Araştırmacılar(30)

• Aliskander, Fater
• Arslan, Mithat Kerim
• Bilici, Sami
• Celebi, Fehmi
• Cimen, Orhan
• Dasiran, F.
• Demiryilmaz, Ismail
• Deniz Firat, Y.
• Eken, Hüseyin
• Eryilmaz, R.
• Firat, Deniz
• Idiz, Oguz
• Inal, Abdullah
• Isik, A.
• Islambekov, Yersultan
• Kamil, Pehlivanoğlu
• Karakose, Oktay
• Memiş, Ufuk
• Okan, I.
• Palazzini, Giorgio
• Pehlivanoglu, Kamil
• Peker, Kemal
• Saad, Ahmad
• Sahin, Azad Gazi
• Sahin, M.
• Sezgin, Efe
• Somay, A.
• Somuncu, Erkan
• Yezhikova, Assel
• Yilmaz, Ismayil

• ArticleAçık Erişim2026/r/ebyu/19332
  Changes in Gastritis During the COVID-19 Pandemic: A Retrospective Comparative Study According to the Sydney Criteria

  Çımen, Ferda Keskın; Çimen, Orhan

  Objective: This study aimed to evaluate whether the coronavirus disease-2019 (COVID-19) pandemic caused changes in the severity of gastritis, as assessed by the Sydney criteria, through a retrospective comparison of patients in the pre- and post-pandemic periods. Methods: Pathology reports of 107 pre-pandemic patients until March 2019 and 96 post-pandemic patients until May 2023, who underwent upper gastrointestinal endoscopy for dyspeptic complaints and were diagnosed with gastritis were retrospectively analyzed. Gastritis severity was assessed according to the Sydney criteria. Percentages were calculated and compared. Results: The pre-pandemic group included 62 women and 45 men (mean age 58.6 years). The post-pandemic group included 50 women and 46 men (mean age 57.6 years). No significant demographic differences were observed. According to the Sydney criteria, no permanent effect of COVID-19 on gastritis severity was identified. Conclusion: Our study found no significant differences in gastritis severity between the periods before and after the COVID-19 pandemic. Larger prospective studies are required to further explore potential long-term effects.

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• ArticleYayıncıda açık erişim2026/r/ebyu/10773
  Effects of ATP and Taxifolin on Atezolizumab-Induced Renal Injury: A Biochemical, Histopathological, and Immunofluorescence Evaluation

  Kilic, Adil Furkan; Sezgin, Esra Tuba; Huseynova, Gulbaniz; Sarigul, Cengiz; Ozkaraca, Mustafa; Gungor, Ali; Mammadov, Renad; Suleyman, Halis; Cimen, Orhan

  Background: Immune checkpoint inhibitors (ICIs), particularly programmed death-ligand 1 (PD-L1) inhibitors such as atezolizumab, have significantly improved outcomes in cancer therapy. However, these agents may cause immune-related adverse effects, including nephrotoxicity associated with oxidative stress and cellular stress responses. This study aimed to investigate and comparatively evaluate the protective effects of adenosine triphosphate (ATP) and taxifolin against atezolizumab-induced renal tissue injury in rats. Methods: Animals were divided into four groups: healthy (HG), atezolizumab (ATZ), ATP + atezolizumab (ATAZ), and taxifolin + atezolizumab (TXAZ). ATP (4 mg/kg, i.p.) and taxifolin (50 mg/kg, oral) were administered for six days, while atezolizumab (10 mg/kg, i.p.) was given on days 1 and 4. On day 7, renal tissues were collected for biochemical, histopathological, and double immunofluorescence analyses. Results: Atezolizumab significantly increased malondialdehyde (MDA) levels and decreased total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) levels, indicating enhanced oxidative stress and impaired antioxidant defense. These changes were accompanied by tubular degeneration and increased expression of apoptotic markers. Both ATP and taxifolin significantly ameliorated these alterations; however, ATP demonstrated a more pronounced protective effect. Conclusions: In conclusion, ATP and taxifolin attenuated the biochemical, histopathological, and immunofluorescence alterations associated with atezolizumab administration. ATP exhibited a more pronounced protective effect than taxifolin under the conditions of this experimental model. Nevertheless, further experimental studies are required to elucidate the mechanisms underlying these effects.

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• ArticleYayıncıda açık erişim2025/r/ebyu/19369
  The Effects of Hyperı̇cum perforatum (St. John's Wort) Oil on Wound Healing and Comparison with Those of Collagenase Drugs

  Koç, Alparslan; Tayfur, Mahir; Huyut, Mehmet Tahir; Memiş, Ufuk; Kahraman, Ibrahim

  Background and Objectives: Wound healing is among the most fundamental problems in the field of health. Oil of Hypericum perforatum (HP) has been used for various ailments, particularly depression, burns, and wound healing, globally for a long period of time. We investigated the healing-promoting effect of HP oil on wound healing histopathologically and macroscopically in an experimental wound model in rats, aiming to compare the results with those of collagenase pomade, which is actively used in the literature. Materials and Methods: A total of 32 male Wistar rats of similar were used for the experiment. The animals were randomly divided into four groups, each consisting of eight rats. After the dorsal areas of the rats were shaved and disinfected with povidone-iodine solution, a 1 cm2 full-thickness wound was created on the backs of each rat. The sham (control) group received dry gauze dressings, while the physiological saline (PS) group was treated with saline-soaked gauze. The collagenase ointment pomade (CP) group and HP groups were treated with gauze impregnated with 0.1 grams of these substances. All wounds were dressed twice daily, in the morning and evening. The second group was treated with physiological saline. The third group was treated with collagenase ointment. And the fourth group was treated with St. John's Wort oil. Wound areas were measured on days 3, 7, 10, 14, and 21. In addition, histopathological evaluation was performed on tissue samples obtained on day 14, and the day of complete wound closure was recorded for each animal. Results: When the findings were statistically analyzed, wounds treated with St. John's Wort oil and collagenase ointment healed significantly faster than the other groups (p < 0.05). Conclusions: In conclusion, St. John’s Wort oil appears to be a promising topical agent for enhancing wound healing, as it accelerates the healing process. However, controlled clinical trials in human subjects would provide the most definitive evidence on this topic.

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• ArticleYayıncıda açık erişim2024/r/ebyu/19183
  Symptomatic and morphometric analysis of lumbosacral transitional vertebrae: assessments by age and gender

  Bingöl, Koray; Arslan, Mithat Kerim

  Aim: Lumbosakral transitional vertebrae (LSTV) are anatomical variations where a vertebra exhibits characteristics of both lumbar and sacral vertebrae. This study aims to assess anatomical changes in LSTV patients by measuring intervertebral disc height (IVDh), vertebral foramen anteroposterior diameter (FVAPd), and intervertebral foramen height (FIVh), with consideration of age and gender differences. Material and Methods: This retrospective study included 274 patients diagnosed with LSTV. All MRI images were acquired with a 1.5T MRI machine and a 32-channel lumbar coil. The presence of LSTV, forming the morphological data, was identified from coronal and sagittal reformat images and was classified as either lumbarization or sacralization. Morphometric data (IVDh, FIVh and FVAPd) were acquired from axial, sagittal, and coronal planes using both soft tissue and bone window settings. Results: The mean patient age was 41.6±13.0 years, with a female majority (55.8%). LSTV was predominantly lumbarization (96.4%), with sacralization in the remaining cases. The overall mean FVAPd was 11.2±2.4 mm, mean IVDh was 9.1±1.8 mm, and mean FIVh was 18.8±2.4 mm on the right and 19.1±2.4 mm on the left. IVDh levels were consistent across age groups, while FVAPd values were similar between genders. Patients aged 40 and under had higher FVAPd and FIVh levels, and male patients had higher IVDh and FIVh levels compared to females. Conclusions: The morphometric characteristics of LSTV may vary according to age and gender. Considering these factors in accurately identifying the anatomical variations of LSTV may play a significant role in determining appropriate treatment and management strategies.

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• ArticleYayıncıda açık erişim2023/r/ebyu/13407
  Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue

  Ubels, Sander; Matthée, Eric; Verstegen, Moniek; Klarenbeek, Bastiaan; Bouwense, Stefan; van Berge Henegouwen, Mark I.; Daams, Freek; Dekker, Jan Willem T.; van Det, Marc J.; van Esser, Stijn

  Introduction: Failure to rescue (FTR) is an important outcome measure after esophagectomy and reflects mortality after postoperative complications. Differences in FTR have been associated with hospital resection volume. However, insight into how centers manage complications and achieve their outcomes is lacking. Anastomotic leak (AL) is a main contributor to FTR. This study aimed to assess differences in FTR after AL between centers, and to identify factors that explain these differences. Methods: TENTACLE – Esophagus is a multicenter, retrospective cohort study, which included 1509 patients with AL after esophagectomy. Differences in FTR were assessed between low-volume (<20 resections), middle-volume (20–60 resections) and high-volume centers (≥60 resections). Mediation analysis was performed using logistic regression, including possible mediators for FTR: case-mix, hospital resources, leak severity and treatment. Results: FTR after AL was 11.7%. After adjustment for confounders, FTR was lower in high-volume vs. low-volume (OR 0.44, 95%CI 0.2–0.8), but not versus middle-volume centers (OR 0.67, 95%CI 0.5–1.0). After mediation analysis, differences in FTR were found to be explained by lower leak severity, lower secondary ICU readmission rate and higher availability of therapeutic modalities in high-volume centers. No statistically significant direct effect of hospital volume was found: high-volume vs. low-volume 0.86 (95%CI 0.4–1.7), high-volume vs. middle-volume OR 0.86 (95%CI 0.5–1.4). Conclusion: Lower FTR in high-volume compared with low-volume centers was explained by lower leak severity, less secondary ICU readmissions and higher availability of therapeutic modalities. To reduce FTR after AL, future studies should investigate effective strategies to reduce leak severity and prevent secondary ICU readmission.

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• ArticleYayıncıda açık erişim2023/r/ebyu/13366
  Global Incidence and Risk Factors Associated with Postoperative Urinary Retention Following Elective Inguinal Hernia Repair: The Retention of Urine after Inguinal Hernia Elective Repair (RETAINER I) Study

  Croghan, Stefanie M.; Mohan, Helen M.; Breen, Kieran J.; McGovern, Ruth; Bennett, Kathleen E.; Boland, Michael R.; Elhadi, Muhammed; Elliott, Jessie A.; Fullard, Anna C.; Lonergan, Peter E.

  Importance: Postoperative urinary retention (POUR) is a well-recognized complication of inguinal hernia repair (IHR). A variable incidence of POUR has previously been reported in this context, and contradictory evidence surrounds potential risk factors. Objective: To ascertain the incidence of, explore risk factors for, and determine the health service outcomes of POUR following elective IHR. Design, Setting, and Participants: The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) study, an international, prospective cohort study, recruited participants between March 1 and October 31, 2021. This study was conducted across 209 centers in 32 countries in a consecutive sample of adult patients undergoing elective IHR. Exposure: Open or minimally invasive IHR by any surgical technique, under local, neuraxial regional, or general anesthesia. Main Outcomes and Measures: The primary outcome was the incidence of POUR following elective IHR. Secondary outcomes were perioperative risk factors, management, clinical consequences, and health service outcomes of POUR. A preoperative International Prostate Symptom Score was measured in male patients. Results: In total, 4151 patients (3882 male and 269 female; median [IQR] age, 56 [43-68] years) were studied. Inguinal hernia repair was commenced via an open surgical approach in 82.2% of patients (n = 3414) and minimally invasive surgery in 17.8% (n = 737). The primary form of anesthesia was general in 40.9% of patients (n = 1696), neuraxial regional in 45.8% (n = 1902), and local in 10.7% (n = 446). Postoperative urinary retention occurred in 5.8% of male patients (n = 224), 2.97% of female patients (n = 8), and 9.5% (119 of 1252) of male patients aged 65 years or older. Risk factors for POUR after adjusted analyses included increasing age, anticholinergic medication, history of urinary retention, constipation, out-of-hours surgery, involvement of urinary bladder within the hernia, temporary intraoperative urethral catheterization, and increasing operative duration. Postoperative urinary retention was the primary reason for 27.8% of unplanned day-case surgery admissions (n = 74) and 51.8% of 30-day readmissions (n = 72). Conclusions: The findings of this cohort study suggest that 1 in 17 male patients, 1 in 11 male patients aged 65 years or older, and 1 in 34 female patients may develop POUR following IHR. These findings could inform preoperative patient counseling. In addition, awareness of modifiable risk factors may help to identify patients at increased risk of POUR who may benefit from perioperative risk mitigation strategies..

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• CorrectionYayıncıda açık erişim2023/r/ebyu/13142
  Erratum to “Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue” [Eur J Surg Oncol 49 (5) (May 2023) 974–982](S074879832300032X)(10.1016/j.ejso.2023.01.010)

  Ubels, Sander; Matthée, Eric; Verstegen, Moniek; Klarenbeek, Bastiaan; Bouwense, Stefan; van Berge Henegouwen, Mark I.; Daams, Freek; Dekker, Jan Willem T.; van Det, Marc J.; van Esser, Stijn

  The publisher regrets that when the article was published the following collaboration authors from the “TENTACLE – Esophagus collaborative group” appeared incorrectly in the main author list due to a technical error: Writing Committee, Joos Heisterkamp, Fatih Polat, Jeroen Schouten, Pritam Singh, Study collaborators. This has now been corrected. The publisher would like to apologise for any inconvenience caused.

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• ArticleYalnız künye2023/r/ebyu/13122
  Invited Commentary: The Efficacy of VAMMFT Compared to “Bogota Bag” in Achieving Sheath Closure Following Temporary Abdominal Closure at Index Laparotomy for Trauma

  Isik, Arda; Memis, Ufuk

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• ArticleYayıncıda açık erişim2023/r/ebyu/13073
  Treatment of anastomotic leak after oesophagectomy for oesophageal cancer: large, collaborative, observational TENTACLE cohort study

  Ubels, Sander; Verstegen, Moniek H.P.; Klarenbeek, Bastiaan R.; Bouwense, Stefan; van Berge Henegouwen, Mark I.; Daams, Freek; van Det, Marc J.; Griffiths, Ewen A.; Haveman, Jan Willem; Heisterkamp, Joos

  Background: Anastomotic leak is a severe complication after oesophagectomy. Anastomotic leak has diverse clinical manifestations and the optimal treatment strategy is unknown. The aim of this study was to assess the efficacy of treatment strategies for different manifestations of anastomotic leak after oesophagectomy. Methods: A retrospective cohort study was performed in 71 centres worldwide and included patients with anastomotic leak after oesophagectomy (2011-2019). Different primary treatment strategies were compared for three different anastomotic leak manifestations: interventional versus supportive-only treatment for local manifestations (that is no intrathoracic collections; well perfused conduit); drainage and defect closure versus drainage only for intrathoracic manifestations; and oesophageal diversion versus continuity-preserving treatment for conduit ischaemia/necrosis. The primary outcome was 90-day mortality. Propensity score matching was performed to adjust for confounders. Results: Of 1508 patients with anastomotic leak, 28.2 per cent (425 patients) had local manifestations, 36.3 per cent (548 patients) had intrathoracic manifestations, 9.6 per cent (145 patients) had conduit ischaemia/necrosis, 17.5 per cent (264 patients) were allocated after multiple imputation, and 8.4 per cent (126 patients) were excluded. After propensity score matching, no statistically significant differences in 90-day mortality were found regarding interventional versus supportive-only treatment for local manifestations (risk difference 3.2 per cent, 95 per cent c.i. -1.8 to 8.2 per cent), drainage and defect closure versus drainage only for intrathoracic manifestations (risk difference 5.8 per cent, 95 per cent c.i. -1.2 to 12.8 per cent), and oesophageal diversion versus continuity-preserving treatment for conduit ischaemia/necrosis (risk difference 0.1 per cent, 95 per cent c.i. -21.4 to 1.6 per cent). In general, less morbidity was found after less extensive primary treatment strategies. Conclusion: Less extensive primary treatment of anastomotic leak was associated with less morbidity. A less extensive primary treatment approach may potentially be considered for anastomotic leak. Future studies are needed to confirm current findings and guide optimal treatment of anastomotic leak after oesophagectomy.

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• ArticleYayıncıda açık erişim2023/r/ebyu/12997
  Vascular e-Learning in the MENA Region during the COVID-19 Pandemic

  Karam, Lamisse; Patelis, Nikolaos; Matheiken, Sean; Bisdas, Theodosios; Jing, Zaiping; Feng, Jiaxuan; Trenner, Matthias; Ocke Reis, Paulo Eduardo; Elkouri, Stephane; Lecis, Alexandre

  Introduction: With the steady rise in interest in e-learning and the sudden boost provoked by the COVID-19 pandemic, it becomes necessary to explore the e-learning experience within the medical community in the MENA region. Methods: An online survey was conducted during the early phase of the COVID-19 pandemic (June 15 - October 15, 2020). Results: Seventy-eight vascular surgeons and trainees from 16 countries participated. 88% of the participants were male. 55% attended more than 4 activities. More than half of the activities did not lead to any official certification. Topic was the primary determinant for attending an activity. National societies and social media played a major role in disseminating activity-related information. Lack of time, increased workload, differences in time zone, and technical issues were the main obstacles cited. 84.7% of the participants had a positive impression. Conclusion: As the COVID-19 pandemic boosted e-learning activities in vascular surgery, a shift was observed in the learning mode and new leadership skills were called upon. Novel ways of quality control are required.

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