Yazarlar
- Suleyman, Halis(167)
- Mammadov, Renad(95)
- Türkeş, Cüneyt(84)
- Aydin, Sonay(83)
- Altuner, Durdu(74)
- Suleyman, Bahadir(68)
- Isik, Arda(67)
- Beydemir, Şükrü(66)
- Kantarci, Mecit(64)
- Kurt, Nezahat(57)
- Demir, Yeliz(54)
- Bulut, Seval(51)
- Arslan, Yusuf Kemal(50)
- Sofu, Hakan(50)
- Coban, Taha Abdulkadir(49)
- Karakeçili, Faruk(47)
- Altay, Ahmet(46)
- Huyut, Mehmet Tahir(46)
- Aydin, Suleyman(45)
- Türkmenoğlu, Burçin(45)
- Kuzucu, Mehmet(40)
- Yazici, Gulce Naz(40)
- Peker, Kemal(39)
- Algul, Oztekin(38)
- Cicek, Betul(37)
- Mertoglu, Cuma(36)
- Camurcu, Yalkin(35)
- Suleyman, Zeynep(34)
- Bozkurt, Aliseydi(32)
- Mendil, Ali Sefa(32)
- Gunay, Murat(31)
- Gözcü, Sefa(31)
- Köksal, Ekrem(31)
- Yuca, Hafize(31)
- Dilek, Esra(30)
- Karakurt, Papatya(30)
- Ozcicek, Fatih(30)
- Süleyman, Halis(30)
- Onk, Didem(29)
- Ucpunar, Hanifi(29)
Yayınlar
- ArticleAçık Erişim2026The effect of Hippophae rhamnoides on Hydroxychloroquine-Induced stomatitis in rats
Dilber, Muhammet; Suleyman, Zeynep; Yucel, Nurinisa; Yazici, Gulce Naz; Mammadov, Renad; Cakir, Osman Kagan; Celik, Fatih; Coban, Taha Abdulkadir; Salcan, Ismail; Baykal, Huseyin
Background: Stomatitis is the most common mucosal side effect associated with Hydroxychloroquine (HCQ). Hippophae Rhamnoides (HR) is known to contain several phytonutrients, including anti-inflammatory, and antioxidant properties. This study aimed whether HR can mitigate HCQ-induced oxidative stress and inflammation in rat cheek tissue and to corroborate biochemical findings with macroscopic and histopathological evaluations. Methods: Twenty four rats were used and split into four groups: healthy control group (HG), receiving HR alone, receiving HCQ alone, and receiving both HR and HCQ (HRHQ). The drugs were administered for 10 days, and at the end of the 10th day, the rats were euthanized with high dose of thiopental sodium anesthesia and the inner cheek tissues removed. Results: HR decreased malondialdehyde, and pro-inflammatory cytokine levels, which increased by HCQ, while it increased anti-oxidant levels, which decreased by HCQ. The inner cheek tissue was examined macroscopically for edema, hemorrhagic cracks, hyperemia and gray appearance that developed due to HCQ use, which were alleviated with HR. Histopathologically, epithelial necrosis, muscle degeneration, scar tissue, polymorphonuclear cell (PMNL) infiltration, haemorrhage and edema were observed in the HCQ group. In contrast, in the HRHQ group, epithelial necrosis, and muscle degeneration were normal, haemorrhage was absent, PMNL infiltration persisted in some-areas, and moderate capillary congestion and dilatation were observed. detected. Conclusion: The results indicate that HR may be a potential candidate for preventing and treating stomatitis associated with HCQ use. Translating these findings into clinical practice could support the safe and effective use of HR as a therapeutic agent.
- ArticleYalnız künye20262-Substituted-5-(4-substitutedsulfonylamido)benzoxazoles as potent cholinesterase inhibitors: Synthesis, in vitro, molecular docking, molecular dynamics simulation, and DFT studies
Faydali, Nagihan; Erol, Meryem; Temiz Arpaci, Özlem; Dilek, Esra; Muhammed, Muhammed Tilahun
Alzheimer's disease (AD), the most worrisome neurological condition in the world, is one of the primary causes of dementia and is characterized by cognitive and memory loss. This disease is multifactorial, and there is currently no cure, although treatments based on the cholinergic hypothesis have been successful in relieving symptoms. This study examined the inhibitory effects of 11 compounds with a sulfonamide group at position 5 of the benzoxazole ring system on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Two of these 11 compounds are original, and FT-IR, ¹H NMR, ¹³C NMR, and mass spectrometry were used to characterize their structures. The compounds showed significantly greater biological activity as inhibitors of both AChE and BChE than the reference drug, donepezil. In particular, 2a showed the highest activity against AChE with a Ki value of 7.45 ± 2.79 nM, and 1b showed the highest activity against BChE with a Ki value of 3.37 ± 0.68 nM. Furthermore, a molecular docking study was performed to investigate the interaction modes of the active compounds with the active sites of the crystal structures of AChE and BChE. Hydrogen bond and π interactions were observed in the protein–ligand interactions. The stabilities of the complexes obtained from docking were assessed using a molecular dynamics (MD) simulation. The MD simulation revealed that the complexes remained stable throughout. Density functional theory (DFT) analysis was also conducted to determine the compounds' most stable conformers and investigate their chemical stability and reactivity.
- ArticleAçık Erişim2026Seasonal and Time-of-Day Variations in Ambulance-Transported Emergency Department Diagnoses: A One-Year Observational Study
Sari, Fatih Mehmet; Bilgin, Yasin; Kilic, Mert; Cimen, Erdem Yakup; Yurttutan, Abdullah Emre; Eden, Arif Onur
Background/Objectives: Ambulance-transported patients represent an important subgroup of emergency department (ED) admissions and may demonstrate distinct temporal presentation patterns. However, studies simultaneously evaluating broad diagnostic categories according to both time-of-day and seasonal variations among ambulance-transported patients remain limited. Methods: This retrospective observational study included 37,188 patients transported to the emergency department of a tertiary university hospital by ambulance between December 1, 2024, and November 30, 2025. Patients were categorized into twelve major diagnostic groups according to ICD-10-based clinical diagnoses. Temporal analyses were performed according to seasons and time-of-day intervals (nighttime, daytime, and evening). Associations between diagnostic categories and temporal variables were evaluated using chi-square analysis. Results: Trauma was the most common diagnostic category (19.9%), followed by cardiovascular (16.3%), gastrointestinal (10.3%), and respiratory diseases (10.1%). Significant associations were observed between diagnostic categories and both seasonal distribution (χ2 = 446.482, df = 33, p < 0.001) and time of presentation (χ2 = 642.883, df = 22, p < 0.001). Respiratory diseases were most frequent during winter (32.7%), whereas trauma-related admissions peaked during summer (32.4%). Psychiatric presentations predominantly occurred during evening hours (53.2%), while gastrointestinal diseases demonstrated the highest proportion of nighttime admissions (24.2%). Trauma-related admissions were more common among males (63.6%), whereas neurological, gastrointestinal, metabolic, and psychiatric presentations were slightly more frequent among females. The mean age of the cohort was 49.02 ± 25.12 years. Conclusions: Ambulance-transported emergency department patients demonstrate significant seasonal and time-of-day variations across major diagnostic categories. Awareness of these temporal patterns may contribute to improved emergency department organization, ambulance deployment, staffing strategies, and healthcare resource management.
- ArticleAçık Erişim2026Social media addiction and cyberbullying sensibility in team sports athletes: the mediating role of digital literacy and the moderating role of difficulties in emotion regulation
Ekinci, Hasan Buğra; Birkok, Mehmet Cüneyt; Kaçay, Zülbiye; Işık, Özkan; Talaghir, Laurentiu Gabriel; Coja, Daniel Mădălin; Berdila, Anamaria; Olaru, Bogdan Sorin
Purpose – This study examined the relationship between social media addiction and cyberbullying sensibility among team sports athletes. In addition, the mediating role of digital literacy and the moderating role of difficulties in emotion regulation were investigated within this relationship. Methodology – The study included 265 licensed team sports athletes from Erzincan, Türkiye. Data were collected using measures of social media addiction, cyberbullying sensibility, digital literacy, and difficulties in emotion regulation. The construct validity of the scales was assessed through confirmatory factor analysis (CFA). Mediation, moderation, and moderated mediation analyses were conducted using PROCESS Macro Models 4 and 14 with bootstrap-based regression procedures. Result – The findings showed that social media addiction was significantly associated with digital literacy, and digital literacy showed a significant positive relationship with cyberbullying sensibility. The indirect relationship between social media addiction and cyberbullying sensibility through digital literacy was statistically significant. In addition, this indirect association was more pronounced among athletes with lower difficulties in emotion regulation, whereas it was not significant among those with higher difficulties in emotion regulation. These findings support a moderated mediation model based on conditional associations. Conclusion – The findings suggest that digital literacy plays a mediating role in the relationship between social media addiction and cyberbullying sensibility among team sports athletes. Furthermore, difficulties in emotion regulation appear to influence the strength of this indirect relationship. The study highlights the importance of considering both digital competencies and emotional processes in understanding athletes' experiences in digital environments.
- ArticleAçık Erişim2026Sulforaphane Against the Metabolic Consequences of a High-Glycemic-Index Diet: Protective and Therapeutic Mechanisms Associated with Obesity and Insulin Resistance
Çubuk, Mihrican; Pınar, Aylin Açıkgöz; Süleyman, Bahadır; Taş, Necip Gökhan
Objective: This study investigated the effects of different doses and timing of sulforaphane (SFN) supplementation on reducing obesity induced by a high-glycemic-index diet (HGID) and on correcting poor glycemic control and dyslipidemia in C57BL/6 mice. Method: For 15 weeks, mice were administered a control diet (control), HGID, HGID + oral 5 mg/kg/day SFN (HGID + LSFN), or HGID + 20 mg/kg/day SFN (HGID + HSFN), and following 15 weeks of HGID, mice were treated with 5 mg/kg/day SFN (PO-HGID + LSFN) or 20 mg/kg/day SFN (PO-HGID + HSFN) for 5 weeks. Results: SFN reduced body weight gain and serum glucose. The lowest levels of HbA1c were observed in the control and HGID + LSFN groups. Mice in the HGID group exhibited impaired glucose clearance and were less sensitive to insulin compared to the control. A remarkable improvement in glucose and insulin tolerance was observed in both PO-HGID + SFN and HGID + SFN groups. Lipid profile parameters and serum insulin levels were found to be lower in the control and HGID + SFN groups compared to the HGID group. SFN increased serum adiponectin levels when administered concurrently with HGID. IRS1 and IRS2 levels were highest in the control and HGID + LSFN groups, and high-dose SFN supplementation suppressed IRS1 independently of timing. Exposure to HGID downregulated the expression of PGC-1α and sirtuins. SIRT1 and SIRT3 gene expressions showed a significant increase at both doses, whereas SIRT2 gene expression increased significantly only at 5 mg/kg/day SFN. FASN expression was upregulated in all HGID-fed groups with or without SFN intervention. Conclusions: SFN may reverse the adverse effects of HGID in a time- and dose-dependent manner by regulating postprandial insulin, inhibiting gluconeogenesis, and enhancing fatty acid oxidation through the activation of sirtuins and PGC-1α.
- ArticleAçık Erişim2026Comparison of clinical outcomes associated with RSV and influenza infections in adults: a multicenter study from Türkiye (for AP-TR)
Akdemir, İrem; Selçuk Özger, Hasan; Hocagil, Tuğba Akkaya; Kayaaslan, Bircan; Alay, Handan; Top, Özge Özgen; Kazak, Esra; Kalın Ünüvar, Gamze; Erbay, Ayşe; Çınar, Güle
Objectives Respiratory syncytial virus (RSV) is an increasingly recognized cause of serious respiratory illness in adults, yet data from middle-income countries remain scarce. This study aimed to compare clinical outcomes of RSV and influenza virus infections in hospitalized and outpatient adults in Türkiye. Methods This retrospective multicenter study included 3299 adult patients (≥18 years) with polymerase chain reaction-confirmed RSV (n = 628) or influenza (n = 2671) from 21 centers across Türkiye between January 2022 and March 2024. The primary outcome was viral infection–related hospitalization. The secondary composite outcome was intensive care unit (ICU) admission and/or 30-day mortality among hospitalized patients. Propensity score–based overlap weighting was used to adjust for baseline differences including age, risk group, clinical severity, co-infection status, and study center. Results After overlap weighting, RSV infection was not significantly associated with increased hospitalization risk compared to influenza (odds ratio [OR]: 0.96, 95% confidence interval [CI]: 0.77-1.20, P = 0.705). Similarly, no significant difference was observed in the composite outcome of ICU admission or 30-day mortality (OR: 1.40, 95% CI: 0.95-2.05, P = 0.088). Age ≥60 years, high-risk comorbidities, and severe acute respiratory infection presentation were the primary independent predictors of both hospitalization and worse outcomes. Bacterial or fungal co-infections and secondary infections were observed in 12.9% and 7.3% of hospitalized patients, respectively, with no significant difference between RSV and influenza groups. Conclusion After adjustment for baseline characteristics, RSV and influenza were associated with comparable risks of hospitalization and severe clinical outcomes in adults. Host-related factors, particularly older age and underlying comorbidities, were the dominant determinants of adverse outcomes. These findings from a largely unvaccinated, middle-income country cohort highlight the need to expand RSV and influenza vaccination programs targeting high-risk adult populations.
- ArticleYalnız künye2026Effects of apigenin, hesperidin and their combinations on different physiopathological pathways in 5-fluorouracil-induced pulmonary damage
Uslu, Hamit; Atila Uslu, Gözde; Çoban, Taha Abdulkadir; Özkaraca, Mustafa; Kurt, Nezahat; Mendil, Ali Sefa
Background: Chemotherapeutics target cancerous cells, but they also have unavoidable toxicities in healthy tissues. Aim: In this study, the effects of the commonly used chemotherapeutic 5-fluorouracil (5FU) on lung tissue were investigated, along with the possible protective benefits of apigenin (API), hesperidin (HES), and their combination. Methodology: The study consisted of control, 5FU, API + 5FU, HES + 5FU, and API+HES + 5FU groups. API 50 mg/kg and HES 200 mg/kg were administered for 7 days. On the 8th day, 5FU was administered a dose of 100 mg/kg. Results: Analyses showed that API and HES were effective in preventing oxidative stress induced by 5FU in lung tissue, attenuating inflammation and apoptosis by suppressing MAPK/NFκB and Caspase-3/Bax/Bcl-2 pathways, suppressing autophagy by decreasing LC3B expression, and regulating Sigmar1 expression. Conclusion: These results suggest that the two flavonoids, when administered separately or in combination, may be useful in reducing side effects that often occur during the use of chemotherapeutics.
- ArticleAçık Erişim2026The mediating role of psychological resilience and the moderating role of professionalism in the effect of mental wellbeing on anger and aggression in Olympic combat sports athletes
Gayretli, Zafer; Secer, Emrah; Baic, Mario; Yavuz, Alisan; Koc, Mustafa Can; Isik, Ozkan
Purpose – This study aimed to examine the effect of mental wellbeing on anger and aggression among combat sports athletes and to investigate the mediating role of psychological resilience and the moderating role of professionalism in this relationship. The study sought to conceptually elucidate the associations between athletes’ psychological resources and their levels of anger and aggression. Method – The study was designed using a relational survey model and included 333 Olympic combat sports athletes (181 males, 152 females). Data were collected using the Warwick–Edinburgh Mental Wellbeing Scale–Short Form, the Competitive Aggressiveness and Anger Scale, the Connor–Davidson Resilience Scale–Short Form, and the Professionalism Scale for Athletes. The validity of the measurement models was tested through confirmatory factor analysis (AMOS 21). Hypotheses were tested using SPSS 25 and Hayes’ PROCESS Macro Models 4, 1, and 14. Results – The indirect effect of mental wellbeing on anger and aggression through psychological resilience was found to be significant (b = −0.302, 95% CI [−0.479, −0.148]), explaining approximately 9% of the total variance. The moderating effect of professionalism was examined, and the interaction between psychological resilience and professionalism was found to be statistically significant (b = −0.032, 95% CI [−0.051, −0.012]). Interaction analyses indicated that the effects were stronger at higher levels of professionalism. A conditional process analysis (PROCESS Model 14) revealed that professionalism moderated the indirect effect (b = −0.029, 95% CI [−0.047, −0.014]); specifically, the effect of mental wellbeing on anger and aggression through psychological resilience became more pronounced when professionalism was high. Conclusion – The findings demonstrate that mental wellbeing has a significant effect on anger and aggression among combat sports athletes through psychological resilience. This effect was stronger among athletes with higher levels of professionalism, highlighting its critical role in reducing anger and aggression. The results suggest that psychological resilience and professionalism are key factors in emotional regulation and performance management among athletes. Future studies may benefit from employing longitudinal and experimental designs to examine the effects of mental wellbeing on psychological resilience over time.
- ArticleAçık Erişim2026Assessment of the relationship between sustainable and healthy eating behaviours, acceptance of alternative protein sources (plant-based products, mushroom protein, algae, artificial meat, edible insects) and food neophobia in young adults; [Evaluación de la relación entre hábitos alimentarios sostenibles y saludables, la aceptación de fuentes alternativas de proteínas (productos vegetales, proteína de hongos, algas, carne artificial, insectos comestibles) y la neofobia alimentaria en adultos jóvenes]
Yılmaz, Sevil Karahan; Güldüren, Sümeyye
Introduction: a growing world population, constraints on natural resources and changing nutritional preferences all point to the need to find an alternative to traditional animal protein sources however food neophobia can come to the fore in this process. Objetive: this study aims to evaluate the relationship between sustainable and healthy eating behaviours, acceptance of alternative protein sources and food neophobia in young adults. Methods: individuals filled out a questionnaire form including self-descriptive information, questions about acceptance of alternative protein sources, Sustainable and Healthy Eating Behaviours Scale and Food Neophobia Scale. Results: the study included 475 individuals, 132 (27.8 %) males and 343 (72.2 %) females, with a mean age of 24.6 ± 4.1 years. The mean scores of sustainable and healthy eating behaviours scale were 4.1 ± 0.8 and 4.2 ± 1.1 for male and female students, respectively. A significant relationship was found between the local food factor scores of the participants according to gender (p < 0.05). There was no significant difference between the food neophobia scale scores of individuals according to gender (p < 0.05). The acceptance of plant-based protein sources from alternative protein sources as an alternative to animal-based proteins was higher, while edible insects were not accepted by any participant. Conclusion: growing world population, increasing demand for animal protein, constraints in natural resources and changing dietary preferences necessitate finding an alternative to traditional animal protein sources and sustainable and healthy nutrition education in young adults is considered necessary for environmental and health sustainability.
- ArticleAçık Erişim2026Joint-Specific and Cross-Joint Strength Profiles in Relation to Maximal Soccer Kicking Speed
Akcan, İbrahim Orkun; Şenyurt, Sultan; Altuğ, Tolga; Ateş, Betül; Acar, Şeyma Tuba; Yücelsoy, Büşra; Kızılörs, Gizem; Taber, Christopher B.; Küçük, Hamza; Aydın, Ahmet Serhat
The purpose of this study was to examine associations between lower-limb mechanical strength, phase-oriented composite strength indices, generalized neuromuscular activation, and maximal soccer ball kicking speed in trained athletes. Twenty-five male soccer players (age: 20.64 ± 2.50 years; height: 179.28 ± 4.27 cm; body mass: 75.80 ± 9.41 kg) participated in this cross-sectional study. Isometric ankle and knee joint torques were assessed using an isokinetic dynamometer, and joint-specific and phase-oriented cross-joint composite indices were computed to represent integrated strength capacity across the kinetic chain. Neuromuscular activation was evaluated via surface electromyography during a standardized squat jump task. Ball-kicking speed was measured using Doppler radar during maximal instep kicks. Associations were analyzed using Pearson correlation coefficients (p ≤ 0.05) with false discovery rate correction for multiple comparisons. In unadjusted analyses, moderate positive correlations were observed for several ankle torque variables and composite ankle strength indices, while swing-phase composite measures demonstrated moderate correlations (r = 0.43–0.55). Knee strength indices and sEMG variables showed no significant relationships. However, none of the variables remained statistically significant after FDR correction, suggesting limited independent explanatory value of isolated isometric strength and non-task-specific neuromuscular activation assessed during a standardized squat jump for maximal kicking performance.
- ArticleAçık Erişim2026Protective effects of multi-strain probiotics against polystyrene nanoplastic-induced parotid gland toxicity: role of NRF2/HO-1 and NF-κB pathways
Kozan, Günay; Üstündağ, Hilal; Kara, Adem
Background – Polystyrene nanoplastics (NPs) represent emerging environmental contaminants with potential adverse effects on salivary glands. This study investigated the protective effects of multi-strain probiotics against NPs-induced toxicity in rat parotid glands. Methods – Forty male Sprague-Dawley rats were allocated into five groups (n = 8): control, NPs (10 mg/kg), probiotics (1010 CFU), NPs + probiotics low dose (109 CFU), and NPs + Pro high dose (1010 CFU). Treatments were administered orally for 35 days. Oxidative stress markers, histopathological changes, and protein expression were evaluated. Results – NPs exposure significantly increased MDA levels (p < 0.05) and decreased SOD activity and GSH content (p < 0.05). Histopathological examination revealed moderate to severe acinar degeneration (++) and fibrosis (++) in NPs-treated animals. Western blot analysis showed significant downregulation of Bcl-2 (p < 0.01), HO-1 (p < 0.0001), NRF2 (p < 0.01), and AQP5 (p < 0.0001), with upregulation of Caspase-3 (p < 0.0001), NF-κB (p < 0.001), IL-1β (p < 0.001), and TNF-α (p < 0.001). Probiotic supplementation significantly ameliorated oxidative stress (p < 0.05), reduced histopathological damage to mild changes (+), and restored beneficial protein expression while suppressing inflammatory markers (p < 0.01-0.001). Conclusion – This study provides the first evidence that NPs induce significant oxidative stress and tissue damage in parotid glands. Multi-strain probiotics provide substantial protection by activating the NRF2/HO-1 pathway and suppressing inflammation, suggesting a promising therapeutic strategy against nanoplastic-induced oral tissue damage.
- ArticleYalnız künye2026SOX17 and TRPS1 in Müllerian, Breast, and Mesothelial Tumors: Tissue-Based Specificity Profiles and Diagnostic Pitfalls in Malignant Serous Effusions
Issin, Gizem; Demir, Fatih; Yaylı, Esra; Çağatay, Diren Vuslat; Yılmaz, İsmail; Girgin, Rabia Burçin; Gamsızkan, Mehmet; Zemheri, Ebru; Şimşek, Hasan Aktuğ; Sayar, İlyas
Background: Malignant serous effusions may be the first manifestation of an underlying malignancy, and accurate primary-site attribution is essential. However, distinguishing Müllerian carcinoma, breast carcinoma, and mesothelioma in effusion cytology remains a challenge because of overlapping immunophenotypes. We evaluated SOX17 and TRPS1 in this setting. Materials and Methods: A multicenter retrospective cohort including 650 tissue specimens (300 breast carcinomas, 300 Müllerian tumors, and 50 mesothelial lesions) and 150 malignant serous effusion cell blocks was analyzed. SOX17 and TRPS1 expression was assessed by immunohistochemistry and compared with established markers, including PAX8, GATA3, WT1, and calretinin. Sensitivity, specificity, and positive predictive value (PPV) were calculated according to the primary diagnosis. Results: In the tissue cohort, SOX17 showed 87% sensitivity and 100% specificity for Müllerian tumors, with no expression in breast carcinomas or mesothelial lesions, including tumors with PAX8/WT1 co-expression. This specificity was retained in cell blocks, yielding a PPV of 100%. TRPS1 showed 98% sensitivity for breast carcinoma and identified 84% of GATA3-negative breast carcinomas. However, TRPS1 expression was also observed in 48% of tubo-ovarian serous carcinomas, limiting its PPV for breast carcinoma in effusions to 55% despite a negative predictive value of 97%. Conclusion: SOX17 is a highly specific confirmatory marker for Müllerian origin and may help resolve diagnostic pitfalls related to PAX8-positive mesothelial lesions. TRPS1 is a complementary marker for breast carcinoma, including GATA3-negative tumors, but its stand-alone diagnostic value is limited by cross-reactivity in Müllerian serous carcinomas. These findings support a panel-based approach for accurate primary-site attribution in malignant serous effusions.
- ArticleAçık Erişim2026AI-Assisted Dialysis Decision-Making: Assessing Agreement Between ChatGPT and Nephrologist in Initial Dialysis Indication and Prescription in Emergency and ICU Settings
Kara, Ali Veysel; Ozturk, Ersin V.; Islamoglu, Mahmut Sami; Ozdemir, Ridvan V.; Hayme, Serhat V.
Background: Material/Methods: Results: Conclusions: Artificial intelligence (AI) is increasingly explored as a clinical decision-support tool in nephrology; however, its real-world applicability for dialysis decision-making in emergency and intensive care unit (ICU) settings remains insufficiently studied. Hemodialysis initiation and prescription are complex, time-sensitive, and dynamic processes that require expert clinical judgment. This retrospective observational study evaluated agreement between AI-generated (ChatGPT) and nephrologistmade dialysis decisions in emergency and ICU settings. Adult patients undergoing first-time dialysis were included. Agreement was assessed for dialysis initiation, modality selection, and key prescription parameters. To ensure clinical relevance, continuous prescription variables were categorized into predefined ranges. Agreement was quantified using Gwet’s AC1 coefficient and Cramér’s V statistic. Eighty-four patients were included. AI demonstrated 100% agreement with nephrologists regarding dialysis initiation. Overall agreement for dialysis modality selection was 92.9% (Cramér’s V=0.87, P<0.001). Agreement for core dialysis prescription parameters – including blood flow rate, dialysate sodium, potassium, and calcium concentrations – was high across modalities (all P<0.001). Lower agreement was observed for ultrafiltration-related parameters, particularly ultrafiltration duration, reflecting the individualized and dynamic nature of volume management during dialysis. AI-assisted decision support demonstrated high agreement with nephrologist decisions for initial dialysis initiation, modality selection, and core prescription parameters in emergency and ICU settings. Discrepancies were primarily confined to ultrafiltration-related decisions, underscoring the necessity of ongoing bedside clinical judgment. These findings support the role of AI as a decision-support tool rather than a replacement for clinician-led dialysis management.
- ArticleAçık Erişim2026Pretreatment of trans-ferulic acid improved neurotoxicity in a thioacetamide-induced hepatic encephalopathy rat model; participation of the MAPK/NF-κb signaling pathway
Kilic, Adil Furkan; Suleyman, Bahadir; Mammadov, Renad; Bulut, Seval; Mendil, Ali Sefa; Suleyman, Halis
Aim – Trans-ferulic acid (TFA), a naturally occurring phenolic compound, has attracted significant attention due to its strong hepatoprotective and neuroprotective properties. Despite extensive research on its overall biological activities, the specific mechanisms by which TFA influences hepatic encephalopathy (HE) remain unclear. This study aims to explore the therapeutic potential of TFA by examining its effects on inflammatory signaling, glial activation, and apoptotic pathways in a thioacetamide (TAA)-induced rat model of HE. Methods – Rats were separated into four groups: a normal control group, the TAA group (which received TAA at 300 mg/kg/day for 3 days), and groups pre-treated with TFA (at doses of 25/50 mg/kg, administered orally) for 10 days, with TAA administered from the eighth to the 10th day. Results – TFA pre-treatment effectively reduced TAA-induced biochemical disturbances, as shown by lower serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and ammonia. This biochemical improvement was complemented by a significant reduction in TAA-related hepatic histopathological damage. TFA also alleviated systemic inflammation by suppressing TAA-induced increases in pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), while also elevating the anti-inflammatory cytokine IL-10. Consistent with these results, TFA further suppressed the activation of MAPK/NF-κB inflammatory signaling pathways in both liver and brain tissues and decreased glial fibrillary acidic protein (GFAP) expression in the brains of TAA-treated rats, indicating reduced neuroinflammation and astrocyte activation. Additionally, immunochemical analysis showed that TFA pre-treatment effectively prevented the TAA-induced increase in pro-apoptotic markers Caspase-3 and Bax in both liver and brain tissues. This study underscores the strong protective effects of TFA against TAA-induced HE, mainly through inhibition of MAPK/NF-κB signaling, suppression of astrocyte activation, and reduction of apoptosis. Conclusion – These outcomes imply that TFA could be an effective treatment for HE.
- ArticleAçık Erişim2026Psychometric Properties of the Turkish Version of the Dietary Fat and Free Sugar-Short Questionnaire (DFS-TR) in Adults: A Validity and Reliability Study
Özenir, Çiler; Çubuk, Mihrican; Altınsoy, Canan; Ağagündüz, Duygu
Background/Objectives: The aim of this study was to translate the Dietary Fat and Free Sugar-Short Questionnaire (DFS) into Turkish (DFS-TR) and to establish its construct validity and reliability. Methods: Quota sampling was used to ensure demographic homogeneity across gender and age groups. Participant distribution by age categories was proportionally aligned with the demographic statistics of the adult Turkish population. The study comprised 314 participants aged 19–64 years (38.78 ± 12.10), of which 54.5% were female. The data collection form consisted of demographic characteristics, anthropometric measurements, information on eating habits, DFS-TR, the Food Frequency Questionnaire (FFQ), and the Power of Food Scale (PFS). Results: Test–retest reliability was confirmed in the 314 participants with a 4-week interval (r = 0.997, p < 0.01). The Cronbach α reliability coefficient was α = 0.777. Using the split-half method, the correlation coefficient between the two halves was 0.681, the Spearman–Brown coefficient was 0.811, and the Guttman coefficient was 0.809. Participants’ total DFS-TR scores and sub-dimension scores varied according to age, education level, income level, anthropometric characteristics, physical activity, and dietary habits, but did not vary according to gender or marital status. To investigate convergent validity, participants’ DFS-TR scores were correlated with the FFQ and PFS. DFS-TR scores showed a significant correlation with the percentage of energy from saturated fat and free sugar assessed by the FFQ. Positive relationships were found between DFS-TR scores and the total PFS score, particularly with the sub-dimension scores for food available and food present. Conclusions: The DFS-TR can be used as a reliable and valid measurement tool for estimating saturated fat and free sugar intake among Turkish adults.
- ArticleYayıncıda açık erişim2026Probiotics as an alternative to eliminate Pseudomonas aeruginosa biofilm
Celebi, Selahattin; Celebi, Ozgur; Celebi, Demet; Baser, Sumeyye; Dabanlioglu, Bulent; Ektas Kalayci, Sila; Aslan, Sumeyye; Islamoglu, Fatma; Taghizadehghalehjoughi, Ali
Pseudomonas aeruginosa is a clinically important opportunistic pathogen characterized by high antibiotic resistance and strong biofilm-forming capacity, posing a major therapeutic challenge, particularly in immunocompromised patients. In this study, we aimed to evaluate the antibiotic resistance profiles and biofilm-forming abilities of clinical isolates, and to investigate the antibiofilm potential of the probiotic strain Lacticaseibacillus rhamnosus. A total of 66 clinical isolates were analyzed, revealing high levels of antibiotic resistance, while 87.9% of isolates demonstrated biofilm-forming capacity. Treatment with L. rhamnosus at 25% and 50% concentrations resulted in significant antimicrobial and antibiofilm effects. MIC and antibiofilm assays indicated that these effects were dose- and cell density-dependent. Scanning electron microscopy analyses confirmed the structural disruption of biofilms following treatment. Furthermore, real-time PCR results demonstrated that the expression levels of key biofilm-associated genes (algD, pelF, pslD, ppgl, and PAPI-1) were reduced by more than 50%. Importantly, this study provides evidence that L. rhamnosus can effectively inhibit both biofilm formation and biofilm-associated gene expression in multidrug-resistant P. aeruginosa isolates, highlighting its potential as a promising alternative or adjunctive biocontrol strategy against biofilm-related infections. These findings contribute to the growing body of research on probiotic-based approaches targeting antimicrobial resistance and biofilm-associated pathogenicity.
- ArticleAçık Erişim2026Effects of Prebiotic Gum Arabic Under Antibiotic-Containing Conditions in Atopic Dermatitis-Associated Bacteria: In Vitro Evaluation and Development of Semisolid Topical Carriers
Doğanay, Derya; Mertoğlu, Esra; Kurt, Ahmet Arif; Özkan, Batuhan Cenk; Bursalıoğlu, Ertuğrul Osman; Bozyel, Mustafa Eray; Aliusta, Reyhan; Türkoğlu, Özlem; Gökçe, Halise Betül; Kızılay, Emine
Background/Objectives: Atopic dermatitis (AD) is associated with gut dysbiosis linked to early-life antibiotic use and Staphylococcus aureus colonization. Gum Arabic (GA), a prebiotic, may modulate this dysbiosis and influence AD-related microbial balance. This study evaluated whether GA could support AD-associated probiotics-Lactobacillus casei, Bifidobacterium bifidum, and Bifidobacterium infantis-under amoxicillin- or azithromycin-containing conditions, examined the response of S. aureus under the same screening conditions, and developed GA-phospholipid-based semisolid carriers for topical application. Methods: Probiotic strains were cultured with 1–5% GA in the presence and absence of antibiotics, and viable cell counts were assessed. Sixteen topical formulations containing propylene glycol or isopropyl myristate in a hydrogenated phosphatidylcholine base were prepared and screened for rheological properties and galactose release using in vitro release testing (IVRT) and HPLC-UV. Results: GA at 1–2% concentrations promoted probiotic growth in antibiotic-free conditions. GA preserved B. infantis viability under azithromycin exposure in this in vitro screening model. For S. aureus, numerical CFU differences were observed between antibiotic-only and GA-containing conditions; however, the present screening design was not intended to determine antibiotic interaction outcomes. Formulations F14 (2% GA + 7% IPM) and F15 (3% GA + 7% IPM) exhibited optimal spreadability. IVRT showed that 6 h cumulative galactose release varied by formulation (F6 > F10 > F14 > F15). Conclusions: GA demonstrated dose-dependent prebiotic activity and preserved B. infantis viability under azithromycin exposure in this in vitro screening model. For S. aureus, the observed CFU differences between antibiotic-only and GA-containing conditions should be considered exploratory only and do not allow for conclusions regarding interference with antibiotic efficacy. Optimized GA-HPC systems with suitable rheological and release characteristics represent promising candidates for further preclinical investigation.
- ArticleAçık Erişim2026First-Line Durvalumab–Tremelimumab in Advanced Hepatocellular Carcinoma: Real-World Data from Turkey
Mıdık, Mustafa Murat; Şahin, Gökhan; Durukan, Bekir Mert; Kuş, Fatih; Haşimoğlu Gürün, Kübra; Ünal, Sinan; Mirili, Cem; Karan, Canan; Hendem, Engin; Şakalar, Teoman
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Although the STRIDE regimen (durvalumab plus tremelimumab) has demonstrated an overall survival benefit in clinical trials, real-world evidence remains limited, particularly in Turkish clinical practice. This study aimed to evaluate the effectiveness and safety of first-line STRIDE therapy in patients with unresectable HCC treated in routine clinical practice. Methods: We conducted a retrospective multicenter study including patients with unresectable HCC who received first-line durvalumab plus tremelimumab through the Turkish national Early Access Program across 18 oncology centers. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method, and exploratory Cox regression analyses were performed to evaluate baseline prognostic factors. Results: Thirty-two patients were included. The median PFS was 7.25 months (95% CI, 3.68–22.29), and the median OS was 11.43 months (95% CI, 4.50–not reached). The underlying liver disease etiology was non-viral in 53.1% of patients, hepatitis B virus in 40.6%, and hepatitis C virus in 6.3%. Grade ≥ 3 treatment-related adverse events occurred in fewer than 10% of patients. Conclusions: In this multicenter real-world cohort, first-line durvalumab plus tremelimumab appeared to be a feasible treatment option and was generally well tolerated in patients with unresectable HCC. However, given the retrospective design, small sample size, and absence of a control group, these findings should be interpreted cautiously and require confirmation in larger prospective comparative studies.
- ArticleYalnız künye2026Clinically relevant depression in patients with type 1 and type 2 diabetes; a nationwide study (TEMD-2 depression)
Guler, Bagdagul Yuksel; Demirci, Ibrahim; Haymana, Cem; Akbay, Esen; Evren, Bahri; Dizdar, Oguzhan Sitki; Demir, Orhan; Agbaht, Kemal; Tasci, Ilker; Ersoy, Canan
Purpose: Depression is a common but underrecognized comorbidity in individuals with diabetes and is associated with adverse clinical outcomes. This nationwide study aimed to determine the prevalence of clinically relevant depression (CRD) among adults with type 1 and type 2 diabetes in Türkiye and to identify clinical and metabolic factors independently associated with CRD. Methods: This cross-sectional analysis was conducted within the Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes mellitus-2 (TEMD-2), a multicenter study including adults followed in tertiary endocrinology centers across Türkiye. CRD was defined as a Patient Health Questionnaire-9 score ≥ 10 and/or current antidepressant use. Results: A total of 5.266 patients were included. The prevalence of CRD was similar in type 1 and type 2 diabetes (29.4% vs. 27.6%, p = 0.345). In both diabetes types, CRD was significantly more common among women. Patients with CRD had higher body mass index, poorer glycemic control, higher rates of hypoglycemia, and lower achievement of metabolic targets. Microvascular and macrovascular complications were more frequent in patients with CRD. In multivariable analyses, female sex, smoking, and polypharmacy were independently associated with CRD in both diabetes types, while obesity, poor glycemic control, and vascular complications were additional independent associates in type 2 diabetes. Conclusion: CRD affects nearly one-third of adults with diabetes, regardless of diabetes type, and is associated with greater comorbidity burden and suboptimal metabolic control. These findings support routine depression screening as an integral component of comprehensive diabetes care. The study is registered at ClinicalTrials.gov (NCT06347445).
- ArticleAçık Erişim2026Uncoupling Systemic Inflammation from Body Mass Index: The Unseen Role of Visceral Adiposity and Metabolic Phenotypes—A Subgroup Analysis of the Nationwide OBREDI-TR Cohort
İşsever, Kubilay; Oral, Alihan; Genç, Ahmed Cihad; Solmaz, Ihsan; Koca, Nizameddin; Topaloglu, Ulas Serkan; Demir, Ismail; Dundar, Ahmet; Kirik, Ali; Basci, Ozge Kama
Objectives: Although obesity is known to cause low-grade chronic inflammation, the extent to which body mass index (BMI) reflects this remains questionable. To investigate this, we classified a national obesity cohort by BMI and evaluated its association with complete blood count (CBC)-derived systemic inflammatory indices. Methods: This retrospective, multi-center study included 6499 adults from the OBREDI-TR cohort with available laboratory data. Patients were categorized by BMI into Class I (30.0–34.9 kg/m2, n = 2751), Class II (35.0–39.9 kg/m2, n = 1804), and Class III (≥40.0 kg/m2, n = 1944) obesity. We compared demographic, clinical, and laboratory parameters, especially in terms of CBC-derived inflammation parameters: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI). Results: The Class III group was younger (42.73 ± 13.21 vs. 45.14 ± 14.12 in Class I) and predominantly female (p < 0.001 for both). None of the evaluated inflammatory indices showed significant differences across the groups (NLR, p = 0.435; PLR, p = 0.141; LMR, p = 0.520; SII, p = 0.326; SIRI, p = 0.459). Interestingly, hypertension was less common in the Class III obesity group (49.0% vs. 53.5% in Class I, p = 0.009). Conclusions: The failure of increasing inflammatory indices to parallel BMI, creating a “ceiling effect,” reflects the inadequacy of BMI in determining inflammatory burden. Evaluating the inflammatory burden of obesity through visceral adiposity and metabolic phenotyping (metabolically healthy (MHO) vs. metabolically unhealthy obesity (MUO) rather than BMI will provide a more accurate basis for objective clinical evaluation and personalized treatment.
