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Intramedullary implants coated with cubic boron nitride enhance bone fracture healing in a rat model

ArticleAçık Erişim

Özet

Background: Boron nitride is a biocompatible and an osteo-inductive material for orthopedic applications. The aim of this study was to evaluate the effects of two different allotrope boron nitride coated implants, cubic boron nitride and hexagonal boron nitride, on fracture healing. Methods: In this experimental study, a total of 24 rats were divided into three groups. Group A was the control group with Kirschner wire without coating, while the wires were coated dominantly by cubic boron nitride in Group B and hexagonal boron nitride in Group C. Then a mid-third femoral fracture was created. The fracture healing was examined in terms of new bone formation with micro-CT analysis and histopathological examination, quantitative measurement of bone turnover metabolites and scintigraphic examination of osteoblastic activity on 28th day post fracture. Results: Micro-CT measurement results revealed a statistically significant increase in bone volume/tissue volume ratio and bone surface values in group B compared to group A. Cortex diameter and osteoblast counts were statistically higher in group B compared to group A. Inflammatory response was increased in group C compared to groups A and B. Biochemical test results showed significantly increased alkaline phosphatase levels and decreased osteocalcin levels in group B compared to group A. The increase in serum phosphorus and decrease in serum calcium levels was statistically significant in group C compared to Group A. Conclusion: Both types of boron nitride coating had superior fracture healing features compared to control group. Therefore, c-BN coating can accelerate the fracture healing and could lead to shorten of union time. © 2020 Elsevier GmbH

Anahtar Kelimeler

BiocompatibleCoated materialsMicro-CTOsteocalcinScintigraphyAnimalsBoron CompoundsCoated Materials, BiocompatibleFracture HealingMaleRadionuclide ImagingRatsX-Ray Microtomographyalkaline phosphataseboron derivativecalciumnitric acid derivativephosphorusbiocompatible coated materialboron nitrideanimal experimentanimal modelanimal tissueArticlebone developmentbone turnoverbone volumecalcium blood levelcell countcoating (procedure)
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/ebyu/13327Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1016/j.jtemb.2020.126599Yayıncı resmi DOI adresi
Tam Kayıt
AlanDeğerDil
dc.contributor.authorÖzmeriç, Ahmet
dc.contributor.authorTanoğlu, Oğuzhan
dc.contributor.authorOcak, Mert
dc.contributor.authorÇelik, Hakan Hamdi
dc.contributor.authorFırat, Ayşegül
dc.contributor.authorKaymaz, Fevziye Figen
dc.contributor.authorKoca, Gökhan
dc.contributor.authorŞenes, Mehmet
dc.contributor.authorAlemdaroğlu, Kadir Bahadır
dc.contributor.authorİltar, Serkan
dc.contributor.authorHacaloğlu, Tuğçe
dc.contributor.authorKaftanoğlu, Bilgin
dc.date.accessioned2026-10-18T20:28:10.086165883Z
dc.date.available2026-10-18T20:28:10.086165883Z
dc.date.issued2020
dc.description.abstractBackground: Boron nitride is a biocompatible and an osteo-inductive material for orthopedic applications. The aim of this study was to evaluate the effects of two different allotrope boron nitride coated implants, cubic boron nitride and hexagonal boron nitride, on fracture healing. Methods: In this experimental study, a total of 24 rats were divided into three groups. Group A was the control group with Kirschner wire without coating, while the wires were coated dominantly by cubic boron nitride in Group B and hexagonal boron nitride in Group C. Then a mid-third femoral fracture was created. The fracture healing was examined in terms of new bone formation with micro-CT analysis and histopathological examination, quantitative measurement of bone turnover metabolites and scintigraphic examination of osteoblastic activity on 28th day post fracture. Results: Micro-CT measurement results revealed a statistically significant increase in bone volume/tissue volume ratio and bone surface values in group B compared to group A. Cortex diameter and osteoblast counts were statistically higher in group B compared to group A. Inflammatory response was increased in group C compared to groups A and B. Biochemical test results showed significantly increased alkaline phosphatase levels and decreased osteocalcin levels in group B compared to group A. The increase in serum phosphorus and decrease in serum calcium levels was statistically significant in group C compared to Group A. Conclusion: Both types of boron nitride coating had superior fracture healing features compared to control group. Therefore, c-BN coating can accelerate the fracture healing and could lead to shorten of union time. © 2020 Elsevier GmbH
dc.description.sponsorshipWe would like to thank to Ankara Research and Training Hospital for the funding of this research. The authors would like to thank to the BOREN Center of Competence for Boron Coatings at the Metal Forming Center of Excellence in Atılım University, Ankara, TURKEY, for the use of facilities for boron nitride coatings on the Kirschner wires. BOREN Center of Competence for Boron Coatings have developed coating techniques for Boron Nitride in different proportions.
dc.identifier.doi10.1016/j.jtemb.2020.126599
dc.identifier.eissn1878-3252
dc.identifier.issn0946-672X
dc.identifier.pmid32629303
dc.identifier.scopus2-s2.0-85087210887
dc.identifier.startpage126599
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/ebyu/13327
dc.identifier.volume62
dc.identifier.wosWOS:000586028000030
dc.language.isoen
dc.publisherElsevier GmbH
dc.relation.ispartofJournal of Trace Elements in Medicine and Biology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiocompatible
dc.subjectCoated materials
dc.subjectMicro-CT
dc.subjectOsteocalcin
dc.subjectScintigraphy
dc.subjectAnimals
dc.subjectBoron Compounds
dc.subjectCoated Materials, Biocompatible
dc.subjectFracture Healing
dc.subjectMale
dc.subjectRadionuclide Imaging
dc.subjectRats
dc.subjectX-Ray Microtomography
dc.subjectalkaline phosphatase
dc.subjectboron derivative
dc.subjectcalcium
dc.subjectnitric acid derivative
dc.subjectphosphorus
dc.subjectbiocompatible coated material
dc.subjectboron nitride
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbone development
dc.subjectbone turnover
dc.subjectbone volume
dc.subjectcalcium blood level
dc.subjectcell count
dc.subjectcoating (procedure)
dc.titleIntramedullary implants coated with cubic boron nitride enhance bone fracture healing in a rat model
dc.typeArticle
dspace.entity.typePublication
rdl.citation.scopus20
rdl.citation.wos17
rdl.departmentErzincan Binali Yıldırım University, Faculty of Medicine, Department of Orthopedics and Traumatology, Erzincan, Turkey. Electronic address: oguzhan.tanoglu@erzincan.edu.tr.
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)