Sürdürülebilir Kalkınma Amaçları
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- ArticleAçık Erişim2017Lack of evidence of HPV etiology of prostate cancer following radical surgery and higher frequency of the Arg/Pro genotype in Turkish men with prostate cancer
Aydin, Merve; Bozkurt, Aliseydi; Cikman, Aytekin; Gulhan, Baris; Karabakan, Mehmet; Gokce, Aysun; Alper, Murat; Kara, Murat
Objectives: The aim of this study was to assess the possible role of HPV in the development of prostate cancer (PCa) and investigate the distribution of the p53 codon 72 polymorphism in PCa in a Turkish population. Materials and methods: A total of 96 tissues, which had been obtained using a radical surgery method, formalin-fixed and parafin-embedded, were used in this study. The study group consisted of 60 PCa tissues (open radical prostatectomy) and the control group contained 36 benign prostatic hyperplasia tissues (BPH) (transvesical open prostatectomy). The presence of HPV and the p53 codon 72 polymorphism was investigated in both groups using real-time PCR and pyrosequencing. Results: The results of the real-time PCR showed no HPV DNA in any of the 36 BPH tissue samples. HPV-DNA was positive in only 1 of the 60 PCa samples (1.7%). The HPV type of this sample was identified as HPV-57. The distribution of the three genotypes, Arg/Arg, Arg/Pro and Pro/Pro was found to be 45.6, 45.6, and 8.8% in the PCa group and 57.1%, 34.3% and 8.6% in the control group, respectively. Compared with the control group, patients with PCa had a higher frequency of the Arg/Pro genotype and Proline allele (odds ratio (OR)=1.67, 95% confidence interval (CI)=0.68-4.09, p=0.044; OR=1.13, 95% CI=0.76-1.68, p=0.021, respectively). Conclusions: The results of the study do not support the hyphothesis that prostate cancer is associated with HPV infection but indicated that Proline allele can be a risk factor in the development of PCa in the Turkish population.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2017Effect of tadalafil 5mg daily treatment on the ejaculatory times, lower urinary tract symptoms and erectile function in patients with erectile dysfunction
Karabakan, Mehmet; Keskin, Ercument; Akdemir, Serkan; Bozkurt, Aliseydi
Objective: To investigate the effect of a 5mg daily tadalafil treatment on the ejaculation time, erectile function and lower urinary tract symptoms (LUTS) in patients with erectile dysfunction. Materials and Methods: A total of 60 patients diagnosed with erectile dysfunction were retrospectively evaluated using the international index of erectile function questionnaire- 5 (IIEF-5), intravaginal ejaculatory latency time (IELT) and international prostate symptoms scores (IPSS). After the patients were treated with 5mg tadalafil once a day for three months, their erection, ejaculation and LUTS were assessed again. The fasting levels of blood glucose, total testosterone, low-density lipoprotein cholesterol, highdensity lipoprotein cholesterol and total cholesterol were measured. The independentsamples t-test was used to compare the pre- and post-treatment scores of the patients. Results: The mean age of the 60 participants was 50.4±7.9 and the mean baseline serum total testosterone, total cholesterol, and fasting blood sugar were 444.6±178.6ng dL-1, 188.7±29.6mg/dL-1,104 (80-360) mg dL-1, respectively. The mean baseline scores were 2.2±1.4 min for IELT, 9.5±3.7 for IIEF-5 and 14.1±4.5 for IPSS. Following the three-month daily 5mg tadalafil treatment, the scores were found to be 3.4±1.9 min, 16.1±4.7, and 10.4±3.8 for IELT, IIEF and IPSS, respectively. When the baseline and post-treatment scores were compared, a statistically significant increase was observed in the IELTs and IIEF-5 values whereas there was a significant decrease in IPSS (p < 0.01). Conclusion: A daily dose of 5mg tadalafil can be safely used in the treatment of erectile dysfunction and LUTS, that prolongs the ejaculatory latency time.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2016Results of tadalafil treatment in patients following an open nerve-sparing radical prostatectomy
Hirik, Erkan; Bozkurt, Aliseydi; Karabakan, Mehmet; Onuk, Özkan; Balci, Mustafa Bahadir Can; Aydin, Memduh; Çakan, Murat; Nuhoglu, Baris
Purpose: To evaluate the effect of postoperatively administering a low daily dose of tadalafil on the erectile function of patients who underwent a nerve-sparing radical prostatectomy(NSRP) due to localized prostate cancer (PCa). Materials and Methods: Of 138 patients, who underwent NSRP due to PCa between 2012 and 2014, 55 patients who had not had pre-operative erectile dysfunction (ED) were included in the study. The mean age of the patients was 64 (54-72). On the 15th day after surgery, after ultrasound evaluation, all 55 patients started on a daily dose of 5 mg tadalafil that was continued for 2.5 months. The erectile function of patients was evaluated pre-operatively, post-operatively, and at the 3rd and 6th month after surgery using the International Index of Erectile Function (IIEF-5) test. None of the patients was treated with hormonal therapy or radiotherapy before or after surgery. Results: Three patients were excluded from the study due to the adverse effects of tadalafil and two patients elected to discontinue the treatment. Of the remaining 50 patients whose pre-operative erectile function had been found normal, at 3 months after surgery, 36 (72%) had normal erectile function; of the remaining patients in the study six (12%) presented with mild, two (4%) with moderate, and six (12%) with severe ED. Six months after surgery, 35 patients (70%) had normal erectile function while seven (14%) had mild, three (6%) moderate and five (10%) severe ED. There was no statistically significant difference between the results obtained at the 3rd and 6thmonth follow-up (p > 0.05). Three patients reported adverse effects with tadalafil including flushes in 2 (3.6%) and a headache in 1 (1.8%). Conclusions: The administration of a 5 mg post-operative dose of tadalafil to patients that had undergone a bilateral NSRP was found to have a positive effect on the recovery and maintenance of erectile function. However, there is still a need to investigate a larger series of cases.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2016Prostatic Urethral Lift: A New Minimally Invasive Treatment for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia
Bozkurt, Aliseydi; Karabakan, Mehmet; Keskin, Ercument; Hirik, Erkan; Can Balci, M.B.; Nuhoglu, Baris
Introduction: Prostatic urethral lift (PUL) is a minimally invasive procedure for the treatment of lower urinary tract symptoms (LUTSs) secondary to benign prostatic hyperplasia (BPH). The PUL procedure involves the placement of implants that retract the obstructing prostate lobes. This procedure achieves quantifiable improvements in functional outcomes and quality of life (QoL), while preserving erectile and ejaculatory functions. Methods: Seventeen patients diagnosed with BPH who had undergone the UroLift procedure between March 2011 and June 2015 were retrospectively evaluated. The parameters evaluated in the pre-operative, intra-operative and 1-year post-operative period were demographic data, and pre-operative, intra-operative and 1-year post-operative results were obtained from the International Prostate Symptom Score (IPSS), Uroflowmetry QoL index, International Index of Erectile Function (IIEF) and Male Sexual Health Questionnaire (MSHQ) for ejaculatory function (MSHQ-EjD). Results: The average improvements from baseline to 12 months after intervention were significant for the total IPSS 9.6. There was a 4.2-point increase in Qmax, a 0.9-point improvement in QoL and a 32% decrease in PVR. No statistically significant difference was found in the IIEF and MSHQ-EjD scores when the pre-operative and post-operative 3rd and 12th month scores were evaluated (p > 0.05). Conclusions: PUL offers rapid improvement in voiding and storage symptoms, QoL and flow rate that is durable to 12 months after intervention. PUL is a minimally invasive procedure that has the moderate effect in treating troublesome LUTS secondary to benign prostatic obstruction and preserving total sexual function.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2015Tiroide Metastaz Yapmış Böbrek Hücreli Kanser
Dinçer, Muhammet Murat; Bozkurt, Aliseydi; Semerciöz, Atilla; Dinçer, Selvi Tabak; Kandirali, Engin
Böbrek hücreli kanseri (BHK) böbreğin en sık görülen kanseridir. Tiroid bezi nadir metastaz bölgeleridir ve tiroid metastazları genellikle on yıl sonra ortaya çıkar. Olgumuzda, radikal nefrektomi (RN)'den 17 ay sonra boyunda şişlik şikayeti ile başvuran tiroide metastaz yapmış BHK'lı olguyu inceledik.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2015Metastasis of Renal Cell Carcinoma into the Thyroid Gland
Dinçer, Murat; Dinçer, Selvi; Bozkurt, Aliseydi; Kandirali, Engin; Semerciöz, Atilla
Renal cell cancer (RCC) is the most common cancer of the kidney. Thyroid gland rarest side of RCC metastasis which usually occur after 10 years. We present a very rare case of metastatic RCC in the thryoid gland in a patient who was referred to our clinic because of a neck mass 17 monts after radical nephrectomy.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2015Impact of Rho-Kinase Inhibitor Hydroxyfasudil in Protamine Sulphate Induced Cystitis Rat Bladder
Akin, Yigit; Bozkurt, Aliseydi; Erol, Huseyin S.; Halici, Mesut; Celebi, Fikret; Kapakin, Kubra A.T.; Gulmez, Hakan; Ates, Mutlu; Coban, Abdulkadir; Nuhoglu, Baris
Objectives: The objective of the present study was to evaluate anti-inflammatory effects of hydroxyfasudil in a protamine sulfate (PS) induced cystitis rat model. Additionally, we investigated prevention of bladder overactivity (BO), and tissue damage in these experiments. Methods: Animals were divided into four groups. In Groups 1 and 2, chemical induced cystitis model was created by administrating intravesical PS with PE50 catheter by the transurethral route. In Group 1, Rho-kinase inhibitor hydroxyfasudil was administered intaperitoneally, and in Group 2, subjects were administered a corresponding volume of saline in the same way. In Group 3, vehicle was administered intravesically and hydroxyfasudil was administrated intraperitoneally. Group 4 was a control Group, and the vehicle was administered intravesically and intraperitoneally. Micturition frequencies were recorded. Biochemical analyses were performed for oxidative stress, and pathological evaluations were investigated. In vitro contractions of bladder tissue strips were measured in tissue-bath. Results: There were significantly lower Lipid peroxidase levels and higher levels of Glutathione in Group 1 than Group 2 (P=0.016, P=0.001, respectively). There was generally more inflammation in Group 2 than the other groups as determined by microscopy. There were significantly higher frequencies of micturition, lower volume, and mean voided maximum urine output after PS administration in Groups 1 and 2. In vitro contraction responses of bladder strips to potassium chloride and acetylcholine were statistically higher in Group 2 than Groups 1 and 3. Conclusions: Significant reduction of inflammation by affecting the anti-oxidant defense systems was provided by hydroxyfasudil. Decreased in vitro responses to contractions of bladder smooth muscle strips were obtained. Hydroxyfasudil may be a potential new therapeutic option for inflammation and BO, in rat bladder.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2015Safety and efficacy of bipolar versus monopolar transurethral resection of the prostate: A comparative study
Hirik, Erkan; Bozkurt, Aliseydi; Karabakan, Mehmet; Aydemir, Huseyin; Aktas, Binhan Kagan; Nuhoglu, Baris
Purpose: Transurethral resection of the prostate (TURP) is considered gold standard for surgical treatment of benign prostatic hyperplasia (BPH). In this study, we aimed to compare post-operative clinical outcomes and adverse effects between monopolar and bipolar TURPs. Materials and Methods: The study included 590 patients who underwent TURP by a single urologist (E.H.) between June 2006 and June 2014 with a diagnosis of BPH. Patients were divided into two groups as monopolar TURP (group 1, n = 300) and bipolar TURP (group 2, n = 290). Patients receiving oral anticoagulants or aspirin and those with prostate cancer diagnosis were not included in the study. Data regarding pre-operative age, International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post voiding residual urine volume (PVR), serum prostate specific antigen (PSA) levels and prostate volume (Vp) of the patients were gathered from medical records. Groups were compared in terms of catheterization, operation time, hemoglobin (Hb) decrease, and IPSS, Qmax, and PVR values at post-operative 12th month follow-up visit. Results: From pre-operative to post-operative period, IPSS, Qmax and PVR showed significant improvements within both groups (P < .001). When groups were compared with each other, bipolar TURP group had significantly lesser catheterization time and hemoglobin decrease than monopolar TURP group, while no significant differences were detected regarding all other variables. Conclusion: Bipolar and monopolar TURPs are both effective and safe treatment modality for BPH. Bipolar TURP is superior to conventional monopolar TURP in terms of catheterization time and Hb decrease.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014İyatrojenik bir intravezikal yabancı cisim, foley sonda parçası: Olgu sunumu
Keleş, Muzaffer Oğuz; Gündoğan, Savaş; Nuhoğlu, Barış; Bozkurt, Aliseydi; Karabakan, Mehmet
Although the cases of intravesical foreign body are rare, it should always be considered in the differential diagnosis of patients presenting with lower urinary tract symptoms. In general, introduction of foreign bodies into the bladder may be self- insertion through the urethra, iatrogenic, migration from adjacent organ or a result of trauma. Here we evaluated a case of intravesical foreign body that emerged following removal of a catheter was evaluated in the light of current literature.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2014Neurogenic Bladder Due to Neuro-Behcet Disease: A Case Report
Karabakan, Mehmet; Guzel, Ozer; Erkmen, Akif Ersoy; Salar, Remzi; Bozkurt, Aliseydi; Akdemir, Serkan
Behcet's disease is defined as a systemic vasculitis that has unknown etiology and characterized by recurrent oral aphthous ulcers, skin rashes, eye involvement (iridocyclitis with hypopyon), and genital ulcers. Involvement of the bladder in neuro-Behcet disease is quite rare, and its incidence has been reported as approximately 0.07%. Our case had Behcet disease for 20 years and lower urinary tract symptoms with urinary incontinence for 2 years. Anti-cholinergic treatment was initiated after the urodynamic examination. This case report has been presented to emphasize the importance of diagnosis in Neuro-Behcet disease with bladder involvement.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2014Comparison of different legation techniques in laparoscopic varicocelectomy
Akin, Yiǧit; Ateş, Mutlu; Yücel, Selçuk; Başara, Işil; Çelik, Orçun; Bozkurt, Aliseydi; Nuhoǧlu, Bariş
Aim: To evaluate the effects of different intracorporeal legation techniques with titanium clips, Plasma Trisector (Gyrus, USA) (PTG), and surgical silk on bilateral laparoscopic varicocelectomy (LPVx). Materials and methods: Between May 2009 and August 2012, 100 patients who underwent bilateral LPVx were evaluated. Te demographic parameters of patients, preoperative radiological findings, semen analysis, operative data, and follow-up were recorded. All of the patients were divided into 3 groups, randomized prospectively. Te patients whose veins were legated by 5-mm titanium clips were included in group I, those whose veins were legated by PTG were included in group II, and those whose veins were legated by surgical silk were included in group III. Te recorded data of the groups were analyzed. Results: Mean follow-up time was 18.8 ± 1.1 months. According to the demographics of age, body mass index, spermiogram, and diameter of veins before surgery, there were no statistical differences between any of the groups (P > 0.05). However, operation time was longer in group III (P < 0.0001), while total numbers of legated veins did not differ among the groups (P > 0.05). Additionally, hospital stay, oral intake, and complications were not different among the groups (P > 0.05). In follow-up the sperm count analysis was higher than the preoperative count analysis for all of the groups (P < 0.05). Conclusion: PTG may provide a shorter operation time than using titanium clips and/or surgical silk in LPVx. Additionally, PTG may increase sperm count with fewer complications than the other legation techniques in LPVx. Terefore, PTG may be the new candidate electrosurgical standard device for LPVx in the nearby future.
RDL Kalıcı Kaydıİncele - ArticleYayıncıda açık erişim2014Relationship of PCNA, C-erbB2 and CD44S expression with tumor grade and stage in urothelial carcinomas of the bladder
Yildirim, Ayhan; Kösem, Mustafa; Sayar, Ilyas; Gelincik, Ibrahim; Yavuz, Alparslan; Bozkurt, Aliseydi; Erkorkmaz, Ünal; Bayram, Irfan
In the present study, the intention was to reveal the relationship of histological grade and stage with c-erbB2, CD44s, and PCNA immunoreactivity in bladder urothelial carcinomas (UC). In our study, we evaluated 46 items of transurethral resection material of patients submitted by YYU Faculty of Medicine, Main Department of Pathology, with a mass revealed in their bladder after clinical and radiological studies at our laboratories and who were diagnosed with urothelial carcinomas. PCNA, c-erbB2, and CD44s were applied in an immunohistochemical manner comprised from nine low-malignant potential papillary urothelial neoplasia, 23 low-grade papillary urothelial carcinoma, and 14 high-grade papillary urothelial carcinoma. Immunostaining was scored according to the percentage of positive cells. The immunohistochemical study demonstrated that the c-erbB2 and PCNA staining ratio increased when an increase occurred in stage and grade. The CD44s staining ratio decreased. C-erbB2, PCNA, and CD44s appear to be a useful marker in the assessment of the prognosis and treatment options in urothelial carcinomas.
RDL Kalıcı Kaydıİncele - Review ArticleYalnız künye2013Renal sinüs lipomatozu
Başara Akın, Işıl; Serter, Selim; Akin, Yigit; Nuhoğlu, Barış; Bozkurt, Aliseydi
AMAÇ: Bu çalıșmanın amacı renal sinüs lipomatozu olan hastaların bulgularını sunmak ve konuyu güncel literatür eșliğinde gözden geçirmektir. YÖNTEM: Mayıs 2010 - Eylül 2011 tarihleri arasında radyoloji departmanında elde edilen bütün bilgisayarlı tomografi görüntüleri retrospektif olarak incelendi. Renal sinüs lipomatozu olan 11 olgu ayırt edildi ve klinik ve laboratuar bulguları ile yeniden değerlendirildiler. BULGULAR: Renal sinüs lipomatozu tanısı alan beș erkek ve altı kadın hasta vardı. Hastaların yașları 36 ve 80 arasında değișmekteydi. Hastalardan yedisinde geyik boynuzu tașı izlendi. Hastaların çoğu asemptomatik olsa da, bazı hastalarda non-spesifik karın ağrısı, akut pankreatit ve pyelonefrit izlendi. SONUÇ: Renal sinüs lipomatozu selim bir hastalık da olsa konvansiyonel tanısal yöntemleri kullanarak urolojik tümörlerden ayıredilmeleri zordur. Bilgisayarlı tomografi kesin tanıda ve adipoz dokunun yaygınlığını belirlemede yararlıdır. Ancak, renal sinüs lipomatozu tanı ve sağaltımı için radyoloji, uroloji ve patoloji departmanlarının multidisipliner çalıșmaları gerekir.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Comparsion between Tubeless and Standard Nephrolithotomy of Renal Resistive Index in Kidneys of Patients
Akin, Yigit; Basara, Isil; Gülmez, Hakan; Yücel, Selcuk; Bozkurt, Aliseydi; Nuhoglu, Baris
Objective: We aimed to compare renal injury and vasculary resistance between standard and tubeless percutaneous nephrolithotomy (PCNL), in patients who were operated for kidney stone, by using colored Doppler ultrasonography (CDU). Methods: All consecutive PCNLs were evaluated between 2009 and 2011. The patients with access to the kidney provided in the lower pole and who visited our outpatient clinic regularly were enrolled in the study. Patients were divided into 2 groups; patients who had standard PCNL were included in Group 1 (n=22) and patients who had tubeless PCNL were included in Group 2 (n=21). The demographic data were collected from files of patients and were recorded. CDU was performed in all patients for evaluating resistive index (RI), parenchymal thickness and parenchymal echogenity before operation, after operation early postoperative (after 7 days nephrostomy catheter was taken off in Group 1, 7 days from operation in Group 2) and midterm postoperative period (6 months after operation). Statistical significant p was accepted as p<0.05. Results: Mean age was 47.18 +/- 1.3 years. There were 8 female and 14 male patients in Group 1 (n=22), 4 female and 17 male patients in Group 2 (n=21). The mean follow-up was 10.71 +/- 1.2 months. There was no statistical difference for mean age, body mass index, stone burden, serum creatine, hemoglobin, delta hemoglobin, complications, urinary culture, stone free rate between groups. Hospital stay was longer in Group 1 than Group 2 (p=0.04). Mean operation time was shorter in Group 2 than Group 1 (p=0.002). In the comparison of before and early postoperative operation, there were differences in groups for CDU, including RI, parenchymal thickness. There was an increase for RI and decrease for parenchymal thickness in midterm follow-up period when comparing RI before operation in the lower pole of the operated kidney. There was no difference in renal echogenity in CDU in groups between before and mid-term follow-up period. Conclusion: Recently, PCNL has been employed as a minimally invasive and safe procedure for kidney stones bigger than 2 cm. Tubeless PCNL was successful as standard PCNL, provided shorter hospital stay than standard PCNL and caused less damage to the kidney in the early follow-up period.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013A Novel Minimally Invasive Treatment Option for Benign Prostat Hyperplasia: Intraprostatic UroLift®, The First Case Series of Turkey with Short Term Follow-up
Akin, Yigit; Bozkurt, Aliseydi; Keles, Muzaffer Oguz; Gülmez, Hakan; Sahin, Murat; Nuhoglu, Baris
Objective: To evaluate feasiblity, effectiveness, applicable of UroLift (R) which is a minimally invasive surgical treatment option in patients with lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). Methods: Between March 2011 and May 2013, data of patients who were operated with UroLift (R), were investigated retrospectively. There were totally 10 patients. Demographic data of patients and internationale prostate symptom score (IPSS), quality of life (QoL) index, internationale index of erectile function (IIEF), roflowmetry (UFM) parameters were recorded before operation. Additionally, operation data, postoperative data and short follow-up were recorded and evaluated. In statistical analysis, statistical p value was accepted as p<0.05. Results: Mean age was 64.8 +/- 10 years, and 10 men evaluated totally. After 1 month and 3 months UroLift (R) implantation, in short follow-up, maximum (respectively; p<0.001, p<0.001) and mean urine flow rate statistical significant increased (respectively; p<0.001, p<0.001). Additionally post mictional residuel volume in bladder statistical significantly decreased (respectively; p=0.025, p=0.016). There was statistically significant decrease in IPSS after 1st and 3rd months of surgery (respectively, p<0.001, p<0.001). Development in QoL index were parallel to develoments in IPSS, after 1 month and 3 months of surgery (respectively; p=0.022, p=0.003). roLift (R) was effective in all patients. Additionally, there was no significant difference in IIEF scores in follow-up. Conclusion: UroLift (R) was effevtive in selected patients. In addition, it was new, safe, a novel minimally invasive surgical treatment option in BPH.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2013Comparison of alpha blockers in treatment of premature ejaculation: A pilot clinical trial
Akin, Yigit; Gulmez, Hakan; Ates, Mutlu; Bozkurt, Aliseydi; Nuhoglu, Baris
Background: Premature ejaculation (PE) is the most common sexual disorder in men and studies reported prevalence up to 30% (1, 2). PE is not a life-threatening medical condition but it influences the quality of life (QoL). Objectives: The aim of this study was to compare the efficiency, and safety of alpha blocker drugs in the treatment of patients with premature ejaculation (PE). Additionally we investigated the quality of life (QoL) in patients with PE who were treated with alpha blocker drugs. Materials and Methods: This study was a pilot clinical trial. Prospectively documented 108 patients with PE were treated and were followed-up in urology outpatient clinic. All patients were divided into 5 groups according to used alpha blocker agents which were determined by simple randomization. Silodosin 4mg (Group 1, n = 21), tamsulosin hydrochloride 0.4mg (Group 2, n = 23), alfuzosin 10mg (Group 3, n = 22), terazosin 5mg (Group 4, n = 21), doksazosin mesylate 4mg (Group5, n = 21), were used for treatment. The demographic parameters of patients, pre and post treatment intravaginal ejaculation latency time (IELT), PE Profile (PEP), and QoL index were recorded and evaluated. Effectiveness of treatment was evaluated by measuring IELT. Additionally, side effects of drugs were recorded. P < 0.05 was considered statistically significant. Results: All alpha blocker drugs were statistically effective for preventing PE. Notably, silodosin seemed to be more effective for preventing PE than other alpha blockers (P < 0.05). However all alpha blockers provided development in QoL scores, silodosin was a little better than other drugs in statistical analyses. Furthermore statistical increase in IELT and decrease in PEP were provided more in Group 1 than other groups (P < 0.05). Conclusions: Silodosin seems to be able to even more prevent PE. Silodosin may provide development in QoL than other alpha blocker agents. Additionally, lower systemic adverse events and more effectivity are the prominent features of silodosin in PE.This study was a pilot clinical trial. Prospectively documented 108 patients with PE were treated and were followed-up in urology outpatient clinic. All patients were divided into 5 groups according to used alpha blocker agents which were determined by simple randomization. Silodosin 4mg (Group 1, n = 21), tamsulosin hydrochloride 0.4mg (Group 2, n = 23), alfuzosin 10mg (Group 3, n = 22), terazosin 5mg (Group 4, n = 21), doksazosin mesylate 4mg (Group5, n = 21), were used for treatment. The demographic parameters of patients, pre and post treatment intravaginal ejaculation latency time (IELT), PE Profile (PEP), and QoL index were recorded and evaluated. Effectiveness of treatment was evaluated by measuring IELT. Additionally, side effects of drugs were recorded. P < 0.05 was considered statistically significant.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2012Benign, premalign ve malign prostat lezyonlarında ki-67, Bcl-2 ve C-erbB2 belirteçlerinin önemi
Sayar, Ilyas; Gelincik, İbrahim; Bayram, İrfan; Bozkurt, Aliseydi
Amaç: Bu çalışmada benign, premalign ve malign prostat lezyonlarında Ki-67, bcl-2 ve c-erbB2 belirteçlerinin önemi ve karsinomun histolojik derecelendirmesinde belirteçlerin yararlılığı incelendi.Hastalar ve Yöntem: 1998-2008 yılları arasında 38 benign prostat hiperplazisi (BPH), 35 adenokarsinom (PCA) ve 16 prostatik intraepitelyal neoplazi (PİN) tanısı almış 89 olguya ait örneklere immünohistokimyasal olarak Ki-67, bcl-2 ve cerb-B2 uygulandı ve pozitif hücrelerin yüzdesine göre immünboyanmalar skorlandı.Bulgular: Ki-67 ile benign lezyonlarda düşük oranda boyanma oranı, karsinomlarda daha yüksek oranda boyanma oranı bulundu. Karsinomlarda Gleason derecesi yüksek olan olguların Ki-67 boyanma oranı, derecesi düşük olanlara göre yüksek bulunarak, Ki-67 immünboyanmasının Gleason skoruyla ilişkili olduğu gösterildi. Bcl-2 ile benign ve premalign lezyonlarda bazal tabakada yüksek oranda boyanma gözlenirken, malign lezyonlarda hiç boyanma saptanmadı. C-erbB2 ile ilginç olarak olguların hiçbirinde boyanma görülmedi.Sonuç: Sonuç olarak Ki-67nin malign lezyonlarda artan histolojik grade ile ilişkili olduğu gözlendi. Ayrıca Ki-67nin benign ve premalign lezyonların ayırıcı tanısında yararlı olabileceği kanısına varıldı. Bcl-2nin bazal tabaka belirteci olarak klasik belirteçlere ek olarak yararlı olabileceği düşünüldü.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2012Nadir bir olgu: Mesane kanserinin gluteal kas metastazı
Başara Akın, Işıl; Akin, Yigit; Nuhoğlu, Barış; Bozkurt, Aliseydi; Birkan, Zülfü
ÖZET Transizyonel hücreli mesane kanserinin, çizgili kas metastazı oldukça nadir görülmektedir. Mesane kanseri, en sık lenf nodları, akciğer, karaciğer, ke- mik ve adrenal bezlere metastaz yapmaktadır. Bu makalede, 59 yaşında erkek hasta, dış merkezde 2 yıl önce; mesane tümörü tanısı konulan bir hasta sunuldu. Hastaya, transüretral mesane tümör rezeksiyonu yapılmış ve patoloji sonucunda, kas invaziv mesane tümörü tanısı aldıktan sonra, definitif radyoterapi ve sistemik kemoterapi tedavisi uygulanmış. Rutin takipleri sırasında; sağ kalça ağrısı nedeniyle yapılan tetkiklerinde, mesane kanserinin gluteus medius kasına metastazı saptandı. Sonraki takiplerinde sistemik metastazları gelişen hasta 6 ay sonra kaybedilmiştir.
RDL Kalıcı Kaydıİncele - Review ArticleYalnız künye2012Post prostatectomy ıncontinence
Akin, Yigit; Nuhoğlu, Barış; Bozkurt, Aliseydi
Benign ya da malign hastalıklar için yapılan prostatektomi sonrasında inkontinans gelişmesi en korkulan komplikasyonlardandır. Benign nedenlerle prostatektomi uygulanan hastalarda post operatif üriner inkontinans nadir iken, radikal prostatektomi sonrasında daha yüksek oranlarda görülür. Bu komplikasyon, hastanın yaşam kalitesini önemli derecede etkilemektedir. Prostatektomi sonrası oluşan idrar kaçırma tedavisinde; konservatif yön- temlerden, invaziv girişimlere kadar değişen farklı yöntemler kullanılır. Sling ve artifisyel üriner sfinkter (AÜS) operasyonları bu amaçla en sık kullanılan cerrahi tedavi yöntemlerdir. Sling yöntemleri, AÜSe göre operasyon sonrası enfeksiyon ve üretral erozyon gibi komplikasyonları açısından düşük risk taşımaktadır. Şiddetli inkontinansta AÜS, günümüzde standart tedavi seçeneği sayılsa da, erkek sling materyallerindeki gelişmeler, ciddi inkontinans vakalarında da sling yöntemlerinin öne çıkacağını göstermektedir. Bu çalışmada prostatektomi sonrası idrar kaçırma ve tedavi yöntemleri güncel bilgi- ler eşliğinde değerlendirildi.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2012A Rare Case: Gluteal Muscle Metastasis of Bladder Cancer
Akin, Yigit; Birkan, Zulfu; Basara, Isil; Bozkurt, Aliseydi; Nuhoglu, Baris
Skeletal metastasis of transitional cell carcinoma of the urinary bladder is very rare. Bladder cancer mostly metastases to lymph nodes, lung, liver, bone and adrenal glands. In this article, a 59-year-old male patient, who had been diagnosed as having a bladder tumor 2 years previously at another center, was presented. Two years earlier, transuretral bladder tumor resection had been performed to the patient and the tumor had been diagnosed as muscle invasive bladder tumor pathologically. After the diagnosis, definitive radiotherapy and systemic chemotheraphy treatment was performed. During routine follow-up procedure, in the investigations which were carried out because of right gluteal pain, gluteus muscle metastasis was diagnosed. During the next follow-up procedures, systemic metastasis occurred and the patient died 6 months later.
RDL Kalıcı Kaydıİncele