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Evaluation of anticholinesterase effect of some Epilobium species and quantification of hyperoside by HPLC

ArticleAçık Erişim

Özet

This article presents the evaluation of anticholinesterase effects of aerial parts of Epilobium angustifolium, E. stevenii and E. hirsutum and isolated flavonoids from E. angustifolium, and quantification of the flavonoids by HPLC. Besides, the highest acetylcholinesterase inhibition was seen in the EtOAc sub-extracts of E. angustifolium and E. stevenii (36.51 ± 1.88 and 39.89 ± 3.09%, respectively), whereas EtOAc sub-extract of E. angustifolium had the best butyrylcholinesterase inhibition (62.09 ± 1.98%). Hyperoside showed strong inhibition activity on both enzymes. The active EtOAc sub-extract of E. angustifolium was quantitatively analyzed for their content of hyperoside (quercetin-3-O-β-D-galactoside) by HPLC. The content of hyperoside in EtOAc sub-extract of E. angustifolium was detected as 3.312%. The anatomical structures of the stem, leaf, sepal, petal, anther, and filament of E. angustifolium were investigated. The anatomical properties given in this study provide a description of E. angustifolium. (Figure presented.). © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Anahtar Kelimeler

AnatomyanticholinesteraseEpilobiumhyperosideOnagraceaeAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsChromatography, High Pressure LiquidPlant ExtractsQuercetincholinesteraseflavonoidhyperincholinesterase inhibitorplant extractArticlecholinesterase inhibitiondrug bindingdrug determinationdrug effectdrug screeningEpilobium angustifoliumEpilobium hirsutumEpilobium steveniihigh performance liquid chromatographymolecular dockingpetioleplant stomaquantitative analysis
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AlanDeğerDil
dc.contributor.authorKarakaya, Songul
dc.contributor.authorSuntar, Ipek
dc.contributor.authorAydin, Bilge
dc.contributor.authorDursunoglu, Benan
dc.contributor.authorGözcu, Sefa
dc.contributor.authorSenol, Onur
dc.contributor.authorBayrak, Burak
dc.contributor.authorOzbek, Hilal
dc.contributor.authorKoca, Mehmet
dc.contributor.authorCeribasi, Songul
dc.contributor.authorYakinci, Omer Faruk
dc.contributor.authorGuvenalp, Zuhal
dc.contributor.authorKadıoglu, Yücel
dc.date.accessioned2026-10-18T20:27:47.087474528Z
dc.date.available2026-10-18T20:27:47.087474528Z
dc.date.issued2022
dc.description.abstractThis article presents the evaluation of anticholinesterase effects of aerial parts of Epilobium angustifolium, E. stevenii and E. hirsutum and isolated flavonoids from E. angustifolium, and quantification of the flavonoids by HPLC. Besides, the highest acetylcholinesterase inhibition was seen in the EtOAc sub-extracts of E. angustifolium and E. stevenii (36.51 ± 1.88 and 39.89 ± 3.09%, respectively), whereas EtOAc sub-extract of E. angustifolium had the best butyrylcholinesterase inhibition (62.09 ± 1.98%). Hyperoside showed strong inhibition activity on both enzymes. The active EtOAc sub-extract of E. angustifolium was quantitatively analyzed for their content of hyperoside (quercetin-3-O-β-D-galactoside) by HPLC. The content of hyperoside in EtOAc sub-extract of E. angustifolium was detected as 3.312%. The anatomical structures of the stem, leaf, sepal, petal, anther, and filament of E. angustifolium were investigated. The anatomical properties given in this study provide a description of E. angustifolium. (Figure presented.). © 2020 Informa UK Limited, trading as Taylor & Francis Group.
dc.description.sponsorshipFunding text 1: The authors thank Prof. Dr. Hayri Duman for his worthwhile support for diagnosing of plant materials. Bilge Aydin and Benan Dursunoglu would like to acknowledge the scholarship during her postgraduate program provided by the Turkish Scientific and Technical Research Council (TUBITAK). ; Funding text 2: This paper was supported by Scientific Research Projects of Atat?rk University (TCD-2018-6674). The authors thank Prof. Dr. Hayri Duman for his worthwhile support for diagnosing of plant materials. Bilge Aydin and Benan Dursunoglu would like to acknowledge the scholarship during her postgraduate program provided by the Turkish Scientific and Technical Research Council (TUBITAK).
dc.identifier.doi10.1080/14786419.2020.1856841
dc.identifier.eissn1478-6427
dc.identifier.endpage1299
dc.identifier.issn1478-6419
dc.identifier.issue5
dc.identifier.pmid33305606
dc.identifier.scopus2-s2.0-85097448674
dc.identifier.startpage1296
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/12931
dc.identifier.volume36
dc.identifier.wosWOS:000597356200001
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofNatural Product Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnatomy
dc.subjectanticholinesterase
dc.subjectEpilobium
dc.subjecthyperoside
dc.subjectOnagraceae
dc.subjectAcetylcholinesterase
dc.subjectButyrylcholinesterase
dc.subjectCholinesterase Inhibitors
dc.subjectChromatography, High Pressure Liquid
dc.subjectPlant Extracts
dc.subjectQuercetin
dc.subjectcholinesterase
dc.subjectflavonoid
dc.subjecthyperin
dc.subjectcholinesterase inhibitor
dc.subjectplant extract
dc.subjectArticle
dc.subjectcholinesterase inhibition
dc.subjectdrug binding
dc.subjectdrug determination
dc.subjectdrug effect
dc.subjectdrug screening
dc.subjectEpilobium angustifolium
dc.subjectEpilobium hirsutum
dc.subjectEpilobium stevenii
dc.subjecthigh performance liquid chromatography
dc.subjectmolecular docking
dc.subjectpetiole
dc.subjectplant stoma
dc.subjectquantitative analysis
dc.titleEvaluation of anticholinesterase effect of some Epilobium species and quantification of hyperoside by HPLC
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus11
rdl.citation.wos11
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)