Araştırmacılar(22)

• Acar, Hatice Kübra
• Altıntaş Başar, Hilal Betül
• Baspinar, Busra
• Can, Esra İrem
• Çebi, Kadir
• Çubuk, Mihrican
• Eskici, Günay
• Gerek, Merve Dilara
• Gökşen, Gülden
• Gungor, Neva
• Kacar, Mihrican
• Kara, Hasan Hüseyin
• Karahan Yllmaz, Sevil
• Kilicgun, Hasan
• Sahin, Hilal
• Varol, Emre
• Yalçın Pehlivan, Ece
• Yangılar, Filiz
• Yi, Sevil Karahan
• Yilmaz, Nazife
• Yilmaz, Sevil Karahan
• Yüksel, Fatma

• ArticleAçık Erişim2026/r/ebyu/19279
  Impact of Teapot Material and Geographical Origin on Consumer Acceptability of Turkish Black Tea

  Varol, Emre; Ağca, Rabia

  This study examined how teapot material (stainless steel, copper, porcelain) and geographical origin (Artvin, Rize, Giresun, Trabzon) affect the sensory attributes and consumer acceptability of Turkish black tea. Sixty naive panellists evaluated tea brewed from Çaykur leaves using standardized protocols. Sensory analysis included colour, brightness, clarity astringency aroma intensity, taste, odour, bitterness and overall acceptability on a 9-point hedonic scale. Results showed that the teapot material, porcelain, produced teas with superior clarity, taste, and overall acceptability compared to those made from stainless steel and copper, significantly influencing key sensory properties. The highest scores were achieved with Artvin-origin tea brewed in porcelain, despite most participants traditionally preferring Rize tea. Principal component analysis indicated that aroma intensity and taste were the primary sensory attributes associated with overall acceptability. The findings suggest that, under standardized brewing conditions, teapot material may exert a stronger influence than geographical origin on tea perception, offering practical insights for improving tea quality and consumer experience.

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• ArticleAçık Erişim2026/r/ebyu/19018
  Nutritional and Inflammatory Indicators for Identifying Sarcopenia in Hemodialysis Patients

  Kara, Ali Veysel; Şahin, Hilal; Doğan Akagündüz, Diğdem

  Objective: Sarcopenia represents a frequent clinical condition in patients receiving maintenance hemodialysis and is linked to adverse functional and health-related outcomes. Owing to its multifactorial nature, early identification of patients at risk remains challenging in routine practice. This study evaluated nutritional and inflammatory indicators associated with sarcopenia and their ability to identify patients with sarcopenia. Methods: This cross-sectional study included 72 clinically stable adults receiving maintenance hemodialysis between August and September 2024. Sarcopenia was defined according to European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria, requiring low muscle strength and reduced muscle mass assessed by handgrip dynamometry and bioelectrical impedance analysis. Nutritional status was evaluated using the Subjective Global Assessment (SGA), and dietary energy and protein intake were assessed using 2 non-consecutive 24-hour recalls analyzed with BEBİS software. Serum albumin, C-reactive protein (CRP), and neutrophil-to-lymphocyte ratio were measured. Multivariable logistic regression and receiver-operating characteristic analyses were performed. Results: Sarcopenia was identified in 18 patients (25%). Sarcopenic individuals had significantly lower protein and energy intake, lower serum albumin levels, and higher CRP concentrations than non-sarcopenic patients. In multivariable analyses, low protein intake (<1.0 g/kg/day), inadequate energy intake (<25 kcal/kg/day), hypoalbuminemia (<3.5 g/dL), elevated CRP (>5 mg/L), and SGA category B/C were independently associated with sarcopenia, whereas adequate energy intake was inversely associated. Receiver-operating characteristic analysis showed acceptable discrimination for individual indicators, with the highest accuracy for serum albumin (area under the curve [AUC] = 0.77). A combined nutritional–inflammatory model integrating dietary intake, albumin, and CRP demonstrated the greatest discriminatory ability (AUC = 0.83). Conclusion: Routinely available nutritional and inflammatory indicators are closely associated with sarcopenia in hemodialysis patients. Their combined assessment may facilitate early identification of individuals with sarcopenia and support timely nutritional evaluation and intervention.

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• ArticleYalnız künye2026/r/ebyu/18581
  Impact of Adherence to Mind Diet on Cognitive Function, Frailty, and Physical Activity Levels Elderly Individuals

  Sahin, Hilal; Sahin, Habibe

  Objective: The study aimed to examine the effect of adherence to the Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet on the cognitive function, frailty, and physical activity levels in elderly individuals. Methods: This cross-sectional study was conducted in primary healthcare centers between November 2020 and October 2021. The Standardized Mini-Mental State Examination (SMMSE), the Fatigue, Resistance, Ambulation, Illnesses, and Loss of weight (FRAIL) scale, and the Physical Activity Scale for the Elderly (PASE) were used to examine the cognitive function, frailty, and physical activity levels of participants, respectively. Adherence to the MIND diet score was calculated based on a food consumption record, and a semi-quantitative food consumption frequency questionnaire. Results: The study sample included 150 elderly, with a mean age of 71.31 +/- 5.15 years. The mean MIND diet, SMMSE, FRAIL, and PASE scores were 9.5(7.5-11.0), 22.54 +/- 3.98, 2.00 +/- 1.64, and 191.3 +/- 62.65, respectively. A weak positive correlation (p<.05) was found between the MIND diet score and SMMSE and FRAIL scales; however, no correlation was found with the PASE total score. A one-point increase in the MIND diet score resulted in a 0.002 increase in the mean SMMSE scale score and a 0.450 increase in the mean FRAIL scale score (p<.05). Conclusions: Adherence to the MIND diet was positively correlated with cognitive functions and frailty in elderly individuals. Long-term studies with larger sample sizes should be conducted to further investigate the effects of the MIND diet on cognitive functions and frailty.

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• ArticleYalnız künye2026/r/ebyu/11323
  Early Dysglycemia Detected by Continuous Glucose Monitoring in a 6-Year-Old Child with Cystic Fibrosis: A Case Report

  Baspinar, Busra; Tekin, Merve Nur; Özçelik, Ayşe Özfer; Çobanoğlu, Nazan

  Background: Cystic fibrosis–related diabetes (CFRD) screening is typically recommended from age 10, yet glucose abnormalities may emerge earlier. Conventional screening tools may fail to detect dysglycemia in young children with cystic fibrosis (CF). Case Presentation: A 6-year-old girl with CF and severe pancreatic insufficiency underwent 14-day continuous glucose monitoring (CGM) as part of an observational study on glucose metabolism in pediatric CF patients. Results: CGM detected marked glycemic variability (38.4%), a mean glucose level of 192 mg/dL, and a time in range of 56%, despite only mildly elevated fasting glucose values. Laboratory workup confirmed CFRD (glycated hemoglobin 8.8%). After insulin initiation, pulmonary function improved substantially, with forced expiratory volume increasing from 76% to 97% of predicted within 2 months. Conclusions: CGM may identify clinically significant dysglycemia in young children with CF who would otherwise go undetected by age-based screening. In selected high-risk pediatric CF patients below the standard screening age, CGM may enable earlier diagnosis and timely intervention—a clinical question that warrants prospective investigation.

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• ArticleYalnız künye2026/r/ebyu/11219
  Evaluation of the Relationship Between Sarcopenia, Nutritional Status, and Frailty in Older Patients with Cancer

  Doğan Akagündüz, Diğdem; Şahin, Hilal; Akagündüz, Baran

  Sarcopenia, malnutrition, and frailty frequently coexist in older adults with cancer, adversely affecting treatment tolerance, functional independence, and survival. While comprehensive geriatric assessment (CGA) is the gold standard for frailty evaluation, its resource-intensive nature limits routine use, and simple tools are needed. This cross-sectional study included 291 patients aged ≥70 years with histologically confirmed cancer, evaluated at a oncology outpatient clinic between January and November 2024. Sarcopenia was defined according to EWGSOP2 criteria: handgrip strength (HGS) and skeletal muscle index (SMI) by bioelectrical impedance analysis (BIA). Nutritional status was assessed with the Mini Nutritional Assessment–Short Form (MNA-SF), and frailty was defined as G8 ≤ 14. Additional measures included SARC-F, Mini-Mental State Examination (MMSE), and Geriatric Depression Scale. The median age was 74 years, and 53% were male. Possible sarcopenia was identified in 39.5%, confirmed sarcopenia in 33.7%, severe sarcopenia in 26.8%. Nutritional risk was observed in 66.7%, and frailty in 44.7%. Frailty correlated strongly with nutritional status and moderately with muscle strength and mass. In multivariable analysis, low HGS, low SMI, nutritional risk, and depression independently predicted frailty. ROC analysis showed, G8 with HGS and nutritional assessment improved predictive accuracy. These findings highlight that simple measures enhance frailty detection and may support personalized care.

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• ArticleYalnız künye2026/r/ebyu/11113
  Measuring food insecurity in Türkiye: validation of the four domain food insecurity scale (4D-FIS)

  Memiç-İnan, Cansu; Başpınar, Büşra; İmrol, Fatih

  The aim was to conduct the Turkish validity and reliability study of the Four-Domain Food Insecurity Scale (4D-FIS). In this cross-sectional study, confirmatory factor analysis (CFA) was used to test the validity of the 4D-FIS scale. The 4D-FIS scale consists of four domains: quantitative, qualitative, psychological, and social. The Cronbach-α of the 4D-FIS scale was 0.84, indicating that the scale was reliable. CFA confirmed the four-factor structure of the 4D-FIS, with fit indices indicating good model fit. The Turkish 4D-FIS scale was found to be valid and reliable for evaluating food security in the quantitative, qualitative, psychological, and social domains.

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• ArticleYalnız künye2026/r/ebyu/11057
  Pomegranate seed powder in bread: effects on acrylamide formation, melanoidin development, antioxidant capacity and sensory quality

  Karagöl, Gülbin; Yalçın Pehlivan, Ece; Rakıcıoğlu, Neslişah

  Pomegranate seed powder (PSP), a phenolic-rich by-product of the food industry, was incorporated into white and whole wheat bread formulations to investigate its effects on physicochemical properties and Maillard reaction–related compounds. PSP was added at levels of 2.5%, 5%, 7.5%, and 10%, and the resulting breads were evaluated for proximate composition, acrylamide levels and melanoidin content, antioxidant capacity (QUENCHER–DPPH assay), and sensory attributes. PSP incorporation exhibited a concentration-dependent effect on Maillard reaction products. Acrylamide levels decreased at moderate inclusion levels (5%) compared to the control, whereas higher inclusion levels (≥7.5%) resulted in a relative increase. In contrast, melanoidin content and antioxidant capacity increased progressively with increasing PSP levels, reaching maximum values in whole wheat bread supplemented with 10% PSP (3.15 g/100 g and 8.11 mmol TE/kg, respectively). A consistent association was observed between melanoidin formation and antioxidant capacity across all formulations. Sensory evaluation indicated a gradual decline in acceptability with increasing PSP levels; however, all samples remained above the acceptable threshold. Overall, the findings suggest that moderate PSP incorporation (around 5%) may provide a favourable balance between reduced acrylamide formation and enhanced antioxidant properties, while maintaining acceptable sensory quality.

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• ArticleAçık Erişim2026/r/ebyu/10870
  Lyophilised walnut milk powders enriched with vitamin B12 and L-Carnitine for vegan athletes

  Acar, Hatice Kübra; Yangılar, Filiz

  This study was to investigate the characteristic properties of functional powder formulations produced by the lyophilization technique, enriched with vitamin B12 and L-carnitine, and containing walnuts, walnut milk, walnut milk powder, and lupin flour, aiming to support the nutritional needs of vegan athletes. Vitamin B12 analysis of vegan powder samples were performed using an HPLC device. Vitamin B12 levels ranged from 3.64% to 3.92%. Sample B (15% carnitine added) exhibited the highest protein content (31.08%), while sample C (20% carnitine added) the most total phenolic content (192 mg GAE/100 g), suggesting a strong potential for oxidative stress mitigation. The formulations displayed high dispersibility (87.28%–92.74%) and yield efficiency (90.68%–92.82%), indicating excellent solubility and practical applicability. Sample B showed the highest antioxidant activity as DPPH (6.61 mmol TE/kg), FRAP (6.57 mmol Fe²⁺/kg), and CUPRAC (8.00 mg TE/g). Additionally, sample C presented the highest energy density (448.73 kcal/100 g) while sample K (520 mg/100 g). The inclusion of 15% L-carnitine in sample B significantly enhanced palatability and overall acceptability.

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• ArticleAçık Erişim2026/r/ebyu/10789
  Isolation of Pseudomonas aeruginosa from food and determination of their antibiotic resistance

  Yilmaz, Nazife; Urganci, Nida Nur; Yildirim, Zeliha

  Despite the fact that Pseudomonas aeruginosa is a well-known opportunist pathogen, it remains an understudied microorganism in the context of food safety. Due to its high adaptation capability, rapid reproduction and minimal growth necessities, P. aeruginosa is a common bacterium in the food chain. The resistance of P. aeruginosa to various antibiotics in clinical isolates has been extensively investigated and in-depth characterized. Conversely, information on food-borne isolates of this genus and species is insufficient. In this study, a total of 208 colonies were isolated from 144 food samples collected from different provinces and subjected to morphological, physiological, and chemical analyses. Based on the results, total 22 isolates obtained from milk (12) and chicken (10) samples and exhibiting characteristics specific to P. aeruginosa were identified at the molecular level using the 16 S rRNA region. The antibiotic resistance profiles of the identified isolates were evaluated against azithromycin and erythromycin (macrolides), cefoperazone and ceftazidime (cephalosporin), meropenem and imipenem (carbapenem), as well as amikacin (aminoglycoside) among others. As a result of 16 S rRNA analysis, it was determined that only the 10 isolates obtained from raw milk samples were P. aeruginosa. The prevalence of antibiotic resistance among P. aeruginosa isolates was found to be variable. All isolates were observed to be susceptible to amikacin, imipenem, and piperacillin/tazobactam, while they were resistant to erythromycin, nalidixic acid, ampicillin, kanamycin, and chloramphenicol. Only the RM16 strain was susceptible to tetracycline, RM18 to meropenem, and RM20 and RM24 showed intermediate susceptibility to gentamicin.

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• ArticleYalnız künye2026/r/ebyu/10782
  Associations Between Nutritional Status, Sleep Quality, and Clinical Factors in Patients With Metastatic Prostate Cancer

  Akagunduz, Digdem Dogan; Sahin, Hilal; Hendem, Engin; Akagunduz, Baran

  PURPOSE – Malnutrition and poor sleep quality are common but underrecognized issues among patients with metastatic prostate cancer (mPC). This study aimed to examine the associations between nutritional status, sleep quality, and clinical outcomes in men with mPC. METHODS – In this cross-sectional study, 91 men with stage IV prostate cancer were evaluated for nutritional status using the Subjective Global Assessment (SGA) and sleep quality using the Pittsburgh Sleep Quality Index (PSQI). Clinical and laboratory parameters, including albumin, hemoglobin, C-reactive protein (CRP), and quality-of-life scores (EORTC QLQ-C30 and QLQ-PR25), were compared across SGA categories and sleep quality groups. Multivariable logistic regression was used to identify predictors of poor sleep (PSQI >5).RESULTS – Overall, 60.4% of patients were castration-resistant, and 38.5% were severely malnourished (SGA C). Poor sleep quality was observed in 65.9% of patients and was significantly more prevalent among those with moderate-to-severe malnutrition (P < .001). Patients with worse nutritional status exhibited lower albumin and hemoglobin levels, higher CRP, poorer performance status, and worse quality-of-life scores across all domains (P < .001). In multivariable analysis, independent predictors of poor sleep included higher CRP (odds ratio [OR], 1.33 [95% CI, 1.11 to 1.61), lower hemoglobin (OR, 0.66 [95% CI, 0.46 to 0.93]), and poorer nutritional status (SGA C v A, OR, 5.06 [95% CI, 1.70 to 15.05]).CONCLUSION – Malnutrition and systemic inflammation are closely linked with impaired sleep quality and diminished quality of life in mPC. Nutritional screening and targeted interventions may represent an important component of supportive care for optimizing well-being in this population.

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