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- Suleyman, Halis(167)
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Yayınlar
- MakaleAçık Erişim2019Robot-assisted laparoscopic radical prostatectomy: A single center initial experience
Karabulut, Ibrahim; Yılmazel, Fatih Kürşat; Yilmaz, Ali Haydar; Keskin, Ercüment
Aim: The aim of this study is to present the surgical, oncologic and functional results of the first 34 robotic radical prostatectomy(RARP) procedures performed in our clinic.Material and Methods: Data of 34 patients who underwent RARP between July 2017 and October 2019 were evaluated.Results: The mean patient age was 58.73±4.94 years, and the mean preoperative serum prostate-specific antigen level was 8.9±2.07ng/mL. Bilateral neurovascular bundle (NVB) sparing, unilateral NVB-sparing, and non-NVB-sparing surgery were performed in7.5, and 22 cases, respectively. The mean prostate weight was 58.73±26.03g. Anterior reconstruction suture was performed in 22(64.7%) cases. Mean console time, intraoperative blood loss, duration of hospital stay, and urethral catheter removal time were195.2±14.03min, 120.3±21.2cc, 7.34±1.62 days, and 7.26±1.26 days, respectively. Biochemi¬cal recurrence was observed in twopatients, one of whom received maximal androgen blockage (MAB), and the other one received pelvic radiotherapy+MAB. All thepatients with at least one-year follow-up were fully continent (0 pads/day). Of the 16 (47%) patients with no preoperative erectiledysfunction (ED) and with at least three-month follow-up, 9 (62.5%) had no ED, with or without any additional medica¬tion includingphosphodiesterase-5 (PDE5) inhibitors.Conclusion: RARP is a safe minimally invasive procedure with acceptable morbidity, excellent operative, pathological and oncologicaloutcomes, and satisfactory functional results.
- MakaleAçık Erişim2019Molecular Epidemiology of Carbapenemresistant Klebsiella pneumoniae Isolates
Davarcı, İsmail; Samasti, Mustafa; Kuşkucu, Mert Ahmet; Senbayrak, Seniha; Kocoglu, M. Esra; Aksaray, Sebahat
Aim: Carbapenem-resistant Klebsiella pneumoniae infection has become an important clinical problem with reduced therapeutic options. This study aimed to investigate the carbapenem resistancerates and responsible resistance genes in K. pneumoniae isolates derived from clinical samples collected in Istanbul.Materials and Methods: This prospective study included a total of 1452 K. pneumoniae isolates frompatients admitted to our hospital between July 2013 and July 2014. VITEK-2 (bioMérieux, MarcyI’Ѐtoile, France) was used for microbial identification and antimicrobial susceptibility testing. Thecarbapenem-resistant isolates identified by VITEK-2 were also found to be resistant to ertapenemby the ertapenem gradient test. Resistance mechanisms of the carbapenem-resistant isolates wereinvestigated using real time-polymerase chain reaction.Results: Of the 1452 K. pneumoniae isolates, 45 (3.1%) were carbapenem-resistant. Of these, 32(71.1%) were blaOXA-48-positive, 9 (20%) blaNDM-positive, and 1 (2.2%) blaVIM-1-positive. None had thegenes blaKPC and blaIMP-1. The greatest susceptibility by the isolated carbapenemase-producing K.pneumoniae was shown to the antimicrobials amikacin and gentamicin.Discussion and Conclusion: In our hospital, there are several mechanisms causing carbapenem resistance, and the blaOXA-48 positivity rate of 71.1% is significant. This resistance may spread rapidly and,through enzymatic resistance gene transfer, lead to hospital epidemics difficult to manage. For thisreason, accurate and rapid laboratory diagnosis is important in infection control. For faster results,molecular methods, as well as phenotypic methods, must be included in the hospital infrastructure.
- MakaleAçık Erişim2019Erzincan İli Farklı Su Kaynaklarından Cryptosporidium spp’ nin Moleküler Yöntemlerle Tespit Edilmesi
Mor, Neriman; Yalçın, Seçil; Yildirim, Nalan
Cryptosporidium son 30 yıldan beri insan ve birçok hayvan türünde önemli enterik protozoon patojen olarakkabul edilmektedir. Su ise Cryptosporidium’ un taşınmasında en önemli araçlardan biri olarak görülmektedir.Bu nedenle günümüzde Cryptosporidium içme sularında kontrol edilmesi gereken yeni ve en önemlikontaminantlardan biri haline gelmiştir. Buna dayanarak yapılan bu çalışmada Erzincan iline bağlı ilçe veköylerden 2016 yılı Mart ve Ağustos ayları arasında, 6 ay boyunca topam 140 farklı noktadan içme ve kullanmasuyu örneği toplanmıştır. Toplanan örneklere PCR ve LAMP tekniği uygulanmıştır. PCR ile toplananörneklerden 6’ sı (% 4,3) pozitif sonuç verirken, LAMP ile 9’ u (% 6,4 ) Cryptosporidium spp. açısından pozitifolarak bulunmuştur. Çalışmamız sonucunda elde edilen veriler ile geçim kaynağı tarım ve hayvancılık olanErzincan ilinin sularındaki bu kirliliğe, enfekte hayvan dışkılarının çevreye bırakılması ve tarımda kullanılanatık suların çevresel sular aracılığı ile su kaynaklarına ulaşmasından kaynaklandığı,yağan yağmur ve nemlihavanın, içme suyu ve çevresel sularda kontaminasyonu arttırdığı düşünülmektedir.
- MakaleAçık Erişim2019Gözenekli Yapıya Sahip Kalça Protezi Tasarımı ve Uyluk Kemiği Üzerinde Sonlu Elemanlar Analizi
Asl Ghahramanzadeh, Hojjat; Yılmaz Özelçi, Serap; Sarı, Ertuğrul
Uyluk kemiğinin yuvarlak başı (head of femur) kırıklarının tedavisinde, kalça protezi uygulanması sıklıklakullanılmaktadır. Bununla birlikte, kullanılan protezlerin tasarımındaki farklılıklar, kullanılan malzemeözellikleri ve kemik hücrelerinin proteze bağlanması protezlerin biyomekanik davranışını büyük ölçüdeetkilemektedir. Bu çalışmada, uyluk kemiği kırıklarında kullanılan gözenekli yapıya sahip kalça protezi tasarımıgerçekleştirilmiştir. Ayrıca kemiğin iyileşme haftalarına göre sergilediği özellikler de dikkate alınarak sonluelemanlar yöntemiyle analizleri gerçekleştirilmiştir. Bu amaçla, iki parçadan oluşan kalça protezi, ayrıca ikifarklı modelde ve üç farklı yoğunluğa sahip gözenekli yapılar SolidWorks 2018 yazılımı kullanılaraktasarlanmıştır. Kalça protezi malzemesi ve ayrıca farklı iyileşme periyotlarında oluşan kallus yapıların malzemeözellikleri de dikkate alınarak efektif elastisite modülü analizleri yapılmıştır. Daha sonra elde edilen sonuçlaragöre kalça protezi uyluk kemiğine monte edilmiştir. Elde edilen modeller, 1000N’luk eksenel kuvvet altındaANSYS 18.0 yazılımı kullanılarak analiz edilmiştir. Gerçekleştirilen analizler sonucunda; kalça protezindegözenekli yapılar kullanıldığından, yapılarda oluşan gerilmelerin daha düşük değerlerde olduğu tespit edilmiştir.Ayrıca kallus yapısının mekanik özelliklerindeki değişimin, kemik-protez yapısı üzerindeki etkiler bakımındanönemli parametre olduğu sonucuna varılmışt
- MakaleAçık Erişim2019Investigation of the In vitro Effects of Sultamycillin, Cefdinir, Vancomycin Hydrochloride and Colistimethate Sodium Agents Used as Antibiotics on Enzyme Activity of Human Serum Paraoxonase-I
Yildirim, Serhat; Özçelik, Merve Berivan; Kandur, Yaşar
Paraoxonase (PON1; E.C.3.1.8.1) is synthesized in the liver and hydrolyzes its specific substrate, paraoxone. It is an enzyme from the group of A-esterases bound to high density lipoprotein (HDL). The aim of this study was to investigate the in vitro effects of sultamicillin, cefdinir, vancomycin hydrochloride and colistimethate sodium active substances on the PON1 enzyme activity in human serum. The PON1 enzyme from the human serum was purified using ammonium sulfate precipitation (in the range of 60-80%), ion exchange chromatography, and gel filtration chromatography techniques approximately 320,7 fold with 44,6% yield. The paraoxonase activity of the enzyme at 412 nm was investigated to investigate the inhibition effects of the active substances. Paraoxone was used as the substrate. Sultamycillin and vancomycin hydrochloride showed noncompetetive inhibition for the PON1 enzyme, whereas cefdinir showed a uncompetitive inhibition and colistimethate sodium showed a competitive inhibition effect. Ki values are determined for sultamycillin as 38.3 mM; for vancomycin hydrochloride as 5.08 mM; for cefdinir as 0.86 mM; and for colistimethate sodium as 17.01 µM. According to the results, it was determined that the most effective inhibitor colistimethate sodium (IC50: 13.59 µM) was found on the PON1 enzyme with 50% reduction in activity at very low concentration.
- MakaleAçık Erişim2019The evaluation of oxidative stress parameters in the benign prostatic hyperplasia, prostatitis and prostate cancer
Gürsul, Cebrail; Sayar, İlyas; Aydın, Merve; Çıkman, Aytekin; Bozkurt, Aliseydi; Karabakan, Mehmet
Aim: Recently, oxidative stress has been well known that it has especially important a role in benign prostatic hyperplasia, prostatitis, and prostate cancer. The present study has planned to estimate parameters of the oxidative stress and the antioxidant status in patients with benign prostatic hyperplasia, prostatitis and prostate cancer.Material and Method: For this aim totally fourty men with benign prostatic hyperplasia (n=14), prostatitis (n=15) and prostate cancer (n=11) without any other chronic disease, and who not use cigarettes and alcohol were subjected. Venous blood samples were taken. Thiobarbituric acid reaction (TBARS), total oxidant status (TOS), total antioxidant capacity (TAC), glutathione (GSH) levels, and catalase (CAT) activity in serum were assessed in patient with prostatitis, and prostate cancer compared to benign prostatic hyperplasia.Results: It was viewed that GSH levels were significantly lower, TBARS and TOS levels were significantly higher in patients with of prostate cancer compared to benign prostatic hyperplasia. Also, GSH and CAT significant different was determined in prostatitis compared to BPH. Oxidative stress may be concluded in prostate cancer and prostatitis, proved via the higher TBARS levels and lower GSH levels.Conclusion: The increased activity of antioxidant enzyme may be a compensatory regulation in response to oxidative stress.
- MakaleAçık Erişim2019Evaluation of Cochlear Nerve Diameter with MRI in Patients with Idiopathic Unilateral Sensorineural Hearing Loss
Taydas, Onur; Inan, Caner
Objective The aim of this study was to evaluate the cochlear nerve diameter in patients with unilateral sensorineural hearing loss and to compare the diameter of the normal sidewith the hearing loss side.Materialsand MethodsA total of 36 patients with idiopathic unilateral sensorineural hearing loss were included in the study. Magnetic resonance imaging (MRI) and pure sound audiogram wereperformed on all the patients. Both cochlear nerve diameters were measured on axial thin-section constructive interference in steady state (CISS) sequences.Results The patients were comprised of 16 males and 20 females with a mean age of 52.3±13.7 years. Hearing loss was in the right ear in 11 patients, and in the left ear in 25. Theaverage cochlear nerve diameter on the side with hearing loss was 0.13 cm while it was 0.19 cm on the normal side. There was a statistically significant difference betweenthe two sides (p < 0.001).Conclusion In patients with unilateral sensorineural hearing loss, MRI allows the assessment of the cochlear nerve with anatomic detail, and enables the exclusion of possible organicpathologies. Demonstration of decreased cochlear nerve diameter in idiopathic sensorineural hearing loss will contribute to elucidating the etiology of this disease in thefuture.
- MakaleAçık Erişim2019Evaluation of Tracheobronchial Changes in Chronic Obstructive Pulmonary Disease with Computed Tomography
Ünver, Edhem; Kupeli, Ali
Objective In this study, we aimed to evaluate the tracheabronchial changes in patients with chronic obstructive pulmonary disease (COPD) with computed tomography (CT). Materials and Methods Between August 2018 and February 2019, 144 patients who underwent pulmonary function test (PFT) and thorax CT were retrospectively evaluated. Patients were divided into two groups as obstructive and normal according to PFT results. Height, weight and body mass index (BMI) of the groups were recorded. Transverse length (TL) and anteroposterior length (APL), tracheal index (TI), right-left tracheobrochial angle (TBA), interbronchial angle (IBA) values and tracheal morphology were recorded from thorax CT. These parameters were compared between the groups. Results Of the 144 patients included in the study, 52 (33.7%) patients (46 males, 6 females; mean age, 63.9 y) had COPD, while 92 of them (66.3%) (53 males, 39 females; mean age, 62.5 y) had normal PFT. There was no statistically significant difference between these two groups in terms of mean age, height, body weight, BMI, TL, right-left TBA and IBA values (p=0.104). APL and TI values were significantly higher in COPD patients (p<0.001). In addition, there was a significantly higher flattened morphology in the trachea in patients with COPD (p<0.001). Conclusion Increases in TI, APL values and flattened tracheal morphology were observed more frequently in patients with COPD.
- MakaleAçık Erişim2019The Diagnosis of Neuromyelitis Optica by Biopsy in a Patient with Long Spinal Cord Lesion: A Case Report
Öcal, Ruhsen; Tanoglu, Ceyda; Toprak, Munire Kilinc
Neuromyelitis Optica Spectrum Diseases (NMOSD) is an inflammatory demyelinating disease, which is characterized by recurrent optic neuritis, longitudinal long-segment transverse myelitis attacks and Aquaporin-4 antibody positivity. Except NMOSD, long-segment longitudinal transverse myelitis can be also detected in systemic autoimmune diseases, spinal cord tumors, spinal vascular pathologies, Early detection and treatment of NMOSD is very important as the disease may cause severe disability in young population. A 23-year-old female patient was admitted to our clinic with acute paraplegia and urine incontinence. Spinal Magnetic Resonance Imaging showed a densly edematose, contrast enhanced lesion longitudinally extending between C7 and T7 in the spinal cord. As the lesion was reported to be an astrocytoma, a biopsy was performed. However, pathological stainings revelaed no tumor. NMOSD was verified later with Aquaporin-4 positivity. Although longitudinally extending spinal cord lesions are not rare in NMOSD, our patient’s lesion was very edematose and longer than expected that deserved reporting.
- MakaleAçık Erişim2019Relationship Between C-Reactive Protein to Albumin Ratio and Thrombus Burden in Patients With Acute Coronary Syndrome
Duman, Hakan; Çinier, Goksel; Bakirci, Eftal Murat; Duman, Handan; Simsek, Ziya; Hamur, Hikmet; Degirmenci, Huesnue; Emlek, Nadir
Increased coronary thrombus burden is known to be a strong predictor of adverse cardiovascular (CV) outcomes. C-reactive protein to albumin ratio (CAR) can be used as a surrogate marker of pro-inflammation which is closely related to prothrombotic state. We aimed to evaluate the association between CAR and coronary thrombus burden in patients who presented with acute coronary syndrome (ACS). Patients who presented with ACS and treated with primary percutaneous coronary intervention were included in the study. Patients were divided into 2 groups as high thrombus burden and low thrombus burden. The study population included 347 patients with non-ST-segment elevation myocardial infarction (169 [48.7%]) and ST-segment elevation myocardial infarction (178 [51.3%]). The CAR was significantly higher in patients with higher thrombus burden (24.4 [1.2-30.2] vs 31.9 [2.2-31.3], P < .001). Independent predictors for increased thrombus burden were higher CRP level (odds ratio [OR]: 0.047; 95% confidence interval [CI]: 0.004-0.486; P = .010), lower serum albumin level (OR: 0.057; 95% CI: 0.033-0.990; P = .049), higher CAR (OR: 1.13; 95% CI: 1.03-1.23; P = .008), higher neutrophil-lymphocyte ratio (OR: 1.18; 95% CI: 1.05-1.31; P = .004), and baseline troponin I level (OR: 1.06; 95% CI: 1.01-1.13; P = .017). Novel CAR can be used as a reliable marker for increased coronary thrombus burden that is associated with adverse CV outcomes.
- BildiriAçık Erişim2019Does Locoregional Treatment in de Novo Stage IV Bone-Only Metastatic Breast Cancer Prolong Survival? An Ongoing Multicenter Registry Study
Soran, Atilla; Isik, Arda; Dogan, Lutfi; Sezgin, Efe; Ozbas, Serdar
- MakaleYalnız künye2019Effect of Hippophae rhamnoides extract on Cisplatin-induced ototoxicity in Guinea Pigs
Erhan, Ertugrul; Mammadov, Renad; Altuner, Durdu; Cimen, Ferda; Kurt, Nezahat; Hacimuftuoglu, Fazil; Turan, Fatih; Terzi, Suat; Celiker, Metin; Suleyman, Halis
No previous studies have examined the effect of Hippophae rhamnoides fruit extract (HRE), which contains both water and fat soluble vitamins, on cisplatin-induced ototoxicity. Therefore, the aim of the study was to investigate the effects of FIRE on cisplatin-induced ototoxicity in Guinea pigs and to evaluate the biochemical, gene expression and histopathological changes associated with cisplatin use. Experimental animals were divided into three groups: healthy (HG), HRE+cisplatin (HRC) and cisplatin control (CCG) groups. Biochemical, gene expression and histopathological examinations were carried on the removed inner ear tissues. In the HRC group, the oxidant parameter was lower and the anti-oxidant parameter was higher than in the CCG. These results are supported by gene expression levels and histopathological results. The use of FIRE against cisplatin-induced oxidative ototoxicity may be easier, more cost effective and more beneficial than the use of vitamins alone or in combination with each other.
- MakaleAçık Erişim2019Microsurgery Results in Vestibular Schwannoma Patients: Retrospective Clinical Study
Can, Halil; Dolgun, Muge; Özgen, Utku; Gömleksiz, Cengiz; Diren, Furkan; Aydoseli, Aydin; Aras, Yavuz; Sencer, Altay
Objective: Nowadays due to developing imaging techniques, vestibular schwannoma cases are monitored more frequently. In this study, the results of the patients who underwent surgery in the Department of Neurosurgery, Istanbul University Istanbul School of Medicine were retrospectively evaluated. Methods: Radiological and clinical findings of 18 patients with vestibular schwannoma diagnosed in our clinic from 2012 to 2017 were evaluated. After describing the possible treatment methods of the disease in detail, oral and written informed consent was obtained from all of them. Results: In our study, 18 patients, consisting of 13 women and 5 males, were examined. Eleven patients were found with a mass diameter below 3 cm, and seven patients were found with mass diameter above 3 cm. All patients underwent mass resection with retrosigmoid craniotomy. Total resection was performed in 11 patients, and subtotal resection was done in 7 patients. In seven patients with total resection (63.6%), a newly developed facial paresis was observed. The newly developed glossopharyngeal nerve paresis was observed in three patients (27.2%), and also abducens nerve paresis in three patients (27.2%). The facial nerve was preserved at a rate of 42% in tumors larger than 3 cm in size. The CSF fistula developed in one patient (5.5%); hydrocephalus developed in one patient (5.5%). Conclusion: In cases of vestibular schwannoma, microsurgery, radiosurgery, and wait/follow approaches are monitored. Although gold is standard microsurgery in tumors sized above 3 cm, the treatment plan for tumors under 3 cm in size is controversial. In this study, postoperative facial paresis was developed in all patients with total resection, which were below the mass size of 3 cm. The fact that the abducens and glossopharyngeal nerve paresis in patients with total resection have been seen less frequently in patients with subtotal resection is a factor that can affect the decision of total-subtotal resection. Therefore, the treatment plan should be taken into consideration (total resection/subtotal resection + radiosurgery) considering the existing neuromonitoring facilities in tumors larger than 3 cm in size.
- MakaleAçık Erişim2019Death Rates and Causes of Death in Turkey Between 2009 and 2016 Based on TUIK Data
Akturan, Selcuk; Gümüs, Burak; Özer, Omer; Balandiz, Huseyin; Erenler, Ali Kemal
Objective: Death statistics are useful in determining the trends and differences in death in society, priorities in biomedical research, public health programs, decisions on the distribution of funding resources, and aspects of epidemiological studies. The death statistics obtained from different sources in regular intervals, and share them with the health care administrators and health professions is a frequently used method in developed countries. In this study, we aimed to provide an important resource, including mortality rates and causes, that can be used by health care administrators and health professions. Methods: In our study, data from differents sources and time intervals were used, which were shared by Turkey Statistical Institute (TUIK) 's. From the TUIK database, the causes of death, death rates and population data between 2009-2016 were collected, analysed and classified Results: Death rate tended to increase in both genders for each year between 2009 and 2016 in Turkey. The most common cause of death was circulatory system diseases. The majority of deaths occurred in winter months. When regional distribution of diseases was investigated, it was determined that death related to circulatory and respiratory systems were higher in Western and Eastern parts of the Karadeniz region. The circulatory system disorders, malignities and respiratory system disorders were the most common causes of death in both genders. Conclusion: Determining of death rates and causes of death help reduce the health expenditures and create more rational policies for the health care services and health budget.
- MakaleAçık Erişim2019Evaluation of Antioxidant, Antimicrobial, Antityrosinase and Cytotoxic Potentials of Isatis cappadocica subsp. alyssifoli as a Potent Pharmaceutical Resource
Güner, Meltem; Kalaycioglu, Atila Taner; Kanbolat, Seyda; Korkmaz, Nuriye; Aliyazicioglu, Rezzan; Abudayyak, Mahmoud; Kandemir, Ali; Karaoglu, Sengul Alpay; Ozgen, Ufuk
Isatis species, which are endemic across most of Turkey, exhibit antibacterial, anticancer and antiviral effects. The aim of this study was to determine of antioxidant, antimicrobial, tyrosinase inhibitor, cytotoxic activities, and phenolic profile of polar extracts of Isatis cappadocica Desv. We analyzed the antioxidant properties of extracts using total phenolic content (TPC), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), and 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity. The phenolic composition of methanolic extract of I. cappadocica was analyzed by reverse phase high performance liquid chromatography (RP-HPLC). Extracts' antimicrobial properties were evaluated based on the agar well diffusion technique. Tyrosinase inhibitory activity was measured colorimetrically. Methanolic extract yielded better FRAP and CUPRAC results and aqueous extract yielded better DPPH activity. Benzoic acid, and sinapic acid were detected as major phenolic compounds. Methanolic extract was particularly effective against all the bacteria investigated, apart from Yersinia pseudotuberculosis. Methanol extract was exhibited tyrosinase inhibitory activity. The methanol extract has caused to death of cells by dosage in the high concentrations cytotoxic activity on the PC-3 and 3T3 cell lines. The results showed that I. cappadocica could be used as a natural source in the food, cosmetic, and drug industries due to their rich antioxidant, antimicrobial, cytotoxic and tyrosinase inhibitor activities.
- MakaleAçık Erişim2019Why Helicobacter Pylori Eradication is Important?
Çinar, Hamza; Akalin, Cagri; Kaya, Yasemin; Büyükakincak, Sercan; Eken, Huseyin
Background: It was aimed to determine the frequency of Helicobacter pylori (Hp) in patients who were made upper gastrointestinal system endoscopy and antrum biopsy due to dyspeptic complaints and to investigate the relation of Sydney classification criteria with Hp. Materials and Methods: Patients who underwent esophagogastroduodenoscopy and taking antrum biopsy for dyspeptic complaints were included in the study between January 2015 and May 2017 at Ordu University Medical Faculty and Ordu State Hospital Endoscopy Units. Biopsy results of the patients were retrospectively analyzed. Results: The number of the patients was 526. 47.7% (n = 251) of the patients were female and 52.3% (n = 275) were male. The mean age of the cases was 53.65 +/- 16.44 years (min 17 -max 93). 68.1% (n: 358) of the patients were Hp positive and 31.9% (n = 168) were Hp negative. In patients; the results of activation (+) in 75.9% (n: 399), intestinal metaplasia in 15.2% (n = 80) (+), glandular atrophy (+) in 8.6% (n = 45) were observed. All biopsies had inflammation. The severity of Inflammation in cases was 47.53% (n = 250) mild, 41.45% (n = 218) moderate, and 11.02% (n = 58) severe. When we evaluate the relationship between inflammation, activation, intestinal metaplasia and glandular atrophy with Hp, it was observed that all the criteria were significantly higher in patients with Hp (+) than Hp (-). There were severe inflammation in 3 (1.78%) of 168 patients with Hp (-) and 55 (15.4%) of 358 patients with Hp (+) (p:0,000). 320 (89.4%) of the 358 patients with Hp (+) and 79 (47%) of the 168 patients with Hp (-) had activation (p:0,000). Intestinal metaplasia was observed in 63 (17.6%) of the 358 patients with Hp (+) and 17 (10.1%) of 168 patients with Hp(-)(p:0,015). Glandular atrophy was observed in 41 (11.45%) of 358 patients with Hp(+) and in 4 (2.38%) of the 168 patients with Hp (-) (p: 0,000). Conclusion: The prevalence of Hp in the community is still high. In patients with Hp (+), activation, inflammation severity, intestinal metaplasia and glandular atrophy rates are higher than those with Hp (-). Intestinal metaplasia and glandular atrophy are precancerous lesions. Early diagnosis and eradication of Hp may prevent the formation of precancerous lesions. Hp eradication can prevent not only stomach cancer but also many stomach diseases at the same time. Early diagnosis and eradication of Hp is important.
- BildiriYalnız künye2019Measurement of myo-inositol oxygenase as an early biomarker in renal ischemia - reperfusion injury in rats
Mertoglu, C.; Ozmen, Z. C.; Firat, F.; Arici, A.; Unsal, V.; Erdemir, F.
- MakaleAçık Erişim2019Determination of Phenolic Contents by HPLC, and Antioxidant, Antimicrobial, Antityrosinase, and Anticholinesterase Activities of Psephellus huber-morathii
Korkmaz, Nuriye; Sener, Sila Ozlem; Balturk, Nuray; Kanbolat, Seyda; Badem, Merve; Aliyazicioglu, Rezzan; Ozgen, Ufuk; Kandemir, Ali; Karaoglu, Sengul Alpay
The goal of our study was to examine of antioxidant, antimicrobial, anticholinesterase activities, and phenolic composition of Psephellus huber-morathii. The antioxidant activities of extracts have been assessed by Ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), and 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging. Phenolic constituents were measured using reverse phase-high performance liquid chromatography (RP-HPLC), and antimicrobial activity was investigated using the agar well diffusion method. Total phenolic content, FRAP, and CUPRAC results of aqueous extract have been better than methanolic extract, except for DPPH activity. Benzoic acid, and p-coumaric acid as major phenolic compounds were specified. Methanolic extract was especially effective against all microorganisms tested except for Yersinia pseudotuberculosis. The methanolic extract have been displayed inhibitory effect on tyrosinase. All extracts have been exhibited lower acetylcholinesterase, and butyrylcholinesterase inhibitory activities than galantamine. P. huber-morathii can be considered in the food, and drug industries due to antioxidant capacity and antimicrobial activities of the species. It can be potential source as anti-browning agents because of its average tyrosinase inhibitory activity.
- MakaleAçık Erişim2019Gratitude, Hope, Optimism and Life Satisfaction as Predictors of Psychological Well-Being
Kardas, Ferhat; Cam, Zekeriya; Eskisu, Mustafa; Gelibolu, Sedat
Purpose: The mainstream psychology has mostly focused on the negative factors that threaten human mental health. With the emergence of positive psychology approach, the human strengths have started to be studied and the number of studies on the issue of happiness and well-being has increased. The aim of this research is to reveal the level of prediction for psychological well-being by the variables of gratitude, hope, optimism and life satisfaction. Method: Research sample consisted of 510 students from various faculties and departments of four different universities. The study group consisted of 359 female (70.4%) and 151 male (29.6%) university students. The age range of participants varied between 17 and 30. Findings: All the variables discussed in the study were positively related to each other, and the variables of gratitude, optimism, hope, and life satisfaction all together accounted for about 51% of the variance of psychological well-being. Gratitude was determined as the most predictive variable for well-being and it was followed by the variables; hope, optimism, and life satisfaction, respectively. Accordingly; gratitude predicted 35.4% of the variance in well-being alone; gratitude and hope predicted 45.4% together; gratitude, hope, and optimism predicted 48.8% together; while gratitude, hope, optimism, and life satisfaction predicted 50.7% percent altogether. Implications for Research and Practice: These findings are thought to be important in terms of revealing variables that predict well-being with a high level of variance. It is thought that these findings can be used in the field of mental health especially by the researchers and practitioners using intervention studies. Especially, since the gratitude level accounts for 35.4% of the variance in well-being alone, gratitude interventions can effectively be used to improve well-being level. (C) 2019 Ani Publishing Ltd. All rights reserved
- MakaleAçık Erişim2019Rare Breast Malignancies
Yildirim, Nilgun; Aldemir, Mehmet Naci; Simsek, Melih; Bilici, Mehmet; Tekin, Salim Basol
Objective: Invasive breast cancer is a heterogeneous disease group that has different biological and pathological features, and characterized with different clinical behavior, treatment results, and consequences. The rarity of most specific neoplasies does not allow large or randomized studies to determine optimal treatment. With this study, we aimed to evaluate the clinical and pathological features and treatment options and results of rare breast carcinoma patients that followed and treated in our clinic. Methods: Files of 1280 breast cancer patients admitted to our center between years 2000 and 2016 were evaluated. From these patients, who have rare breast carcinoma subtypes were included and patients with pathological diagnosis of invasive ductal carcinoma and invasive lobular carcinoma were excluded. Seventy-three patients that included in the study were analyzed retrospectively in terms of age, menopausal status, family history, tumor-lymph node-metastasis stage, histological grade, hormone receptor level, human epidermal growth factor receptor2 expression, operation type and overall survival (OS). Results: Eight histological subtypes of breast tumors were evaluated. Significant difference wasn't found between groups in terms of mean age of the patients. In terms of histological subtypes, the most eldest patients were in papillary group, the youngest patients were in tubular group. The mean tumor diameter was also significantly different between groups (p=0.02). The mean age of the patients diagnosed with tubular and mucinous type breast carcinomas were younger than the one reported in literature and the mean tumor diameter was also larger in these tumors. Ratio of patients diagnosed at advanced stages was high (43%). While mucinous and tubular carcinomas were the histological subtypes with the best prognosis, the shortest OS was in primary breast sarcoma and neuroendocrine carcinoma group. Conclusion: Rare breast cancers are a heterogeneous malignity group with different behavior and prognosis. Our results, except some cases, were generally concordant with the data obtained from other studies. These exceptions may be related to race, regional factors, different pathological evaluation, and environmental factors. Nevertheless, comprehensive clinical studies are required because of the rare occurrence these tumors.
