Effect of Cinnamon Extract on Ovarian Torsion Detorsion Damage in Rats

Background and Objective: The torsion and subsequent detortion of the ovaries causes oxidative and inflammatory damage. Cinnamon is an herbal agent with many activities such as antioxidant and anti-inflammatory. This study investigates biochemically and histopathologically the protective effect of cinnamon extract (CE) in potential ischemia-reperfusion (I/R) injury induced by torsion detorsion of ovarian tissue in rats. Materials and Methods: The rats were divided into healthy (HG), sham operation (SOG), ovarian I/R (OIR) and CE (100 mg kgG1 CE, oral, 6 days)+ovarian I/R (COIR) groups. For I/R, right ovaries were subjected to ischaemia for 3 hrs followed by reperfusion for 6 days. Ovarian tissues were analysed for oxidants, antioxidants and proinflammatory cytokines. The histological structure of the excised tissues was also examined. Results: Oxidants (malondialdehyde) and proinflammatory cytokines (nuclear factor kappa B, tumor necrosis factor-alpha, interleukin 1-beta, interleukin-6) increased and antioxidants (total glutathione, superoxide dismutase, catalase) decreased in ovarian tissues of OIR compared to HG (p<0.001). Oxidant and proinflammatory cytokines were lower and antioxidants were higher in rats receiving CE treatment with the I/R procedure compared to OIR (p<0.001). Histological damage observed in the OIR group was found to be attenuated in the COIR group. Conclusion: The CE may protect the ovarian tissue from I/R damage with its antioxidant and anti-inflammatory activity.