Araştırmacılar(7)

• Alan, Cumali
• Karadogan, Muhammed Talha
• Kolkiran, Abdulselim
• Korkmaz, Levent
• Peker, Necla Aydın
• Topal, Ismail
• Yeter, Bahtinur

• ArticleAçık Erişim2026/r/ebyu/19209
  Comprehensive MEFV Variant Spectrum in Pediatric Patients with Suspected Familial Mediterranean Fever: A Whole-Gene Sequencing Study

  Gunay, Murat; Demir, Abdussamed Yasin; Yeter, Bahtinur

  Objective: To determine the Mediterranean Fever (MEFV) variant spectrum using whole-gene next-generation sequencing (NGS) in pediatric cases with suspected Familial Mediterranean Fever (FMF). Methods: This retrospective cross-sectional study included 471 pediatric cases referred for MEFV analysis. All exons were analyzed using NGS, and variants were classified according to American College of Medical Genetics and Genomics criteria. Results: At least one MEFV variant was detected in 59.4% of cases. A total of 23 variants were identified, predominantly in exon 10 (43.5%) and exon 2 (34.8%). The most frequent variants were R202Q (43.3%), E148Q (16.3%), and M694V (13.7%). A low-frequency variants of uncertain significance, G150R, was detected in one case. Heterozygous genotypes were the most common (59.6%). Conclusion: Whole-gene sequencing enables the detection of both common and rare MEFV variants that may be missed by limited mutation panels. However, frequently detected variants, such as R202Q, require careful interpretation because of their high population frequency and controversial pathogenicity.

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• ArticleAçık Erişim2026/r/ebyu/10501
  Syringic acid pretreatment potentiates antioxidant mechanism and downregulates inflammatory signaling towards doxorubicin-related oxidoinflammatory hepatorenal damage in rats

  Karadogan, Muhammed Talha; Yeni, Yesim; Yeter, Bahtinur; Gungor, Ali; Altuner, Durdu; Azade, Faraz; Gursul, Cebrail; Suleyman, Halis

  Although doxorubicin (DOX) is a first-line antineoplastic drug, its clinical use is limited due to its widespread side effects. Hepatic and renal metabolic clearance causes DOX accumulation in these organ systems, ultimately leading to oxidative-inflammatory damage. This study investigated the potential impact of syringic acid (SA), a natural antioxidant phenolic compound, against in vivo DOX-evoked hepatorenal damage. SA was orally administered to rats at 100 mg/kg body weight for 10 consecutive days. On the 8th day of the study, DOX was administered at 20 mg/kg by single-dose intraperitoneal injection to prompt hepatorenal toxicity. Hepatorenal toxicity was assessed by measuring serum alanine transferase (ALT), aspartate transferase (AST), blood urea nitrogen (BUN), and creatinine (Cre). Histopathological evaluation of kidney and liver tissues was also performed to observe DOX-related damage. The concentrations of malondialdehyde (MDA) and glutathione (GSH), along with the activities of catalase (CAT) and superoxide dismutase (SOD), were measured in the hepatorenal tissues, in addition to the concentration of 8-OHdG in serum, to determine the protective effect of SA against oxidative stress. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were investigated with molecular and immunohistochemical analysis in hepatorenal tissues, evaluating the inflammation. SA treatment prevented DOX-aberrant elevation of hepatorenal biomarkers in serum, besides histopathological alterations in rats’ liver and kidney. Additionally, SA markedly counteracted DOX-provoked oxidative damage as evidenced by outstanding reduction in lipid peroxidation and 8-OHdG, conjointly promoted GSH contents, and amelioration of activities of SOD and CAT. Similarly, SA-treated rats exhibited attenuation of hepatorenal inflammation via diminished TNF-α and IL-6 levels. SA exerted a hepatorenal protective effect in rats by exhibiting antioxidant and anti-inflammatory activities.

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• ArticleAçık Erişim2025/r/ebyu/19454
  The Role of IL-17 in the Pathogenesis of Acute Rheumatic Fever

  Akcurin, Gayaz; Uygun, Dilara Fatma Kocacik; Yeter, Bahtinur; Sallakci, Nilgun

  Objective: In this study, our aim is to determine the interleukin 17 (IL-17) and interleukin 22 (IL-22) levels in acute rheumatic fever (ARF) and rheumatic heart disease (RHD) patients and their relationship with rheumatic fever pathogenesis. Methods: Newly diagnosed 7 ARF patients and 14 RHD patients who are followed by Akdeniz University Faculty of Medicine, Pediatric Cardiology Department and 15 age and sex-appropriate healthy children as the control group were enrolled in this study. Interleukin 17 and interleukin 22 levels were determined with an enzyme-linked immunosorbent assay. Results: IL-17 levels were undetectable, while the IL-22 level was increased in 1 patient in the ARF group. Eleven of 14 RHD patients had IL-17 under detectable levels, while 3 had detectable levels. None of the patients had detectable IL-22 levels. In the control group, none had detectable IL-17 or IL-22 levels. Conclusion: Our results showed that IL-17 and IL-22 do not have an important role in ARF pathogenesis.

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• ArticleAçık Erişim2025/r/ebyu/11794
  Anemia, inflammation, circadian rhythm and season effects in febrile convulsions

  Surucu Kara, Ilknur; Aydin Peker, Necla; Arslan, Yusuf Kemal; Mertoglu, Cuma

  OBJECTIVE: Our aim in the study is to investigate circadian rhythm, season, age, gender, and hemogram parameters in children diagnosed with febrile convulsions. METHODS: The data of a total of 478 children, consisting of 160 patients with febrile convulsions (90 male/70 female) and 318 control groups (healthy, convulsiyon free-febrile), were compared. RESULTS: The average age of all patients was 25.7±14.7 (minimum 6-maximum 60) months, and the most common convulsion age was 13-18 months. Circadian rhythm was similar, application seasons were similar. The male/female ratio was 1.3. MPV in winter was lower than other seasons (p=0.002). At younger ages, lymphocyte count was higher (p=0.048) and NLR was lower (p=0.036). NLR was lower in patients with febrile convulsions with anemia than in patients with febrile convulsions without anemia (p=0.029). NLR was lower in patients with febrile convulsions with anemia than in the convulsion-free febrile control group with anemia (p=0.001). In patients with febrile convulsions, MPV was lower (p=0.033) and NLR was higher (p=0.001) than in the convulsion-free febrile control group. One third of the patients had hypocapnia. CONCLUSION: Young age, anemia, inflammation, and hypocapnia may facilitate the occurrence of febrile convulsions. MPV and NLO, which are hemogram parameters, can guide us about inflammation. Blood gases may provide information regarding hypocapnia. These rapid examinations may help elucidate the etiology. Prospective studies are needed for circadian rhythm in febrile convulsions.

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• ArticleYalnız künye2024/r/ebyu/19792
  Çocuk hastalarda göğüs ağrısı şikayetinin farklı basamaklardaki hekimler tarafından yönetimi

  Yakut, Kahraman; Uzuner, Selcuk; Karadoğan, Muhammed Talha; Durak, Umut; Yozgat, Yilmaz; Fırat, Cem Koray

  Amaç: Göğüs ağrısı şikayeti olan çocuk hastalarda, farklı basamaklardaki hekimlerin hasta yönetimi konusundaki uygulamalarını incelemeyi amaçladık. Yöntem: Göğüs ağrısı olan çocuklar için hazırlanan anket formundaki sorular çocuk sağlığı ve hastalıkları uzmanları (ÇSHU), aile hekimi uzmanları (AHU) ve çocuk sağlığı ve hastalıkları asistanlarına (ÇSHA) internet üzerinden ulaştırıldı. Mart 2021- Haziran 2021 tarihleri arasında hekimlerin isim belirtmeden Bulgular: Bütün gruplardaki hekimlerin göğüs ağrısının en sık kas- iskelet sistemi ilişkili olduğunu düşündükleri belirlendi (ÇSHU %86.7, ÇSHA %81, AHU %76.7). Göğüs ağrısı olan çocukların, hekimler tarafından en sık çocuk kardiyoloji polikliniğine yönlendirildiği ve bu oranının çocuk sağlığı ve hastalıkları alanında eğitim düzeyi arttıkça arttığı belirlendi (ÇSHU %87.8, ÇSHA %84.7, AHU %70.4). Siyanoz AHU için en önemli yönlendirme neden iken (%95.2), ailede erken yaşta miyokard infarktüsü geçirme öyküsü ÇSHU (%95.3) ve ÇSHA (%93) için ilk sırada gelen neden idi. Diğer gruplarla karşılaştırıldığında tanı testlerine ulaşabilen AHU oranlarının biraz daha düşük olduğu belirlendi. EKG tüm gruplar için en ulaşılabilir (ÇSHU %98.4, ÇSHA %98.8, AHU %92.5) ve en çok kullanılan tanı aracıydı (ÇSHU %95.6, ÇSHA %97.6, AHU %94.2). Pediatrik EKG’yi çok iyi değerlendirebildiğini düşünen hekim sayısı oranı tüm gruplarda düşüktü (ÇSHU%16.3, ÇSHA %8.6, AHU %4.6). Sonuç: Bu çalışmada tüm hekim grupları tarafından çocuklardaki göğüs ağrısının en sık nedeni kas-iskelet sistemi olarak düşünülmektedir. Tanı araçlarına ulaşmakta güçlük çekilmediği halde sevk sistemine çok sık başvurulduğu görülmektedir. Kardiyak kökenli ğöğüs ağrısı oranı düşük olduğu halde, en sık yönlendirme kardiyoloji polikliniklerine olduğu izlenmektedir.

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• ArticleYayıncıda açık erişim2024/r/ebyu/12373
  Protective effects of thiamine pyrophosphate and cinnamon against oxidative liver damage induced by an isoniazid and rifampicin combination in rats.; [Efectos protectores del pirofosfato de tiamina y la canela contra el daño hepático oxidativo inducido por la combinación de isoniazida y rifampicina en ratas]

  Yeter, Bahtınur; Mammadov, Renad; Koc, Zeynep; Bulut, Seval; Tastan, Tugba Bal; Gulaboglu, Mine; Suleyman, Halis

  Isoniazid and rifampicin (IRC) have been shown to cause hepatotoxicity in both clinical and preclinical studies. Oxidative stress and inflammation have been held responsible for the pathogenesis of IRC-induced hepatotoxicity. Antioxidative and anti-inflammatory effects of thiamine pyrophosphate (TPP) and cinnamon extract (CE) have been shown in previous studies. Therefore, our study investigated the protective effects of TPP and CE on possible liver damage caused by IRC treatment in rats. Twenty-four albino Wistar rats were categorized into four groups: a healthy group (HG), an IRC group (IRG), a TPP+IRC group (TIRG), and a CE+IRC group (CIRG). TPP (25 mg/kg) was administered intraperitoneally to TIRG, while CE (100 mg/kg) was administered orally to CIRG. In IRG, TIRG, and CIRG, isoniazid (50 mg/ kg) and rifampicin (50 mg/kg) were administered orally one hour after these treatments. For seven days, this procedure was repeated once a day. After this period, blood samples were taken from the tail veins, and the rats were sacrificed. The removed liver tissues were analyzed for oxidant, antioxidant, and proinflammatory cytokines and subjected to histopathological evaluation. Serum alanine aminotransferase and aspartate aminotransferase activities were also measured. An increase in malondialdehyde, nuclear factor kappa B, tumor necrosis factor-alpha, interleukin 1 beta, and interleukin-6 levels, a decrease in total glutathione levels, superoxide dismutase and catalase activities, and an increase in alanine aminotransferase and aspartate aminotransferase activities were found with IRC treatment (p<0.001). The histopathological analysis of the IRG suggested hepatotoxicity (p<0.001). TPP and CE administered with IRC inhibited the biochemical changes (p<0.001). In the TIRG, this inhibition was higher than in the CIRG (p<0.05). Histological damage was inhibited by TPP (p<0.001). CE prevented biochemical changes but not histological changes except inflammatory cell infiltration. Therefore, TPP may be better than CE in preventing IRC-induced hepatotoxicity.

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• ArticleAçık Erişim2024/r/ebyu/12294
  Risk Factors for Lower Respiratory Tract Infection and Recurrent Lower Respiratory Tract Infection in Children

  Kara, İlknur Sürücü; Peker, Necla Aydın; Arslan, Yusuf Kemal; Topal, İsmail

  Introduction: A survey was administered to the families of children hospitalized due to lower respiratory tract infections in winter. Risk factors that may cause non-recurrent LRTI and recurrent LRTI in hospitalized children were compared. Materials and Methods: Survey questions were asked to the families of pediatric patients who were hospitalized with a diagnosis of LRTI in the training and research hospital during the winter period and did not have a known chronic disease. Patients were divided into two groups: children hospitalized due to recurrent LRTI and non-recurrent LRTI (first hospitalization). Factors that may cause LRTI were compared between the two groups. Results: 47 of 77 patients (61%) were male. There were 43 (55.8%) patients between 1 and 6 months. There were 25 (32.5%) patients living in crowded houses. The number of patients exposed to cigarette smoke was 61 (79.2%). 28 (36.4%) of the patients lived in a damp house. Five of the six patients with a history of premature birth had been recurrently hospitalized (p= 0.013). Among those with a f amily history of atopy, 80.6% had non-recurrent LRTI and 19.4% had recurrent LRTI (p=0.004). There was a positive relationship between household population and the number of smokers. Conclusion: Risk factors for LRTI include young age, male gender, atopic family history, low socioeconomic level, exposure to cigarette smoke and premature birth. History of premature birth, young age, and atopic family history are risk factors for recurrent LRTI.

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• ArticleYalnız künye2024/r/ebyu/11970
  Evaluating the gonads of left-handed children using ultrasonography and comparing the findings with those of right-handed ones

  Kara, İlknur Sürücü; Karavaş, Erdal; Yalçın, Ahmet; Arslan, Yusuf Kemal; Orbak, Zerrin

  Hand use varies according to which brain hemisphere is dominant. Early androgen exposure causes right hemisphere dominance. This study is aimed at comparing the testes and ovary sizes of healthy left-handed girls and boys with those of healthy right-handed children and investigating whether or not lateralization affects the gonads. The ovarian and testicular sizes of healthy left- and right-handed boys and girls who were similar in height, weight, and age were compared by ultrasonography. One hundred and eleven (111) children—including 26 left- and 26 right-handed girls and 31 left- and 28 right-handed boys—were included in this study. The mean age of left-handed girls was 77.2 ± 25.3 months, and the mean age of right-handed girls was 74.4 ± 25.2 months. Right transverse diameter (p = 0.004), right longitudinal diameter (p = 0.009), and right ovarian volume (p = 0.020) were larger in left-handed girls above 8 years of age than in left-handed girls below 8 years of age. However, these values were similar in right-handed girls above and below 8 years of age. In right-handed girls, the transverse diameter was larger in the right ovary than in the left ovary (0.014). Other ovarian values were similar. The mean age of left-handed boys was 85.2 ± 41.3 months, whereas the mean age of right-handed ones was 81 ± 41.2 months. Prepubertal and pubertal right- and left-handed boys had similar mean right and left testicular diameters and volumes (p > 0.05). Conclusion: Lateralization affected gonad size in girls. In boys, gonads were not affected by lateralization. Cerebral lateralization may affect the hypothalamic-pituitary–gonadal axis in girls. (Table presented.).

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• ArticleYayıncıda açık erişim2023/r/ebyu/19913
  Kronik Öksürüğü Olan Çocuk Hastalarının Değerlendirilmesi

  Arslan, Yusuf Kemal; Kara, İlknur Sürücü; Peker, Necla Aydın; Alan, Cumali; Kucuksumbul, Vildan

  Giriş: Kronik öksürüğü olan çocuklarda ilişkili faktörleri, uygulanan tedavi yöntemlerini, algoritma ve anamnezin önemini araştırmayı amaçladık. Yöntem: Çocuk Sağlığı ve Hastalıkları biriminde kronik öksürük tanısı konulan hastalara öykü, semptom ve bulgularla ilgili anket yapıldı. Bilgileri kaydedildi. Çalışma bitiminde hastalara yazılan ilaçlar, tanı ve tetkikleri kontrol edildi. Bulgular: Erkek 51 (%54.3), kız 43 (%45.7) olmak üzere toplam 94 vakanın yaş ortalaması 4.8±3.1 yıl, normal doğum öyküsü 59 (%62.8) kişi, ortalama doğum haftası 37.9± 2.1, anne sütü alma süresi 17.5 (min 0- max 67) ay idi. Hastaların %70’inde ilk üç yaşta kronik öksürük, 80 (%85.1) kişide alerjen ajan maruziyeti, 38 (%40.4) kişide atopik aile öyküsü, 53 (%56.4) kişide reaktif hava yolu hastalığı bulgusu vardı. Hastaların 15 (%15.9)’ ine astım tanısı konuldu, 18 (%19.1)’ine ilaç başlanmadı, 35 (%37.2)’ine antibiyotik, 45 (%47.8)’ine montelukast-antihistaminik başlandı ve takibe alındı, 37 (% 39.4)’si geldiğinde alternatif tıp yöntemlerini kullanıyordu. Sonuç: Kronik öksürüğün sebebi, takip ve tedavisi önemlidir. Çocuklarda kronik öksürük, en sık küçük yaşta görülür, alerjen ajan maruziyeti, doğum şekli, doğum haftası önemlidir. Hastalık süresi uzadıkça aileler geleneksel ve alternatif tıp yöntemlerinde çare aramaktadır. Poliklinikte uygun algoritma ile doğru anamnez alınması hekimin işini kolaylaştırarak hızlı ve daha doğru tanı konmasını sağlayabilir.

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• LetterAçık Erişim2023/r/ebyu/18818
  Concurrent medulloblastoma and Chiari Type-I deformity in a pediatric case

  Kara, Ilknur Sueruecue; Caki, Tayfun

  Concurrence of medulloblastoma and Chiari deformity (type-1) in a pediatric patient is extremely rarely seen. 10 years old girl. She had first complained of nausea, abdominal pain, and vomiting. She had a mild headache for three days. Computed tomography was taken. There were sequelae related to her previous illness and noticed the appearance of the left cerebellar tonsils down to the foramen magnum level and mild prominence in the third ventricle. Cranial imaging was performed with magnetic resonance imaging. There was a lesion as a solid mass, about 60 mm sized in the level right cerebellar, a cerebellar tonsil hernia (11 mm), and ventricular dilatation in magnetic resonance imaging. Histologically, the lesion was a classic type of medulloblastoma. The coexistence of two diseases may occur in the same patient. Magnetic resonance imaging, which indicates the craniovertebral junction can be used singly.Because MRG is the first method to be selected for diagnosis.

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