Yazarlar
- Suleyman, Halis(167)
- Mammadov, Renad(95)
- Türkeş, Cüneyt(84)
- Aydin, Sonay(83)
- Altuner, Durdu(74)
- Suleyman, Bahadir(68)
- Isik, Arda(67)
- Beydemir, Şükrü(66)
- Kantarci, Mecit(64)
- Kurt, Nezahat(57)
- Demir, Yeliz(54)
- Bulut, Seval(51)
- Arslan, Yusuf Kemal(50)
- Sofu, Hakan(50)
- Coban, Taha Abdulkadir(49)
- Karakeçili, Faruk(47)
- Altay, Ahmet(46)
- Huyut, Mehmet Tahir(46)
- Aydin, Suleyman(45)
- Türkmenoğlu, Burçin(45)
- Kuzucu, Mehmet(40)
- Yazici, Gulce Naz(40)
- Peker, Kemal(39)
- Algul, Oztekin(38)
- Cicek, Betul(37)
- Mertoglu, Cuma(36)
- Camurcu, Yalkin(35)
- Suleyman, Zeynep(34)
- Bozkurt, Aliseydi(32)
- Mendil, Ali Sefa(32)
- Gunay, Murat(31)
- Gözcü, Sefa(31)
- Köksal, Ekrem(31)
- Yuca, Hafize(31)
- Dilek, Esra(30)
- Karakurt, Papatya(30)
- Ozcicek, Fatih(30)
- Süleyman, Halis(30)
- Onk, Didem(29)
- Ucpunar, Hanifi(29)
Yayınlar
- ArticleAçık Erişim2015The importance of speckle tracking echocardiography in the early detection of left ventricular dysfunction in patients with polycystic ovary syndrome
Demirelli, Selami; Degirmenci, Husnu; Ermis, Emrah; Inci, Sinan; Nar, Gokay; Ayhan, Mehmet Emin; Fırtına, Serdar; Hamur, Hikmet; Durmaz, Senay Arikan
Polycystic ovary syndrome (PCOS) is characterized by hormonal and metabolic abnormalities and is thought to increase a risk for cardiovascular diseases. In this study we use speckle tracking echocardiography (STE) to evaluate left ventricular (LV) dysfunction in the early period of the disease. We enrolled 31 patients with PCOS and 32 healthy volunteers as a control group. The participants’ ages ranged between 18 and 40 years. PCOS was diagnosed according to the Rotterdam criteria. LV strain (LS) and strain rate (SR) were evaluated using apical two-chamber (2C), three-chamber (3C), and four-chamber (4C) imaging. Global LS and SR were calculated as average of three apical views. The waist-to-hip ratio, homeostasis model assessment-insulin resistance (HOMA-IR), and fasting insulin and triglyceride levels were higher in the PCOS group than in the controls (p = 0.001, p = 0.001, p = 0.001, and p = 0.005, respectively). In the PCOS group, the mitral A wave, deceleration time (DT), and isovolumetric relaxation time (IVRT) were significantly higher than in the controls (all p < 0.05). The LV global longitudinal strain (GLS) and global longitudinal SR systolic (GLSRS) were significantly lower in the PCOS patient group (both p = 0.001). There were strong negative correlations between GLS and both fasting insulin (r = −0.64) and DT (r =-0.62) (both p < 0.05). The study demonstrated that PCOS patients had decreased LV function using STE. Therefore, STE imaging appears to be useful for the early detection of subclinical LV dysfunction in patients with PCOS.
- ArticleYalnız künye2015Neurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic study
Tuğ Kılkış, Buket; Er, Kürşat; Taşdemir, Tamer; Yildirim, Mehmet; Taskesen, Fatih; Tümkaya, Levent; Kalkan, Yıldıray; Serper, Ahmet
Objectives: The aim of this study was to compare the neurotoxicity of various root canal sealers on rat sciatic nerve by electrophysiologic and histopathologic analyses. Materials and methods: A total of 40 male rats were randomly divided into five groups: Control, AH Plus, GuttaFlow, Sealapex and Smartpastebio. Sciatic nerves of the rats were uncovered using the surgical procedures, and the prepared sealers were then applied on nerves with a polyethylene tube vehicle for 15 days. Nerve potentials were recorded at initial exposure, 5, 30 and 120 min (early phase), and 15 days (late phase) by an electrophysiologic analysis system for all groups. The obtained measurements were then used to calculate the nerve conduction velocities (NCV). Subsequently, all rats were sacrificed, and their sciatic nerves were removed for histopathologic analysis. Statistical analysis was performed using the Kruskal-Wallis and Mann-Whitney U tests for intergroup variables and the Friedman and Wilcoxon test for intragroup variables. Statistical significance was set at P < 0.05. Results: There was no significant difference between early and late phase results in the control group. This group showed little or no lasting damage to nerve tissue. All sealers decreased the NCV in the early phase time periods, but this decrease was only statistically significant in the AH Plus group at 120-min time period (P < 0.0125). During the late phase, the AH Plus and GuttaFlow groups almost reached initial NCV values, and it was lower than the initial values in the Sealapex and Smartpastebio groups. However, this decrease was not statistically significant. When intergroup comparisons were performed, statistically significant differences occurred at 30 min in the Sealapex group and 120 min in the AH Plus group compared with the control group (P < 0.0125). All sealers induced neurotoxicity as a result of degenerative and inflammatory responses of nerve tissue in histologic analysis. Histologic analysis revealed Sealapex and GuttaFlow to be the most and least neurotoxic, respectively. Conclusions: All tested root canal sealers exhibited a variable degree of neurotoxicity depending on their chemical compositions. Clinical relevance: Apical extrusion of endodontic filling materials may cause undesired consequences, such as inflammation and severe neurotoxic damage; therefore, extrusion factor plays an important role during the root canal treatment.
- ArticleYalnız künye2015Transverse Subtrochanteric Shortening Osteotomy During Cementless Total Hip Arthroplasty in Crowe Type-III or IV Developmental Dysplasia
Sofu, Hakan; Kockara, Nizamettin; Gursu, Sarper; Issin, Ahmet; Oner, Ali; Sahin, Vedat
The purpose of this study was to review the outcomes of transverse subtrochanteric shortening osteotomy during cementless total hip arthroplasty in Crowe Type-III or IV developmental dysplasia. Seventy-three osteotomies were included in our study. Mean follow-up was 61. months. Harris hip score, leg length discrepancy, neurological status, union status of the osteotomy, and femoral component stability were the criteria for evaluation. All complications were noted. The mean Harris hip score improved from 38.6 points to 83.7 points. The mean leg length discrepancy decreased from 56.5. mm to 10.7 at the latest follow-up. The mean union time was 5.2. months. We observed 4 non-unions. Transverse subtrochanteric shortening osteotomy is an effective and reliable method in restoration of a more normal limb.
- ArticleAçık Erişim2015Rare tumors of the gallbladder: Clear cell carcinoma
Eken, Huseyin; Balci, Mecdi Gurhan; Buyukakincak, Sercan; Isik, Arda; Firat, Deniz; Cimen, Orhan
Introduction Gallbladder cancer is a rare tumor in the gastrointestinal tract has poor prognosis, low survival and is difficult to diagnose. The most common type of gallbladder cancer is adenocarcinoma, and the incidence of clear cell carcinoma is low. Mostly, it is difficult to determine whether the isolated tumor is a primary tumor in the gallbladder or a metastatic tumor from another region. Before accepting a clear cell carcinoma as a primary gallbladder tumor, the kidneys and other possible secondary focuses are clinically considered in terms of metastases. Presentation of case Here, we present a rarely seen case of gallbladder clear cell carcinoma, which was diagnosed by pathological examination after the surgery. Discussion Prior to establishing that clear cell carcinoma is a primary gallbladder cancer, it is appropriate to clinically investigate possible secondary focuses, in particular the kidneys in terms of metastasis. Conclusion Our goal in presenting this case was to emphasize the importance of taking an accurate medical history in patients with clear cell carcinoma, a rarely seen gallbladder cancer.
- ArticleAçık Erişim2015Prognostic factors, treatment and outcome in a Turkish population with endometrial stromal sarcoma
Donertas, Ayla; Nayki, Umit; Nayki, Cenk; Ulug, Pasa; Gultekin, Emre; Yildirim, Yusuf
Purpose: To analyze treatment modalities and prognostic factors in patients with Stage I-II endometrial stromal sarcoma (ESS). Materials and Methods: Twenty four patients (nineteen with low-grade ESS [LGESS] and five with high-grade ESS [HGESS]) were assessed retrospectively in terms of general characteristics, prognostic factors, treatment methods and survival. Results: Twenty patients were at Stage I and three were at Stage II. The stage of one patient could not be determined. With respect to age and comorbidity, no statistically significant difference was found among disease-free survival (DFS) (p=0.990; p=0.995). However, DFS was significantly shorter in Stage II than Stage I patients (p=0.002). It was also significantly shorter in HGESS patients than in LGESS patients (p=0.000). There was no statistically significant differences among the overall survival (OVS) times of patients with respect to age at diagnosis and comorbid disease (p=0.905; p=0.979) but OVS was significantly shorter in patients with HGESS (p=0.00) and Stage II disease (p=0.001). No statistically significant difference was found with respect to OVS between patients who received radiotherapy (RT) and those who did not receive RT (p=0.055). It was not statistically possible to include other treatment modalities in the analysis because of the small sample size. Conclusions: Grade and stage of a tumour were found to be the most important prognostic factors. It was not possible to determine the optimal surgical method and the effect of adjuvant treatment since the number of cases was insufficient.
- ArticleYalnız künye2015Terminal QRS distortion and severity of coronary artery disease in ST-elevation myocardial infarction; [Terminaler QRS-Verformung und Schweregrad der koronaren Herzkrankheit bei ST-Hebungs-Infarkt]
Bakirci, E.M.; Kalkan, K.; Hamur, H.; Buyuklu, M.; Cetin, M.; Degirmenci, H.; Duman, H.; Kucuksu, Z.; Tanboga, I.H.; Topal, E.
Background: Grade 3 ischemia (G3I) is defined as ST elevation with distortion of the terminal portion of the QRS complex on electrocardiograms (ECGs) of patients with ST-segment elevation myocardial infarction (STEMI). Although the association between G3I and short- and long-term cardiovascular events is well established, its mechanism is unclear. We assessed the association between G3I on the admission ECG and SYNTAX score (SS) in patients with STEMI undergoing primary percutaneous coronary intervention. Patients and methods: The study population consisted of 312 patients with STEMI. Baseline ECGs of the patients were analyzed for grade of ischemia; the online latest updated version (2.11) of the SS calculator was used to determine the SS (http://www.syntaxscore.com). Patients were divided into two groups according to their grade of ischemia: grade 2 ischemia (G2I) or G3I. Also, patients were classified according to their SS as SS < 22 (low) or SS ≥ 22 (high). Results: There were 211 patients in the low SS group and 101 patients in the high SS group. G3I was present in 31.1 % (n = 97) of the study population. SS was significantly higher in patients with G3I than in patients with G2I (20.1 ± 8.8 vs. 13.7 ± 7.1, p < 0.001). G3I was significantly higher in patients with high SS (50.5 % vs. 21.8 %, p < 0.001). Multivariate logistic regression analysis revealed that G3I (p < 0.001), diabetes (p = 0.013), age (p = 0.016), and anterior MI (p = 0.011), were independent predictors of high SS. Conclusion: In conclusion, G3I was independently related to high SS. We suggest that elevated SS in patients with G3I may explain the relationship between G3I and the poor outcome observed in these patients. Furthermore, the prediction of high SS by means of G3I in patients with STEMI may help determine the most appropriate revascularization method and prevent procedure failure.
- ArticleAçık Erişim2015Increased epicardial adipose tissue thickness is associated with angiographic thrombus burden in the patients with non-ST-segment elevation myocardial infarction
Bakirci, Eftal Murat; Degirmenci, Husnu; Duman, Hakan; Inci, Sinan; Hamur, Hikmet; Buyuklu, Mutlu; Ceyhun, Gokhan; Topal, Ergun
We aimed to evaluate the relation among epicardial adipose tissue (EAT) thickness, angiographic presence of thrombus, and the no-reflow in the patients with non-ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The study population consisted of 229 patients. The EAT thickness and neutrophil to lymphocyte ratio (NLR) were significantly higher in the patients with coronary thrombus than in those without coronary thrombus (6.1 ± 1.1 vs 5.1 ± 1.3 mm, P <.001 and 3.4 ± 0.9 vs 2.5 ± 0.7, P <.001, respectively) and in the patients with no-reflow compared to patients with reflow. The EAT thickness was found to be correlated positively with the degree of the thrombus burden, NLR, and waist circumference and negatively with high-density lipoprotein cholesterol. Multivariate logistic regression analysis demonstrated that EAT thickness and NLR independently predicted coronary thrombus formation and no-reflow. We have suggested that EAT can play an important role in the pathophysiology of coronary thrombus formation and the no-reflow.
- ArticleAçık Erişim2015The relation between the effect of a subhypnotic dose of thiopental on claw pain threshold in rats and adrenalin, noradrenalin and dopamine levels
Aksoy, Mehmet; Ahiskalioglu, Ali; Ince, Ilker; Celik, Mine; Dostbil, Aysenur; Kuyrukluyildiz, Ufuk; Altuner, Durdu; Kurt, Nezahat; Suleyman, Halis
Thiopental sodium (TPS) needs to be applied together with adrenalin in order to establish its analgesic effect in general anesthesia. We aimed to investigate the effect of TPS on the claw pain threshold in rats and evaluated its relationship with endogenous adrenalin (ADR), noradrenalin (NDR), and dopamine (DOP) levels. Intact and adrenalectomized rats were used in the experiment. Intact animals were divided into the following groups: 15 mg/kg TPS (TS), 0.3 mg/kg ADR+15 mg/kg TPS (ATS) and 0.3 mg/kg ADR alone (ADR). Adrenalectomized animals were divided into the following groups: 15 mg/kg TPS (A-TS), 0.3 mg/kg ADR+15 mg/kg TPS (A-ATS) and 0.3 mg/kg ADR alone (A-ADR). Claw pain threshold and blood ADR, NDR, and DOP levels were measured. The TS group’s claw pain threshold was found low. However, the claw pain thresholds of the ATS and ADR groups increased significantly. In the A-TS group, the pain threshold decreased compared with normal, and in the A-ATS and A-ADR groups, the pain threshold increased. TPS reduced the blood ADR levels in intact rats; however, no significant changes were observed in the NDR and DOP levels. #TPS provides hyperalgesia by reducing the production of ADR in rats. The present study shows that to achieve analgesic activity, TPS needs to be applied together with ADR.
- ArticleAçık Erişim2015An investigation of the risk factors and prevalence of alzheimer’s disease in the eastern region of Turkey : A population based door-to-door survey; [Türkiyenin doğu bölgesinde alzheimer hastalığının prevalansı ve risk faktörlerinin arastırılması : Toplum dayalı kapı kapı bir Çalışma]
Ertekin, Ayfer; Demir, Recep; Özdemir, Gökhan; Özel, Lütfi; Özyıldırım, Ercan; Ulvi, Hızır
The relationships between the prevalence of AD, socio-demographic characteristics, and other chronic diseases were researched within the population aged 65 and over living in Erzurum city center. The study was realized between June of 2010 and July of 2011. It involved 455 people over age 65 living in Erzurum city center. The Mini-Mental State Examination and Daily Living Scale were applied to participants. A total of 455 people participated in the study. AD was detected in 29 people. Twenty-one participants were female, and eight were male. The prevalence of AD was calculated to be 6.4%. According to the results of a logistic regression analysis, the AD prevalence detection rate in the a 75-84 age group was ten times greater than in the 65-74 age group, and the rate in the 85 and over group was 36 times greater than in the 65-74 age group. AD is more common in women than in men. The rate increases 4.1-fold among those with AD diabetes mellitus disease, 3.9-fold among those with Parkinson’s disease, 2.6-fold among those with heart disease, and 4.2-fold among those with dementia in their families. AD prevalence for those age of 65 and over was shown to be 6.4% in our study. The risk of AD increases 17-fold with increasing age. The risk of developing AD also increases in cases of chronic diseases.
- ArticleAçık Erişim2015Retroperitoneal malignant peripheral nerve sheath tumour: A rare case report
Deger, Ayse Nur; Bayar, Mehmet Akif; Caydere, Muzaffer; Deger, Hakki; Tayfur, Mahir
Malignant nerve sheath tumours (MPNST) are rare neoplasias and retroperitoneal cases are fairly rare and clinically difficult to be detected, but they are very agressive neoplasias. MPNST are frequently seen in head, neck and upper extremities. In patients with NF1; MPNST,a poor-prognostic lesion, may result from a malignant degeneration of a former plexiform neurofibroma. It is necessary to be aware of a potential malignancy in patients diagnosed with plexiform neurofibroma. We present a 21-year-old female with a diagnosis of MPNST. The patient was admited to the hospital because of a tumour in the subcutaneous region on her left buttock. The surgeon’s clinical diagnosis was lipoma. After the pathological examination of biopsy specimen, the lesion was identified as “plexiform neurofibroma” and then the patient was diagnosed with Neurofibromatosis Type 1 (NF1). Simultaneously, another mass on the retroperitoneal region was identified as malignant peripheral nerve sheath tumour (MPNST).
- ArticleYalnız künye2015Effect of Psychosocial Skills Training on Disease Symptoms, Insight, Internalized Stigmatization, and Social Functioning in Patients with Schizophrenia
Yıldırım, Arzu; Hacıhasanoğlu Aşılar, Rabia; Camcıoğlu, Tuba Hale; Erdiman, Sezgin; Karaağaç, Ebru
Purpose: This study was performed for the purpose of determining the effect of psychosocial skills training (PSST) on disease symptoms, insight, internalized stigmatization, and social functioning in patients with schizophrenia. Design: One group pretest–posttest model. Method: The study was carried out with 25 outpatients who were diagnosed with schizophrenia. The PSST was given to three groups of eight to nine patients once a week in 24 sessions, each lasting 90-120 minutes for a period of 6 months. Findings: The program had significant results in schizophrenic patients in improving the level of symptoms, increasing the level of functioning, and coping with stigmatization. Conclusion: The PSST program, adjuvant to pharmacological treatments, can be considered as a significant modality in daily practice due to its effect on improving symptoms, insight, and level of functioning and decreasing internalized stigmatization. Clinical Relevances: PSST in patients with schizophrenia can contribute to the use of evidence-based education strategies in psychiatric nursing practice to improve coping skills with the disease.
- ArticleYalnız künye2015Insulin resistance during laparoscopic or open mesh repairs of inguinal hernia in young males
Eken, Huseyin; Karagul, Servet; Buyukakıncak, Sercan; Cimen, Orhan; Sinan, Huseyin; Koca, Bulent; Bicer, Senol; Malazgirt, Zafer
Background: We aimed to compare the post-operative insulin resistance and early-term clinical outcomes of laparoscopic total extraperitoneal (TEP) repair and open mesh repair (Lichtenstein) in congenital-type inguinal hernias in young males. Material/Methods: A randomized, prospective, and double-blind study was planned. Twenty-six male patients with either type I or type II inguinal hernia according to Zollinger classification were operated on using the Lichtenstein technique or total extraperitoneal (TEP) technique. Insulin sensitivity measurement was performed twice on patients by using the hyperinsulinemic-euglycemic glucose clamp technique, once on the day before the operation and once 30 minutes postoperatively. We evaluated complications, pain, and life quality at 1 week and 1 month after surgery. Pain level was determined by visual analogue pain scale and life quality was determined by shortform 36 life quality assessment scales. Results: There was no difference between the Lichtenstein group M values (mean 4.91±2.25) and TEP group M values (mean 4.89±1.74) in terms of preoperative M values. There was a significant difference between Lichtenstein group M values (mean 3.60±2.34) and TEP group M values (mean 2.05±1.39) in terms of postoperative M values. Complication rates and visual analogue pain scale values of both groups were similar. In the short-form 36 life quality assessment scale, TEP group patients had higher scores in terms of emotional role at 1 week after surgery compared to the Lichtenstein group, but at 1 month after surgery we observed that the difference had disappeared. Conclusions: For small- and medium-sized indirect inguinal hernia repairs in young males, the Lichtenstein technique causes fewer injuries than the TEP technique in the short-term, but in the long-term both techniques have similar durations of improvement.
- ArticleAçık Erişim2015Identification of longevity, fertility and growth-promoting properties of pomegranate in Caenorhabditis elegans
Kiliçgün, Hasan; Arda, Nazli; Uçar, Evren
Background: Pomegranate (Punica granatum L.) is commonly consumed as fresh fruit and fruit juice. It is also used in the production of jam, wine, food coloring agent, and flavor enhancer. Objective: The aim of this study was to identify the possible longevity, fertility and growth promoting properties of different ethanolic extract concentrations of pomegranate in Caenorhabditis elegans, which is increasingly popular and has proven to be a very useful experimental model organism for aging studies as well as for testing antioxidants and other compounds for effects on longevity. Materials and Methods: In this study, five experimental groups (20, 10, 5, 2.5 and 1.25 mg pomegranate extract/mL and one control group) were used to determine the most effective dose of pomegranate in terms of longevity, fertility and growth parameters. Results: It was seen that, pomegranate extracts up to the concentration of 5 mg/mL, had the potential to promote for the longevity, formation of new generations, fertility of new generations and growth properties of C. elegans although higher concentrations significantly reduced these parameters. Conclusion: these findings indicated that pomegranate could be used as a supplement to enhance longevity, fertility and growth rate for the other living organisms and human beings, but the dose should be carefully adjusted to avoid adverse effects.
- ArticleAçık Erişim2015On-pump beating heart coronary revascularization: Is it valid for emergency revascularization?
Aydin, Ahmet; Erkut, Bilgehan
Background: On-pump beating heart coronary artery bypass grafting (CABG) may be considered as an alternative to the conventional on-pump surgery in patients presenting with acute coronary syndrome requiring emergency revascularization. This study reports our clinical experience and early outcomes with the on-pump beating heart coronary surgery on patients with acute coronary syndrome. Design and Settings: A retrospective study conducted from August 2009 to October, 2015, in a regional training and research hospital in Turkey. Methods: A total of 1432 patients underwent isolated CABG at our institution. A total of 316 of these patients underwent the on-pump beating heart procedure without cardioplegic arrest by the same surgeon. Results: The time interval from the onset of acute myocardial infarction to CABG was 10 (2.2) hours. The mean number of grafts was 3.0 (0.6). Hospital mortality was 2.9% (9 patients). Twelve patients had low cardiac output syndromes after surgery. Eight of them had renal dysfunction but none of them needed hemodialysis. The mean intensive care unit stay was 3 (2) days and the mean hospital length of stay was 7 (4) days. Conclusion: We think that the on-pump beating heart revascularization technique can be a good choice for emergency CABG of high-risk patients with a multivessel coronary artery disease.
- ArticleAçık Erişim2015Relation of angiographic thrombus burden with severity of coronary artery disease in patients with st segment elevation myocardial infarction
Duman, Hakan; Çetin, Mustafa; Durakoğlugil, Murtaza Emre; Değirmenci, Hüsnü; Hamur, Hikmet; Bostan, Mehmet; Karadağ, Zakir; Çiçek, Yüksel
Background: We planned to investigate the relationship of thrombus burden with SYNTAX score in patients with ST elevation myocardial infarction (STEMI). Material/Methods: We retrospectively enrolled 780 patients who underwent PPCI in our clinic due to STEMI. Clinical, laboratory, and demographic properties of the patients were recorded. Angiographic coronary thrombus burden was classified using thrombolysis in myocardial infarction (TIMI) thrombus grades. Results: Patients with high thrombus burden were older, with higher diabetes prevalence longer pain to balloon time, higher leukocyte count, higher admission troponin, and admission CK-MB concentrations. SYNTAX score was higher and myocardial perfusion grades were lower in patients with high thrombus burden. Multivariate logistic regression analysis revealed SYNTAX score as the strongest predictor of thrombus burden. ROC analysis demonstrated a sensitivity of 75.5%, specificity of 61.2%, and cut-off value of >14 (area under the curve (AUC): 0.702; 95% confidence interval [CI]: 0.773-0.874;P<0.001) for high thrombus burden. Conclusions: SYNTAX score may have additional value in predicting higher thrombus burden besides being a marker of coronary artery disease severity and complexity.
- ArticleAçık Erişim2015Glyceryl trinitrate for the treatment of preterm labor
Çalışkan, Şafak; Narin, Mehmet Ali; Dede, Faruk Suat; Narin, Raziye; Dede, Hülya; Kandemir, Ömer
Objective: This study was conducted to compare the tocolytic efficacy of glyceryltrinitrate (GTN) with that of magnesium sulfate (MgSO4) and to investigate serum nitric oxide metabolites before and after tocolysis. Material and Methods: In total, 48 women between 27 and 34 weeks’ gestation with threatened preterm labor and intact membranes were randomly allocated to receive either GTN or MgSO4 tocolysis. Main outcome measures included tocolytic efficacy and maternal side effect(s) of the tocolytic agent. Obstetric and neonatal outcomes as well as pretreatment and posttreatment nitric oxide (NO) metabolites were assessed. Results: Forty-one patients were included into the final analysis. Uterine contraction cessation times were 3.66±1.28 and 6.83±3.47 hours for GTN and MgSO4 groups, respectively. Similarly, maternal side effects were significantly lower in the GTN group than in the MgSO4 group, and no serious maternal side effects were recorded. Serum NO metabolite levels before treatment were significantly lower in the treatment groups than in the controls. Serum nitrite levels were significantly increased after tocolytic treatment both in MgSO4 and GTN groups. Conclusion: GTN effectively delays preterm delivery and reduces neonatal morbidity and mortality with less maternal side effects and seems to be an effective and safe alternative to MgSO4.
- Review ArticleAçık Erişim2015A systemic review of randomized controlled studies about prevention with pharmacologic agents of adhesion formation in the rat uterine horn model
Oner, Gokalp; Ulug, Pasa
Introduction: Evaluation of treatment attempts in postoperative adhesion formation is pivotal for the prevention of several morbidities including infertility, pelvic pain, bowel obstruction, and subsequent intraoperative complications. The purpose of this systemic review was to assess the literature on the rat uterine horn model for adhesion formation and treatment modalities to prevent adhesion in the most frequently used experimental animal model. Material and methods: We performed a systemic review of publications from January 1st 2000 to December 31st 2013 via a PubMed search. A high number of agents were evaluated for the prevention of postoperative adhesion formation in the rat uterine horn model. Results: According to most of the studies, adjuvants such as antiinflamatuars, antiestrogens, antioxidants were effective to prevent adhesion formation. Conclusions: Prevention of adhesion formation is pivotal and numerous types of agents were described in the literature were summarized in this review.
- ArticleAçık Erişim2015Multisystemic side effects of an indispensable old drug: A case report of chronic lithium use (A patient with multiple side effects of lithium)
Demirtas, Levent; Akbas, Emin Murat; Degirmenci, Husnu; Gurel, Ali; Duzgun, Eren
Presented here is a case of long-term lithium use, with multiple emerging lithium-associated side effects. An 82-year-old woman was brought into the emergency department because of loss of consciousness. According to the physical examination and laboratory analyses, patient was diagnosed with lithium-associated hypercalcemia, hyperparathyroidism, nephrogenic diabetes insipidus (NDI), symptomatic sinus bradycardia, and thyroid dysfunction. In the literature, there is a limited number of case reports with lithium induced multiple clinical conditions. Multiple clinical manifestations due to the side effects of chronic lithium use might be seen. Health care professionals should keep in mind that lithium-related side effects might trigger or exacerbate each other. To avoid toxicity, close follow-up and clinical supervision are important for the early diagnosis and treatment of these side effects, due to the narrow therapeutic index and obscure clinical signs and symptoms of toxicity.
- ArticleAçık Erişim2015Giant cell tumor of the capitate: An unusual case with 10 years follow-up
Duman, Serda; Sofu, Hakan; Camurcu, Yalkin; Gursu, Sarper; Oke, Ramadan
Giant cell tumor of the small bones, particularly the carpal bones of the hand, is exceedingly rare. We present a case report of giant cell tumor of the capitate in a 24 year-old female with 10 years postoperative follow-up. Although carpal bones are extremely unusual location, orthopedic surgeons should always keep in mind that differential diagnosis must include giant cell tumor of bone whenever an expansile osteolytic lesion with well-defined but nonsclerotic margins is identified in a young adult with closed physes.
- Conference ObjectYalnız künye2015New inflammatory markers for prediction of non-dipper blood pressure pattern in patients with essential hypertension: Serum YKL-40/Chitinase 3-like protein 1 levels and echocardiographic epicardial adipose tissue thickness
Bakirci, Eftal Murat; Degirmenci, Husnu; Hamur, Hikmet; Gunay, Murat; Gulhan, Barïs; Aydin, Merve; Kucuksu, Zafer; Ceyhun, Gokhan; Topal, Ergun
The aim of the present study was to investigate whether YKL-40 levels and epicardial adipose tissue (EAT) thickness were associated with non-dipping pattern in essential hypertension (HT). Age- and sex-matched 40 dipper hypertensive patients and 40 non-dipper hypertensive patients were included in the study. Non-dippers had significantly increased EAT thickness and higher YKL-40 and high-sensitivity C-reactive protein levels than dippers. Multivariate logistic regression analysis showed that the EAT thickness and serum levels of YKL-40 and high-sensitivity C-reactive protein were independent predictors of non-dipping pattern in essential HT. In essential HT, presence of non-dipping pattern is associated with increased inflammatory response.
