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- ArticleAçık Erişim2026Effects of Subconjunctival Bevacizumab and Ranibizumab on Corneal and Systemic Oxidative Stress Biomarkers in an Alkali Injury Model
Yarbağ, Abdulhekim; Bardaş Özkan, Ebru; Ulaş, Mustafa; Arslan, Yusuf Kemal
The study tests the efficacy of subconjunctival ranibizumab and bevacizumab treatments in determining the oxidant and antioxidant levels during alkali-induced corneal neovascularisation. The researchers assigned 24 New Zealand White rabbits into four different groups, which included a healthy control, an alkali-injured control, a BV-treated group, and an RN-treated group, with six rabbits per group. All animals received alkali injury treatment except for the HC group. The AC group received six doses of subconjunctival saline 24 h after their injury, while the BV group and RN group received one dose of 0.5 mg of their respective treatment. The researchers conducted 14-day assays on normal tissue, blood plasma, and erythrocytes to determine total antioxidant status and total oxidant status. The researchers performed biochemical assays for total antioxidant status TAS and total oxidant status TOS on samples that were collected after the 14-day observation period. The corneal TOS levels increased in all injured groups when matched against the HC group. The RN group showed the highest corneal TOS levels, but the difference between the RN and AC and BV groups did not reach statistical significance. The injured groups showed higher corneal TAS levels than HC (p = 0.002), but the AC, BV, and RN groups showed no differences. The injured groups showed a significant decrease in erythrocyte TAS compared with HC (p < 0.001), but the injured groups showed lower plasma TOS levels than HC (p < 0.001). The researchers found no other systemic differences between the groups that received anti-VEGF treatment. The study results show that alkali injury leads to both local and systemic changes in redox status. The two anti-VEGF agents caused numerical changes in corneal oxidative parameters, but these changes did not achieve statistical significance. The research requires further investigation to understand potential agent-related effects on corneal redox balance, which should take place in larger, more detailed studies.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2025Irisin and adropin decrease in preobese or obese individuals with nonalcoholic fatty liver disease
Mertoğlu, Cuma; Örek, Yaprak Şule; Albayrak, Bülent; Arslan, Yusuf Kemal; Çoban, Abdulkadir
Background/aim: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease that is commonly observed in individuals with obesity. The present study investigates the irisin and adropin levels of sera in preobese or obese adults with NAFLD. Materials and methods: Included in the study were 89 patients who were categorized into four groups: Group 1: 25 normal-weight individuals without NAFLD (Control group); Group 2: 17 preobese or obese individuals without NAFLD; Group 3: 24 preobese or obese individuals with Grade 1 NAFLD; and Group 4: 23 preobese or obese individuals with Grade 2–3 NAFLD. The demographic details of all participants were recorded. Abdominal ultrasonography and anthropometric assessments were conducted. Serum adropin and irisin levels were determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: Serum adropin and irisin levels were lower in Groups 3 and 4 than in Group 1 (between the all groups; p = 0.006, p = 0.001, respectively), but were comparable between Groups 3 and 4. Furthermore, the atherogenic index of Group 1 was lower than that of Group 4 (p < 0.001). Among the hemogram parameters, the red cell distribution width value was higher in Group 3 than in Group 1 (p = 0.031). Conclusion: Serum adropin and irisin levels decrease in the presence of NAFLD, regardless of disease severity, which may play a role in the development and exacerbation of NAFLD in preobese and obese individuals.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2025Anemia, inflammation, circadian rhythm and season effects in febrile convulsions
Surucu Kara, Ilknur; Aydin Peker, Necla; Arslan, Yusuf Kemal; Mertoglu, Cuma
OBJECTIVE: Our aim in the study is to investigate circadian rhythm, season, age, gender, and hemogram parameters in children diagnosed with febrile convulsions. METHODS: The data of a total of 478 children, consisting of 160 patients with febrile convulsions (90 male/70 female) and 318 control groups (healthy, convulsiyon free-febrile), were compared. RESULTS: The average age of all patients was 25.7±14.7 (minimum 6-maximum 60) months, and the most common convulsion age was 13-18 months. Circadian rhythm was similar, application seasons were similar. The male/female ratio was 1.3. MPV in winter was lower than other seasons (p=0.002). At younger ages, lymphocyte count was higher (p=0.048) and NLR was lower (p=0.036). NLR was lower in patients with febrile convulsions with anemia than in patients with febrile convulsions without anemia (p=0.029). NLR was lower in patients with febrile convulsions with anemia than in the convulsion-free febrile control group with anemia (p=0.001). In patients with febrile convulsions, MPV was lower (p=0.033) and NLR was higher (p=0.001) than in the convulsion-free febrile control group. One third of the patients had hypocapnia. CONCLUSION: Young age, anemia, inflammation, and hypocapnia may facilitate the occurrence of febrile convulsions. MPV and NLO, which are hemogram parameters, can guide us about inflammation. Blood gases may provide information regarding hypocapnia. These rapid examinations may help elucidate the etiology. Prospective studies are needed for circadian rhythm in febrile convulsions.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2025The relationship between rheumatoid arthritis and epicardial fat thickness, and serum levels of chemerin, adropin, and betatrophin
Ekinci, Bilge; Mertoglu, Cuma; Coskun, Resit; Arslan, Yusuf Kemal; Coban, Taha Abdulkadir; Ozcicek, Fatih
Background. Cardiovascular diseases (CVDs) are highly prevalent among patients with rheumatoid arthritis (RA). Epicardial adipose tissue, serum betatrophin, chemerin, and adropin levels are factors associated with atherosclerosis and cardiovascular involvement. Objectives. This study aimed to investigate the relationship between RA and epicardial fat thickness (EFT), as well as serum betatrophin, chemerin and adropin levels. Materials and methods. This cross-sectional study included 80 patients (62 women and 18 men) diagnosed with RA according to the American College of Rheumatology/The European Alliance of Associations for Rheumatology (ACR/EULAR) 2010 RA classification criteria and 80 healthy controls (64 women and 16 men). Exclusion criteria comprised other autoimmune diseases, CVDs, diabetes mellitus, other endocrine disorders, acute or chronic pancreatic disorders, malignancy, pregnancy, breastfeeding, or antihyperlipidemic drug usage. Serum betatrophin, chemerin and adropin concentrations were measured. Epicardial fat thickness was evaluated with transthoracic echocardiography. Results. Adropin levels were significantly lower in the RA group compared to the control group (p < 0.001). Chemerin levels and EFT were significantly higher in the RA group than in the control group (p = 0.016, p < 0.001, respectively). When assessing the relationship between biomarkers and EFT in RA patients, a strong positive correlation was observed between chemerin and EFT (r = 0.73, p = 0.046) in patients with high disease activity. Conclusions. Epicardial fat thickness, as an indicator of cardiovascular involvement, is higher in patients with RA. Moreover, high chemerin levels and low adropin levels in these patients may be indicative of cardiovascular involvement. Copyright by Author(s)
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Pain Assessment and Affecting Factors in Hemodialysis Patients
Arslan, Yusuf Kemal; Ergül, Emine Esra; Ergül, Cetin
Objective: As a result of long-term damage to the nerves caused by harmful molecules in chronic renal failure patients who are treated with hemodialysis, the clinical manifestation defined as uremic neuropathy may occur in patients. In our study, we aimed to determine the prevalence of neuropathic pain in hemodialysis patients and to evaluate risk factors. Methods: Patients over the age of 18 who underwent hemodialysis treatment were included in our study. Demographic characteristics of the patients, duration of dialysis, and comorbidities were recorded. The Brief Pain Inventory was used to assess the patients’ pain intensity. The Neuropathic Pain Questionnaire and Neuropathic Pain Questionnaire; Short Form was employed for the evaluation of neuropathic pain. Results: Neuropathic pain was detected in 25 (41.7%) of 60 hemodialysis patients. Chronic pain was evaluated with a Likert scale as 0: no pain 10: the worst pain I can imagine. The averages for the past week were categorized as pain worst, pain least, pain average, and pain now, and recorded as 5.9, 6.5, 6.4, and 6.4, respectively. The number of comorbid disorders and the scores of neuropathic pain questionnaire in short form were determined to be statistically associated (P = .040). Conclusion: Neuropathic pain in hemodialysis patients was detected in 41.7% of the patients; it is a common symptom and is associated with the number of comorbid diseases. This study is an exemplary study in terms of evaluating the prevalence of neuropathic pain in hemodialysis patients. It has been a guide to start supportive treatments at an earlier period.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Investigation of the Relationship Between Hemoglobin and Hemoglobin A1c Levels in Diabetes Mellitus Patients with and Without Anemia
Akbas, Emin Murat; Arslan, Yusuf Kemal; Davarci, Ismail; Davarcı, Pınar Zehra; Admış, Özlem
Objective: Hemoglobin A1c (HbA1c) is a glycosylated protein and shows the glycemic status for the last 2-3 months, and it is the most commonly used marker in routine practice. In this study we aimed to investigate the relationship between hemoglobin and HbA1c levels. Methods: In total, 4278 patients with type 2 diabetes mellitus included in this study. The study was cross-sectional, and the data of the patients were recorded by scanning the hospital automation system. Hemoglobin A1c levels of patients with and without anemia who had the same fasting blood glucose levels were compared. Results: At similar fasting blood glucose levels, HbA1c levels were found to be lower in patients with anemia than those without anemia Conclusion: Anemia status of the patients should be considered when evaluating HbA1c.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Hemogram Parameters of Children with Bell’s Palsy at the Time of Admission and Their Findings in the Follow-up
Arslan, Yusuf Kemal; Kara, İlknur Sürücü
Objective: The exact cause of idiopathic facial paralysis (Bell’s palsy) is not clear. The objective of our study was to investigate the relationship between certain hemogram parameters and the clinical prognosis in pediatric patients with facial paralysis. Material and Methods: The files of patients with Bell’s palsy under the age of 18 who applied to our hospital were evaluated retrospectively. Leukocyte, neutrophil, lymphocyte, platelet count, red cell distribution width, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio were compared between patients with Bell’s palsy and the control group. Information about their last health status recorded. Results: A total of seventeen children with Bell’s palsy and 17 control groups were included in the study. There were 7 boys (41.20%) and 10 girls (58.70%) in each group, the mean age was 11.80±4.40 (minimum 3.0-maximum 17.9) years. While the median neutrophil-lymphocyte ratio was 1.25 (0.41-7.63) in patients with Bell’s palsy and 1.40 (0.42-2.52) in the control group, the median mean platelet volume level was 9.30 fL (8.20-12.30) in patients with Bell’s palsy and 9.95 fL (9.30-11.70) in the control group, and the median red cell distribution width level was 12.75 % (11.50-26.30) in patients with Bell’s palsy and 12.70% (12.10-26.30) in the control group. None of them were statistically significant. There were six patients with Bell’s palsy with low mean platelet volume levels and no patients with low mean platelet volume levels in the control group (p=0.007). There was a positive correlation between the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio and the recovery time of patients with Bell’s palsy. Conclusion: Bell’s palsy may show a better prognosis in girls. High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio may be indicators of delayed recovery, inflammation, and microvascular ischemia in Bell’s palsy.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2024Effect of Rutin on Cisplatin-Induced Oxidative Skeletal Muscle Damage in Rats
Yasar, Hasan; Cimen, Ferda Keskin; Suleyman, Halis; Kurt, Nezahat; Arslan, Yusuf Kemal
Background and Objective: Cisplatin is a drug used to treat cancer, but it causes oxidative damage to muscle tissue. Rutin has an antioxidant effect. The study aims to investigate the biochemical and histopathological effects of rutin on the oxidative damage of cisplatin in skeletal muscle tissue. Materials and Methods: Rats were divided into four groups: A control group (CG), an only cisplatin-administered group (CIS), a cisplatin and rutin 50 mg kg(-1)-administered group (R-50) and a cisplatin and rutin 100 mg kg(-1)-administered group (R-100). Analyses were performed from the hindlimb muscles of experimental animals. Analyses of malondialdehyde (MDA), Total Glutathione (tGSH), glutathione reductase (GSHRd), glutathione S-transferase (GST) and superoxide dismutase (SOD) were performed. Histopathologic examination was performed in all groups. The CG and the other groups were compared. Results: The CG and R-100 groups were similar in all biochemical examinations. A statistically significant difference was detected between the control group and the CIS and R-50 groups in all examinations. Histopathological examinations revealed oxidative damage of cisplatin in the CIS group and R-50 group. The findings in the R-100 group were similar to the control group. Conclusion: Cisplatin causes oxidative damage to skeletal muscle tissue. Rutin has the potential to prevent the formation of such oxidative damage.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Host Genetic Polymorphisms and Disease Severity in Pregnant Women with COVID-19 in Türkiye
Polat, Seher; Kiremitli, Sevil; Kiremitli, Tunay; Kirkinci, Ahmet; Kurnuç, Fatma Zehra; Arslan, Yusuf Kemal
Objective: The study aimed to analyze the association between coronavirus disease-2019 (COVID-19) disease severity and genetic susceptibility in pregnant women. Material and Methods: The research included 54 pregnant women with confirmed COVID-19 diagnosis. All volunteers were evaluated physically and biochemically. Angiotensin-converting enzyme (ACE)2 (p.T27A A>G, p.G326E G>A, p.K419T A>C, ACE (p.T776T A>G, and g.16471_16472delinsALU (I/D), AGTR1 c.*86A>C, methylenetetrahydrofolate-reductase (MTHFR) p.A222V C>T and PAI-1-844 G>A were analyzed. Results: The allele frequency was also compared with control groups of the different studies made on Turkish women. MTHFR “CT” genotype compared to “CC” had lower platelet counts (p=0.015). In ACE “ID” genotype, there was a lower D-dimer level compared to “DD” genotype (p=0.02). In PAI-1-844G>A, the AA vs. AG+GG genotype and AA vs. GG genotype elevate the risk of hospitalization 6.4-fold (OR: 6.4 95% (Cl): 1.6-25.8 p=0.009), and 4.6-fold (OR: 4.6 95% CI:1.0-21.6 p=0.049), respectively. In MTHFR p.A222V, to have CC vs. CT genotype increased the risk of enoxaparin and antibiotic use 4.1-fold and 3.2-fold at the borderline significance (OR: 4.1 95% Cl: 0.99-16.9 p=0.052 and OR: 3.2 95% Cl: 0.98-10.5 p=0.053), respectively. An allele frequency difference wasn't found between the patient and the healthy women related to the investigated polymorphisms. Conclusion: PAI-1-844G>A, MTHFR p.A222V, and ACE (I/D) associated with a poor COVID-19 outcome, the risk of enoxaparin and antibiotic use, and also increased risk of hospitalization. Allele frequencies of the genes were not different between healthy control women and women with COVID-19; genetic variation may not influence the risk of infection but disease severity.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2024Risk Factors for Lower Respiratory Tract Infection and Recurrent Lower Respiratory Tract Infection in Children
Kara, İlknur Sürücü; Peker, Necla Aydın; Arslan, Yusuf Kemal; Topal, İsmail
Introduction: A survey was administered to the families of children hospitalized due to lower respiratory tract infections in winter. Risk factors that may cause non-recurrent LRTI and recurrent LRTI in hospitalized children were compared. Materials and Methods: Survey questions were asked to the families of pediatric patients who were hospitalized with a diagnosis of LRTI in the training and research hospital during the winter period and did not have a known chronic disease. Patients were divided into two groups: children hospitalized due to recurrent LRTI and non-recurrent LRTI (first hospitalization). Factors that may cause LRTI were compared between the two groups. Results: 47 of 77 patients (61%) were male. There were 43 (55.8%) patients between 1 and 6 months. There were 25 (32.5%) patients living in crowded houses. The number of patients exposed to cigarette smoke was 61 (79.2%). 28 (36.4%) of the patients lived in a damp house. Five of the six patients with a history of premature birth had been recurrently hospitalized (p= 0.013). Among those with a f amily history of atopy, 80.6% had non-recurrent LRTI and 19.4% had recurrent LRTI (p=0.004). There was a positive relationship between household population and the number of smokers. Conclusion: Risk factors for LRTI include young age, male gender, atopic family history, low socioeconomic level, exposure to cigarette smoke and premature birth. History of premature birth, young age, and atopic family history are risk factors for recurrent LRTI.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2024Evaluating the gonads of left-handed children using ultrasonography and comparing the findings with those of right-handed ones
Kara, İlknur Sürücü; Karavaş, Erdal; Yalçın, Ahmet; Arslan, Yusuf Kemal; Orbak, Zerrin
Hand use varies according to which brain hemisphere is dominant. Early androgen exposure causes right hemisphere dominance. This study is aimed at comparing the testes and ovary sizes of healthy left-handed girls and boys with those of healthy right-handed children and investigating whether or not lateralization affects the gonads. The ovarian and testicular sizes of healthy left- and right-handed boys and girls who were similar in height, weight, and age were compared by ultrasonography. One hundred and eleven (111) children—including 26 left- and 26 right-handed girls and 31 left- and 28 right-handed boys—were included in this study. The mean age of left-handed girls was 77.2 ± 25.3 months, and the mean age of right-handed girls was 74.4 ± 25.2 months. Right transverse diameter (p = 0.004), right longitudinal diameter (p = 0.009), and right ovarian volume (p = 0.020) were larger in left-handed girls above 8 years of age than in left-handed girls below 8 years of age. However, these values were similar in right-handed girls above and below 8 years of age. In right-handed girls, the transverse diameter was larger in the right ovary than in the left ovary (0.014). Other ovarian values were similar. The mean age of left-handed boys was 85.2 ± 41.3 months, whereas the mean age of right-handed ones was 81 ± 41.2 months. Prepubertal and pubertal right- and left-handed boys had similar mean right and left testicular diameters and volumes (p > 0.05). Conclusion: Lateralization affected gonad size in girls. In boys, gonads were not affected by lateralization. Cerebral lateralization may affect the hypothalamic-pituitary–gonadal axis in girls. (Table presented.).
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2023Obez hastalarda beden kitle indeksi ve aterojenik indeksin retınal mikrovasküler yapı üzerine etkileri
Akbas, Emin Murat; Arslan, Yusuf Kemal; İçel, Erel; İçel, Aykut; Akbaş, Nergis
Amaç: Bu çalışmada, obez hastalarda retinal mikrovasküler yapısında meydana gelen değişiklikleri değerlendirmeyi ve bu değişikliklerin klinik özelliklerle ilişkisini belirlemeyi amaçladık. Gereç ve Yöntemler: Tüm katılımcılarda kolesterol, açlık kan şekeri, açlık insülini,CRP ve HbA1C düzeylerini içeren biyokimyasal incelemeler yapıldı. Plazma aterojenik indeksi(AI) plazma trigliserid (TG) düzeyinin yüksek yoğunluklu lipoprotein (HDL) düzeyine oranının logaritması [log (TG/HDL-K)] olarak hesaplandı. Vücut Kitle İndeksi (VKİ) ≤25 kg/m2 olan hastalar kontrol grubuna dahil edildi. Obez hastalar VKİ'lerine göre üç gruba ayrıldı: grup 1 (VKİ: 30-34,99 kg/m2), grup 2 (VKİ: 35-39.99 kg/m2) ve grup 3 (VKİ ≥ 40 kg/m2) . Optik koherens tomografi anjiografi (OKT-A) ile foveal avasküler zon (FAZ), makulada yüzeyel ve derin kapiller pleksusun damar dansitesi (VD) ile radial peripapiller kapiller pleksus VD ölçüldü. Bulgular: Çalışmaya 27 kontrol ve 83 obez hasta olmak üzere toplam 110 hasta dahil edildi. Kontrol vakalarına kıyasla obez hastalarda HbA1C, açlık insülini, HOMA-IR, C-reaktif protein ve AI seviyeleri anlamlı derecede yüksekti. Obez hastalarda retinanın yüzeyel (p=0,003) ve derin (p=0,001)VD'leri anlamlı olarak azaldı ve FAZ anlamlı olarak arttı (p=0,032). Klinik özellikler ile OKT-A bulguları arasında yapılan korelasyon analizinde yüzeyel ve derin VD'ler yaş, VKİ, HbA1C ve AI ile ters orantılıydı. Sonuç: Obez hastalarda retina yüzeyel ve derin VD'leri azalmıştı ve retinal VD'ler ile yaş, VKI, HbA1C ve AI arasında ters bir ilişki vardı.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2023Determination of Eating Disorders Level and Risk Factors of University Students Studying Sports Education
Arslan, Yusuf Kemal; Eskici, Günay; Yarar, Hakan; Çolak, Mergül
Eating disorder has become an increasingly common problem among athletes. This study aims to determine eating disorder levels and risk factors of students studying sports education. This study was carried out on 1773 university students, 1084 (61.1%) of whom are female and 689 (38.9%) male, in the field of sports education in different provinces in Turkey. The information of the participants was collected with an individual information form and an Eating Disorder Examination Questionnaire (EDE-Q). All EDEQ sub-dimension scores and the total score were found to be statistically significantly higher in males than in females (p <0.05) except for the restraint score. It was found that, as BMI (Body Mass Index) value increased, there was a statistically significant increase in all sub-dimensions of EDEQ and EDEQ total score (p<0.05). Eating concern and shape concern scores were found to be statistically higher in those who did not perform physical activities than those who performed physical activities (respectively; p=0.030, p=0.004). An increase in the EDE-Q score indicates an increased risk of eating disorders. It can be said that being a male, having a high BMI, and engaging in strength/power sports increase the risk of eating disorders in individuals who receive sports education.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2023Kronik Öksürüğü Olan Çocuk Hastalarının Değerlendirilmesi
Arslan, Yusuf Kemal; Kara, İlknur Sürücü; Peker, Necla Aydın; Alan, Cumali; Kucuksumbul, Vildan
Giriş: Kronik öksürüğü olan çocuklarda ilişkili faktörleri, uygulanan tedavi yöntemlerini, algoritma ve anamnezin önemini araştırmayı amaçladık. Yöntem: Çocuk Sağlığı ve Hastalıkları biriminde kronik öksürük tanısı konulan hastalara öykü, semptom ve bulgularla ilgili anket yapıldı. Bilgileri kaydedildi. Çalışma bitiminde hastalara yazılan ilaçlar, tanı ve tetkikleri kontrol edildi. Bulgular: Erkek 51 (%54.3), kız 43 (%45.7) olmak üzere toplam 94 vakanın yaş ortalaması 4.8±3.1 yıl, normal doğum öyküsü 59 (%62.8) kişi, ortalama doğum haftası 37.9± 2.1, anne sütü alma süresi 17.5 (min 0- max 67) ay idi. Hastaların %70’inde ilk üç yaşta kronik öksürük, 80 (%85.1) kişide alerjen ajan maruziyeti, 38 (%40.4) kişide atopik aile öyküsü, 53 (%56.4) kişide reaktif hava yolu hastalığı bulgusu vardı. Hastaların 15 (%15.9)’ ine astım tanısı konuldu, 18 (%19.1)’ine ilaç başlanmadı, 35 (%37.2)’ine antibiyotik, 45 (%47.8)’ine montelukast-antihistaminik başlandı ve takibe alındı, 37 (% 39.4)’si geldiğinde alternatif tıp yöntemlerini kullanıyordu. Sonuç: Kronik öksürüğün sebebi, takip ve tedavisi önemlidir. Çocuklarda kronik öksürük, en sık küçük yaşta görülür, alerjen ajan maruziyeti, doğum şekli, doğum haftası önemlidir. Hastalık süresi uzadıkça aileler geleneksel ve alternatif tıp yöntemlerinde çare aramaktadır. Poliklinikte uygun algoritma ile doğru anamnez alınması hekimin işini kolaylaştırarak hızlı ve daha doğru tanı konmasını sağlayabilir.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2023The role of polymorphonuclear leukocytes in distant organ (lung) oxidative damage of liver ischemia/reperfusion and the protective effect of rutin
Olmez, Hasan; Tosun, Mustafa; Unver, Edhem; Cimen, Ferda Keskin; Arslan, Yusuf Kemal; Gulaboglu, Mine; Suleyman, Bahadir
Background. Ischemia/reperfusion (I/R) can cause damage to distant organs. Rutin is known to have antioxidant and anti-inflammatory properties, and inhibits cytokine and polymorphonuclear leukocyte (PMNL) infiltration. It may prevent the development of reperfusion injury. Objectives. This study aimed to examine the role of PMNLs in distant organ (lung) injury after a liver I/R procedure, and to evaluate the protective effects of rutin in rats using biochemical and immunohistochemical methods. Materials and methods. In this study, 18 Wistar albino male rats (255–275 g) were used. Experimental animals were divided into 3 groups: a liver I/R (LIR) group, a 50 mg/kg rutin+liver I/R (RLIR) group and a sham operation (SG) control group. Experimental results obtained from the RLIR group were compared with the LIR and SG groups. Results. Blood malondialdehyde (MDA) levels in the RLIR and SG groups were significantly lower compared to the LIR group (p < 0.001). Blood myeloperoxidase (MPO) activity in the RLIR and SG groups was significantly lower compared to the LIR group (p < 0.001). Total glutathione (tGSH) levels in the RLIR and SG groups were significantly higher compared to the LIR group (p < 0.001). Conclusions. Rutin can be used to prevent distant organ (lung) damage due to liver I/R. However, more extensive studies are needed on this issue. Copyright by Author(s).
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2023The effects of sorafenib in healthy and cisplatin-treated rats
Demirtas, Levent; Gürbüzel, Mehmet; Tahirler, Hilal; Akbas, Emin Murat; Karatas, Ozhan; Arslan, Yusuf Kemal
Background. Sorafenib is a multikinase inhibitor currently used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer. Objectives. The literature on this agent is scarce. This study aimed to evaluate the effects of sorafenib when administered to both healthy and cisplatin-induced rats. Materials and methods. The animals were divided into 4 groups: 1) control group that received 0.9% saline intraperitoneally (C); 2) group administered a single dose (7 mg/kg) of cisplatin (Cis); 3) a group administered 20 mg/kg of sorafenib for 7 days (Sor); 4) group administered 20 mg/kg of sorafenib followed by 7 mg/kg of cisplatin for 7 days (Cis+Sor). All animals were sacrificed 7 days after the completion of their treatment arm, and serum and tissue samples were taken. Results. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and interleukin 38 (IL-38) levels were increased in the Sor and Cis+Sor groups compared to the control group. When compared with the control group, serum urea, creatinine, kidney IL-1β, and tumor necrosis factor alpha (TNF-α) levels did not change in the Sor group. When compared to the Cis group, the levels of these parameters decreased in the Cis+Sor group. Conclusions. According to the data obtained, sorafenib caused liver toxicity when given to both healthy and cisplatin-induced rats. While sorafenib did not cause any significant changes in the kidneys when given to healthy rats, it had a healing effect in kidneys after stress induced by cisplatin.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2023The Relationship Between Vitamin-D Deficiency and Protein Oxidation Among Obese Children
Surucu Kara, Ilknur; Mertoglu, Cuma; Siranli, Gülsah; Arslan, Yusuf Kemal; Gok, Gamze; Erel, Ozcan
Aim: The aim of the study is to examine the relationship between obesity, Vitamin-D deficiency, and protein oxidation. Methods: Thiol-disulfide homeostasis, Vitamin-D, ischemia modified albumin, insulin, and lipid levels were compared among obese, pre-obese and normal-weight healthy children. Results: A total of 136 children (69 boys and 67 girls) were included in the study. The vitamin-D levels of obese children were lower than those of pre-obese and normal weight (p < 0.05). In the normal weight group, total thiol and native thiol were lower in the pubertal period than in adolescence; were higher in those with sufficient Vitamin-D level than those with insufficient and deficient Vitamin-D (p < 0.05). Vitamin-D level was lower in pre-obese girls than boys (p < 0.05). Those with high triglycerides had high disulfide/total thiol, disulfide, and disulfide/native thiol and low native thiol/total thiol (p < 0.05). Conclusion: Thiol-disulfide homeostasis is negatively affected by low vitamin D levels, pubertal period and high triglyceride levels.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022Evaluation of epicardial adipose tissue thickness and inflammatory parameters in smokers and non-smokers
Arslan, Yusuf Kemal; Mertoglu, Cuma; Ozcicek, Adalet; Ozcicek, Fatih; Soylu, Yasin Emrah; Çoşkun, Reşit
Smoking is the leading cause of preventable death. Epicardial adipose tissue (EAT) surrounds the heart surface and creates local and systemic effects secreting the hormones, cytokines, inflammatory mediators. Previous studies demonstrated that both smoking and EAT have a strong association with inflammation and atherosclerosis.Our study aimed to determine the relationship of smoking with EAT thickness and inflammation by evaluating smokers and non-smokers. A total of 259 healthy male and female participants between the ages of 18-65, without a history of chronic disease and with a body mass index within normal limits, were included in a study. EAT thickness measurements were made by transthoracic echocardiography and EAT thicknesses of smokers and non-smokers were compared. In addition, the effects of smoking and EAT thickness on different inflammatory parameters were evaluated. When the EAT thicknesses were compared between smokers and non-smokers (2.60±1.2), a statistically significant difference was found in favor of smokers (3.84±1.84) (p<0.001). A moderate positive correlation was found among age, body mass index, smoking duration in years, pack/year and EAT thickness. The difference among waist circumference, the number of cigarettes smoked daily, diastolic blood pressure, fasting blood glucose, ALT, AST, total cholesterol, triglyceride, LDL-cholesterol, CRP, uric acid, platelet count, MPV values, platelet/lymphocyte ratio and EAT thickness were found meaningful, but the weak correlation in different ratios were determined. Smoking was found to be the most important determinant of EAT thickness. Other determinants of EAT thickness were age, body mass index, CRP and female gender. The significant statistical relationship between smoking and EAT thickness suggests that smoking increases EAT thickness and inflammatory parameters. Co-assessment of the EAT and blood inflammatory parameters in smokers may guide the initiation of medical treatment in primary prevention or other therapies.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2022Can Hematological Indexes Predict Prognosis in Intensive Care COVID-19 Patients?
Arslan, Yusuf Kemal; Tosun, Mustafa
Objective: In coronavirus disease 2019, which affects the whole world, it is difficult to predict the prognosis in advance. The tim- ing of anti-inflammatory and anti-cytokine treatments to be given in case of a bad course of the disease is very important. In this study, we aimed to determine the predictive effect of inflammation-based markers such as neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, systemic inflammatory index, and plasma atherogenic index on the prognosis of coronavirus disease 2019. Methods: In this retrospective study, 217 patients hospitalized in the intensive care unit with a confirmed diagnosis of corona- virus disease 2019 were included. The patients were divided into 2 groups as survivors and nonsurvivors. Indices were calculated from the laboratory results of the patients. Receiver operating characteristic curve analysis was used to determine whether the indices had a diagnostic value. Results: Males (n = 133) made up 61.3% of the patients, and the average age of all patients was 70.5 ± 13.7 years. The patients were identified as survivors (group 1, n=140) and nonsurvi- vors (group 2, n=77). C-reactive protein, procalcitonin, ferritin, d-dimer, lactate, urea, creatine, and neutrophil values of the patients who died in group 2 were significantly higher, while high- density lipoprotein, hemoglobin, platelet, and lymphocyte count were significantly lower. Neutrophil/lymphocyte ratio, platelet/ lymphocyte ratio, systemic inflammatory index, and plasma ath- erogenic index were found to be significantly higher in the group of nonsurvivor patients than in the group of surviving patients. In addition, the plasma atherogenic index (P = .024, area under the curve = 0.605, cutoff = 0.504) had the highest specificity with 80.3%, and the neutrophil/lymphocyte ratio was the second with 76.1% (P < .001, area under the curve = 0.691, cutoff=17.5).
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2022Febril Nötropenide Fungal Pnömonilerin Yeri, Klinik ve Mikrobiyolojik Özellikleri
Arslan, Yusuf Kemal; Candevir, Aslıhan; Kurtaran, Behice; Kibar, Filiz; Duman, Zehra; Gurkan, Emel; Ozyilmaz, Ezgi; Inal, Ayse Seza; Komur, Suheyla; Tasova, Yesim
Amaç: Nötropenik hastalarda akciğer enfeksiyonları önemli bir morbidite ve mortalite nedenidir. Bu çalışmada febril nötropenik hastalarda akciğer enfeksiyonlarında fungal etkenlerin neler olduğu, klinik ve mikrobiyolojik özelliklerinin belirlenmesi amaçlandı. Gereç ve Yöntem: Kasım 2015-Şubat 2017 tarihleri arasında geniş spektrumlu antibakteriyel tedaviye rağmen ateşi gerilemeyen ve invaziv fungal enfeksiyon şüphesi bulunan febril nötropenik olgulardan posterior-anterior akciğer grafisinde yeni gelişen infiltrasyon veya toraks bilgisayar tomografisinde yeni gelişen nodül, ʺhalo belirtisiʺ, konsolidasyon, ʺters halo belirtisiʺ, kavitasyon, hava-hilal işareti saptananlar çalışmaya dahil edildi. Akciğer bulguları olan 72 hastadan antibakteriyel ve antifungal tedavi başlanması veya değişikliği öncesinde 77 serum, 28 bronkoalveolar lavaj (BAL) örneği alındı ve mikroskobik inceleme, bakteri ve mantar kültür ekimi, galaktomannan (GM) antijen, Aspergillus fumigatus ve Pneumocystis jirovecii polimeraz zincir reaksiyon (PZR) testleri yapıldı. Bulgular: Avrupa Kanser Araştırma ve Tedavi organizasyonu ile Mikoz Çalışma Grubu’nun hazırlamış olduğu kriterlere göre iki hasta kesin, 32 hasta olası, 12 hasta şüpheli invaziv fungal enfeksiyon (İFE) ve 27 hasta invaziv fungal enfeksiyon olmayan olarak sınıflandırıldı. GM antijen testinin serumda duyarlılığı ve özgüllüğü sırasıyla %74,4, %100, BAL’da duyarlılığı ve özgüllüğü cut-off değer 0,5 ve 1 alınarak sırasıyla %66,7, %71,4, %47,6, %100 olarak bulundu. LightMix Aspergillus fumigatus PZR testinin serumda duyarlılığı ve özgüllüğü sırasıyla %67,9, %5,9, BAL’da duyarlılığı ve özgüllüğü %81, %14,3 olarak hesaplandı. Sonuç: BAL kültüründeki üremenin azlığından ve testlerdeki düşük duyarlılıktan örnekler alınmadan önce uygulanmış olan antifungal tedavilerin/profilaksilerin sorumlu olabileceği düşünüldü. İFE tanısında LightMix Aspergillus fumigatus PZR testi serumdansa BAL’da daha yol gösterici olabilir. Antifungal tedavilerin/profilaksi kullanan hastalarda BAL GM tanıda daha değerlidir.
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