Sürdürülebilir Kalkınma Amaçları
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- ArticleAçık Erişim2020The Effect of Ozone Treatment on Thermal Burn Wound Healing; an Experimental Study
Peker, Kemal; Yilmaz, Ismayil; Demiryilmaz, Ismail; Isik, Arda; Sayar, Ilyas; Gursul, Cebrail; Cankaya, Murat; Coban, Taha Abdulkadir
Objective: Ozone has been advised as a metabolic excitative in cell, immunomodulatory agent and antioxidant enzyme actuator. The present study was performed to designate the profit of ozone therapy on the burn wound healing in the rats. Methods: 40 adult Wistar type rats divided into 4 groups: a control group (burn not created and topical and systemic agents not used), a burn group (burn created but only saline given), a burn+silver sulfadiazine group (silver sulfadiazine was applied for 21 days), a burn+ozone/oxygen mixture group (ozone/oxygen mixture was applied for 21 days).After anesthetizing, second-degree burn (2 cm2 areas) was done on the dorsal of the animals byaluminum plate in boiling hot water (100 degrees C for 15 seconds) and other groups except control group were treated topically, based on the time scheduled. Tissue samples were harvested on day 7st and 21st after burn injury. Biochemical and histological analyzes were performed in tissue and blood samples. The results were assessed with appropriate statistical tests and given as Means +/- SD. Results: The histopathologic damage level was significantly different in all groups. Fibrosis and inflamation levels decreased in ozone treatment and silver sulphadiazine groups compared to burn+normal saline group on the 21 days according to 7 days. In the ozone treatment group, Glucose 6-phosphate dehydrogenase activities were significantly higher than the silver sulfadiazine treated group. But glutathione reductase enzyme activities were lover in the ozone treated group and hydroxyproline concentration decreased in ozone group compared to burn+normal saline group on 7 and 21 days. Conclusions: Ozone has a detractive effect in the development of inflamation, fibrosis, and granulation via decreasing tissue damage and increasing the antioxidant enzyme activity on burn wound healing.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2018Breast Skin Necrosis After Methylene Blue Dye İnjection: Breast İmage
Isik, Arda; Yılmaz, İsmayil; Firat, Deniz; İnal, Abdullah; Çelebi, Fehmi; Peker, Kemal
Sentinel lymph node dissection is the gold standard treatment for non-lymph node metastatic breast cancers. Here we present, a 41-yearoldwoman with a BIRADS-5 mass in the left retroareolar area. After sentinel lymph node biopsy, she had breast skin necrosis.( Sakarya Med J 2018, 8(1):153-156 )
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2018A survey of current approaches to thyroid nodules and thyroid operations
Isik, Arda; Firat, Deniz; Yilmaz, Ismayil; Peker, Kemal; Idiz, Oguz; Yilmaz, Bahri; Demiryilmaz, Ismail; Celebi, Fehmi
Introduction: Thyroid nodules are commonly seen. Our aim is to learn the behaviors and operational attitudes of surgeons approaching the thyroid nodules. In a literature search, our study is the first and only study performed merely on surgeons. Materials- Metods: This cross-sectional study was done between June 2014–January 2015. The questionnaire consists of 25 questions. Initially, general questions consisting of demographic findings were asked. In step 2, questions consisting of the index case and case variants were asked. Results were compared with American Thyroid Association, European Thyroid Association guidelines, and Australia survey results. In the last step, questions about thyroid operations were asked. Results: A total of 301 surgeons responded to the survey. The response rate was approximately 20%. Thirty nine were female and 262 were male. For the question that asks the diameter of the thyroid nodule that will require a thyroid fine needle aspiration biopsy (TFNAB), 47.5% of the surgeons will require a TFNAB for 1–2 cm solid nodules. 40.15% of the surgeons required a TFNAB regardless of size. 46.1% of the surgeons who required a TFNAB between 1 and 2 cm solid nodules also required scintigraphy at diagnosis of suppressed TSH case variant. Conclusion: In this survey, we identified differences from up-to-date guidelines about approaching thyroid nodules and perioperative thyroid surgery. From our perspective, surgeons need updated training requirements. This can be done with updated seminars across the country. Thereby approaches may become standard and consequently patients may have qualified services.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2017Correlation of Bowel Wall Thickening Seen Using Computerized Tomography With Colonoscopies: A Preliminary Study
Isik, Arda; Soyturk, Mehmet; Süleyman, Sakir; Firat, Deniz; Peker, Kemal; Yilmaz, Ismayil; Celebi, Fehmi
Purpose: Bowel wall thickening (BWT) is a common finding in abdominal computerized tomography imaging (CTi). The purpose of the present study was a prospective assessment and management of patients who have BWT in abdominal CTi. Materials and Methods: This study was conducted between January 2012 and July 2014 at Erzincan University Hospital, Turkey, with 64 patients who were admitted to the emergency and general surgery department. All of the patients had received colonoscopies due to BWT seen in abdominal CTi. Results: Twenty-three (36%) female and 41 (64%) male patients were included in the study. The mean age was 56.2 years (range, 14 to 84 y). The positive predictive value of CTi for BWT was 87.5%. The positive predictive value of a CTi diagnosis of the disease according to a radiologist's report was 78.1%. Common pathologies detected by colonoscopy included neoplasia and inflammatory bowel disease. Conclusions: Diagnosis of BWT by abdominal CTi reveals pathologies in many cases. Colonoscopies will be helpful in the differential diagnosis.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2017Metalloproteinases and Their Inhibitors in Patients with Inguinal Hernia
Isik, Arda; Gursul, Cebrail; Peker, Kemal; Aydın, Merve; Fırat, Deniz; Yılmaz, İsmayil
Aim: The aim of this prospective study is to investigate if there is a relationship between inguinal hernia, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs). Materials and methods: This case control study was performed on patients admitted to the general surgery department of Erzincan University Hospital. Four groups were created: control, indirect hernia, direct hernia, and bilateral hernia. All groups were comprised of 11 patients. Serum and tissue levels of MMP-1, MMP-2, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3, and hydroxyproline were evaluated. Results: MMPs values were significantly high at hernia groups, especially at bilateral hernia group (p < 0.05), whereas TIMPs values were significantly low at bilateral hernia group (p < 0.05). MMPs values were increasing at hernia groups in an order as control, indirect, direct, and bilateral. TIMPs values were decreasing at hernia groups in an order as control, indirect, direct, and bilateral. Conclusion: Increased levels of MMP-1-2-9-13 and decreased levels of TIMP-1-2-3 may have played role in the formation of inguinal hernia. Hernia is not only a local defect, but a reflection of systemic disease. This is even more significant for bilateral hernias.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2017Endoscopic treatment of a fistula, which is developed by anastomotic leakage with fibrin glue
Peker, Kemal; Demiryilmaz, Imsmail
Surgeons have been using sutures made up of different materials to reunite disrupted tissues, throughout centuries. However, these materials may have certain disadvantages like foreign body reaction, infection, scarring, need for removal and cost. Their application is time-consuming and needs skill and experience. Whereas tissue adhesives is one of alternative to conventional suturing and has some additional advantages. The use of fibrin glue, as in concentrated human fibrinogen in combination with thrombin for hemostasis and tissue adhesion has been an important advance in a variety of surgical applications. The purpose of this study is to share our experience about fibrin glue.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2017The effects of Naringin & ozone in hepatic ischemia reperfusion injury: An experimental study
Gursul, Cebrail; Peker, Kemal; Coban, Abdulkadir; Kilicgun, Hasan; Sayar, Ilyas; Akdemir, Fazile Nur Ekinci; Cankaya, Murat; Gul, Mustafa
Background and Aim. Hepatic ischemia reperfusion (I/R) injury is located between complications widely seen in clinical. Aim of this study was to investigate the protective roles of naringin and ozone effects and synergistic effects induced I/R injury on the liver in rats. Methods. Thirty five Adult male Sprague Dawley rats were divided into five groups (n=7 in each group): sham-operated, I/R, I/R with 80 mg/kg naringin, I/R with 0.5 mg/kg ozone, and I/R with 80 mg/kg naringin+0.5 mg/kg ozone. Before hepatic I/R was induced, ozone and naringin was injected intraperitoneally at doses of 80 mg/kg and 0.5 mg/kg. After 70-min ischemia and a 120-min reperfusion period, later at the end of experiment, liver tissues were excised. The levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD), glutathione reductase (GR), catalase (CAT) were measured in hepatic tissue. Results. SOD, GR, and CAT activities decreased and MDA level, as a biomarker of the lipid peroxidation, increased in I/R group compared to Sham-operated group. In addition, SOD, GR, and CAT activities increased by the naringin, ozone, and naringin+ozone treatment. Conclusions. The results of this study suggest that naringin, ozone, and naringin+ozone. may be strongly protective against hepatic I/R injury. This effect can be achieved by antioxidant and antiapoptotic activities.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2016Protective effects of ellagic acid and ozone on rat ovaries with an ischemia/reperfusion injury
Sayar, Ilyas; Bicer, Senol; Gursul, Cebrail; Gürbüzel, Mehmet; Peker, Kemal; Işik, Arda
Aim This study investigated the effects of the antioxidant agents, ozone (O) and ellagic acid (EA), on ischemia/reperfusion (I/R) injuries developed from an ovarian torsion-detorsion model. Materials and Methods Arteries in the left ovaries of rats were clamped for two hours to achieve torsion, and then the clamps were removed for a two-hour detorsion period. Thirty-five female Sprague-Dawley rats were randomly divided into five groups: control: administered only with anesthesia, rats were not subjected to torsion-detorsion; I/R: subjected to torsion and subsequent detorsion, without administering any treatment agent; and I/R + EA, I/R + O and I/R + O + EA: subjected to torsion and detorsion processes and administered with EA, O or EA + O at the 75th minute of torsion. The rats were then sacrificed under general anesthesia and the ovarian tissues were excised. The tissues were homogenized and levels of glutathione reductase, catalase, superoxide dismutase and malondialdehyde (MDA) were analyzed. Tissue damage was evaluated in terms of histopathological parameters, such as hemorrhage, congestion, edema and inflammation. Results Antioxidant enzyme activity and MDA levels in the ovary tissue increased in the I/R group and decreased in the O, EA and O + EA groups (P < 0.05). Histopathological examination revealed that tissue damage in the O, EA and O + EA groups decreased in comparison with the I/R group (P < 0.05). Conclusions These biochemical and histopathological findings suggest that EA and O are effective against ovarian I/R injury.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2016Use of ozone to treat ileostomy dermatitis in an experimental rat model
Biçer, Şenol; Sayar, İlyas; Gürsul, Cebrail; Işık, Arda; Aydın, Merve; Peker, Kemal; Demiryilmaz, İsmail
Background: Dermatitis associated with ileostomy is an important problem that affects many people, especially children. The aim of this study was to investigate the therapeutic effects of ozone on dermatitis due to ileostomy, and to develop an alternative treatment option. Material/Methods: A total of 28 rats were divided into 4 groups: control, ileostomy, ozone, and zinc oxide. Ileostomy was performed in all rats except the control group. After a 1-week waiting time, the ozone group was administered ozone therapy and the zinc oxide group was administered zinc oxide cream locally once a day for a total of 7 days. All rats were sacrificed at the end of this period. The efficacy of treatment was examined by biochemical, histopathological, and immunohistochemical parameters. The levels of malondialdehyde (MDA), total glutathione (tGSH), total antioxidant capacity (TAC), and total oxidant status (TOS) were measured from tissue. Vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) were examined immunohistochemically. Results: Dermatitis occurred pathologically in all rats that underwent ileostomy surgery. The lowest dermatitis score was in the ozone treatment group (p<0.05). Ileostomy dermatitis caused increased levels of MDA and TOS. Ozone treatment resulted in reduced MDA and TOS levels, while the levels of tGSH and TAC were increased (p<0.05). Both VEGF and PCNA immunostaining were augmented in the ozone treatment group (p<0.05). Conclusions: Local ozone application may be a good alternative compared to the conventional treatment methods for the prevention of skin lesions that develop after ileostomy.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2016Male Mondor's Disease is a Rare Entity
Isik, Arda; Karavas, Erdal; Peker, Kemal; Soyturk, Mehmet; Yilmaz, Ismayil
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2015Percutaneous Endoscopic Gastrostomy Our Experience: Evaluation of 66 Cases
Eken, Hüseyin; Isik, Arda; Özçiçek, Adalet; Yılmaz, İsmayil; Sekban, Nurdan; Çimen, Orhan; Peker, Kemal; Biçer, Şenol; Demiryılmaz, İsmail
Objective: While the patients who will not to be fed orally for less than a month are fed enterally with nasoenteral feeding tube, for the patients who are not able to take food orally more than a month gastrostomy application is recommended. Different gastrostomy techniques are used for this purpose. We aimed to discuss indications of percutaneous endoscopic gastrostomy (PEG) in the patients who underwent PEG operation, their early or late complications and the management of these complications. Material and Methods: This study was performed simultaneously in two different hospitals between 01.06.2010- 05.01.2014. The files of 66 patients whose oral feeding is not possible and PEG administered for enteral nutrition were reviewed retrospectively. Results: The most common indications for PEG placement in 47 patients (71.2 %) was malnutrition due to cerebrovascular diseases. A major complication related to procedure was not observed. The most common minor complications were feeding intolerance in 5 (7.6 %) patients and occlusion of tube in 5 (7.6 %) patients. Serious wound infection accompanied by necrosis that requires surgical debridement developed in 3 (4.6 %) patients. Conclusion: PEG offers great advantages because of ease of application especially in the critical patients who are not able to be fed orally due to a problem at proximal part while their gastrointestinal system are intact, and with its capability of being applied even at bedside, not requiring serious anesthesia and team. It is gaining widespread use with the improvement of intensive care units in terms of number of beds and facilities. Major and minor complications encountered require a surgical overview because application is an ostomy procedure. Therefore, we consider that in the PEG applications performed by the physicians other than surgeons, it would be appropriate to follow up these patients together with surgery clinics.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2015Surgeons' Approaches and Professional Perspectives on Breast Masses: A National Survey in Turkey
Emiroglu, Mustafa; Inal, Abdullah; Sert, Ismail; Karaali, Cem; Peker, Kemal; Ilhan, Enver; Gülçelik, Mehmet Ali; Erol, Varlik; Can, Didem; Aydin, Cengiz
Objective: General surgeons' approaches to breast masses in their daily practices and their perspectives for issues on breast diseases and breast surgery are investigated through a survey. Materials and Methods: Answers of 524 general surgeons for the survey Approach to breast diseases and breast surgery between November 2012 and February 2013 were assessed. Demographic features, approaches to the breast masses, and answers for the clinical scenerios of surgeons were questioned. Surgeons were asked about management of breast cancer and the future role of surgeons for oncoplastic breast surgery and breast diseases. Results: Participants were representing 14.6% of all general surgeons in Turkey. The survey revealed that breast diseases are the most common cause for admission in general surgery outpatient clinics. Needle biopsies were employed by 241 (60%) respondents. Three hundred and seventy-one (71%) participants indicated that breast cancer management could be accurately conducted by the general surgeons. Two hundred and seventy-three (52%) respondents think that oncoplastic breast surgery should be performed by a general surgeon and 241 (41%) respondents predict that the role of general surgeons for breast diseases and breast surgery will decrease in the future. Conclusion: Basic approaches towards breast masses need to be improved in our country despite the highest frequency of breast diseases in outpatient admissions. The views and opinions of surgeons on breast diseases and the course of breast surgery in different regions and different communities need to be defined and clarified.
RDL Kalıcı Kaydıİncele - EditorialAçık Erişim2015Spontaneous Milk Fistula from an Accessory Breast: An Extremely Rare Case
Firat, Deniz; Idiz, Oguz; Isik, Arda; Peker, Kemal; Atar, Nilgun; Gul, Eylem
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2015Diagnostic evaluation and treatment of patients with rectus abdominis hematoma
Isik, Arda; Peker, Kemal; Soyturk, Mehmet; Firat, Deniz; Yoruker, Uygar; Yilmaz, Ismayil
Purpose: To identify clinical characteristics, treatment modalities, and course of spontaneous rectus sheath hematoma (SRSH). In the literature, there is no prospective clinical trial that is intended for treatment in clinical research. Methods: Seventeen SRSH patients diagnosed and treated between March 2012 and March 2014 at the general Surgery Department of Erzincan University Training and Research Hospital were included. Age, sex, weight, height, predisposing factors, comorbid diseases, Charlson index, current medical treatment, physical examination signs, imaging methods, lowest hemoglobin value, blood type, SRSH type, INR/Factor V Leiden mutation/Factor VII/Factor VIII/Factor X/Protein S/Protein C values, treatment method, transfusions hospitalization duration, and outcome were studied. Results: Thirteen patients were female. The mean age was 63.3 +/- 18.7 years (range, 22-87 years), and the mean BMI was 27.8 +/- 3.5 (range, 20.9-33.7). Six patients had Grade I SRSH, 5 had Grade II SRSH, and 6 had Grade III SRSH. Thirteen were hospitalized for a mean duration of 9.3 +/- 8.1 days (range, 1-30 days). The death rate attributable to SRSH was 5.8%. Conclusion: Early diagnosis of SRSH by ultrasonography and/or computerized tomography is important for a low mortality rate. Even though medical treatments are important, arterial embolization by interventional radiology, or more radical interventions such as surgery, may be required. (C) 2014 AEC. Published by Elsevier Espana, S.L.U. All rights reserved.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2015MRCP in the prognosis of acute pancreatitis
Cimen, Orhan; Ağaoglu, Nazım; Peker, Kemal; Kerim Aslan, Mithat; Soyturk, Mehmet; Eken, Huseyin; Demiryilmaz, Ismail; Yazıcı, Ahmet; Burak Cekic, Arif; Kocyigit, Sema
Background: Acute pancreatitis (AP) is a serious disease characterized by inflammation of the pancreas. Material/Methods: We prospectively investigated a total of 42 patients treated at Karadeniz Technical University Faculty of Medicine General Surgery Department with the preliminary diagnosis of AP from January 2010 to June 2011, and who underwent biochemical tests and magnetic resonance cholangiopancreatography (MRCP). Patient age, sex, amylase levels, and other biochemical parameters, as well as treatment type, complications, etiologic factors, morbidity rates, hospital length of stay, and Ranson scores, were included in the evaluation. Results: Our study population consisted of 24 women and 18 men. The serum amylase levels ranged between 146 and 3086 U/L (mean 1271.07 U/L). When patients were scored according to the Ranson scoring system, 3 (7.1%) patients had a Ranson score of 0, 10 (23.8%) patients had a score of 1, 15 (35.7%) patients had a score of 2, 11 (26.2%) patients had a score of 3, 2 (4.8%) patients had a score of 4, and only 1 (2.4%) patient had a score of 5. We found abnormal pancreatic duct morphology in 10.3% of the patients who had mild pancreatitis attacks and 33.3% of the patients who had moderate pancreatitis attacks. Although we observed a correlation between the Ranson score and pancreatic duct morphology, this relationship was not significant (P>0.05). Conclusions: Based on the results of our study, we believe that MRCP and MR are as effective as CT in the follow-up and treatment of acute pancreatitis.
RDL Kalıcı Kaydıİncele - CorrectionAçık Erişim2015Erratum to How do surgeons approach breast cancer surgery in Turkey? A national survey (Breast Cancer, (2013), 10.1007/s12282-013-0500-4)
Emiroğlu, Mustafa; Inal, Abdullah; Sert, İsmail; İlhan, Enver; Peker, Kemal; Gulcelik, Mehmet Ali; Güngör, Hilmi; Salimoğlu, Semra; Can, Didem; Ellidokuz, Hülya
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2015The effect of ozone and naringin on intestinal ischemia/reperfusion injury in an experimental model
Isik, Arda; Peker, Kemal; Gursul, Cebrail; Sayar, Ilyas; Firat, Deniz; Yilmaz, Ismayil; Demiryilmaz, Ismail
Background: The aim of the study was to evaulate the effect of ozone and naringin on the intestine after intestinal ischemia-reperfusion(II/R) injury. Methods: Thirty five rats divided into 5 groups of 7 animals: control, II/R, ozone, naringin and naringin + ozone. Only laparotomy and exploration of the superior mesenteric artery (SMA) were done in control group. In the experimental groups, SAM was occluded for 1 h and reperfused for 1 h. 15 min after ischemia, ozone (25 μg/ml, 0.5 mg/kg), naringin (80 mg/kg) and naringin + ozone(80 mg/kg + 25 μg/ml, 0.5 mg/kg) were infused intraperitoneally to each groups. Ileum tissues were harvested to determine intestinal mucosal injury and oxidative stress markers. For SMA occlusion, different than literature, silk suture binding was used. Results: Oxidative stress markers were significantly low in experimental groups compared with II/R group (p < 0.05). Histopathologically, the injury score was significantly low at experimental groups compared with II/R group (p < 0.05). The lowest injury score was encountered at naringine + ozone group. Conclusions: Ozone alone or combined with naringin has a protective effect for mesenteric ischemia. Instead of using instruments such as clamps in the II/R rat model, silk binding may be used safely.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2015Relationship among mismatch repair deficiency, CDX2 loss, p53 and E-cadherin in colon carcinoma and suitability of using a double panel of mismatch repair proteins by immunohistochemistry
Sayar, Ilyas; Akbas, Emin Murat; Isik, Arda; Gokce, Aysun; Peker, Kemal; Demirtas, Levent; Gürbüzel, Mehmet
Biomarkers such as mismatch repair proteins, CDX2, p53, and E-cadherin are blamed for colon cancers, but the relationships of these biomarkers with each other and with pathological risk factors in colon carcinoma are still not clear. The aim of this study was to evaluate the association of these biomarkers with each other by using immunohistochemical staining and to compare their expression with pathological risk factors for colonic adenocarcinoma. We also aimed to study the usability of a double panel of mismatch repair proteins. One hundred and eleven cases with colonic adenocarcinoma were examined. There was a statistically significant relationship between tumor histological differentiation and perineural invasion, vascular invasion, mismatch repair deficiency, p53, CDX2, and E-cadherin (p < 0.05). PMS2 and MSH6 loss covered 100% of cases with mismatch repair deficiency. Mismatch repair deficiency was correlated with CDX2 loss and E-cadherin expression (p < 0.05). It was also observed that cases with PMS2 loss covered all the cases with CDX2 loss. In conclusion, this double panel may be used instead of a quadruple panel for detecting mismatch repair deficiency. Association of CDX2 and PMS2 in the present study is necessary to conduct further genetic and pathological studies focusing on these two markers together.
RDL Kalıcı Kaydıİncele - ArticleYalnız künye2015How do surgeons approach breast cancer surgery in Turkey? A national survey
Emiroğlu, Mustafa; Inal, Abdullah; Sert, İsmail; İlhan, Enver; Peker, Kemal; Gürçelik, Mehmet Ali; Güngör, Hilmi; Salimoğlu, Semra; Can, Didem; Ellidokuz, Hülya
Background: The aim of this study was to investigate the experience, practice and approaches of general surgeons in relation to the treatment of breast cancer in Turkey. Methods: A survey was conducted between November 2012 and February 2013 with 453 general surgeons who claimed to perform breast surgery. Initial and most preferred approaches for breast cancer surgery and demographic features of participants were questioned. Initial approaches of surgeons for a suspected breast mass were assessed with a clinical scenario. Results: A total of 12.6 % of practicing general surgeons in Turkey responded to the survey. A multidisciplinary assessment was employed by 57.2 % of participants. The most frequently used diagnostic tool was needle biopsies (64.9 %) and the most frequently performed surgery for early stage cancers was breast-conserving surgery (72.2 %). The initial approach for locally advanced breast cancer was neoadjuvant chemotherapy (59.8 %) and mastectomy for metastatic cancer (22.7 %). Sentinel lymph node biopsies were utilized by 59.2 % of participants by different methods in appropriate cases. Oncoplastic breast surgery was performed by 9.0 % of participants, frequently or constantly. The surgeons’ initial approaches for the clinical scenario were imaging (56.7 %) and biopsy (40.6 %). Conclusions: Although there are efforts to improve up-to-date approaches towards breast cancer surgery by surgeons, currently there are significant inadequacies for evidence-based medicine practices.
RDL Kalıcı Kaydıİncele - ArticleAçık Erişim2015Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
Sahin, Murat; Gullu, Huriye; Peker, Kemal; Sayar, Ilyas; Binici, Orhan; Yildiz, Huseyin
The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia.
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