Synthesis and Biological Evaluation of New 2-Ethoxy-6-[(4,5- dihydro-1H-1,2,4-triazol-5-one-4-yl)iminomethyl]phenyl 4-nitro-benzoate Derivatives

In the present study, 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) reacted with 3-ethoxy-2-(4- nitrobenzoxy)-benzaldehyde (2) to afford 2-ethoxy-6-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl) iminomethyl]phenyl 4-nitrobenzoates (3). The structures of new nine compounds were established from the elemental analyses, IR, 1 H NMR and 13C NMR spectral data. The synthesized compounds were analyzed for their in vitro potential antioxidant activities in three different methods. In addition, these new compounds were screened for their antimicrobial activities.