subjectovary disease
dc.subjectovary tissue
dc.subjectrat
dc.titleThe effect of resveratrol on oxidative ovary-damage induced by methotrexate in rats (Resveratrol oxidative ovary-damage)
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus14
rdl.citation.wos11
rdl.departmentErzincan University Medical Faculty, Gynaecology and Obstetrics Department, Erzincan, Turkey.
rdl.oa.statusgold
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)