Investigation of Changes in Malondialdehyde Level, Superoxide Dismutase and Catalase Activity in Liver Tissue of Capoeta umbla exposed to 2,4-Dichlorophenoxyacetic Acid

In this study, changes in malondialdehyde level (MDA), superoxide dismutase (SOD) and catalase (CAT) activity in fish liver tissue were investigated by applying two doses of 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide to Capoeta umbla fish for 72 hours. Changes in MDA level, CAT and SOD activity were determined by spectrophotometric methods. As a result of the study, it was determined that there was a statistically significant increase in MDA level, CAT and SOD activity in C. umbla liver tissue exposed to different doses of herbicide (p < 0.05). It was observed that 2,4-D herbicide disrupted the oxidant/antioxidant balance in fish liver tissue. However, these two antioxidant enzymes, which are the primary defense mechanism, appear to be resistant to the toxic effect of 2,4-D.